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Q86Y26

- NUTM1_HUMAN

UniProt

Q86Y26 - NUTM1_HUMAN

Protein

NUT family member 1

Gene

NUTM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei5 – 62Breakpoint for translocation to form BRD4-NUT and BRD3-NUT fusion proteins

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NUT family member 1
    Alternative name(s):
    Nuclear protein in testis
    Gene namesi
    Name:NUTM1
    Synonyms:C15orf55, NUT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:29919. NUTM1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Shuttles between nucleus and cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUT fusion protein.1 Publication
    A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUT fusion protein.1 Publication

    Organism-specific databases

    PharmGKBiPA162378206.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11321132NUT family member 1PRO_0000311394Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1026 – 10261Phosphoserine1 Publication
    Modified residuei1029 – 10291Phosphoserine1 Publication
    Modified residuei1031 – 10311Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ86Y26.
    PRIDEiQ86Y26.

    PTM databases

    PhosphoSiteiQ86Y26.

    Expressioni

    Tissue specificityi

    Specifically expressed in testis.1 Publication

    Gene expression databases

    ArrayExpressiQ86Y26.
    BgeeiQ86Y26.
    CleanExiHS_C15orf55.
    GenevestigatoriQ86Y26.

    Organism-specific databases

    HPAiHPA040421.

    Interactioni

    Protein-protein interaction databases

    BioGridi129174. 1 interaction.
    STRINGi9606.ENSP00000329448.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86Y26.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi10 – 182173Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NUT family.Curated

    Phylogenomic databases

    eggNOGiNOG39838.
    HOGENOMiHOG000112470.
    HOVERGENiHBG107898.
    InParanoidiQ86Y26.
    OMAiGAMWGDD.
    OrthoDBiEOG7F24S5.
    PhylomeDBiQ86Y26.
    TreeFamiTF337728.

    Family and domain databases

    InterProiIPR024310. NUT/FAM22.
    IPR024313. NUT_C.
    IPR024309. NUT_N.
    [Graphical view]
    PANTHERiPTHR22879. PTHR22879. 1 hit.
    PfamiPF12882. NUT_C. 1 hit.
    PF12881. NUT_N. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86Y26-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASDGASALP GPDMSMKPSA APSPSPALPF LPPTSDPPDH PPREPPPQPI     50
    MPSVFSPDNP LMLSAFPSSL LVTGDGGPCL SGAGAGKVIV KVKTEGGSAE 100
    PSQTQNFILT QTALNSTAPG TPCGGLEGPA PPFVTASNVK TILPSKAVGV 150
    SQEGPPGLPP QPPPPVAQLV PIVPLEKAWP GPHGTTGEGG PVATLSKPSL 200
    GDRSKISKDV YENFRQWQRY KALARRHLSQ SPDTEALSCF LIPVLRSLAR 250
    LKPTMTLEEG LPLAVQEWEH TSNFDRMIFY EMAERFMEFE AEEMQIQNTQ 300
    LMNGSQGLSP ATPLKLDPLG PLASEVCQQP VYIPKKAASK TRAPRRRQRK 350
    AQRPPAPEAP KEIPPEAVKE YVDIMEWLVG THLATGESDG KQEEEGQQQE 400
    EEGMYPDPGL LSYINELCSQ KVFVSKVEAV IHPQFLADLL SPEKQRDPLA 450
    LIEELEQEEG LTLAQLVQKR LMALEEEEDA EAPPSFSGAQ LDSSPSGSVE 500
    DEDGDGRLRP SPGLQGAGGA ACLGKVSSSG KRAREVHGGQ EQALDSPRGM 550
    HRDGNTLPSP SSWDLQPELA APQGTPGPLG VERRGSGKVI NQVSLHQDGH 600
    LGGAGPPGHC LVADRTSEAL PLCWQGGFQP ESTPSLDAGL AELAPLQGQG 650
    LEKQVLGLQK GQQTGGRGVL PQGKEPLAVP WEGSSGAMWG DDRGTPMAQS 700
    YDQNPSPRAA GERDDVCLSP GVWLSSEMDA VGLELPVQIE EVIESFQVEK 750
    CVTEYQEGCQ GLGSRGNISL GPGETLVPGD TESSVIPCGG TVAAAALEKR 800
    NYCSLPGPLR ANSPPLRSKE NQEQSCETVG HPSDLWAEGC FPLLESGDST 850
    LGSSKETLPP TCQGNLLIMG TEDASSLPEA SQEAGSRGNS FSPLLETIEP 900
    VNILDVKDDC GLQLRVSEDT CPLNVHSYDP QGEGRVDPDL SKPKNLAPLQ 950
    ESQESYTTGT PKATSSHQGL GSTLPRRGTR NAIVPRETSV SKTHRSADRA 1000
    KGKEKKKKEA EEEDEELSNF AYLLASKLSL SPREHPLSPH HASGGQGSQR 1050
    ASHLLPAGAK GPSKLPYPVA KSGKRALAGG PAPTEKTPHS GAQLGVPREK 1100
    PLALGVVRPS QPRKRRCDSF VTGRRKKRRR SQ 1132
    Length:1,132
    Mass (Da):120,314
    Last modified:November 2, 2010 - v2
    Checksum:i5CB58C1B030399F4
    GO
    Isoform 2 (identifier: Q86Y26-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         235-365: Missing.
         565-573: LQPELAAPQ → PPTNGESQC
         574-1132: Missing.

