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Protein

B melanoma antigen 5

Gene

BAGE5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Unknown. Candidate gene encoding tumor antigens.

Enzyme and pathway databases

BioCyciZFISH:G66-33071-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
B melanoma antigen 5
Alternative name(s):
Cancer/testis antigen 2.5
Short name:
CT2.5
Gene namesi
Name:BAGE5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:15732. BAGE5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25246.

Polymorphism and mutation databases

DMDMi37537778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002077818 – 43B melanoma antigen 5Add BLAST26

Proteomic databases

PaxDbiQ86Y27.
PRIDEiQ86Y27.

Expressioni

Tissue specificityi

Not expressed in normal tissues except in testis. Expressed in melanoma, bladder and lung carcinomas.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000472450.

Structurei

3D structure databases

ProteinModelPortaliQ86Y27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAGE family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG050656.
PhylomeDBiQ86Y27.

Family and domain databases

InterProiIPR012530. BAGE.
[Graphical view]
PfamiPF08180. BAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86Y27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MAAGAVFLAL SAQLLQARLM KEESPVVSWR LEPEDGTALC FIF
Length:43
Mass (Da):4,711
Last modified:June 1, 2003 - v1
Checksum:iC6F3AACE4012F1A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF339516 mRNA. Translation: AAO32636.1.
RefSeqiNP_872290.1. NM_182484.1.
UniGeneiHs.545789.

Genome annotation databases

GeneIDi85316.
KEGGihsa:85316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF339516 mRNA. Translation: AAO32636.1.
RefSeqiNP_872290.1. NM_182484.1.
UniGeneiHs.545789.

3D structure databases

ProteinModelPortaliQ86Y27.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000472450.

Polymorphism and mutation databases

DMDMi37537778.

Proteomic databases

PaxDbiQ86Y27.
PRIDEiQ86Y27.

Protocols and materials databases

DNASUi85316.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi85316.
KEGGihsa:85316.

Organism-specific databases

CTDi85316.
GeneCardsiBAGE5.
HGNCiHGNC:15732. BAGE5.
neXtProtiNX_Q86Y27.
PharmGKBiPA25246.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG050656.
PhylomeDBiQ86Y27.

Enzyme and pathway databases

BioCyciZFISH:G66-33071-MONOMER.

Miscellaneous databases

GenomeRNAii85316.
PROiQ86Y27.

Family and domain databases

InterProiIPR012530. BAGE.
[Graphical view]
PfamiPF08180. BAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBAGE5_HUMAN
AccessioniPrimary (citable) accession number: Q86Y27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.