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Protein

Zinc finger protein 354C

Gene

ZNF354C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcription repressor. Binds to 5'-CCACA-3' core sequence. Suppresses osteogenic effects of RUNX2. May be involved in osteoblastic differentiation (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri216 – 238C2H2-type 1Add BLAST23
Zinc fingeri244 – 266C2H2-type 2Add BLAST23
Zinc fingeri272 – 294C2H2-type 3Add BLAST23
Zinc fingeri300 – 322C2H2-type 4Add BLAST23
Zinc fingeri328 – 350C2H2-type 5Add BLAST23
Zinc fingeri356 – 378C2H2-type 6Add BLAST23
Zinc fingeri384 – 406C2H2-type 7Add BLAST23
Zinc fingeri412 – 434C2H2-type 8Add BLAST23
Zinc fingeri440 – 462C2H2-type 9Add BLAST23
Zinc fingeri468 – 490C2H2-type 10Add BLAST23
Zinc fingeri496 – 518C2H2-type 11Add BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 354C
Alternative name(s):
Kidney, ischemia, and developmentally-regulated protein 3
Short name:
hKID3
Gene namesi
Name:ZNF354C
Synonyms:KID3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000177932.6.
HGNCiHGNC:16736. ZNF354C.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177932.
PharmGKBiPA38184.

Polymorphism and mutation databases

BioMutaiZNF354C.
DMDMi74762464.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804081 – 554Zinc finger protein 354CAdd BLAST554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki111Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki531Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ86Y25.
MaxQBiQ86Y25.
PaxDbiQ86Y25.
PeptideAtlasiQ86Y25.
PRIDEiQ86Y25.

PTM databases

iPTMnetiQ86Y25.
PhosphoSitePlusiQ86Y25.

Expressioni

Tissue specificityi

Expressed in kidney and skeletal muscle. Very low expression in brain and heart.1 Publication

Developmental stagei

Expressed in brain. Very low expression in lung and liver.1 Publication

Gene expression databases

BgeeiENSG00000177932.
CleanExiHS_ZNF354C.
GenevisibleiQ86Y25. HS.

Organism-specific databases

HPAiHPA030904.

Interactioni

Subunit structurei

Interacts with RUNX2. Binds consensus element OSE2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi119048. 17 interactors.
STRINGi9606.ENSP00000324064.

Structurei

3D structure databases

ProteinModelPortaliQ86Y25.
SMRiQ86Y25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 83KRABAdd BLAST72

Domaini

KRAB domain is not required for nuclear targeting or for DNA binding.By similarity
Zinc finger region is involved in nuclear targeting and DNA-binding.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri216 – 238C2H2-type 1Add BLAST23
Zinc fingeri244 – 266C2H2-type 2Add BLAST23
Zinc fingeri272 – 294C2H2-type 3Add BLAST23
Zinc fingeri300 – 322C2H2-type 4Add BLAST23
Zinc fingeri328 – 350C2H2-type 5Add BLAST23
Zinc fingeri356 – 378C2H2-type 6Add BLAST23
Zinc fingeri384 – 406C2H2-type 7Add BLAST23
Zinc fingeri412 – 434C2H2-type 8Add BLAST23
Zinc fingeri440 – 462C2H2-type 9Add BLAST23
Zinc fingeri468 – 490C2H2-type 10Add BLAST23
Zinc fingeri496 – 518C2H2-type 11Add BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139426.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ86Y25.
KOiK09228.
OMAiCFQIYPG.
OrthoDBiEOG091G02KC.
PhylomeDBiQ86Y25.
TreeFamiTF350822.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.

Sequencei

Sequence statusi: Complete.

Q86Y25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDLLSAQE PVTFRDVAVF FSQDEWLHLD SAQRALYREV MLENYSSLVS
60 70 80 90 100
LGIPFSMPKL IHQLQQGEDP CMVEREVPSD TRLGFKTWLE TEALPHRQDI
110 120 130 140 150
FIEETSQGMV KKESIKDGHW DINFEEAVEF ESEIEEEQEK KPLRQMIDSH
160 170 180 190 200
EKTISEDGNH TSLELGKSLF TNTALVTQQS VPIERIPNMY YTFGKDFKQN
210 220 230 240 250
FDLMKCFQIY PGGKPHICNE CGKSFKQNLH LIEHQRIHTG EKPYKCNECE
260 270 280 290 300
KTFSHRSSLL SHQRIHTGEK PYKCNECEKA FSNSSTLIKH LRVHTGEKPY
310 320 330 340 350
RCRECGKAFS QCSTLTVHQR IHTGEKLYKC GECEKAFNCR AKLHRHQRIH
360 370 380 390 400
TGEKPYKCSE CGKGYSQFTS LAEHQRFHTG EQLYTCLECG RTFTRIVTLI
410 420 430 440 450
EHQRIHTGQK PYQCNECEKA FNQYSSFNEH RKIHTGEKLY TCEECGKAFG
460 470 480 490 500
CKSNLYRHQR IHTGEKPYQC NQCGKAFSQY SFLTEHERIH TGEKLYKCME
510 520 530 540 550
CGKAYSYRSN LCRHKKVHTK EKLYKWKEYG KPFICSSSLT QYQRFFKGDK

AYEV
Length:554
Mass (Da):64,847
Last modified:June 1, 2003 - v1
Checksum:i3B95DED46CCECFFC
GO

Sequence cautioni

The sequence AAH63312 differs from that shown. Reason: Frameshift at position 473.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti375Q → H in AAM69676 (Ref. 3) Curated1
Sequence conflicti415N → T in AAM69676 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031138250E → K1 PublicationCorresponds to variant dbSNP:rs17855823Ensembl.1
Natural variantiVAR_031139546F → L. Corresponds to variant dbSNP:rs1445846Ensembl.1
Natural variantiVAR_031140553E → K. Corresponds to variant dbSNP:rs1445845Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525463 mRNA. Translation: AAO83897.1.
BC063312 mRNA. Translation: AAH63312.1. Frameshift.
AF395540 mRNA. Translation: AAM69676.1.
CCDSiCCDS4443.1.
RefSeqiNP_055409.1. NM_014594.2.
XP_016864898.1. XM_017009409.1.
UniGeneiHs.272328.

Genome annotation databases

EnsembliENST00000315475; ENSP00000324064; ENSG00000177932.
GeneIDi30832.
KEGGihsa:30832.
UCSCiuc003mju.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZ354C_HUMAN
AccessioniPrimary (citable) accession number: Q86Y25
Secondary accession number(s): Q6P4P9, Q8NFX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families