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Q86Y22

- CONA1_HUMAN

UniProt

Q86Y22 - CONA1_HUMAN

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Protein

Collagen alpha-1(XXIII) chain

Gene

COL23A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. collagen catabolic process Source: Reactome
  2. extracellular matrix disassembly Source: Reactome
  3. extracellular matrix organization Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_121139. Collagen biosynthesis and modifying enzymes.
REACT_13552. Integrin cell surface interactions.
REACT_150401. Collagen degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXIII) chain
Gene namesi
Name:COL23A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:22990. COL23A1.

Subcellular locationi

Cell membrane By similarity; Single-pass type II membrane protein By similarity; Extracellular side By similarity

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. endoplasmic reticulum lumen Source: Reactome
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134899251.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Collagen alpha-1(XXIII) chainPRO_0000245226Add
BLAST

Post-translational modificationi

Undergoes proteolytic cleavage by furin protease to yield a 60 kDa soluble form that forms a homotrimer and exhibits a low affinity interaction with heparin.By similarity

Proteomic databases

PaxDbiQ86Y22.
PRIDEiQ86Y22.

PTM databases

PhosphoSiteiQ86Y22.

Expressioni

Gene expression databases

BgeeiQ86Y22.
CleanExiHS_COL23A1.
GenevestigatoriQ86Y22.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi124839. 1 interaction.
IntActiQ86Y22. 1 interaction.
STRINGi9606.ENSP00000375069.

Structurei

3D structure databases

ProteinModelPortaliQ86Y22.
SMRiQ86Y22. Positions 450-478.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini57 – 540484ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5622Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 243120Collagen-like 1Add
BLAST
Domaini251 – 30555Collagen-like 2Add
BLAST
Domaini321 – 38060Collagen-like 3Add
BLAST
Domaini412 – 46049Collagen-like 4Add
BLAST
Domaini463 – 52260Collagen-like 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 536535Gly-richAdd
BLAST

Sequence similaritiesi

Contains 5 collagen-like domains.Curated

Keywords - Domaini

Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320189.
GeneTreeiENSGT00760000118927.
HOGENOMiHOG000085653.
HOVERGENiHBG004933.
InParanoidiQ86Y22.
OMAiIPGRKGV.
OrthoDBiEOG7D59P1.
PhylomeDBiQ86Y22.
TreeFamiTF338175.

Family and domain databases

InterProiIPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86Y22-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPGERAGGG GDAGKGNAAG GGGGGRSATT AGSRAVSALC LLLSVGSAAA
60 70 80 90 100
CLLLGVQAAA LQGRVAALEE ERELLRRAGP PGALDAWAEP HLERLLREKL
110 120 130 140 150
DGLAKIRTAR EAPSECVCPP GPPGRRGKPG RRGDPGPPGQ SGRDGYPGPL
160 170 180 190 200
GLDGKPGLPG PKGEKGAPGD FGPRGDQGQD GAAGPPGPPG PPGARGPPGD
210 220 230 240 250
TGKDGPRGAQ GPAGPKGEPG QDGEMGPKGP PGPKGEPGVP GKKGDDGTPS
260 270 280 290 300
QPGPPGPKGE PGSMGPRGEN GVDGAPGPKG EPGHRGTDGA AGPRGAPGLK
310 320 330 340 350
GEQGDTVVID YDGRILDALK GPPGPQGPPG PPGIPGAKGE LGLPGAPGID
360 370 380 390 400
GEKGPKGQKG DPGEPGPAGL KGEAGEMGLS GLPGADGLKG EKGESASDSL
410 420 430 440 450
QESLAQLIVE PGPPGPPGPP GPMGLQGIQG PKGLDGAKGE KGASGERGPS
460 470 480 490 500
GLPGPVGPPG LIGLPGTKGE KGRPGEPGLD GFPGPRGEKG DRSERGEKGE
510 520 530 540
RGVPGRKGVK GQKGEPGPPG LDQPCPVGPD GLPVPGCWHK
Length:540
Mass (Da):51,944
Last modified:June 1, 2003 - v1
Checksum:iD64D3CA50F729297
GO
Isoform 2 (identifier: Q86Y22-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.
     28-98: ATTAGSRAVS...EPHLERLLRE → MESRSGIQAG...GTNSRHTLTV
     140-148: Missing.
     296-345: APGLKGEQGD...GAKGELGLPG → DVRDPGLGSV...RAGRHSGDRL
     346-540: Missing.

Note: No experimental confirmation available.

