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Q86Y22 (CONA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Collagen alpha-1(XXIII) chain
Gene names
Name:COL23A1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Homotrimer By similarity.

Subcellular location

Cell membrane; Single-pass type II membrane protein; Extracellular side By similarity.

Post-translational modification

Undergoes proteolytic cleavage by furin protease to yield a 60 kDa soluble form that forms a homotrimer and exhibits a low affinity interaction with heparin By similarity.

Sequence similarities

Contains 5 collagen-like domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86Y22-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86Y22-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.
     28-98: ATTAGSRAVS...EPHLERLLRE → MESRSGIQAG...GTNSRHTLTV
     140-148: Missing.
     296-345: APGLKGEQGD...GAKGELGLPG → DVRDPGLGSV...RAGRHSGDRL
     346-540: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540Collagen alpha-1(XXIII) chain
PRO_0000245226

Regions

Topological domain1 – 3434Cytoplasmic Potential
Transmembrane35 – 5622Helical; Signal-anchor for type II membrane protein; Potential
Topological domain57 – 540484Extracellular Potential
Domain124 – 243120Collagen-like 1
Domain251 – 30555Collagen-like 2
Domain321 – 38060Collagen-like 3
Domain412 – 46049Collagen-like 4
Domain463 – 52260Collagen-like 5
Compositional bias2 – 536535Gly-rich

Natural variations

Alternative sequence1 – 2727Missing in isoform 2.
VSP_019627
Alternative sequence28 – 9871ATTAG…RLLRE → MESRSGIQAGVRCRDLGSLQ PPPLALKQFSSLSLPSSWDY RRLPPRCGFLFEVSETTNPP AGTNSRHTLTV in isoform 2.
VSP_019628
Alternative sequence140 – 1489Missing in isoform 2.
VSP_019629
Alternative sequence296 – 34550APGLK…LGLPG → DVRDPGLGSVSSCSQRLASS SKKNGSEPPPGCAGCPRPQG RAGRHSGDRL in isoform 2.
VSP_019630
Alternative sequence346 – 540195Missing in isoform 2.
VSP_019631
Natural variant2871T → A.
Corresponds to variant rs890802 [ dbSNP | Ensembl ].
VAR_026964

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: D64D3CA50F729297

FASTA54051,944
        10         20         30         40         50         60 
MGPGERAGGG GDAGKGNAAG GGGGGRSATT AGSRAVSALC LLLSVGSAAA CLLLGVQAAA 

        70         80         90        100        110        120 
LQGRVAALEE ERELLRRAGP PGALDAWAEP HLERLLREKL DGLAKIRTAR EAPSECVCPP 

       130        140        150        160        170        180 
GPPGRRGKPG RRGDPGPPGQ SGRDGYPGPL GLDGKPGLPG PKGEKGAPGD FGPRGDQGQD 

       190        200        210        220        230        240 
GAAGPPGPPG PPGARGPPGD TGKDGPRGAQ GPAGPKGEPG QDGEMGPKGP PGPKGEPGVP 

       250        260        270        280        290        300 
GKKGDDGTPS QPGPPGPKGE PGSMGPRGEN GVDGAPGPKG EPGHRGTDGA AGPRGAPGLK 

       310        320        330        340        350        360 
GEQGDTVVID YDGRILDALK GPPGPQGPPG PPGIPGAKGE LGLPGAPGID GEKGPKGQKG 

       370        380        390        400        410        420 
DPGEPGPAGL KGEAGEMGLS GLPGADGLKG EKGESASDSL QESLAQLIVE PGPPGPPGPP 

       430        440        450        460        470        480 
GPMGLQGIQG PKGLDGAKGE KGASGERGPS GLPGPVGPPG LIGLPGTKGE KGRPGEPGLD 

       490        500        510        520        530        540 
GFPGPRGEKG DRSERGEKGE RGVPGRKGVK GQKGEPGPPG LDQPCPVGPD GLPVPGCWHK 

« Hide

Isoform 2 [UniParc].

Checksum: C5FE20DAFA84FBE9
Show »

FASTA30930,672

References

« Hide 'large scale' references
[1]"Type XXIII collagen, a new transmembrane collagen identified in metastatic tumor cells."
Banyard J., Bao L., Zetter B.R.
J. Biol. Chem. 278:20989-20994(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]Koch M., Burgeson R.E., Gordon M.K.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Placenta.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-540.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY158895 mRNA. Translation: AAO18361.1.
AY898961 mRNA. Translation: AAX84028.1.
BC042428 mRNA. Translation: AAH42428.1.
AL137461 mRNA. Translation: CAB70749.1.
CCDSCCDS4436.1. [Q86Y22-1]
PIRT46404.
RefSeqNP_775736.2. NM_173465.3. [Q86Y22-1]
UniGeneHs.660026.

3D structure databases

ProteinModelPortalQ86Y22.
SMRQ86Y22. Positions 495-523.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124839. 1 interaction.
IntActQ86Y22. 1 interaction.
STRING9606.ENSP00000375069.

PTM databases

PhosphoSiteQ86Y22.

Polymorphism databases

DMDM74723551.

Proteomic databases

PaxDbQ86Y22.
PRIDEQ86Y22.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000390654; ENSP00000375069; ENSG00000050767. [Q86Y22-1]
ENST00000407622; ENSP00000385092; ENSG00000050767. [Q86Y22-2]
GeneID91522.
KEGGhsa:91522.
UCSCuc021yiy.1. human. [Q86Y22-1]

Organism-specific databases

CTD91522.
GeneCardsGC05M177664.
HGNCHGNC:22990. COL23A1.
MIM610043. gene.
neXtProtNX_Q86Y22.
PharmGKBPA134899251.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG320189.
HOGENOMHOG000085653.
HOVERGENHBG004933.
InParanoidQ86Y22.
OMAIPGRKGV.
OrthoDBEOG7D59P1.
PhylomeDBQ86Y22.
TreeFamTF338175.

Enzyme and pathway databases

ReactomeREACT_118779. Extracellular matrix organization.

Gene expression databases

BgeeQ86Y22.
CleanExHS_COL23A1.
GenevestigatorQ86Y22.

Family and domain databases

InterProIPR008160. Collagen.
[Graphical view]
PfamPF01391. Collagen. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi91522.
NextBio77272.
PROQ86Y22.
SOURCESearch...

Entry information

Entry nameCONA1_HUMAN
AccessionPrimary (citable) accession number: Q86Y22
Secondary accession number(s): Q8IVR4, Q9NT93
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM