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Protein

Zinc finger protein 677

Gene

ZNF677

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri263 – 28523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri291 – 31323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 36923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 677
Gene namesi
Name:ZNF677
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28730. ZNF677.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670478.

Polymorphism and mutation databases

BioMutaiZNF677.
DMDMi74759507.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Zinc finger protein 677PRO_0000233997Add
BLAST

Proteomic databases

EPDiQ86XU0.
PaxDbiQ86XU0.
PeptideAtlasiQ86XU0.
PRIDEiQ86XU0.

PTM databases

iPTMnetiQ86XU0.
PhosphoSiteiQ86XU0.

Expressioni

Gene expression databases

BgeeiENSG00000197928.
CleanExiHS_ZNF677.
ExpressionAtlasiQ86XU0. baseline and differential.
GenevisibleiQ86XU0. HS.

Organism-specific databases

HPAiHPA023106.
HPA024796.

Interactioni

Protein-protein interaction databases

BioGridi131210. 2 interactions.
IntActiQ86XU0. 2 interactions.
STRINGi9606.ENSP00000334394.

Structurei

3D structure databases

ProteinModelPortaliQ86XU0.
SMRiQ86XU0. Positions 9-47, 186-567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 9083KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri263 – 28523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri291 – 31323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 36923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ86XU0.
KOiK09228.
OMAiNICGKVC.
OrthoDBiEOG091G02KC.
PhylomeDBiQ86XU0.
TreeFamiTF341892.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86XU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSQGLFTF KDVAIEFSQE EWECLDPAQR ALYRDVMLEN YRNLLSLDED
60 70 80 90 100
NIPPEDDISV GFTSKGLSPK ENNKEELYHL VILERKESHG INNFDLKEVW
110 120 130 140 150
ENMPKFDSLW DYDVKNYKGM PLTCNKNLTH RKDQQHNKSS IHFSLKQSVS
160 170 180 190 200
IRDSAHQYFI HDKPFIRNLL KLKNNIRYAG NKYVKCFENK IGLSLQAQLA
210 220 230 240 250
ELQRFQTGEK MYECNPVEKS INSSSVSPLP PCVKNICNKY RKILKYPLLH
260 270 280 290 300
TQYGRTHIRE KSYKCNDCGK AFSKSSNLTN HQRIHSGQRP YKCNECGKAF
310 320 330 340 350
NQCSNLTRHQ RVHTGEKPYQ CNICGKVCSQ NSNLASHQRM HTGEKPYKCN
360 370 380 390 400
ECGKAFIQRS HLWGHERIHT GEKPYKCNEC DKAFAERSSL TQHKRIHTGE
410 420 430 440 450
KPYICNECGK AFKQCSHLTR HQNIHPGEKP HKCNVCGRAF IQSSSLVEHQ
460 470 480 490 500
RIHTGEKPYK CNKCDKAFIK RSHLWGHQRT HTGEKPYKCT ECGKAFTERS
510 520 530 540 550
NLTQHKKIHT GEKPYKCTEC GKAFTQFANL TRHQKIHIEK KHCKHNIHGN
560 570 580
ALFQSSNLGD HQKSYNREKH IKYNETKIKY SSCT
Length:584
Mass (Da):67,996
Last modified:June 1, 2003 - v1
Checksum:iF111E49F528CB29F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561D → N.
Corresponds to variant rs11881131 [ dbSNP | Ensembl ].
VAR_052889
Natural varianti254 – 2541G → E.
Corresponds to variant rs10425706 [ dbSNP | Ensembl ].
VAR_052890

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC050038 mRNA. Translation: AAH50038.1.
CCDSiCCDS12861.1.
RefSeqiNP_001304927.1. NM_001317998.1.
NP_872415.1. NM_182609.3.
XP_011525214.1. XM_011526912.2.
UniGeneiHs.20506.

Genome annotation databases

EnsembliENST00000333952; ENSP00000334394; ENSG00000197928.
ENST00000598513; ENSP00000469391; ENSG00000197928.
GeneIDi342926.
KEGGihsa:342926.
UCSCiuc002qbg.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC050038 mRNA. Translation: AAH50038.1.
CCDSiCCDS12861.1.
RefSeqiNP_001304927.1. NM_001317998.1.
NP_872415.1. NM_182609.3.
XP_011525214.1. XM_011526912.2.
UniGeneiHs.20506.

3D structure databases

ProteinModelPortaliQ86XU0.
SMRiQ86XU0. Positions 9-47, 186-567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131210. 2 interactions.
IntActiQ86XU0. 2 interactions.
STRINGi9606.ENSP00000334394.

PTM databases

iPTMnetiQ86XU0.
PhosphoSiteiQ86XU0.

Polymorphism and mutation databases

BioMutaiZNF677.
DMDMi74759507.

Proteomic databases

EPDiQ86XU0.
PaxDbiQ86XU0.
PeptideAtlasiQ86XU0.
PRIDEiQ86XU0.

Protocols and materials databases

DNASUi342926.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333952; ENSP00000334394; ENSG00000197928.
ENST00000598513; ENSP00000469391; ENSG00000197928.
GeneIDi342926.
KEGGihsa:342926.
UCSCiuc002qbg.2. human.

Organism-specific databases

CTDi342926.
GeneCardsiZNF677.
HGNCiHGNC:28730. ZNF677.
HPAiHPA023106.
HPA024796.
neXtProtiNX_Q86XU0.
PharmGKBiPA142670478.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ86XU0.
KOiK09228.
OMAiNICGKVC.
OrthoDBiEOG091G02KC.
PhylomeDBiQ86XU0.
TreeFamiTF341892.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii342926.
PROiQ86XU0.

Gene expression databases

BgeeiENSG00000197928.
CleanExiHS_ZNF677.
ExpressionAtlasiQ86XU0. baseline and differential.
GenevisibleiQ86XU0. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN677_HUMAN
AccessioniPrimary (citable) accession number: Q86XU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.