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Protein

Vacuolar protein sorting-associated protein 37D

Gene

VPS37D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

GO - Biological processi

  • autophagy Source: ParkinsonsUK-UCL
  • endosomal transport Source: Reactome
  • intracellular transport of virus Source: Reactome
  • multivesicular body assembly Source: ParkinsonsUK-UCL
  • protein transport Source: UniProtKB-KW
  • viral budding via host ESCRT complex Source: ParkinsonsUK-UCL
  • viral life cycle Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-162588. Budding and maturation of HIV virion.
R-HSA-174490. Membrane binding and targetting of GAG proteins.
R-HSA-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 37D
Alternative name(s):
ESCRT-I complex subunit VPS37D
Williams-Beuren syndrome chromosomal region 24 protein
Gene namesi
Name:VPS37DImported
Synonyms:WBSCR24Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18287. VPS37D.

Subcellular locationi

GO - Cellular componenti

  • endosome membrane Source: Reactome
  • ESCRT I complex Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • late endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Involvement in diseasei

VPS37D is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Keywords - Diseasei

Williams-Beuren syndrome

Organism-specific databases

OpenTargetsiENSG00000176428.
PharmGKBiPA38308.

Polymorphism and mutation databases

BioMutaiVPS37D.
DMDMi182702221.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003289271 – 251Vacuolar protein sorting-associated protein 37DAdd BLAST251

Proteomic databases

PaxDbiQ86XT2.
PeptideAtlasiQ86XT2.
PRIDEiQ86XT2.

PTM databases

iPTMnetiQ86XT2.
PhosphoSitePlusiQ86XT2.

Expressioni

Gene expression databases

BgeeiENSG00000176428.
CleanExiHS_VPS37D.
ExpressionAtlasiQ86XT2. baseline and differential.
GenevisibleiQ86XT2. HS.

Organism-specific databases

HPAiHPA040978.

Interactioni

Subunit structurei

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101 and MVB12A. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoechiometry.2 Publications

Protein-protein interaction databases

BioGridi127583. 9 interactors.
IntActiQ86XT2. 1 interactor.
MINTiMINT-6173498.
STRINGi9606.ENSP00000320416.

Structurei

3D structure databases

ProteinModelPortaliQ86XT2.
SMRiQ86XT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 182VPS37 C-terminalPROSITE-ProRule annotationAdd BLAST90

Sequence similaritiesi

Belongs to the VPS37 family.Sequence analysis
Contains 1 VPS37 C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IX4Z. Eukaryota.
ENOG4111T7T. LUCA.
GeneTreeiENSGT00530000063123.
HOGENOMiHOG000057287.
HOVERGENiHBG095499.
InParanoidiQ86XT2.
KOiK12185.
OMAiLEDSMHR.
OrthoDBiEOG091G0J9K.
PhylomeDBiQ86XT2.
TreeFamiTF321840.

Family and domain databases

InterProiIPR009851. Mod_r.
[Graphical view]
PfamiPF07200. Mod_r. 1 hit.
[Graphical view]
PROSITEiPS51314. VPS37_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86XT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRARAARAG PEPGSPGRFG ILSTGQLRDL LQDEPKLDRI VRLSRKFQGL
60 70 80 90 100
QLEREACLAS NYALAKENLA LRPRLEMGRA ALAIKYQELR EVAENCADKL
110 120 130 140 150
QRLEESMHRW SPHCALGWLQ AELEEAEQEA EEQMEQLLLG EQSLEAFLPA
160 170 180 190 200
FQRGRALAHL RRTQAEKLQE LLRRRERSAQ PAPTSAADPP KSFPAAAVLP
210 220 230 240 250
TGAARGPPAV PRSLPPLDSR PVPPLKGSPG CPLGPAPLLS PRPSQPEPPH

R
Length:251
Mass (Da):27,730
Last modified:April 8, 2008 - v2
Checksum:iA07E752409455026
GO

Sequence cautioni

The sequence AAL91075 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081952 mRNA. Translation: AAL91075.1. Different initiation.
AC073846 Genomic DNA. No translation available.
BC064621 mRNA. Translation: AAH64621.2.
CCDSiCCDS43596.1.
RefSeqiNP_001071089.1. NM_001077621.1.
UniGeneiHs.647037.

Genome annotation databases

EnsembliENST00000324941; ENSP00000320416; ENSG00000176428.
GeneIDi155382.
KEGGihsa:155382.
UCSCiuc003tyr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081952 mRNA. Translation: AAL91075.1. Different initiation.
AC073846 Genomic DNA. No translation available.
BC064621 mRNA. Translation: AAH64621.2.
CCDSiCCDS43596.1.
RefSeqiNP_001071089.1. NM_001077621.1.
UniGeneiHs.647037.

3D structure databases

ProteinModelPortaliQ86XT2.
SMRiQ86XT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127583. 9 interactors.
IntActiQ86XT2. 1 interactor.
MINTiMINT-6173498.
STRINGi9606.ENSP00000320416.

PTM databases

iPTMnetiQ86XT2.
PhosphoSitePlusiQ86XT2.

Polymorphism and mutation databases

BioMutaiVPS37D.
DMDMi182702221.

Proteomic databases

PaxDbiQ86XT2.
PeptideAtlasiQ86XT2.
PRIDEiQ86XT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324941; ENSP00000320416; ENSG00000176428.
GeneIDi155382.
KEGGihsa:155382.
UCSCiuc003tyr.4. human.

Organism-specific databases

CTDi155382.
GeneCardsiVPS37D.
HGNCiHGNC:18287. VPS37D.
HPAiHPA040978.
MIMi610039. gene.
neXtProtiNX_Q86XT2.
OpenTargetsiENSG00000176428.
PharmGKBiPA38308.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX4Z. Eukaryota.
ENOG4111T7T. LUCA.
GeneTreeiENSGT00530000063123.
HOGENOMiHOG000057287.
HOVERGENiHBG095499.
InParanoidiQ86XT2.
KOiK12185.
OMAiLEDSMHR.
OrthoDBiEOG091G0J9K.
PhylomeDBiQ86XT2.
TreeFamiTF321840.

Enzyme and pathway databases

ReactomeiR-HSA-162588. Budding and maturation of HIV virion.
R-HSA-174490. Membrane binding and targetting of GAG proteins.
R-HSA-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Miscellaneous databases

GenomeRNAii155382.
PROiQ86XT2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176428.
CleanExiHS_VPS37D.
ExpressionAtlasiQ86XT2. baseline and differential.
GenevisibleiQ86XT2. HS.

Family and domain databases

InterProiIPR009851. Mod_r.
[Graphical view]
PfamiPF07200. Mod_r. 1 hit.
[Graphical view]
PROSITEiPS51314. VPS37_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVP37D_HUMAN
AccessioniPrimary (citable) accession number: Q86XT2
Secondary accession number(s): Q6P2C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.