    Show »
    Length:442
    Mass (Da):46,352
    Checksum:i95BABF1664CEE540
    GO
    Isoform 3 (identifier: Q86Y26-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-4: MASD → MFQRSNQDLKLGPYRKFSALSY

    Note: No experimental confirmation available.

    Show »
    Length:1,150
    Mass (Da):122,542
    Checksum:i2E4F0F3BB53FC785
    GO
    Isoform 4 (identifier: Q86Y26-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MVVTLGPGPDCLILEASRQPQLVPKPERM

    Note: No experimental confirmation available.

    Show »
    Length:1,160
    Mass (Da):123,341
    Checksum:iD315516EBE03B8E5
    GO

    Sequence cautioni

    The sequence AAO22237.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti332 – 3321Y → H in BAG63912. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 221P → L.4 Publications
    Corresponds to variant rs374230 [ dbSNP | Ensembl ].
    VAR_037239
    Natural varianti781 – 7811T → M.
    Corresponds to variant rs16959028 [ dbSNP | Ensembl ].
    VAR_037240
    Natural varianti785 – 7851V → E.
    Corresponds to variant rs17236868 [ dbSNP | Ensembl ].
    VAR_037241
    Natural varianti973 – 9731T → N.
    Corresponds to variant rs2279683 [ dbSNP | Ensembl ].
    VAR_037242
    Natural varianti985 – 9851P → R.
    Corresponds to variant rs2279684 [ dbSNP | Ensembl ].
    VAR_037243
    Natural varianti1113 – 11131R → H.
    Corresponds to variant rs2279685 [ dbSNP | Ensembl ].
    VAR_037244

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 44MASD → MFQRSNQDLKLGPYRKFSAL SY in isoform 3. 1 PublicationVSP_055644
    Alternative sequencei1 – 11M → MVVTLGPGPDCLILEASRQP QLVPKPERM in isoform 4. 1 PublicationVSP_055645
    Alternative sequencei235 – 365131Missing in isoform 2. 1 PublicationVSP_029559Add
    BLAST
    Alternative sequencei565 – 5739LQPELAAPQ → PPTNGESQC in isoform 2. 1 PublicationVSP_029560
    Alternative sequencei574 – 1132559Missing in isoform 2. 1 PublicationVSP_029561Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF482429 mRNA. Translation: AAO39268.1.
    AY166680 mRNA. Translation: AAO22237.1. Different initiation.
    AK098568 mRNA. Translation: BAC05337.1.
    AK302656 mRNA. Translation: BAH13770.1.
    AK302680 mRNA. Translation: BAG63912.1.
    AC021822 Genomic DNA. No translation available.
    AC025678 Genomic DNA. No translation available.
    CH471125 Genomic DNA. Translation: EAW92304.1.
    BC114518 mRNA. Translation: AAI14519.1.
    BC114567 mRNA. Translation: AAI14568.1.
    AL137416 mRNA. Translation: CAB70729.1.
    CCDSiCCDS32190.1. [Q86Y26-1]
    PIRiT46461.
    RefSeqiNP_001271222.1. NM_001284293.1.
    NP_786883.1. NM_175741.2.
    UniGeneiHs.525769.

