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Protein

NUT family member 1

Gene

NUTM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
NUT family member 1
Alternative name(s):
Nuclear protein in testis
Gene namesi
Name:NUTM1
Synonyms:C15orf55, NUT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:29919. NUTM1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUT fusion protein.1 Publication
A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUT fusion protein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei5 – 6Breakpoint for translocation to form BRD4-NUT and BRD3-NUT fusion proteins2

Organism-specific databases

DisGeNETi256646.
MalaCardsiNUTM1.
OpenTargetsiENSG00000184507.
PharmGKBiPA162378206.

Polymorphism and mutation databases

BioMutaiNUTM1.
DMDMi311033405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113941 – 1132NUT family member 1Add BLAST1132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1026Phosphoserine1 Publication1
Modified residuei1029Phosphoserine1 Publication1
Modified residuei1031Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ86Y26.
PeptideAtlasiQ86Y26.
PRIDEiQ86Y26.

PTM databases

iPTMnetiQ86Y26.
PhosphoSitePlusiQ86Y26.

Expressioni

Tissue specificityi

Specifically expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000184507.
CleanExiHS_C15orf55.
GenevisibleiQ86Y26. HS.

Organism-specific databases

HPAiHPA040421.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi129174. 23 interactors.
IntActiQ86Y26. 24 interactors.
STRINGi9606.ENSP00000329448.

Structurei

3D structure databases

ProteinModelPortaliQ86Y26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 182Pro-richAdd BLAST173

Sequence similaritiesi

Belongs to the NUT family.Curated

Phylogenomic databases

eggNOGiENOG410IJ5E. Eukaryota.
ENOG4111830. LUCA.
GeneTreeiENSGT00410000025793.
HOGENOMiHOG000112470.
HOVERGENiHBG107898.
InParanoidiQ86Y26.
OMAiTQTALNW.
OrthoDBiEOG091G04K7.
PhylomeDBiQ86Y26.
TreeFamiTF337728.

Family and domain databases

InterProiView protein in InterPro
IPR024310. NUT.
IPR024309. NUT_N.
PANTHERiPTHR22879. PTHR22879. 1 hit.
PfamiView protein in Pfam
PF12881. NUT. 2 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86Y26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASDGASALP GPDMSMKPSA APSPSPALPF LPPTSDPPDH PPREPPPQPI
60 70 80 90 100
MPSVFSPDNP LMLSAFPSSL LVTGDGGPCL SGAGAGKVIV KVKTEGGSAE
110 120 130 140 150
PSQTQNFILT QTALNSTAPG TPCGGLEGPA PPFVTASNVK TILPSKAVGV
160 170 180 190 200
SQEGPPGLPP QPPPPVAQLV PIVPLEKAWP GPHGTTGEGG PVATLSKPSL
210 220 230 240 250
GDRSKISKDV YENFRQWQRY KALARRHLSQ SPDTEALSCF LIPVLRSLAR
260 270 280 290 300
LKPTMTLEEG LPLAVQEWEH TSNFDRMIFY EMAERFMEFE AEEMQIQNTQ
310 320 330 340 350
LMNGSQGLSP ATPLKLDPLG PLASEVCQQP VYIPKKAASK TRAPRRRQRK
360 370 380 390 400
AQRPPAPEAP KEIPPEAVKE YVDIMEWLVG THLATGESDG KQEEEGQQQE
410 420 430 440 450
EEGMYPDPGL LSYINELCSQ KVFVSKVEAV IHPQFLADLL SPEKQRDPLA
460 470 480 490 500
LIEELEQEEG LTLAQLVQKR LMALEEEEDA EAPPSFSGAQ LDSSPSGSVE
510 520 530 540 550
DEDGDGRLRP SPGLQGAGGA ACLGKVSSSG KRAREVHGGQ EQALDSPRGM
560 570 580 590 600
HRDGNTLPSP SSWDLQPELA APQGTPGPLG VERRGSGKVI NQVSLHQDGH
610 620 630 640 650
LGGAGPPGHC LVADRTSEAL PLCWQGGFQP ESTPSLDAGL AELAPLQGQG
660 670 680 690 700
LEKQVLGLQK GQQTGGRGVL PQGKEPLAVP WEGSSGAMWG DDRGTPMAQS
710 720 730 740 750
YDQNPSPRAA GERDDVCLSP GVWLSSEMDA VGLELPVQIE EVIESFQVEK
760 770 780 790 800
CVTEYQEGCQ GLGSRGNISL GPGETLVPGD TESSVIPCGG TVAAAALEKR
810 820 830 840 850
NYCSLPGPLR ANSPPLRSKE NQEQSCETVG HPSDLWAEGC FPLLESGDST
860 870 880 890 900
LGSSKETLPP TCQGNLLIMG TEDASSLPEA SQEAGSRGNS FSPLLETIEP
910 920 930 940 950
VNILDVKDDC GLQLRVSEDT CPLNVHSYDP QGEGRVDPDL SKPKNLAPLQ
960 970 980 990 1000
ESQESYTTGT PKATSSHQGL GSTLPRRGTR NAIVPRETSV SKTHRSADRA
1010 1020 1030 1040 1050
KGKEKKKKEA EEEDEELSNF AYLLASKLSL SPREHPLSPH HASGGQGSQR
1060 1070 1080 1090 1100
ASHLLPAGAK GPSKLPYPVA KSGKRALAGG PAPTEKTPHS GAQLGVPREK
1110 1120 1130
PLALGVVRPS QPRKRRCDSF VTGRRKKRRR SQ
Length:1,132
Mass (Da):120,314
Last modified:November 2, 2010 - v2
Checksum:i5CB58C1B030399F4
GO
Isoform 2 (identifier: Q86Y26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     235-365: Missing.
     565-573: LQPELAAPQ → PPTNGESQC
     574-1132: Missing.

