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Protein

Thioredoxin domain-containing protein 6

Gene

NME9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be a regulator of microtubule physiology.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 6
Alternative name(s):
Thioredoxin-like protein 2
Short name:
Txl-2
Gene namesi
Name:NME9
Synonyms:TXL2, TXNDC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:21343. NME9.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmcytoskeleton By similarity

  • Note: Associated with microtubules. Detected in cilia of lung epithelium, and associated with the spermatid tail and manchette (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909407.

Polymorphism and mutation databases

BioMutaiNME9.
DMDMi47606157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Thioredoxin domain-containing protein 6PRO_0000120161Add
BLAST

Proteomic databases

PRIDEiQ86XW9.

Expressioni

Tissue specificityi

Detected at very low levels in testis, lung and brain.1 Publication

Gene expression databases

BgeeiQ86XW9.
CleanExiHS_TXNDC6.
ExpressionAtlasiQ86XW9. baseline and differential.
GenevisibleiQ86XW9. HS.

Organism-specific databases

HPAiCAB020943.

Interactioni

Subunit structurei

Monomer and homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ86XW9.
SMRiQ86XW9. Positions 12-110, 155-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 115105ThioredoxinAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni157 – 303147NDKAdd
BLAST

Sequence similaritiesi

Belongs to the NDK family.Curated
Contains 1 thioredoxin domain.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119146.
HOGENOMiHOG000121771.
HOVERGENiHBG079293.
InParanoidiQ86XW9.
KOiK19869.
OMAiFQKMRIE.
OrthoDBiEOG79KPFK.
PhylomeDBiQ86XW9.
TreeFamiTF106374.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86XW9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSRKKEIAL QVNISTQELW EEMLSSKGLT VVDVYQGWCG PCKPVVSLFQ
60 70 80 90 100
KMRIEVGLDL LHFALAEADR LDVLEKYRGK CEPTFLFYAG GELVAVVRGA
110 120 130 140 150
NAPLLQKTIL DQLEAEKKVL AEGRERKVIK DEALSDEDEC VSHGKNNGED
160 170 180 190 200
EDMVSSERTC TLAIIKPDAV AHGKTDEIIM KIQEAGFEIL TNEERTMTEA
210 220 230 240 250
EVRLFYQHKA GEEAFEKLVH HMCSGPSHLL ILTRTEGFED VVTTWRTVMG
260 270 280 290 300
PRDPNVARRE QPESLRAQYG TEMPFNAVHG SRDREDADRE LALLFPSLKF
310 320 330
SDKDTEAPQG GEAEATAGPT EALCFPEDVD
Length:330
Mass (Da):36,856
Last modified:June 1, 2003 - v1
Checksum:iD6D8072D1B905E6C
GO
Isoform 2 (identifier: Q86XW9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     90-128: Missing.
     311-330: GEAEATAGPTEALCFPEDVD → ESSTQPRLKITDLD

Note: No experimental confirmation available.
Show »
Length:263
Mass (Da):29,683
Checksum:iFEA8DC6C78722981
GO
Isoform 3 (identifier: Q86XW9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-128: Missing.
     311-330: GEAEATAGPTEALCFPEDVD → ESSTQPRLKITDLD

Note: No experimental confirmation available.
Show »
Length:261
Mass (Da):29,437
Checksum:iD455C721486FCB48
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti214 – 2141A → V in AAQ16116 (Ref. 3) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2222Missing in isoform 2. 1 PublicationVSP_010375Add
BLAST
Alternative sequencei66 – 12863Missing in isoform 3. 1 PublicationVSP_010376Add
BLAST
Alternative sequencei90 – 12839Missing in isoform 2. 1 PublicationVSP_010377Add
BLAST
Alternative sequencei311 – 33020GEAEA…PEDVD → ESSTQPRLKITDLD in isoform 2 and isoform 3. 2 PublicationsVSP_010378Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196568 mRNA. Translation: AAG28497.1.
AK094830 mRNA. Translation: BAC04430.1.
AY336746 mRNA. Translation: AAQ16116.1.
CCDSiCCDS3099.1. [Q86XW9-2]
RefSeqiNP_835231.1. NM_178130.3. [Q86XW9-2]
XP_011511073.1. XM_011512771.1. [Q86XW9-1]
UniGeneiHs.660992.

Genome annotation databases

EnsembliENST00000317876; ENSP00000321929; ENSG00000181322. [Q86XW9-2]
ENST00000333911; ENSP00000335444; ENSG00000181322. [Q86XW9-1]
ENST00000383180; ENSP00000372667; ENSG00000181322. [Q86XW9-2]
ENST00000484930; ENSP00000419882; ENSG00000181322. [Q86XW9-3]
GeneIDi347736.
KEGGihsa:347736.
UCSCiuc003ese.1. human. [Q86XW9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196568 mRNA. Translation: AAG28497.1.
AK094830 mRNA. Translation: BAC04430.1.
AY336746 mRNA. Translation: AAQ16116.1.
CCDSiCCDS3099.1. [Q86XW9-2]
RefSeqiNP_835231.1. NM_178130.3. [Q86XW9-2]
XP_011511073.1. XM_011512771.1. [Q86XW9-1]
UniGeneiHs.660992.

3D structure databases

ProteinModelPortaliQ86XW9.
SMRiQ86XW9. Positions 12-110, 155-295.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiNME9.
DMDMi47606157.

Proteomic databases

PRIDEiQ86XW9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317876; ENSP00000321929; ENSG00000181322. [Q86XW9-2]
ENST00000333911; ENSP00000335444; ENSG00000181322. [Q86XW9-1]
ENST00000383180; ENSP00000372667; ENSG00000181322. [Q86XW9-2]
ENST00000484930; ENSP00000419882; ENSG00000181322. [Q86XW9-3]
GeneIDi347736.
KEGGihsa:347736.
UCSCiuc003ese.1. human. [Q86XW9-1]

Organism-specific databases

CTDi347736.
GeneCardsiNME9.
HGNCiHGNC:21343. NME9.
HPAiCAB020943.
neXtProtiNX_Q86XW9.
PharmGKBiPA134909407.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119146.
HOGENOMiHOG000121771.
HOVERGENiHBG079293.
InParanoidiQ86XW9.
KOiK19869.
OMAiFQKMRIE.
OrthoDBiEOG79KPFK.
PhylomeDBiQ86XW9.
TreeFamiTF106374.

Miscellaneous databases

ChiTaRSiNME9. human.
GenomeRNAii347736.
NextBioi99274.
PROiQ86XW9.

Gene expression databases

BgeeiQ86XW9.
CleanExiHS_TXNDC6.
ExpressionAtlasiQ86XW9. baseline and differential.
GenevisibleiQ86XW9. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of human thioredoxin-like 2. A novel microtubule-binding thioredoxin expressed predominantly in the cilia of lung airway epithelium and spermatid manchette and axoneme."
    Sadek C.M., Jimenez A., Damdimopoulos A.E., Kieselbach T., Nord M., Gustafsson J.-A., Spyrou G., Davis E.C., Oko R., van der Hoorn F.A., Miranda-Vizuete A.
    J. Biol. Chem. 278:13133-13142(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Caudate nucleus.
  3. Zhou G., Yu R., Zheng G., Li H., Shen C., Xiao W., Li M., Zhong G., Lin L., Yang S.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-330 (ISOFORM 3).

Entry informationi

Entry nameiTXND6_HUMAN
AccessioniPrimary (citable) accession number: Q86XW9
Secondary accession number(s): Q7Z4A8, Q8N1V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Shows no detectable enzyme activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.