ID   ANGL5_HUMAN             Reviewed;         388 AA.
AC   Q86XS5; A8K658; Q86VR9;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   21-SEP-2011, entry version 59.
DE   RecName: Full=Angiopoietin-related protein 5;
DE   AltName: Full=Angiopoietin-like protein 5;
DE   Flags: Precursor;
GN   Name=ANGPTL5; ORFNames=UNQ5795/PRO19600;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   MEDLINE=22511164; PubMed=12624729; DOI=10.1007/s100380300025;
RA   Zeng L., Dai J., Ying K., Zhao E., Jin W., Ye Y., Dai J., Xu J.,
RA   Xie Y., Mao Y.;
RT   "Identification of a novel human angiopoietin-like gene expressed
RT   mainly in heart.";
RL   J. Hum. Genet. 48:159-162(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pericardium;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA   Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA   FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA   Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA   Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA   Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- TISSUE SPECIFICITY: Mainly expressed in adult heart.
CC   -!- SIMILARITY: Contains 1 fibrinogen C-terminal domain.
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DR   EMBL; AY169281; AAO38749.1; -; mRNA.
DR   EMBL; AY358827; AAQ89186.1; -; mRNA.
DR   EMBL; AK291523; BAF84212.1; -; mRNA.
DR   EMBL; AP003383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC049170; AAH49170.1; -; mRNA.
DR   IPI; IPI00328963; -.
DR   RefSeq; NP_835228.2; NM_178127.4.
DR   UniGene; Hs.318370; -.
DR   ProteinModelPortal; Q86XS5; -.
DR   SMR; Q86XS5; 103-385.
DR   STRING; Q86XS5; -.
DR   PRIDE; Q86XS5; -.
DR   Ensembl; ENST00000334289; ENSP00000335255; ENSG00000187151.
DR   GeneID; 253935; -.
DR   KEGG; hsa:253935; -.
DR   CTD; 253935; -.
DR   GeneCards; GC11M097686; -.
DR   H-InvDB; HIX0026172; -.
DR   HGNC; HGNC:19705; ANGPTL5.
DR   HPA; HPA038516; -.
DR   MIM; 607666; gene.
DR   neXtProt; NX_Q86XS5; -.
DR   PharmGKB; PA134944139; -.
DR   eggNOG; prNOG10692; -.
DR   GeneTree; ENSGT00600000084399; -.
DR   HOGENOM; HBG715866; -.
DR   HOVERGEN; HBG050502; -.
DR   InParanoid; Q86XS5; -.
DR   OMA; ICGEAVQ; -.
DR   OrthoDB; EOG4QFWD7; -.
DR   Bgee; Q86XS5; -.
DR   CleanEx; HS_ANGPTL5; -.
DR   Genevestigator; Q86XS5; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005102; F:receptor binding; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   InterPro; IPR014715; Fibrinogen_a/b/g_C_2.
DR   InterPro; IPR020837; Fibrinogen_CS.
DR   Gene3D; G3DSA:3.90.215.10; Fibrinogen_a/b/g_C_1; 1.
DR   Gene3D; G3DSA:4.10.530.10; Fibrinogen_a/b/g_C_2; 1.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   SUPFAM; SSF56496; Fibrinogen_a/b/g_C; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Complete proteome; Disulfide bond; Glycoprotein;
KW   Polymorphism; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     25       Potential.
FT   CHAIN        26    388       Angiopoietin-related protein 5.
FT                                /FTId=PRO_0000009127.
FT   DOMAIN      141    383       Fibrinogen C-terminal.
FT   COILED       98    123       Potential.
FT   CARBOHYD     53     53       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    238    238       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    329    329       N-linked (GlcNAc...) (Potential).
FT   DISULFID    310    314       By similarity.
FT   DISULFID    324    338       By similarity.
FT   VARIANT     175    175       S -> P (in dbSNP:rs7946238).
FT                                /FTId=VAR_055803.
FT   CONFLICT    192    192       R -> W (in Ref. 1; AAO38749, 2; AAQ89186,
FT                                3; BAF84212 and 5; AAH49170).
FT   CONFLICT    281    281       N -> S (in Ref. 1; AAO38749).
SQ   SEQUENCE   388 AA;  44144 MW;  4060C998885151BF CRC64;
     MMSPSQASLL FLNVCIFICG EAVQGNCVHH STDSSVVNIV EDGSNAKDES KSNDTVCKED
     CEESCDVKTK ITREEKHFMC RNLQNSIVSY TRSTKKLLRN MMDEQQASLD YLSNQVNELM
     NRVLLLTTEV FRKQLDPFPH RPVQSHGLDC TDIKDTIGSV TKTPSGLYII HPEGSSYPFE
     VMCDMDYRGG GRTVIQKRID GIIDFQRLWC DYLDGFGDLL GEFWLGLKKI FYIVNQKNTS
     FMLYVALESE DDTLAYASYD NFWLEDETRF FKMHLGRYSG NAGDAFRGLK KEDNQNAMPF
     STSDVDNDGC RPACLVNGQS VKSCSHLHNK TGWWFNECGL ANLNGIHHFS GKLLATGIQW
     GTWTKNNSPV KIKSVSMKIR RMYNPYFK
//