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Q86Y26

- NUTM1_HUMAN

UniProt

Q86Y26 - NUTM1_HUMAN

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Protein

NUT family member 1

Gene

NUTM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei5 – 62Breakpoint for translocation to form BRD4-NUT and BRD3-NUT fusion proteins

Names & Taxonomyi

Protein namesi
Recommended name:
NUT family member 1
Alternative name(s):
Nuclear protein in testis
Gene namesi
Name:NUTM1
Synonyms:C15orf55, NUT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:29919. NUTM1.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Shuttles between nucleus and cytoplasm.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUT fusion protein.1 Publication
A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUT fusion protein.1 Publication

Organism-specific databases

PharmGKBiPA162378206.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11321132NUT family member 1PRO_0000311394Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1026 – 10261Phosphoserine1 Publication
Modified residuei1029 – 10291Phosphoserine1 Publication
Modified residuei1031 – 10311Phosphoserine1 Publication

Post-translational modificationi

Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ86Y26.
PRIDEiQ86Y26.

PTM databases

PhosphoSiteiQ86Y26.

Expressioni

Tissue specificityi

Specifically expressed in testis.1 Publication

Gene expression databases

BgeeiQ86Y26.
CleanExiHS_C15orf55.
ExpressionAtlasiQ86Y26. baseline and differential.
GenevestigatoriQ86Y26.

Organism-specific databases

HPAiHPA040421.

Interactioni

Protein-protein interaction databases

BioGridi129174. 2 interactions.
STRINGi9606.ENSP00000329448.

Structurei

3D structure databases

ProteinModelPortaliQ86Y26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 182173Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the NUT family.Curated

Phylogenomic databases

eggNOGiNOG39838.
GeneTreeiENSGT00410000025793.
HOGENOMiHOG000112470.
HOVERGENiHBG107898.
InParanoidiQ86Y26.
OMAiGAMWGDD.
OrthoDBiEOG7F24S5.
PhylomeDBiQ86Y26.
TreeFamiTF337728.

Family and domain databases

InterProiIPR024310. NUT/FAM22.
IPR024313. NUT_C.
IPR024309. NUT_N.
[Graphical view]
PANTHERiPTHR22879. PTHR22879. 1 hit.
PfamiPF12882. NUT_C. 1 hit.
PF12881. NUT_N. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86Y26-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASDGASALP GPDMSMKPSA APSPSPALPF LPPTSDPPDH PPREPPPQPI
60 70 80 90 100
MPSVFSPDNP LMLSAFPSSL LVTGDGGPCL SGAGAGKVIV KVKTEGGSAE
110 120 130 140 150
PSQTQNFILT QTALNSTAPG TPCGGLEGPA PPFVTASNVK TILPSKAVGV
160 170 180 190 200
SQEGPPGLPP QPPPPVAQLV PIVPLEKAWP GPHGTTGEGG PVATLSKPSL
210 220 230 240 250
GDRSKISKDV YENFRQWQRY KALARRHLSQ SPDTEALSCF LIPVLRSLAR
260 270 280 290 300
LKPTMTLEEG LPLAVQEWEH TSNFDRMIFY EMAERFMEFE AEEMQIQNTQ
310 320 330 340 350
LMNGSQGLSP ATPLKLDPLG PLASEVCQQP VYIPKKAASK TRAPRRRQRK
360 370 380 390 400
AQRPPAPEAP KEIPPEAVKE YVDIMEWLVG THLATGESDG KQEEEGQQQE
410 420 430 440 450
EEGMYPDPGL LSYINELCSQ KVFVSKVEAV IHPQFLADLL SPEKQRDPLA
460 470 480 490 500
LIEELEQEEG LTLAQLVQKR LMALEEEEDA EAPPSFSGAQ LDSSPSGSVE
510 520 530 540 550
DEDGDGRLRP SPGLQGAGGA ACLGKVSSSG KRAREVHGGQ EQALDSPRGM
560 570 580 590 600
HRDGNTLPSP SSWDLQPELA APQGTPGPLG VERRGSGKVI NQVSLHQDGH
610 620 630 640 650
LGGAGPPGHC LVADRTSEAL PLCWQGGFQP ESTPSLDAGL AELAPLQGQG
660 670 680 690 700
LEKQVLGLQK GQQTGGRGVL PQGKEPLAVP WEGSSGAMWG DDRGTPMAQS
710 720 730 740 750
YDQNPSPRAA GERDDVCLSP GVWLSSEMDA VGLELPVQIE EVIESFQVEK
760 770 780 790 800
CVTEYQEGCQ GLGSRGNISL GPGETLVPGD TESSVIPCGG TVAAAALEKR
810 820 830 840 850
NYCSLPGPLR ANSPPLRSKE NQEQSCETVG HPSDLWAEGC FPLLESGDST
860 870 880 890 900
LGSSKETLPP TCQGNLLIMG TEDASSLPEA SQEAGSRGNS FSPLLETIEP
910 920 930 940 950
VNILDVKDDC GLQLRVSEDT CPLNVHSYDP QGEGRVDPDL SKPKNLAPLQ
960 970 980 990 1000
ESQESYTTGT PKATSSHQGL GSTLPRRGTR NAIVPRETSV SKTHRSADRA
1010 1020 1030 1040 1050
KGKEKKKKEA EEEDEELSNF AYLLASKLSL SPREHPLSPH HASGGQGSQR
1060 1070 1080 1090 1100
ASHLLPAGAK GPSKLPYPVA KSGKRALAGG PAPTEKTPHS GAQLGVPREK
1110 1120 1130
PLALGVVRPS QPRKRRCDSF VTGRRKKRRR SQ
Length:1,132
Mass (Da):120,314
Last modified:November 2, 2010 - v2
Checksum:i5CB58C1B030399F4
GO
Isoform 2 (identifier: Q86Y26-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     235-365: Missing.
     565-573: LQPELAAPQ → PPTNGESQC
     574-1132: Missing.

Show »
Length:442
Mass (Da):46,352
Checksum:i95BABF1664CEE540
GO
Isoform 3 (identifier: Q86Y26-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MASD → MFQRSNQDLKLGPYRKFSALSY

Note: No experimental confirmation available.

Show »
Length:1,150
Mass (Da):122,542
Checksum:i2E4F0F3BB53FC785
GO
Isoform 4 (identifier: Q86Y26-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVVTLGPGPDCLILEASRQPQLVPKPERM

Note: No experimental confirmation available.

Show »
Length:1,160
Mass (Da):123,341
Checksum:iD315516EBE03B8E5
GO

Sequence cautioni

The sequence AAO22237.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti332 – 3321Y → H in BAG63912. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221P → L.4 Publications
Corresponds to variant rs374230 [ dbSNP | Ensembl ].
VAR_037239
Natural varianti781 – 7811T → M.
Corresponds to variant rs16959028 [ dbSNP | Ensembl ].
VAR_037240
Natural varianti785 – 7851V → E.
Corresponds to variant rs17236868 [ dbSNP | Ensembl ].
VAR_037241
Natural varianti973 – 9731T → N.
Corresponds to variant rs2279683 [ dbSNP | Ensembl ].
VAR_037242
Natural varianti985 – 9851P → R.
Corresponds to variant rs2279684 [ dbSNP | Ensembl ].
VAR_037243
Natural varianti1113 – 11131R → H.
Corresponds to variant rs2279685 [ dbSNP | Ensembl ].
VAR_037244

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 44MASD → MFQRSNQDLKLGPYRKFSAL SY in isoform 3. 1 PublicationVSP_055644
Alternative sequencei1 – 11M → MVVTLGPGPDCLILEASRQP QLVPKPERM in isoform 4. 1 PublicationVSP_055645
Alternative sequencei235 – 365131Missing in isoform 2. 1 PublicationVSP_029559Add
BLAST
Alternative sequencei565 – 5739LQPELAAPQ → PPTNGESQC in isoform 2. 1 PublicationVSP_029560
Alternative sequencei574 – 1132559Missing in isoform 2. 1 PublicationVSP_029561Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF482429 mRNA. Translation: AAO39268.1.
AY166680 mRNA. Translation: AAO22237.1. Different initiation.
AK098568 mRNA. Translation: BAC05337.1.
AK302656 mRNA. Translation: BAH13770.1.
AK302680 mRNA. Translation: BAG63912.1.
AC021822 Genomic DNA. No translation available.
AC025678 Genomic DNA. No translation available.
CH471125 Genomic DNA. Translation: EAW92304.1.
BC114518 mRNA. Translation: AAI14519.1.
BC114567 mRNA. Translation: AAI14568.1.
AL137416 mRNA. Translation: CAB70729.1.
CCDSiCCDS32190.1. [Q86Y26-1]
CCDS61584.1. [Q86Y26-3]
CCDS61585.1. [Q86Y26-4]
PIRiT46461.
RefSeqiNP_001271221.1. NM_001284292.1.
NP_001271222.1. NM_001284293.1.
NP_786883.1. NM_175741.2.
UniGeneiHs.525769.

