Q86Y27 (BAGE5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
B melanoma antigen 5

Alternative name(s):
Cancer/testis antigen 2.5
Short name=CT2.5

Gene names

Name:

BAGE5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	43 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Unknown. Candidate gene encoding tumor antigens.
Subcellular location	Secreted Potential.
Tissue specificity	Not expressed in normal tissues except in testis. Expressed in melanoma, bladder and lung carcinomas.
Miscellaneous	The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.
Sequence similarities	Belongs to the BAGE family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 43	26	B melanoma antigen 5		PRO_0000020778

Sequences

	Sequence		Length	Mass (Da)
	Q86Y27 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: C6F3AACE4012F1A6	FASTA	43	4,711
	10 20 30 40 MAAGAVFLAL SAQLLQARLM KEESPVVSWR LEPEDGTALC FIF

References

[1]	"New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile." Ruault M., van der Bruggen P., Brun M.-E., Boyle S., Roizes G., De Sario A. Eur. J. Hum. Genet. 10:833-840(2002) [PubMed: 12461691] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"BAGE genes generated by juxtacentromeric reshuffling in the hominidae lineage are under selective pressure." Ruault M., Ventura M., Galtier N., Brun M.-E., Archidiacono N., Roizes G., De Sario A. Genomics 81:391-399(2003) [PubMed: 12676563] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF339516 mRNA. Translation: AAO32636.1.
IPI	IPI00334199.
RefSeq	NP_872290.1. NM_182484.1.
UniGene	Hs.545789.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q86Y27.
Polymorphism databases
DMDM	37537778.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	85316.
KEGG	hsa:85316.
UCSC	uc002yiu.1. human.
Organism-specific databases
CTD	85316.
GeneCards	GC13U990073.
HGNC	HGNC:15732. BAGE5.
neXtProt	NX_Q86Y27.
PharmGKB	PA25246.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG050656.
Gene expression databases
ArrayExpress	Q86Y27.
Genevestigator	Q86Y27.
Family and domain databases
InterPro	IPR012530. BAGE. [Graphical view]
Pfam	PF08180. BAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	75815.

Entry information

Entry name

BAGE5_HUMAN

Accession

Primary (citable) accession number: Q86Y27

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.