Show »
Length:309
Mass (Da):30,672
Checksum:iC5FE20DAFA84FBE9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti287 – 2871T → A.
Corresponds to variant rs890802 [ dbSNP | Ensembl ].
VAR_026964

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727Missing in isoform 2. 1 PublicationVSP_019627Add
BLAST
Alternative sequencei28 – 9871ATTAG…RLLRE → MESRSGIQAGVRCRDLGSLQ PPPLALKQFSSLSLPSSWDY RRLPPRCGFLFEVSETTNPP AGTNSRHTLTV in isoform 2. 1 PublicationVSP_019628Add
BLAST
Alternative sequencei140 – 1489Missing in isoform 2. 1 PublicationVSP_019629
Alternative sequencei296 – 34550APGLK…LGLPG → DVRDPGLGSVSSCSQRLASS SKKNGSEPPPGCAGCPRPQG RAGRHSGDRL in isoform 2. 1 PublicationVSP_019630Add
BLAST
Alternative sequencei346 – 540195Missing in isoform 2. 1 PublicationVSP_019631Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY158895 mRNA. Translation: AAO18361.1.
AY898961 mRNA. Translation: AAX84028.1.
BC042428 mRNA. Translation: AAH42428.1.
AL137461 mRNA. Translation: CAB70749.1.
CCDSiCCDS4436.1. [Q86Y22-1]
PIRiT46404.
RefSeqiNP_775736.2. NM_173465.3. [Q86Y22-1]
UniGeneiHs.660026.

Genome annotation databases

EnsembliENST00000390654; ENSP00000375069; ENSG00000050767. [Q86Y22-1]
GeneIDi91522.
KEGGihsa:91522.
UCSCiuc021yiy.1. human. [Q86Y22-1]

Polymorphism databases

DMDMi74723551.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY158895 mRNA. Translation: AAO18361.1 .
AY898961 mRNA. Translation: AAX84028.1 .
BC042428 mRNA. Translation: AAH42428.1 .
AL137461 mRNA. Translation: CAB70749.1 .
CCDSi CCDS4436.1. [Q86Y22-1 ]
PIRi T46404.
RefSeqi NP_775736.2. NM_173465.3. [Q86Y22-1 ]
UniGenei Hs.660026.

3D structure databases

ProteinModelPortali Q86Y22.
SMRi Q86Y22. Positions 450-478.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124839. 1 interaction.
IntActi Q86Y22. 1 interaction.
STRINGi 9606.ENSP00000375069.

PTM databases

PhosphoSitei Q86Y22.

Polymorphism databases

DMDMi 74723551.

Proteomic databases

PaxDbi Q86Y22.
PRIDEi Q86Y22.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000390654 ; ENSP00000375069 ; ENSG00000050767 . [Q86Y22-1 ]
GeneIDi 91522.
KEGGi hsa:91522.
UCSCi uc021yiy.1. human. [Q86Y22-1 ]

Organism-specific databases

CTDi 91522.
GeneCardsi GC05M177664.
HGNCi HGNC:22990. COL23A1.
MIMi 610043. gene.
neXtProti NX_Q86Y22.
PharmGKBi PA134899251.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320189.
GeneTreei ENSGT00760000118927.
HOGENOMi HOG000085653.
HOVERGENi HBG004933.
InParanoidi Q86Y22.
OMAi IPGRKGV.
OrthoDBi EOG7D59P1.
PhylomeDBi Q86Y22.
TreeFami TF338175.

Enzyme and pathway databases

Reactomei REACT_121139. Collagen biosynthesis and modifying enzymes.
REACT_13552. Integrin cell surface interactions.
REACT_150401. Collagen degradation.

Miscellaneous databases

GenomeRNAii 91522.
NextBioi 77272.
PROi Q86Y22.
SOURCEi Search...

Gene expression databases

Bgeei Q86Y22.
CleanExi HS_COL23A1.
Genevestigatori Q86Y22.

Family and domain databases

InterProi IPR008160. Collagen.
[Graphical view ]
Pfami PF01391. Collagen. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Type XXIII collagen, a new transmembrane collagen identified in metastatic tumor cells."
    Banyard J., Bao L., Zetter B.R.
    J. Biol. Chem. 278:20989-20994(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Koch M., Burgeson R.E., Gordon M.K.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-540.
    Tissue: Testis.

Entry informationi

Entry nameiCONA1_HUMAN
AccessioniPrimary (citable) accession number: Q86Y22
Secondary accession number(s): Q8IVR4, Q9NT93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3