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Protein

Serine/threonine-protein kinase VRK2

Gene

VRK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.
Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

RAN inhibits its autophosphorylation and its ability to phosphorylate histone H3.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61ATPPROSITE-ProRule annotation1
Active sitei166Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi35 – 43ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein domain specific binding Source: MGI
  • protein kinase binding Source: MGI
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • cellular response to oxidative stress Source: UniProtKB
  • peptidyl-serine phosphorylation Source: GO_Central
  • protein autophosphorylation Source: UniProtKB
  • protein phosphorylation Source: ProtInc
  • regulation of cell shape Source: GO_Central
  • regulation of interleukin-1-mediated signaling pathway Source: UniProtKB
  • regulation of MAPK cascade Source: UniProtKB
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Host-virus interaction

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS00461-MONOMER.
ReactomeiR-HSA-2993913. Clearance of Nuclear Envelope Membranes from Chromatin.
R-HSA-2995383. Initiation of Nuclear Envelope Reformation.
SignaLinkiQ86Y07.
SIGNORiQ86Y07.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase VRK2 (EC:2.7.11.1)
Alternative name(s):
Vaccinia-related kinase 2
Gene namesi
Name:VRK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12719. VRK2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei487 – 507Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • endoplasmic reticulum Source: HPA
  • endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial membrane Source: UniProtKB
  • nucleus Source: UniProtKB
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7444.
OpenTargetsiENSG00000028116.
PharmGKBiPA37331.

Chemistry databases

ChEMBLiCHEMBL1649059.
GuidetoPHARMACOLOGYi2276.

Polymorphism and mutation databases

BioMutaiVRK2.
DMDMi90116515.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000868061 – 508Serine/threonine-protein kinase VRK2Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphothreonineCombined sources1
Modified residuei406PhosphoserineCombined sources1

Post-translational modificationi

Isoform 1 and isoform 2 are autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86Y07.
MaxQBiQ86Y07.
PaxDbiQ86Y07.
PeptideAtlasiQ86Y07.
PRIDEiQ86Y07.

PTM databases

iPTMnetiQ86Y07.
PhosphoSitePlusiQ86Y07.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1 inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis.3 Publications

Gene expression databases

BgeeiENSG00000028116.
ExpressionAtlasiQ86Y07. baseline and differential.
GenevisibleiQ86Y07. HS.

Organism-specific databases

HPAiCAB046459.
HPA047503.

Interactioni

Subunit structurei

Isoform 1 interacts with MAP3K7, MAP2K7, MAP2K1 and KSR1. Isoform 1 and isoform 2 interact with RAN and MAPK8IP1. Isoform 1 interacts with Epstein-Barr virus BHRF1; this interaction is involved in protecting cells from apoptosis.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2L1Q07817-12EBI-1207633,EBI-287195
BHRF1P031827EBI-1207615,EBI-1207659From a different organism.
KSR1Q8IVT54EBI-1207615,EBI-486984
Ksr1Q610978EBI-1207633,EBI-1536336From a different organism.
MAP2K1Q027502EBI-1207615,EBI-492564
Map3k7Q620733EBI-1207633,EBI-1775345From a different organism.
Mapk8ip1Q9WVI9-22EBI-1207636,EBI-288464From a different organism.
NFATC2Q134694EBI-1207636,EBI-716258
Nfatc2Q605912EBI-1207633,EBI-643104From a different organism.
RANP628262EBI-1207633,EBI-286642
Tab1Q8CF892EBI-1207633,EBI-1778503From a different organism.

GO - Molecular functioni

  • protein domain specific binding Source: MGI
  • protein kinase binding Source: MGI

Protein-protein interaction databases

BioGridi113283. 29 interactors.
IntActiQ86Y07. 29 interactors.
MINTiMINT-6597566.
STRINGi9606.ENSP00000342381.

Chemistry databases

BindingDBiQ86Y07.

Structurei

Secondary structure

1508
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi20 – 22Combined sources3
Beta strandi28 – 34Combined sources7
Beta strandi43 – 51Combined sources9
Helixi53 – 55Combined sources3
Beta strandi58 – 64Combined sources7
Helixi69 – 80Combined sources12
Helixi83 – 93Combined sources11
Beta strandi103 – 113Combined sources11
Beta strandi115 – 122Combined sources8
Beta strandi124 – 127Combined sources4
Helixi128 – 131Combined sources4
Helixi134 – 136Combined sources3
Helixi140 – 159Combined sources20
Helixi169 – 171Combined sources3
Beta strandi172 – 178Combined sources7
Beta strandi181 – 184Combined sources4
Beta strandi191 – 194Combined sources4
Helixi195 – 197Combined sources3
Helixi206 – 208Combined sources3
Turni214 – 216Combined sources3
Helixi219 – 223Combined sources5
Helixi229 – 245Combined sources17
Helixi251 – 253Combined sources3
Helixi257 – 269Combined sources13
Turni270 – 272Combined sources3
Helixi273 – 278Combined sources6
Helixi286 – 296Combined sources11
Helixi306 – 313Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V62X-ray1.70A/B14-335[»]
ProteinModelPortaliQ86Y07.
SMRiQ86Y07.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86Y07.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 319Protein kinasePROSITE-ProRule annotationAdd BLAST291

