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Protein

B melanoma antigen 5

Gene

BAGE5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Unknown. Candidate gene encoding tumor antigens.

Miscellaneous

The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.

Names & Taxonomyi

Protein namesi
Recommended name:
B melanoma antigen 5
Alternative name(s):
Cancer/testis antigen 2.5
Short name:
CT2.5
Gene namesi
Name:BAGE5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:15732. BAGE5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25246.

Polymorphism and mutation databases

DMDMi37537778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002077818 – 43B melanoma antigen 5Add BLAST26

Proteomic databases

PaxDbiQ86Y27.
PRIDEiQ86Y27.

Expressioni

Tissue specificityi

Not expressed in normal tissues except in testis. Expressed in melanoma, bladder and lung carcinomas.

Interactioni

Protein-protein interaction databases

IntActiQ86Y27. 1 interactor.

Family & Domainsi

Sequence similaritiesi

Belongs to the BAGE family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG050656.
PhylomeDBiQ86Y27.

Family and domain databases

InterProiView protein in InterPro
IPR012530. BAGE.
PfamiView protein in Pfam
PF08180. BAGE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86Y27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MAAGAVFLAL SAQLLQARLM KEESPVVSWR LEPEDGTALC FIF
Length:43
Mass (Da):4,711
Last modified:June 1, 2003 - v1
Checksum:iC6F3AACE4012F1A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF339516 mRNA. Translation: AAO32636.1.
RefSeqiNP_872290.1. NM_182484.1.
UniGeneiHs.545789.

Genome annotation databases

GeneIDi85316.
KEGGihsa:85316.

Similar proteinsi

Entry informationi

Entry nameiBAGE5_HUMAN
AccessioniPrimary (citable) accession number: Q86Y27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: August 30, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families