Genome annotation databases

EnsembliENST00000333756; ENSP00000329448; ENSG00000184507. [Q86Y26-1]
ENST00000438749; ENSP00000407031; ENSG00000184507. [Q86Y26-3]
ENST00000537011; ENSP00000444896; ENSG00000184507. [Q86Y26-4]
ENST00000614490; ENSP00000478903; ENSG00000184507. [Q86Y26-1]
GeneIDi256646.
KEGGihsa:256646.

Polymorphism databases

DMDMi311033405.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF482429 mRNA. Translation: AAO39268.1 .
AY166680 mRNA. Translation: AAO22237.1 . Different initiation.
AK098568 mRNA. Translation: BAC05337.1 .
AK302656 mRNA. Translation: BAH13770.1 .
AK302680 mRNA. Translation: BAG63912.1 .
AC021822 Genomic DNA. No translation available.
AC025678 Genomic DNA. No translation available.
CH471125 Genomic DNA. Translation: EAW92304.1 .
BC114518 mRNA. Translation: AAI14519.1 .
BC114567 mRNA. Translation: AAI14568.1 .
AL137416 mRNA. Translation: CAB70729.1 .
CCDSi CCDS32190.1. [Q86Y26-1 ]
CCDS61584.1. [Q86Y26-3 ]
CCDS61585.1. [Q86Y26-4 ]
PIRi T46461.
RefSeqi NP_001271221.1. NM_001284292.1.
NP_001271222.1. NM_001284293.1.
NP_786883.1. NM_175741.2.
UniGenei Hs.525769.

3D structure databases

ProteinModelPortali Q86Y26.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129174. 2 interactions.
STRINGi 9606.ENSP00000329448.

PTM databases

PhosphoSitei Q86Y26.

Polymorphism databases

DMDMi 311033405.

Proteomic databases

PaxDbi Q86Y26.
PRIDEi Q86Y26.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333756 ; ENSP00000329448 ; ENSG00000184507 . [Q86Y26-1 ]
ENST00000438749 ; ENSP00000407031 ; ENSG00000184507 . [Q86Y26-3 ]
ENST00000537011 ; ENSP00000444896 ; ENSG00000184507 . [Q86Y26-4 ]
ENST00000614490 ; ENSP00000478903 ; ENSG00000184507 . [Q86Y26-1 ]
GeneIDi 256646.
KEGGi hsa:256646.

Organism-specific databases

CTDi 256646.
GeneCardsi GC15P034636.
HGNCi HGNC:29919. NUTM1.
HPAi HPA040421.
MIMi 608963. gene.
neXtProti NX_Q86Y26.
PharmGKBi PA162378206.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39838.
GeneTreei ENSGT00410000025793.
HOGENOMi HOG000112470.
HOVERGENi HBG107898.
InParanoidi Q86Y26.
OMAi GAMWGDD.
OrthoDBi EOG7F24S5.
PhylomeDBi Q86Y26.
TreeFami TF337728.

Miscellaneous databases

ChiTaRSi NUTM1. human.
GenomeRNAii 256646.
NextBioi 35476356.
PROi Q86Y26.
SOURCEi Search...

Gene expression databases

Bgeei Q86Y26.
CleanExi HS_C15orf55.
ExpressionAtlasi Q86Y26. baseline and differential.
Genevestigatori Q86Y26.

Family and domain databases

InterProi IPR024310. NUT/FAM22.
IPR024313. NUT_C.
IPR024309. NUT_N.
[Graphical view ]
PANTHERi PTHR22879. PTHR22879. 1 hit.
Pfami PF12882. NUT_C. 1 hit.
PF12881. NUT_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma."
    French C.A., Miyoshi I., Kubonishi I., Grier H.E., Perez-Atayde A.R., Fletcher J.A.
    Cancer Res. 63:304-307(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DISEASE, CHROMOSOMAL TRANSLOCATION WITH BRD4, TISSUE SPECIFICITY, VARIANT LEU-22.
    Tissue: Carcinoma and Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), VARIANT LEU-22.
    Tissue: Testis.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-22.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-22.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 890-1132 (ISOFORM 1).
    Tissue: Testis.
  7. "BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells."
    French C.A., Ramirez C.L., Kolmakova J., Hickman T.T., Cameron M.J., Thyne M.E., Kutok J.L., Toretsky J.A., Tadavarthy A.K., Kees U.R., Fletcher J.A., Aster J.C.
    Oncogene 27:2237-2242(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH BRD3, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-1026; SER-1029 AND SER-1031.

Entry informationi

Entry nameiNUTM1_HUMAN
AccessioniPrimary (citable) accession number: Q86Y26
Secondary accession number(s): B4DZ00
, B7Z7Y4, E7EVE8, F5H4I6, Q86YS8, Q8N7F2, Q9NTB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 2, 2010
Last modified: November 26, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3