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni397 – 508Interaction with MAP3K71 PublicationAdd BLAST112

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1164. Eukaryota.
ENOG410XPGP. LUCA.
GeneTreeiENSGT00850000132311.
HOVERGENiHBG007532.
InParanoidiQ86Y07.
KOiK08816.
OMAiHQDFTSP.
OrthoDBiEOG091G05V5.
PhylomeDBiQ86Y07.
TreeFamiTF106473.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86Y07-1) [UniParc]FASTAAdd to basket
Also known as: VRK2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPKRNEKYK LPIPFPEGKV LDDMEGNQWV LGKKIGSGGF GLIYLAFPTN
60 70 80 90 100
KPEKDARHVV KVEYQENGPL FSELKFYQRV AKKDCIKKWI ERKQLDYLGI
110 120 130 140 150
PLFYGSGLTE FKGRSYRFMV MERLGIDLQK ISGQNGTFKK STVLQLGIRM
160 170 180 190 200
LDVLEYIHEN EYVHGDIKAA NLLLGYKNPD QVYLADYGLS YRYCPNGNHK
210 220 230 240 250
QYQENPRKGH NGTIEFTSLD AHKGVALSRR SDVEILGYCM LRWLCGKLPW
260 270 280 290 300
EQNLKDPVAV QTAKTNLLDE LPQSVLKWAP SGSSCCEIAQ FLVCAHSLAY
310 320 330 340 350
DEKPNYQALK KILNPHGIPL GPLDFSTKGQ SINVHTPNSQ KVDSQKAATK
360 370 380 390 400
QVNKAHNRLI EKKVHSERSA ESCATWKVQK EEKLIGLMNN EAAQESTRRR
410 420 430 440 450
QKYQESQEPL NEVNSFPQKI SYTQFPNSFY EPHQDFTSPD IFKKSRSPSW
460 470 480 490 500
YKYTSTVSTG ITDLESSTGL WPTISQFTLS EETNADVYYY RIIIPVLLML

VFLALFFL
Length:508
Mass (Da):58,141
Last modified:March 7, 2006 - v3
Checksum:i9F3F6FCC9280568F
GO
Isoform 2 (identifier: Q86Y07-2) [UniParc]FASTAAdd to basket
Also known as: VRK2B

The sequence of this isoform differs from the canonical sequence as follows:
     395-397: EST → VEA
     398-508: Missing.

Show »
Length:397
Mass (Da):45,030
Checksum:i0308378DD02D85EC
GO
Isoform 3 (identifier: Q86Y07-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Note: No experimental confirmation available.
Show »
Length:485
Mass (Da):55,446
Checksum:i425363D6092A57FC
GO
Isoform 4 (identifier: Q86Y07-4) [UniParc]FASTAAdd to basket
Also known as: 5

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.

Show »
Length:390
Mass (Da):44,411
Checksum:i9F320B446A872E5D
GO
Isoform 5 (identifier: Q86Y07-5) [UniParc]FASTAAdd to basket
Also known as: 6

The sequence of this isoform differs from the canonical sequence as follows:
     395-396: ES → FR
     397-508: Missing.

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):45,034
Checksum:i773C8DD02D85EC43
GO

