Q86Y22 (CONA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Collagen alpha-1(XXIII) chain

Gene names

Name:

COL23A1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	540 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Homotrimer By similarity.
Subcellular location	Cell membrane; Single-pass type II membrane protein; Extracellular side By similarity.
Post-translational modification	Undergoes proteolytic cleavage by furin protease to yield a 60 kDa soluble form that forms an homotrimer and exhibits a low affinity interaction with heparin By similarity.
Sequence similarities	Contains 5 collagen-like domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Collagen Repeat Signal-anchor Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	collagen Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86Y22-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86Y22-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.
     28-98: ATTAGSRAVS...EPHLERLLRE → MESRSGIQAG...GTNSRHTLTV
     140-148: Missing.
     296-345: APGLKGEQGD...GAKGELGLPG → DVRDPGLGSV...RAGRHSGDRL
     346-540: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 540	540	Collagen alpha-1(XXIII) chain		PRO_0000245226
Regions
	Topological domain	1 – 34	34	Cytoplasmic Potential
	Transmembrane	35 – 56	22	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	57 – 540	484	Extracellular Potential
	Domain	124 – 243	120	Collagen-like 1
	Domain	251 – 305	55	Collagen-like 2
	Domain	321 – 380	60	Collagen-like 3
	Domain	412 – 460	49	Collagen-like 4
	Domain	463 – 522	60	Collagen-like 5
	Compositional bias	2 – 536	535	Gly-rich
Natural variations
	Alternative sequence	1 – 27	27	Missing in isoform 2.		VSP_019627
	Alternative sequence	28 – 98	71	ATTAG…RLLRE → MESRSGIQAGVRCRDLGSLQ PPPLALKQFSSLSLPSSWDY RRLPPRCGFLFEVSETTNPP AGTNSRHTLTV in isoform 2.		VSP_019628
	Alternative sequence	140 – 148	9	Missing in isoform 2.		VSP_019629
	Alternative sequence	296 – 345	50	APGLK…LGLPG → DVRDPGLGSVSSCSQRLASS SKKNGSEPPPGCAGCPRPQG RAGRHSGDRL in isoform 2.		VSP_019630
	Alternative sequence	346 – 540	195	Missing in isoform 2.		VSP_019631
	Natural variant	287	1	T → A. Corresponds to variant rs890802 [ dbSNP | Ensembl ].		VAR_026964

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: D64D3CA50F729297	FASTA	540	51,944
	10 20 30 40 50 60 MGPGERAGGG GDAGKGNAAG GGGGGRSATT AGSRAVSALC LLLSVGSAAA CLLLGVQAAA 70 80 90 100 110 120 LQGRVAALEE ERELLRRAGP PGALDAWAEP HLERLLREKL DGLAKIRTAR EAPSECVCPP 130 140 150 160 170 180 GPPGRRGKPG RRGDPGPPGQ SGRDGYPGPL GLDGKPGLPG PKGEKGAPGD FGPRGDQGQD 190 200 210 220 230 240 GAAGPPGPPG PPGARGPPGD TGKDGPRGAQ GPAGPKGEPG QDGEMGPKGP PGPKGEPGVP 250 260 270 280 290 300 GKKGDDGTPS QPGPPGPKGE PGSMGPRGEN GVDGAPGPKG EPGHRGTDGA AGPRGAPGLK 310 320 330 340 350 360 GEQGDTVVID YDGRILDALK GPPGPQGPPG PPGIPGAKGE LGLPGAPGID GEKGPKGQKG 370 380 390 400 410 420 DPGEPGPAGL KGEAGEMGLS GLPGADGLKG EKGESASDSL QESLAQLIVE PGPPGPPGPP 430 440 450 460 470 480 GPMGLQGIQG PKGLDGAKGE KGASGERGPS GLPGPVGPPG LIGLPGTKGE KGRPGEPGLD 490 500 510 520 530 540 GFPGPRGEKG DRSERGEKGE RGVPGRKGVK GQKGEPGPPG LDQPCPVGPD GLPVPGCWHK
	Isoform 2 [UniParc]. Checksum: C5FE20DAFA84FBE9	FASTA	309	30,672
	10 20 30 40 50 60 MESRSGIQAG VRCRDLGSLQ PPPLALKQFS SLSLPSSWDY RRLPPRCGFL FEVSETTNPP 70 80 90 100 110 120 AGTNSRHTLT VKLDGLAKIR TAREAPSECV CPPGPPGRRG KPGRRGDPGP PGPLGLDGKP 130 140 150 160 170 180 GLPGPKGEKG APGDFGPRGD QGQDGAAGPP GPPGPPGARG PPGDTGKDGP RGAQGPAGPK 190 200 210 220 230 240 GEPGQDGEMG PKGPPGPKGE PGVPGKKGDD GTPSQPGPPG PKGEPGSMGP RGENGVDGAP 250 260 270 280 290 300 GPKGEPGHRG TDGAAGPRGD VRDPGLGSVS SCSQRLASSS KKNGSEPPPG CAGCPRPQGR AGRHSGDRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Type XXIII collagen, a new transmembrane collagen identified in metastatic tumor cells." Banyard J., Bao L., Zetter B.R. J. Biol. Chem. 278:20989-20994(2003) [PubMed: 12644459] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	Koch M., Burgeson R.E., Gordon M.K. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Placenta.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-540. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY158895 mRNA. Translation: AAO18361.1. AY898961 mRNA. Translation: AAX84028.1. BC042428 mRNA. Translation: AAH42428.1. AL137461 mRNA. Translation: CAB70749.1.
IPI	IPI00217102. IPI00251596.
PIR	T46404.
RefSeq	NP_775736.2. NM_173465.3.
UniGene	Hs.660026.
3D structure databases
ProteinModelPortal	Q86Y22.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86Y22. 1 interaction.
STRING	Q86Y22.
Polymorphism databases
DMDM	74723551.
Proteomic databases
PRIDE	Q86Y22.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000390654; ENSP00000375069; ENSG00000050767.
GeneID	91522.
KEGG	hsa:91522.
UCSC	uc003mje.1. human.
Organism-specific databases
CTD	91522.
GeneCards	GC05M177664.
H-InvDB	HIX0200749.
HGNC	HGNC:22990. COL23A1.
MIM	610043. gene.
neXtProt	NX_Q86Y22.
PharmGKB	PA134899251.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18773.
GeneTree	ENSGT00530000063274.
HOGENOM	HBG444750.
HOVERGEN	HBG004933.
InParanoid	Q86Y22.
OMA	REAPTEC.
OrthoDB	EOG4N5VZ2.
PhylomeDB	Q86Y22.
Gene expression databases
ArrayExpress	Q86Y22.
Bgee	Q86Y22.
CleanEx	HS_COL23A1.
Genevestigator	Q86Y22.
GermOnline	ENSG00000050767. Homo sapiens.
Family and domain databases
InterPro	IPR008160. Collagen. [Graphical view]
Pfam	PF01391. Collagen. 8 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	77272.
SOURCE	Search...

Entry information

Entry name

CONA1_HUMAN

Accession

Primary (citable) accession number: Q86Y22
Secondary accession number(s): Q8IVR4, Q9NT93

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.