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Q86Y22

- CONA1_HUMAN

UniProt

Q86Y22 - CONA1_HUMAN

Protein

Collagen alpha-1(XXIII) chain

Gene

COL23A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. collagen catabolic process Source: Reactome
    2. extracellular matrix disassembly Source: Reactome
    3. extracellular matrix organization Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_121139. Collagen biosynthesis and modifying enzymes.
    REACT_13552. Integrin cell surface interactions.
    REACT_150401. Collagen degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(XXIII) chain
    Gene namesi
    Name:COL23A1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:22990. COL23A1.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type II membrane protein By similarity; Extracellular side By similarity

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. endoplasmic reticulum lumen Source: Reactome
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134899251.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 540540Collagen alpha-1(XXIII) chainPRO_0000245226Add
    BLAST

    Post-translational modificationi

    Undergoes proteolytic cleavage by furin protease to yield a 60 kDa soluble form that forms a homotrimer and exhibits a low affinity interaction with heparin.By similarity

    Proteomic databases

    PaxDbiQ86Y22.
    PRIDEiQ86Y22.

    PTM databases

    PhosphoSiteiQ86Y22.

    Expressioni

    Gene expression databases

    BgeeiQ86Y22.
    CleanExiHS_COL23A1.
    GenevestigatoriQ86Y22.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    BioGridi124839. 1 interaction.
    IntActiQ86Y22. 1 interaction.
    STRINGi9606.ENSP00000375069.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86Y22.
    SMRiQ86Y22. Positions 495-523.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini57 – 540484ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5622Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini124 – 243120Collagen-like 1Add
    BLAST
    Domaini251 – 30555Collagen-like 2Add
    BLAST
    Domaini321 – 38060Collagen-like 3Add
    BLAST
    Domaini412 – 46049Collagen-like 4Add
    BLAST
    Domaini463 – 52260Collagen-like 5Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 536535Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 5 collagen-like domains.Curated

    Keywords - Domaini

    Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320189.
    HOGENOMiHOG000085653.
    HOVERGENiHBG004933.
    InParanoidiQ86Y22.
    OMAiIPGRKGV.
    OrthoDBiEOG7D59P1.
    PhylomeDBiQ86Y22.
    TreeFamiTF338175.

    Family and domain databases

    InterProiIPR008160. Collagen.
    [Graphical view]
    PfamiPF01391. Collagen. 8 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86Y22-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGPGERAGGG GDAGKGNAAG GGGGGRSATT AGSRAVSALC LLLSVGSAAA    50
    CLLLGVQAAA LQGRVAALEE ERELLRRAGP PGALDAWAEP HLERLLREKL 100
    DGLAKIRTAR EAPSECVCPP GPPGRRGKPG RRGDPGPPGQ SGRDGYPGPL 150
    GLDGKPGLPG PKGEKGAPGD FGPRGDQGQD GAAGPPGPPG PPGARGPPGD 200
    TGKDGPRGAQ GPAGPKGEPG QDGEMGPKGP PGPKGEPGVP GKKGDDGTPS 250
    QPGPPGPKGE PGSMGPRGEN GVDGAPGPKG EPGHRGTDGA AGPRGAPGLK 300
    GEQGDTVVID YDGRILDALK GPPGPQGPPG PPGIPGAKGE LGLPGAPGID 350
    GEKGPKGQKG DPGEPGPAGL KGEAGEMGLS GLPGADGLKG EKGESASDSL 400
    QESLAQLIVE PGPPGPPGPP GPMGLQGIQG PKGLDGAKGE KGASGERGPS 450
    GLPGPVGPPG LIGLPGTKGE KGRPGEPGLD GFPGPRGEKG DRSERGEKGE 500
    RGVPGRKGVK GQKGEPGPPG LDQPCPVGPD GLPVPGCWHK 540
    Length:540
    Mass (Da):51,944
    Last modified:June 1, 2003 - v1
    Checksum:iD64D3CA50F729297
    GO
    Isoform 2 (identifier: Q86Y22-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-27: Missing.
         28-98: ATTAGSRAVS...EPHLERLLRE → MESRSGIQAG...GTNSRHTLTV
         140-148: Missing.
         296-345: APGLKGEQGD...GAKGELGLPG → DVRDPGLGSV...RAGRHSGDRL
         346-540: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:309
    Mass (Da):30,672
    Checksum:iC5FE20DAFA84FBE9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti287 – 2871T → A.
    Corresponds to variant rs890802 [ dbSNP | Ensembl ].
    VAR_026964

