Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Insulin-like growth factor-binding protein 3 receptor

Gene

TMEM219

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

SignaLinkiQ86XT9.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 3 receptor
Short name:
IGFBP-3R
Alternative name(s):
Transmembrane protein 219
Gene namesi
Name:TMEM219
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25201. TMEM219.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 204166ExtracellularSequence analysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence analysisAdd
BLAST
Topological domaini226 – 24015CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406570.

Polymorphism and mutation databases

BioMutaiTMEM219.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838Sequence analysisAdd
BLAST
Chaini39 – 240202Insulin-like growth factor-binding protein 3 receptorPRO_0000329049Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86XT9.
PRIDEiQ86XT9.

Expressioni

Tissue specificityi

Widely expressed in normal tissues but suppressed in prostate and breast tumor.1 Publication

Gene expression databases

BgeeiQ86XT9.
CleanExiHS_TMEM219.
ExpressionAtlasiQ86XT9. baseline and differential.
GenevisibleiQ86XT9. HS.

Organism-specific databases

HPAiHPA059185.

Interactioni

Subunit structurei

Interacts with IGFBP3. Interacts with CASP8.1 Publication

Protein-protein interaction databases

BioGridi125865. 10 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ86XT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWEC. Eukaryota.
ENOG4110155. LUCA.
GeneTreeiENSGT00390000013671.
HOGENOMiHOG000154627.
HOVERGENiHBG095163.
InParanoidiQ86XT9.
OMAiGSHIVGL.
OrthoDBiEOG7VX8X2.
PhylomeDBiQ86XT9.
TreeFamiTF338507.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86XT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNCQAGHNL HLCLAHHPPL VCATLILLLL GLSGLGLGSF LLTHRTGLRS
60 70 80 90 100
PDIPQDWVSF LRSFGQLTLC PRNGTVTGKW RGSHVVGLLT TLNFGDGPDR
110 120 130 140 150
NKTRTFQATV LGSQMGLKGS SAGQLVLITA RVTTERTAGT CLYFSAVPGI
160 170 180 190 200
LPSSQPPISC SEEGAGNATL SPRMGEECVS VWSHEGLVLT KLLTSEELAL
210 220 230 240
CGSRLLVLGS FLLLFCGLLC CVTAMCFHPR RESHWSRTRL
Length:240
Mass (Da):25,724
Last modified:June 1, 2003 - v1
Checksum:i8985EB036BB37EE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ748884 mRNA. Translation: ACQ72822.1.
CH471238 Genomic DNA. Translation: EAW79966.1.
BC017488 mRNA. Translation: AAH17488.1.
BC050051 mRNA. Translation: AAH50051.1.
CCDSiCCDS42145.1.
RefSeqiNP_001077082.1. NM_001083613.1.
NP_919256.1. NM_194280.3.
XP_005255180.1. XM_005255123.1.
UniGeneiHs.460574.

Genome annotation databases

EnsembliENST00000279396; ENSP00000279396; ENSG00000149932.
ENST00000414689; ENSP00000388485; ENSG00000149932.
ENST00000561899; ENSP00000456960; ENSG00000149932.
ENST00000566848; ENSP00000457492; ENSG00000149932.
GeneIDi124446.
KEGGihsa:124446.
UCSCiuc002duw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ748884 mRNA. Translation: ACQ72822.1.
CH471238 Genomic DNA. Translation: EAW79966.1.
BC017488 mRNA. Translation: AAH17488.1.
BC050051 mRNA. Translation: AAH50051.1.
CCDSiCCDS42145.1.
RefSeqiNP_001077082.1. NM_001083613.1.
NP_919256.1. NM_194280.3.
XP_005255180.1. XM_005255123.1.
UniGeneiHs.460574.

3D structure databases

ProteinModelPortaliQ86XT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125865. 10 interactions.

Polymorphism and mutation databases

BioMutaiTMEM219.

Proteomic databases

PaxDbiQ86XT9.
PRIDEiQ86XT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279396; ENSP00000279396; ENSG00000149932.
ENST00000414689; ENSP00000388485; ENSG00000149932.
ENST00000561899; ENSP00000456960; ENSG00000149932.
ENST00000566848; ENSP00000457492; ENSG00000149932.
GeneIDi124446.
KEGGihsa:124446.
UCSCiuc002duw.3. human.

Organism-specific databases

CTDi124446.
GeneCardsiTMEM219.
HGNCiHGNC:25201. TMEM219.
HPAiHPA059185.
neXtProtiNX_Q86XT9.
PharmGKBiPA162406570.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWEC. Eukaryota.
ENOG4110155. LUCA.
GeneTreeiENSGT00390000013671.
HOGENOMiHOG000154627.
HOVERGENiHBG095163.
InParanoidiQ86XT9.
OMAiGSHIVGL.
OrthoDBiEOG7VX8X2.
PhylomeDBiQ86XT9.
TreeFamiTF338507.

Enzyme and pathway databases

SignaLinkiQ86XT9.

Miscellaneous databases

GenomeRNAii124446.
NextBioi81277.
PROiQ86XT9.

Gene expression databases

BgeeiQ86XT9.
CleanExiHS_TMEM219.
ExpressionAtlasiQ86XT9. baseline and differential.
GenevisibleiQ86XT9. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer."
    Ingermann A.R., Yang Y.F., Han J., Mikami A., Garza A.E., Mohanraj L., Fan L., Idowu M., Ware J.L., Kim H.S., Lee D.Y., Oh Y.
    J. Biol. Chem. 285:30233-30246(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH IGFBP3 AND CASP8, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.

Entry informationi

Entry nameiTM219_HUMAN
AccessioniPrimary (citable) accession number: Q86XT9
Secondary accession number(s): D5FK14, Q8WVV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: March 16, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.