Sequence cautioni

The sequence CAD54446 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti419K → E in AAO73048 (Ref. 3) Curated1
Sequence conflicti419K → E in AAO73049 (Ref. 3) Curated1
Sequence conflicti419K → E in AAO73051 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04129350N → D.1 PublicationCorresponds to variant rs34130684dbSNPEnsembl.1
Natural variantiVAR_041294157I → M.1 PublicationCorresponds to variant rs35966666dbSNPEnsembl.1
Natural variantiVAR_017095167I → V.4 PublicationsCorresponds to variant rs1051061dbSNPEnsembl.1
Natural variantiVAR_051681211N → S.Corresponds to variant rs36081172dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0085341 – 118Missing in isoform 4. 2 PublicationsAdd BLAST118
Alternative sequenceiVSP_0085331 – 23Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_008537395 – 397EST → VEA in isoform 2. 1 Publication3
Alternative sequenceiVSP_008535395 – 396ES → FR in isoform 5. 1 Publication2
Alternative sequenceiVSP_008536397 – 508Missing in isoform 5. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_008538398 – 508Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000450 mRNA. Translation: BAA19109.1.
AJ512204 mRNA. Translation: CAD54446.2. Sequence problems.
AY228367 mRNA. Translation: AAO73047.1.
AY228368 mRNA. Translation: AAO73048.1.
AY228369 mRNA. Translation: AAO73049.1.
AY228370 mRNA. Translation: AAO73050.1.
AY228371 mRNA. Translation: AAO73051.1.
AY228372 mRNA. Translation: AAO73052.1.
AK296611 mRNA. Translation: BAG59222.1.
AK223540 mRNA. Translation: BAD97260.1.
AC007250 Genomic DNA. Translation: AAY15019.1.
AC068193 Genomic DNA. Translation: AAX93262.1.
AC073215 Genomic DNA. Translation: AAY14648.1.
CH471053 Genomic DNA. Translation: EAX00062.1.
CH471053 Genomic DNA. Translation: EAX00064.1.
CH471053 Genomic DNA. Translation: EAX00066.1.
CH471053 Genomic DNA. Translation: EAX00067.1.
CH471053 Genomic DNA. Translation: EAX00068.1.
BC027854 mRNA. Translation: AAH27854.1.
CCDSiCCDS1859.1. [Q86Y07-1]
CCDS46291.1. [Q86Y07-5]
CCDS46292.1. [Q86Y07-3]
RefSeqiNP_001123952.1. NM_001130480.2. [Q86Y07-1]
NP_001123953.1. NM_001130481.2. [Q86Y07-1]
NP_001123954.1. NM_001130482.2. [Q86Y07-3]
NP_001123955.1. NM_001130483.2. [Q86Y07-5]
NP_001275765.1. NM_001288836.1. [Q86Y07-4]
NP_001275766.1. NM_001288837.1. [Q86Y07-1]
NP_001275767.1. NM_001288838.1. [Q86Y07-5]
NP_001275768.1. NM_001288839.1. [Q86Y07-4]
NP_006287.2. NM_006296.6. [Q86Y07-1]
XP_005264597.1. XM_005264540.4. [Q86Y07-1]
XP_006712153.1. XM_006712090.3. [Q86Y07-2]
XP_006712154.1. XM_006712091.3. [Q86Y07-5]
XP_006712155.1. XM_006712092.3. [Q86Y07-4]
XP_006712156.1. XM_006712093.3. [Q86Y07-4]
XP_011531394.1. XM_011533092.2. [Q86Y07-1]
XP_016860347.1. XM_017004858.1. [Q86Y07-2]
XP_016860348.1. XM_017004859.1. [Q86Y07-4]
XP_016860349.1. XM_017004860.1. [Q86Y07-4]
XP_016860350.1. XM_017004861.1. [Q86Y07-4]
XP_016860351.1. XM_017004862.1. [Q86Y07-4]
XP_016860352.1. XM_017004863.1. [Q86Y07-4]
UniGeneiHs.715298.
Hs.744058.

