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Q86Y26 (NUTM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NUT family member 1
Alternative name(s):
Nuclear protein in testis
Gene names
Name:NUTM1
Synonyms:C15orf55, NUT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1132 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasm. Nucleus. Note: Shuttles between nucleus and cytoplasm. Ref.7

Tissue specificity

Specifically expressed in testis. Ref.1

Post-translational modification

Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.

Involvement in disease

A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUT fusion protein. Ref.1

A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUT fusion protein.

Sequence similarities

Belongs to the NUT family.

Sequence caution

The sequence AAO22237.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Chromosomal rearrangement
Polymorphism
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86Y26-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86Y26-2)

The sequence of this isoform differs from the canonical sequence as follows:
     235-365: Missing.
     565-573: LQPELAAPQ → PPTNGESQC
     574-1132: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11321132NUT family member 1
PRO_0000311394

Regions

Compositional bias10 – 182173Pro-rich

Sites

Site5 – 62Breakpoint for translocation to form BRD4-NUT and BRD3-NUT fusion proteins

Amino acid modifications

Modified residue10261Phosphoserine Probable
Modified residue10291Phosphoserine Probable
Modified residue10311Phosphoserine Probable

Natural variations

Alternative sequence235 – 365131Missing in isoform 2.
VSP_029559
Alternative sequence565 – 5739LQPELAAPQ → PPTNGESQC in isoform 2.
VSP_029560
Alternative sequence574 – 1132559Missing in isoform 2.
VSP_029561
Natural variant221P → L. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs374230 [ dbSNP | Ensembl ].
VAR_037239
Natural variant7811T → M.
Corresponds to variant rs16959028 [ dbSNP | Ensembl ].
VAR_037240
Natural variant7851V → E.
Corresponds to variant rs17236868 [ dbSNP | Ensembl ].
VAR_037241
Natural variant9731T → N.
Corresponds to variant rs2279683 [ dbSNP | Ensembl ].
VAR_037242
Natural variant9851P → R.
Corresponds to variant rs2279684 [ dbSNP | Ensembl ].
VAR_037243
Natural variant11131R → H.
Corresponds to variant rs2279685 [ dbSNP | Ensembl ].
VAR_037244

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 2, 2010. Version 2.
Checksum: 5CB58C1B030399F4

FASTA1,132120,314
        10         20         30         40         50         60 
MASDGASALP GPDMSMKPSA APSPSPALPF LPPTSDPPDH PPREPPPQPI MPSVFSPDNP 

        70         80         90        100        110        120 
LMLSAFPSSL LVTGDGGPCL SGAGAGKVIV KVKTEGGSAE PSQTQNFILT QTALNSTAPG 

       130        140        150        160        170        180 
TPCGGLEGPA PPFVTASNVK TILPSKAVGV SQEGPPGLPP QPPPPVAQLV PIVPLEKAWP 

       190        200        210        220        230        240 
GPHGTTGEGG PVATLSKPSL GDRSKISKDV YENFRQWQRY KALARRHLSQ SPDTEALSCF 

       250        260        270        280        290        300 
LIPVLRSLAR LKPTMTLEEG LPLAVQEWEH TSNFDRMIFY EMAERFMEFE AEEMQIQNTQ 

       310        320        330        340        350        360 
LMNGSQGLSP ATPLKLDPLG PLASEVCQQP VYIPKKAASK TRAPRRRQRK AQRPPAPEAP 

       370        380        390        400        410        420 
KEIPPEAVKE YVDIMEWLVG THLATGESDG KQEEEGQQQE EEGMYPDPGL LSYINELCSQ 

       430        440        450        460        470        480 
KVFVSKVEAV IHPQFLADLL SPEKQRDPLA LIEELEQEEG LTLAQLVQKR LMALEEEEDA 

       490        500        510        520        530        540 
EAPPSFSGAQ LDSSPSGSVE DEDGDGRLRP SPGLQGAGGA ACLGKVSSSG KRAREVHGGQ 

       550        560        570        580        590        600 
EQALDSPRGM HRDGNTLPSP SSWDLQPELA APQGTPGPLG VERRGSGKVI NQVSLHQDGH 

       610        620        630        640        650        660 
LGGAGPPGHC LVADRTSEAL PLCWQGGFQP ESTPSLDAGL AELAPLQGQG LEKQVLGLQK 

       670        680        690        700        710        720 
GQQTGGRGVL PQGKEPLAVP WEGSSGAMWG DDRGTPMAQS YDQNPSPRAA GERDDVCLSP 