Show »
Length:442
Mass (Da):46,352
Checksum:i95BABF1664CEE540
GO
Isoform 3 (identifier: Q86Y26-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MASD → MFQRSNQDLKLGPYRKFSALSY

Note: No experimental confirmation available.
Show »
Length:1,150
Mass (Da):122,542
Checksum:i2E4F0F3BB53FC785
GO
Isoform 4 (identifier: Q86Y26-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVVTLGPGPDCLILEASRQPQLVPKPERM

Note: No experimental confirmation available.
Show »
Length:1,160
Mass (Da):123,341
Checksum:iD315516EBE03B8E5
GO

Sequence cautioni

The sequence AAO22237 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti332Y → H in BAG63912 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03723922P → L4 PublicationsCorresponds to variant dbSNP:rs374230Ensembl.1
Natural variantiVAR_037240781T → M. Corresponds to variant dbSNP:rs16959028Ensembl.1
Natural variantiVAR_037241785V → E. Corresponds to variant dbSNP:rs17236868Ensembl.1
Natural variantiVAR_037242973T → N. Corresponds to variant dbSNP:rs2279683Ensembl.1
Natural variantiVAR_037243985P → R. Corresponds to variant dbSNP:rs2279684Ensembl.1
Natural variantiVAR_0372441113R → H. Corresponds to variant dbSNP:rs2279685Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0556441 – 4MASD → MFQRSNQDLKLGPYRKFSAL SY in isoform 3. 1 Publication4
Alternative sequenceiVSP_0556451M → MVVTLGPGPDCLILEASRQP QLVPKPERM in isoform 4. 1 Publication1
Alternative sequenceiVSP_029559235 – 365Missing in isoform 2. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_029560565 – 573LQPELAAPQ → PPTNGESQC in isoform 2. 1 Publication9
Alternative sequenceiVSP_029561574 – 1132Missing in isoform 2. 1 PublicationAdd BLAST559

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF482429 mRNA. Translation: AAO39268.1.
AY166680 mRNA. Translation: AAO22237.1. Different initiation.
AK098568 mRNA. Translation: BAC05337.1.
AK302656 mRNA. Translation: BAH13770.1.
AK302680 mRNA. Translation: BAG63912.1.
AC021822 Genomic DNA. No translation available.
AC025678 Genomic DNA. No translation available.
CH471125 Genomic DNA. Translation: EAW92304.1.
BC114518 mRNA. Translation: AAI14519.1.
BC114567 mRNA. Translation: AAI14568.1.
AL137416 mRNA. Translation: CAB70729.1.
CCDSiCCDS32190.1. [Q86Y26-1]
CCDS61584.1. [Q86Y26-3]
CCDS61585.1. [Q86Y26-4]
PIRiT46461.
RefSeqiNP_001271221.1. NM_001284292.1.
NP_001271222.1. NM_001284293.1.
NP_786883.1. NM_175741.2.
UniGeneiHs.525769.

Genome annotation databases

EnsembliENST00000333756; ENSP00000329448; ENSG00000184507. [Q86Y26-1]
ENST00000438749; ENSP00000407031; ENSG00000184507. [Q86Y26-3]
ENST00000537011; ENSP00000444896; ENSG00000184507. [Q86Y26-4]
ENST00000614490; ENSP00000478903; ENSG00000184507. [Q86Y26-1]
GeneIDi256646.
KEGGihsa:256646.
UCSCiuc001zif.4. human. [Q86Y26-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF482429 mRNA. Translation: AAO39268.1.
AY166680 mRNA. Translation: AAO22237.1. Different initiation.
AK098568 mRNA. Translation: BAC05337.1.
AK302656 mRNA. Translation: BAH13770.1.
AK302680 mRNA. Translation: BAG63912.1.
AC021822 Genomic DNA. No translation available.
AC025678 Genomic DNA. No translation available.
CH471125 Genomic DNA. Translation: EAW92304.1.
BC114518 mRNA. Translation: AAI14519.1.
BC114567 mRNA. Translation: AAI14568.1.
AL137416 mRNA. Translation: CAB70729.1.
CCDSiCCDS32190.1. [Q86Y26-1]
CCDS61584.1. [Q86Y26-3]
CCDS61585.1. [Q86Y26-4]
PIRiT46461.
RefSeqiNP_001271221.1. NM_001284292.1.
NP_001271222.1. NM_001284293.1.
NP_786883.1. NM_175741.2.
UniGeneiHs.525769.

3D structure databases

ProteinModelPortaliQ86Y26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129174. 23 interactors.
IntActiQ86Y26. 24 interactors.
STRINGi9606.ENSP00000329448.

PTM databases

iPTMnetiQ86Y26.
PhosphoSitePlusiQ86Y26.

Polymorphism and mutation databases

BioMutaiNUTM1.
DMDMi311033405.

Proteomic databases

PaxDbiQ86Y26.
PeptideAtlasiQ86Y26.
PRIDEiQ86Y26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333756; ENSP00000329448; ENSG00000184507. [Q86Y26-1]
ENST00000438749; ENSP00000407031; ENSG00000184507. [Q86Y26-3]
ENST00000537011; ENSP00000444896; ENSG00000184507. [Q86Y26-4]
ENST00000614490; ENSP00000478903; ENSG00000184507. [Q86Y26-1]
GeneIDi256646.
KEGGihsa:256646.
UCSCiuc001zif.4. human. [Q86Y26-1]

Organism-specific databases

CTDi256646.
DisGeNETi256646.
GeneCardsiNUTM1.
HGNCiHGNC:29919. NUTM1.
HPAiHPA040421.
MalaCardsiNUTM1.
MIMi608963. gene.
neXtProtiNX_Q86Y26.
OpenTargetsiENSG00000184507.
PharmGKBiPA162378206.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ5E. Eukaryota.
ENOG4111830. LUCA.
GeneTreeiENSGT00410000025793.
HOGENOMiHOG000112470.
HOVERGENiHBG107898.
InParanoidiQ86Y26.
OMAiTQTALNW.
OrthoDBiEOG091G04K7.
PhylomeDBiQ86Y26.
TreeFamiTF337728.

Miscellaneous databases

ChiTaRSiNUTM1. human.
GenomeRNAii256646.
PROiPR:Q86Y26.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184507.
CleanExiHS_C15orf55.
GenevisibleiQ86Y26. HS.

Family and domain databases

InterProiView protein in InterPro
IPR024310. NUT.
IPR024309. NUT_N.
PANTHERiPTHR22879. PTHR22879. 1 hit.
PfamiView protein in Pfam
PF12881. NUT. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNUTM1_HUMAN
AccessioniPrimary (citable) accession number: Q86Y26
Secondary accession number(s): B4DZ00
, B7Z7Y4, E7EVE8, F5H4I6, Q86YS8, Q8N7F2, Q9NTB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 2, 2010
Last modified: June 7, 2017
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.