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Protein

Thioredoxin domain-containing protein 6

Gene

NME9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be a regulator of microtubule physiology.

Miscellaneous

Shows no detectable enzyme activity.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 6
Alternative name(s):
Thioredoxin-like protein 2
Short name:
Txl-2
Gene namesi
Name:NME9
Synonyms:TXL2, TXNDC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000181322.13.
HGNCiHGNC:21343. NME9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi347736.
OpenTargetsiENSG00000181322.
PharmGKBiPA134909407.

Polymorphism and mutation databases

BioMutaiNME9.
DMDMi47606157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001201611 – 330Thioredoxin domain-containing protein 6Add BLAST330

Proteomic databases

PeptideAtlasiQ86XW9.
PRIDEiQ86XW9.

PTM databases

iPTMnetiQ86XW9.
PhosphoSitePlusiQ86XW9.

Expressioni

Tissue specificityi

Detected at very low levels in testis, lung and brain.1 Publication

Gene expression databases

BgeeiENSG00000181322.
CleanExiHS_TXNDC6.
ExpressionAtlasiQ86XW9. baseline and differential.
GenevisibleiQ86XW9. HS.

Organism-specific databases

HPAiHPA040000.
HPA043881.

Interactioni

Subunit structurei

Monomer and homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ86XW9.
SMRiQ86XW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 115ThioredoxinAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 303NDKAdd BLAST147

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119146.
HOGENOMiHOG000121771.
HOVERGENiHBG079293.
InParanoidiQ86XW9.
KOiK19869.
OMAiFQKMRIE.
OrthoDBiEOG091G03O2.
PhylomeDBiQ86XW9.
TreeFamiTF106374.

Family and domain databases

Gene3Di3.30.70.141. 2 hits.
InterProiView protein in InterPro
IPR034907. NDK-like_dom.
IPR036850. NDK-like_dom_sf.
IPR001564. Nucleoside_diP_kinase.
IPR036249. Thioredoxin-like_sf.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
PfamiView protein in Pfam
PF00334. NDK. 1 hit.
PF00085. Thioredoxin. 1 hit.
PRINTSiPR01243. NUCDPKINASE.
SMARTiView protein in SMART
SM00562. NDK. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF54919. SSF54919. 1 hit.
PROSITEiView protein in PROSITE
PS00194. THIOREDOXIN_1. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86XW9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSRKKEIAL QVNISTQELW EEMLSSKGLT VVDVYQGWCG PCKPVVSLFQ
60 70 80 90 100
KMRIEVGLDL LHFALAEADR LDVLEKYRGK CEPTFLFYAG GELVAVVRGA
110 120 130 140 150
NAPLLQKTIL DQLEAEKKVL AEGRERKVIK DEALSDEDEC VSHGKNNGED
160 170 180 190 200
EDMVSSERTC TLAIIKPDAV AHGKTDEIIM KIQEAGFEIL TNEERTMTEA
210 220 230 240 250
EVRLFYQHKA GEEAFEKLVH HMCSGPSHLL ILTRTEGFED VVTTWRTVMG
260 270 280 290 300
PRDPNVARRE QPESLRAQYG TEMPFNAVHG SRDREDADRE LALLFPSLKF
310 320 330
SDKDTEAPQG GEAEATAGPT EALCFPEDVD
Length:330
Mass (Da):36,856
Last modified:June 1, 2003 - v1
Checksum:iD6D8072D1B905E6C
GO
Isoform 2 (identifier: Q86XW9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     90-128: Missing.
     311-330: GEAEATAGPTEALCFPEDVD → ESSTQPRLKITDLD

Note: No experimental confirmation available.
Show »
Length:263
Mass (Da):29,683
Checksum:iFEA8DC6C78722981
GO
Isoform 3 (identifier: Q86XW9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-128: Missing.
     311-330: GEAEATAGPTEALCFPEDVD → ESSTQPRLKITDLD

Note: No experimental confirmation available.
Show »
Length:261
Mass (Da):29,437
Checksum:iD455C721486FCB48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti214A → V in AAQ16116 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0103751 – 22Missing in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_01037666 – 128Missing in isoform 3. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_01037790 – 128Missing in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_010378311 – 330GEAEA…PEDVD → ESSTQPRLKITDLD in isoform 2 and isoform 3. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196568 mRNA. Translation: AAG28497.1.
AK094830 mRNA. Translation: BAC04430.1.
AY336746 mRNA. Translation: AAQ16116.1.
CCDSiCCDS3099.1. [Q86XW9-2]
RefSeqiNP_835231.1. NM_178130.3. [Q86XW9-2]
UniGeneiHs.660992.

Genome annotation databases

EnsembliENST00000317876; ENSP00000321929; ENSG00000181322. [Q86XW9-2]
ENST00000333911; ENSP00000335444; ENSG00000181322. [Q86XW9-1]
ENST00000383180; ENSP00000372667; ENSG00000181322. [Q86XW9-2]
ENST00000484930; ENSP00000419882; ENSG00000181322. [Q86XW9-3]
GeneIDi347736.
KEGGihsa:347736.
UCSCiuc003ese.1. human. [Q86XW9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTXND6_HUMAN
AccessioniPrimary (citable) accession number: Q86XW9
Secondary accession number(s): Q7Z4A8, Q8N1V7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families