       730        740        750        760        770        780 
GVWLSSEMDA VGLELPVQIE EVIESFQVEK CVTEYQEGCQ GLGSRGNISL GPGETLVPGD 

       790        800        810        820        830        840 
TESSVIPCGG TVAAAALEKR NYCSLPGPLR ANSPPLRSKE NQEQSCETVG HPSDLWAEGC 

       850        860        870        880        890        900 
FPLLESGDST LGSSKETLPP TCQGNLLIMG TEDASSLPEA SQEAGSRGNS FSPLLETIEP 

       910        920        930        940        950        960 
VNILDVKDDC GLQLRVSEDT CPLNVHSYDP QGEGRVDPDL SKPKNLAPLQ ESQESYTTGT 

       970        980        990       1000       1010       1020 
PKATSSHQGL GSTLPRRGTR NAIVPRETSV SKTHRSADRA KGKEKKKKEA EEEDEELSNF 

      1030       1040       1050       1060       1070       1080 
AYLLASKLSL SPREHPLSPH HASGGQGSQR ASHLLPAGAK GPSKLPYPVA KSGKRALAGG 

      1090       1100       1110       1120       1130 
PAPTEKTPHS GAQLGVPREK PLALGVVRPS QPRKRRCDSF VTGRRKKRRR SQ 

« Hide

Isoform 2 [UniParc].

Checksum: 95BABF1664CEE540
Show »

FASTA44246,352

References

« Hide 'large scale' references
[1]"BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma."
French C.A., Miyoshi I., Kubonishi I., Grier H.E., Perez-Atayde A.R., Fletcher J.A.
Cancer Res. 63:304-307(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DISEASE, CHROMOSOMAL TRANSLOCATION WITH BRD4, TISSUE SPECIFICITY, VARIANT LEU-22.
Tissue: Carcinoma and Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LEU-22.
Tissue: Testis.
[3]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-22.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-22.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 890-1132 (ISOFORM 1).
Tissue: Testis.
[7]"BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells."
French C.A., Ramirez C.L., Kolmakova J., Hickman T.T., Cameron M.J., Thyne M.E., Kutok J.L., Toretsky J.A., Tadavarthy A.K., Kees U.R., Fletcher J.A., Aster J.C.
Oncogene 27:2237-2242(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL TRANSLOCATION WITH BRD3, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-1026; SER-1029 AND SER-1031.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF482429 mRNA. Translation: AAO39268.1.
AY166680 mRNA. Translation: AAO22237.1. Different initiation.
AK098568 mRNA. Translation: BAC05337.1.
AC021822 Genomic DNA. No translation available.
AC025678 Genomic DNA. No translation available.
CH471125 Genomic DNA. Translation: EAW92304.1.
BC114518 mRNA. Translation: AAI14519.1.
BC114567 mRNA. Translation: AAI14568.1.
AL137416 mRNA. Translation: CAB70729.1.
PIRT46461.
RefSeqNP_001271222.1. NM_001284293.1.
NP_786883.1. NM_175741.2.
UniGeneHs.525769.

3D structure databases

ProteinModelPortalQ86Y26.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129174. 1 interaction.
STRING9606.ENSP00000329448.

PTM databases

PhosphoSiteQ86Y26.

Polymorphism databases

DMDM311033405.

Proteomic databases

PaxDbQ86Y26.
PRIDEQ86Y26.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333756; ENSP00000329448; ENSG00000184507. [Q86Y26-1]
GeneID256646.
KEGGhsa:256646.

Organism-specific databases

CTD256646.
GeneCardsGC15P034636.
HGNCHGNC:29919. NUTM1.
HPAHPA040421.
MIM608963. gene.
neXtProtNX_Q86Y26.
PharmGKBPA162378206.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39838.
HOVERGENHBG107898.
InParanoidQ86Y26.
PhylomeDBQ86Y26.
TreeFamTF337728.

Gene expression databases

ArrayExpressQ86Y26.
BgeeQ86Y26.
CleanExHS_C15orf55.
GenevestigatorQ86Y26.

Family and domain databases

InterProIPR024310. NUT/FAM22.
IPR024313. NUT_C.
IPR024309. NUT_N.
[Graphical view]
PANTHERPTHR22879. PTHR22879. 1 hit.
PfamPF12882. NUT_C. 1 hit.
PF12881. NUT_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi256646.
NextBio92844.
PROQ86Y26.
SOURCESearch...

Entry information

Entry nameNUTM1_HUMAN
AccessionPrimary (citable) accession number: Q86Y26
Secondary accession number(s): Q86YS8, Q8N7F2, Q9NTB3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 2, 2010
Last modified: March 19, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM