Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Spermatogenesis-associated serine-rich protein 2

Gene

SPATS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated serine-rich protein 2
Alternative name(s):
Serine-rich spermatocytes and round spermatid 59 kDa protein
p59scr
Gene namesi
Name:SPATS2
Synonyms:SCR59, SPATA10
ORF Names:Nbla00526
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:18650. SPATS2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871579.

Polymorphism and mutation databases

BioMutaiSPATS2.
DMDMi74750549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 545545Spermatogenesis-associated serine-rich protein 2PRO_0000307697Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei143 – 1431PhosphoserineBy similarity
Modified residuei146 – 1461PhosphoserineCombined sources
Modified residuei148 – 1481PhosphoserineBy similarity
Modified residuei520 – 5201PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86XZ4.
MaxQBiQ86XZ4.
PaxDbiQ86XZ4.
PRIDEiQ86XZ4.

PTM databases

iPTMnetiQ86XZ4.
PhosphoSiteiQ86XZ4.

Expressioni

Gene expression databases

BgeeiQ86XZ4.
CleanExiHS_SPATS2.
ExpressionAtlasiQ86XZ4. baseline and differential.
GenevisibleiQ86XZ4. HS.

Organism-specific databases

HPAiHPA038642.
HPA038643.

Interactioni

Protein-protein interaction databases

BioGridi122410. 20 interactions.
IntActiQ86XZ4. 10 interactions.
STRINGi9606.ENSP00000326841.

Structurei

3D structure databases

ProteinModelPortaliQ86XZ4.
SMRiQ86XZ4. Positions 28-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi86 – 9712Poly-LysAdd
BLAST
Compositional biasi364 – 41451Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the SPATS2 family.Curated

Phylogenomic databases

eggNOGiENOG410IJV6. Eukaryota.
ENOG410Y9WN. LUCA.
GeneTreeiENSGT00390000001138.
HOGENOMiHOG000013053.
HOVERGENiHBG059711.
InParanoidiQ86XZ4.
OMAiYRPQGQK.
OrthoDBiEOG76T9R1.
PhylomeDBiQ86XZ4.
TreeFamiTF320553.

Family and domain databases

InterProiIPR009816. DUF1387.
IPR009060. UBA-like.
[Graphical view]
PfamiPF07139. DUF1387. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86XZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKQNQKDS SGFIFDLQSN TVLAQGGAFE NMKEKINAVR AIVPNKSNNE
60 70 80 90 100
IILVLQHFDN CVDKTVQAFM EGSASEVLKE WTVTGKKKNK KKKNKPKPAA
110 120 130 140 150
EPSNGIPDSS KSVSIQEEQS APSSEKGGMN GYHVNGAIND TESVDSLSEG
160 170 180 190 200
LETLSIDARE LEDPESAMLD TLDRTGSMLQ NGVSDFETKS LTMHSIHNSQ
210 220 230 240 250
QPRNAAKSLS RPTTETQFSN MGMEDVPLAT SKKLSSNIEK SVKDLQRCTV
260 270 280 290 300
SLARYRVVVK EEMDASIKKM KQAFAELESC LMDREVALLA EMDKVKAEAM
310 320 330 340 350
EILLSRQKKA ELLKKMTHVA VQMSEQQLVE LRADIKHFVS ERKYDEDLGR
360 370 380 390 400
VARFTCDVET LKKSIDSFGQ VSHPKNSYST RSRCSSVTSV SLSSPSDASA
410 420 430 440 450
ASSSTCASPP SLTSANKKNF APGETPAAIA NSSGQPYQPL REVLPGNRRG
460 470 480 490 500
GQGYRPQGQK SNDPMNQGRH DSMGRYRNSS WYSSGSRYQS APSQAPGNTI
510 520 530 540
ERGQTHSAGT NGTGVSMEPS PPTPSFKKGL PQRKPRTSQT EAVNS
Length:545
Mass (Da):59,545
Last modified:June 1, 2003 - v1
Checksum:iE203EA5BA3FDB0BF
GO

Sequence cautioni

The sequence BAB14448.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14958.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti393 – 3931S → N in BAB14958 (PubMed:14702039).Curated
Sequence conflicti514 – 5141G → R in BAB14460 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075515 mRNA. Translation: BAE45760.1.
AK023179 mRNA. Translation: BAB14448.1. Different initiation.
AK023202 mRNA. Translation: BAB14460.1.
AK024678 mRNA. Translation: BAB14958.1. Different initiation.
AK292334 mRNA. Translation: BAF85023.1.
CH471111 Genomic DNA. Translation: EAW58068.1.
BC048299 mRNA. Translation: AAH48299.1.
CCDSiCCDS31794.1.
RefSeqiNP_001280214.1. NM_001293285.1.
NP_001280215.1. NM_001293286.1.
NP_075559.2. NM_023071.3.
XP_011536992.1. XM_011538690.1.
XP_011536993.1. XM_011538691.1.
UniGeneiHs.654826.

Genome annotation databases

EnsembliENST00000321898; ENSP00000326841; ENSG00000123352.
ENST00000552918; ENSP00000447947; ENSG00000123352.
ENST00000553127; ENSP00000448228; ENSG00000123352.
GeneIDi65244.
KEGGihsa:65244.
UCSCiuc001rud.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075515 mRNA. Translation: BAE45760.1.
AK023179 mRNA. Translation: BAB14448.1. Different initiation.
AK023202 mRNA. Translation: BAB14460.1.
AK024678 mRNA. Translation: BAB14958.1. Different initiation.
AK292334 mRNA. Translation: BAF85023.1.
CH471111 Genomic DNA. Translation: EAW58068.1.
BC048299 mRNA. Translation: AAH48299.1.
CCDSiCCDS31794.1.
RefSeqiNP_001280214.1. NM_001293285.1.
NP_001280215.1. NM_001293286.1.
NP_075559.2. NM_023071.3.
XP_011536992.1. XM_011538690.1.
XP_011536993.1. XM_011538691.1.
UniGeneiHs.654826.

3D structure databases

ProteinModelPortaliQ86XZ4.
SMRiQ86XZ4. Positions 28-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122410. 20 interactions.
IntActiQ86XZ4. 10 interactions.
STRINGi9606.ENSP00000326841.

PTM databases

iPTMnetiQ86XZ4.
PhosphoSiteiQ86XZ4.

Polymorphism and mutation databases

BioMutaiSPATS2.
DMDMi74750549.

Proteomic databases

EPDiQ86XZ4.
MaxQBiQ86XZ4.
PaxDbiQ86XZ4.
PRIDEiQ86XZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321898; ENSP00000326841; ENSG00000123352.
ENST00000552918; ENSP00000447947; ENSG00000123352.
ENST00000553127; ENSP00000448228; ENSG00000123352.
GeneIDi65244.
KEGGihsa:65244.
UCSCiuc001rud.3. human.

Organism-specific databases

CTDi65244.
GeneCardsiSPATS2.
HGNCiHGNC:18650. SPATS2.
HPAiHPA038642.
HPA038643.
MIMi611667. gene.
neXtProtiNX_Q86XZ4.
PharmGKBiPA134871579.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJV6. Eukaryota.
ENOG410Y9WN. LUCA.
GeneTreeiENSGT00390000001138.
HOGENOMiHOG000013053.
HOVERGENiHBG059711.
InParanoidiQ86XZ4.
OMAiYRPQGQK.
OrthoDBiEOG76T9R1.
PhylomeDBiQ86XZ4.
TreeFamiTF320553.

Miscellaneous databases

ChiTaRSiSPATS2. human.
GenomeRNAii65244.
NextBioi67362.
PROiQ86XZ4.
SOURCEiSearch...

Gene expression databases

BgeeiQ86XZ4.
CleanExiHS_SPATS2.
ExpressionAtlasiQ86XZ4. baseline and differential.
GenevisibleiQ86XZ4. HS.

Family and domain databases

InterProiIPR009816. DUF1387.
IPR009060. UBA-like.
[Graphical view]
PfamiPF07139. DUF1387. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
    Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
    Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neuroblastoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSPAS2_HUMAN
AccessioniPrimary (citable) accession number: Q86XZ4
Secondary accession number(s): A8K8G9
, Q9H7D4, Q9H8Y7, Q9H8Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.