Genome annotation databases

EnsembliENST00000340157; ENSP00000342381; ENSG00000028116. [Q86Y07-1]
ENST00000412104; ENSP00000404156; ENSG00000028116. [Q86Y07-4]
ENST00000417641; ENSP00000402375; ENSG00000028116. [Q86Y07-5]
ENST00000435505; ENSP00000408002; ENSG00000028116. [Q86Y07-1]
ENST00000440705; ENSP00000398323; ENSG00000028116. [Q86Y07-3]
GeneIDi7444.
KEGGihsa:7444.
UCSCiuc002rzo.3. human. [Q86Y07-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000450 mRNA. Translation: BAA19109.1.
AJ512204 mRNA. Translation: CAD54446.2. Sequence problems.
AY228367 mRNA. Translation: AAO73047.1.
AY228368 mRNA. Translation: AAO73048.1.
AY228369 mRNA. Translation: AAO73049.1.
AY228370 mRNA. Translation: AAO73050.1.
AY228371 mRNA. Translation: AAO73051.1.
AY228372 mRNA. Translation: AAO73052.1.
AK296611 mRNA. Translation: BAG59222.1.
AK223540 mRNA. Translation: BAD97260.1.
AC007250 Genomic DNA. Translation: AAY15019.1.
AC068193 Genomic DNA. Translation: AAX93262.1.
AC073215 Genomic DNA. Translation: AAY14648.1.
CH471053 Genomic DNA. Translation: EAX00062.1.
CH471053 Genomic DNA. Translation: EAX00064.1.
CH471053 Genomic DNA. Translation: EAX00066.1.
CH471053 Genomic DNA. Translation: EAX00067.1.
CH471053 Genomic DNA. Translation: EAX00068.1.
BC027854 mRNA. Translation: AAH27854.1.
CCDSiCCDS1859.1. [Q86Y07-1]
CCDS46291.1. [Q86Y07-5]
CCDS46292.1. [Q86Y07-3]
RefSeqiNP_001123952.1. NM_001130480.2. [Q86Y07-1]
NP_001123953.1. NM_001130481.2. [Q86Y07-1]
NP_001123954.1. NM_001130482.2. [Q86Y07-3]
NP_001123955.1. NM_001130483.2. [Q86Y07-5]
NP_001275765.1. NM_001288836.1. [Q86Y07-4]
NP_001275766.1. NM_001288837.1. [Q86Y07-1]
NP_001275767.1. NM_001288838.1. [Q86Y07-5]
NP_001275768.1. NM_001288839.1. [Q86Y07-4]
NP_006287.2. NM_006296.6. [Q86Y07-1]
XP_005264597.1. XM_005264540.4. [Q86Y07-1]
XP_006712153.1. XM_006712090.3. [Q86Y07-2]
XP_006712154.1. XM_006712091.3. [Q86Y07-5]
XP_006712155.1. XM_006712092.3. [Q86Y07-4]
XP_006712156.1. XM_006712093.3. [Q86Y07-4]
XP_011531394.1. XM_011533092.2. [Q86Y07-1]
XP_016860347.1. XM_017004858.1. [Q86Y07-2]
XP_016860348.1. XM_017004859.1. [Q86Y07-4]
XP_016860349.1. XM_017004860.1. [Q86Y07-4]
XP_016860350.1. XM_017004861.1. [Q86Y07-4]
XP_016860351.1. XM_017004862.1. [Q86Y07-4]
XP_016860352.1. XM_017004863.1. [Q86Y07-4]
UniGeneiHs.715298.
Hs.744058.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V62X-ray1.70A/B14-335[»]
ProteinModelPortaliQ86Y07.
SMRiQ86Y07.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113283. 29 interactors.
IntActiQ86Y07. 29 interactors.
MINTiMINT-6597566.
STRINGi9606.ENSP00000342381.

Chemistry databases

BindingDBiQ86Y07.
ChEMBLiCHEMBL1649059.
GuidetoPHARMACOLOGYi2276.

PTM databases

iPTMnetiQ86Y07.
PhosphoSitePlusiQ86Y07.

Polymorphism and mutation databases

BioMutaiVRK2.
DMDMi90116515.

Proteomic databases

EPDiQ86Y07.
MaxQBiQ86Y07.
PaxDbiQ86Y07.
PeptideAtlasiQ86Y07.
PRIDEiQ86Y07.

Protocols and materials databases

DNASUi7444.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340157; ENSP00000342381; ENSG00000028116. [Q86Y07-1]
ENST00000412104; ENSP00000404156; ENSG00000028116. [Q86Y07-4]
ENST00000417641; ENSP00000402375; ENSG00000028116. [Q86Y07-5]
ENST00000435505; ENSP00000408002; ENSG00000028116. [Q86Y07-1]
ENST00000440705; ENSP00000398323; ENSG00000028116. [Q86Y07-3]
GeneIDi7444.
KEGGihsa:7444.
UCSCiuc002rzo.3. human. [Q86Y07-1]

Organism-specific databases

CTDi7444.
DisGeNETi7444.
GeneCardsiVRK2.
H-InvDBHIX0002070.
HGNCiHGNC:12719. VRK2.
HPAiCAB046459.
HPA047503.
MIMi602169. gene.
neXtProtiNX_Q86Y07.
OpenTargetsiENSG00000028116.
PharmGKBiPA37331.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1164. Eukaryota.
ENOG410XPGP. LUCA.
GeneTreeiENSGT00850000132311.
HOVERGENiHBG007532.
InParanoidiQ86Y07.
KOiK08816.
OMAiHQDFTSP.
OrthoDBiEOG091G05V5.
PhylomeDBiQ86Y07.
TreeFamiTF106473.

Enzyme and pathway databases

BioCyciZFISH:HS00461-MONOMER.
ReactomeiR-HSA-2993913. Clearance of Nuclear Envelope Membranes from Chromatin.
R-HSA-2995383. Initiation of Nuclear Envelope Reformation.
SignaLinkiQ86Y07.
SIGNORiQ86Y07.

Miscellaneous databases

ChiTaRSiVRK2. human.
EvolutionaryTraceiQ86Y07.
GeneWikiiVRK2.
GenomeRNAii7444.
PROiQ86Y07.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000028116.
ExpressionAtlasiQ86Y07. baseline and differential.
GenevisibleiQ86Y07. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVRK2_HUMAN
AccessioniPrimary (citable) accession number: Q86Y07
Secondary accession number(s): B4DKL0
, D6W5D4, D6W5D6, Q49AK9, Q53EU9, Q53S39, Q53S77, Q53TU1, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 155 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.