    Genome annotation databases

    EnsembliENST00000333756; ENSP00000329448; ENSG00000184507. [Q86Y26-1]
    ENST00000438749; ENSP00000407031; ENSG00000184507. [Q86Y26-3]
    ENST00000537011; ENSP00000444896; ENSG00000184507. [Q86Y26-4]
    GeneIDi256646.
    KEGGihsa:256646.

    Polymorphism databases

    DMDMi311033405.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF482429 mRNA. Translation: AAO39268.1 .
    AY166680 mRNA. Translation: AAO22237.1 . Different initiation.
    AK098568 mRNA. Translation: BAC05337.1 .
    AK302656 mRNA. Translation: BAH13770.1 .
    AK302680 mRNA. Translation: BAG63912.1 .
    AC021822 Genomic DNA. No translation available.
    AC025678 Genomic DNA. No translation available.
    CH471125 Genomic DNA. Translation: EAW92304.1 .
    BC114518 mRNA. Translation: AAI14519.1 .
    BC114567 mRNA. Translation: AAI14568.1 .
    AL137416 mRNA. Translation: CAB70729.1 .
    CCDSi CCDS32190.1. [Q86Y26-1 ]
    PIRi T46461.
    RefSeqi NP_001271222.1. NM_001284293.1.
    NP_786883.1. NM_175741.2.
    UniGenei Hs.525769.

    3D structure databases

    ProteinModelPortali Q86Y26.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129174. 1 interaction.
    STRINGi 9606.ENSP00000329448.

    PTM databases

    PhosphoSitei Q86Y26.

    Polymorphism databases

    DMDMi 311033405.

    Proteomic databases

    PaxDbi Q86Y26.
    PRIDEi Q86Y26.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333756 ; ENSP00000329448 ; ENSG00000184507 . [Q86Y26-1 ]
    ENST00000438749 ; ENSP00000407031 ; ENSG00000184507 . [Q86Y26-3 ]
    ENST00000537011 ; ENSP00000444896 ; ENSG00000184507 . [Q86Y26-4 ]
    GeneIDi 256646.
    KEGGi hsa:256646.

    Organism-specific databases

    CTDi 256646.
    GeneCardsi GC15P034636.
    HGNCi HGNC:29919. NUTM1.
    HPAi HPA040421.
    MIMi 608963. gene.
    neXtProti NX_Q86Y26.
    PharmGKBi PA162378206.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39838.
    HOGENOMi HOG000112470.
    HOVERGENi HBG107898.
    InParanoidi Q86Y26.
    OMAi GAMWGDD.
    OrthoDBi EOG7F24S5.
    PhylomeDBi Q86Y26.
    TreeFami TF337728.

    Miscellaneous databases

    ChiTaRSi C15orf55. human.
    GenomeRNAii 256646.
    NextBioi 92844.
    PROi Q86Y26.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86Y26.
    Bgeei Q86Y26.
    CleanExi HS_C15orf55.
    Genevestigatori Q86Y26.

    Family and domain databases

    InterProi IPR024310. NUT/FAM22.
    IPR024313. NUT_C.
    IPR024309. NUT_N.
    [Graphical view ]
    PANTHERi PTHR22879. PTHR22879. 1 hit.
    Pfami PF12882. NUT_C. 1 hit.
    PF12881. NUT_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma."
      French C.A., Miyoshi I., Kubonishi I., Grier H.E., Perez-Atayde A.R., Fletcher J.A.
      Cancer Res. 63:304-307(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DISEASE, CHROMOSOMAL TRANSLOCATION WITH BRD4, TISSUE SPECIFICITY, VARIANT LEU-22.
      Tissue: Carcinoma and Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), VARIANT LEU-22.
      Tissue: Testis.
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-22.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-22.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 890-1132 (ISOFORM 1).
      Tissue: Testis.
    7. "BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells."
      French C.A., Ramirez C.L., Kolmakova J., Hickman T.T., Cameron M.J., Thyne M.E., Kutok J.L., Toretsky J.A., Tadavarthy A.K., Kees U.R., Fletcher J.A., Aster J.C.
      Oncogene 27:2237-2242(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION WITH BRD3, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-1026; SER-1029 AND SER-1031.

    Entry informationi

    Entry nameiNUTM1_HUMAN
    AccessioniPrimary (citable) accession number: Q86Y26
    Secondary accession number(s): B4DZ00
    , B7Z7Y4, E7EVE8, F5H4I6, Q86YS8, Q8N7F2, Q9NTB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3