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2727Missing in isoform 2. 1 PublicationVSP_019627Add
    BLAST
    Alternative sequencei28 – 9871ATTAG…RLLRE → MESRSGIQAGVRCRDLGSLQ PPPLALKQFSSLSLPSSWDY RRLPPRCGFLFEVSETTNPP AGTNSRHTLTV in isoform 2. 1 PublicationVSP_019628Add
    BLAST
    Alternative sequencei140 – 1489Missing in isoform 2. 1 PublicationVSP_019629
    Alternative sequencei296 – 34550APGLK…LGLPG → DVRDPGLGSVSSCSQRLASS SKKNGSEPPPGCAGCPRPQG RAGRHSGDRL in isoform 2. 1 PublicationVSP_019630Add
    BLAST
    Alternative sequencei346 – 540195Missing in isoform 2. 1 PublicationVSP_019631Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY158895 mRNA. Translation: AAO18361.1.
    AY898961 mRNA. Translation: AAX84028.1.
    BC042428 mRNA. Translation: AAH42428.1.
    AL137461 mRNA. Translation: CAB70749.1.
    CCDSiCCDS4436.1. [Q86Y22-1]
    PIRiT46404.
    RefSeqiNP_775736.2. NM_173465.3. [Q86Y22-1]
    UniGeneiHs.660026.

    Genome annotation databases

    EnsembliENST00000390654; ENSP00000375069; ENSG00000050767. [Q86Y22-1]
    ENST00000407622; ENSP00000385092; ENSG00000050767. [Q86Y22-2]
    GeneIDi91522.
    KEGGihsa:91522.
    UCSCiuc021yiy.1. human. [Q86Y22-1]

    Polymorphism databases

    DMDMi74723551.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY158895 mRNA. Translation: AAO18361.1 .
    AY898961 mRNA. Translation: AAX84028.1 .
    BC042428 mRNA. Translation: AAH42428.1 .
    AL137461 mRNA. Translation: CAB70749.1 .
    CCDSi CCDS4436.1. [Q86Y22-1 ]
    PIRi T46404.
    RefSeqi NP_775736.2. NM_173465.3. [Q86Y22-1 ]
    UniGenei Hs.660026.

    3D structure databases

    ProteinModelPortali Q86Y22.
    SMRi Q86Y22. Positions 495-523.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124839. 1 interaction.
    IntActi Q86Y22. 1 interaction.
    STRINGi 9606.ENSP00000375069.

    PTM databases

    PhosphoSitei Q86Y22.

    Polymorphism databases

    DMDMi 74723551.

    Proteomic databases

    PaxDbi Q86Y22.
    PRIDEi Q86Y22.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000390654 ; ENSP00000375069 ; ENSG00000050767 . [Q86Y22-1 ]
    ENST00000407622 ; ENSP00000385092 ; ENSG00000050767 . [Q86Y22-2 ]
    GeneIDi 91522.
    KEGGi hsa:91522.
    UCSCi uc021yiy.1. human. [Q86Y22-1 ]

    Organism-specific databases

    CTDi 91522.
    GeneCardsi GC05M177664.
    HGNCi HGNC:22990. COL23A1.
    MIMi 610043. gene.
    neXtProti NX_Q86Y22.
    PharmGKBi PA134899251.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320189.
    HOGENOMi HOG000085653.
    HOVERGENi HBG004933.
    InParanoidi Q86Y22.
    OMAi IPGRKGV.
    OrthoDBi EOG7D59P1.
    PhylomeDBi Q86Y22.
    TreeFami TF338175.

    Enzyme and pathway databases

    Reactomei REACT_121139. Collagen biosynthesis and modifying enzymes.
    REACT_13552. Integrin cell surface interactions.
    REACT_150401. Collagen degradation.

    Miscellaneous databases

    GenomeRNAii 91522.
    NextBioi 77272.
    PROi Q86Y22.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86Y22.
    CleanExi HS_COL23A1.
    Genevestigatori Q86Y22.

    Family and domain databases

    InterProi IPR008160. Collagen.
    [Graphical view ]
    Pfami PF01391. Collagen. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Type XXIII collagen, a new transmembrane collagen identified in metastatic tumor cells."
      Banyard J., Bao L., Zetter B.R.
      J. Biol. Chem. 278:20989-20994(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Koch M., Burgeson R.E., Gordon M.K.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-540.
      Tissue: Testis.

    Entry informationi

    Entry nameiCONA1_HUMAN
    AccessioniPrimary (citable) accession number: Q86Y22
    Secondary accession number(s): Q8IVR4, Q9NT93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3