ID   ANGL5_HUMAN             Reviewed;         388 AA.
AC   Q86XS5; A8K658; Q86VR9;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   27-MAR-2024, entry version 139.
DE   RecName: Full=Angiopoietin-related protein 5;
DE   AltName: Full=Angiopoietin-like protein 5;
DE   Flags: Precursor;
GN   Name=ANGPTL5; ORFNames=UNQ5795/PRO19600;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=12624729; DOI=10.1007/s100380300025;
RA   Zeng L., Dai J., Ying K., Zhao E., Jin W., Ye Y., Dai J., Xu J., Xie Y.,
RA   Mao Y.;
RT   "Identification of a novel human angiopoietin-like gene expressed mainly in
RT   heart.";
RL   J. Hum. Genet. 48:159-162(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pericardium;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q86XS5; Q8N423: LILRB2; NbExp=5; IntAct=EBI-15485927, EBI-2816428;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in adult heart.
CC       {ECO:0000269|PubMed:12624729}.
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DR   EMBL; AY169281; AAO38749.1; -; mRNA.
DR   EMBL; AY358827; AAQ89186.1; -; mRNA.
DR   EMBL; AK291523; BAF84212.1; -; mRNA.
DR   EMBL; AP003383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC049170; AAH49170.1; -; mRNA.
DR   CCDS; CCDS8312.1; -.
DR   RefSeq; NP_835228.2; NM_178127.4.
DR   AlphaFoldDB; Q86XS5; -.
DR   SMR; Q86XS5; -.
DR   BioGRID; 128996; 1.
DR   DIP; DIP-59887N; -.
DR   IntAct; Q86XS5; 3.
DR   STRING; 9606.ENSP00000335255; -.
DR   GlyCosmos; Q86XS5; 3 sites, No reported glycans.
DR   GlyGen; Q86XS5; 5 sites, 1 O-linked glycan (2 sites).
DR   iPTMnet; Q86XS5; -.
DR   PhosphoSitePlus; Q86XS5; -.
DR   BioMuta; ANGPTL5; -.
DR   DMDM; 296439430; -.
DR   MassIVE; Q86XS5; -.
DR   PaxDb; 9606-ENSP00000335255; -.
DR   PeptideAtlas; Q86XS5; -.
DR   Antibodypedia; 31728; 208 antibodies from 30 providers.
DR   DNASU; 253935; -.
DR   Ensembl; ENST00000334289.7; ENSP00000335255.3; ENSG00000187151.7.
DR   GeneID; 253935; -.
DR   KEGG; hsa:253935; -.
DR   MANE-Select; ENST00000334289.7; ENSP00000335255.3; NM_178127.5; NP_835228.2.
DR   UCSC; uc001pgl.3; human.
DR   AGR; HGNC:19705; -.
DR   CTD; 253935; -.
DR   DisGeNET; 253935; -.
DR   GeneCards; ANGPTL5; -.
DR   HGNC; HGNC:19705; ANGPTL5.
DR   HPA; ENSG00000187151; Tissue enhanced (breast, ovary).
DR   MIM; 607666; gene.
DR   neXtProt; NX_Q86XS5; -.
DR   OpenTargets; ENSG00000187151; -.
DR   PharmGKB; PA134944139; -.
DR   VEuPathDB; HostDB:ENSG00000187151; -.
DR   eggNOG; KOG2579; Eukaryota.
DR   GeneTree; ENSGT00940000161966; -.
DR   HOGENOM; CLU_038628_3_2_1; -.
DR   InParanoid; Q86XS5; -.
DR   OMA; KEQCLVP; -.
DR   OrthoDB; 3134470at2759; -.
DR   PhylomeDB; Q86XS5; -.
DR   TreeFam; TF351983; -.
DR   PathwayCommons; Q86XS5; -.
DR   SignaLink; Q86XS5; -.
DR   BioGRID-ORCS; 253935; 64 hits in 1139 CRISPR screens.
DR   ChiTaRS; ANGPTL5; human.
DR   GenomeRNAi; 253935; -.
DR   Pharos; Q86XS5; Tbio.
DR   PRO; PR:Q86XS5; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q86XS5; Protein.
DR   Bgee; ENSG00000187151; Expressed in calcaneal tendon and 77 other cell types or tissues.
DR   ExpressionAtlas; Q86XS5; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   CDD; cd00087; FReD; 1.
DR   Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR020837; Fibrinogen_CS.
DR   NCBIfam; NF040941; GGGWT_bact; 1.
DR   PANTHER; PTHR19143:SF185; ANGIOPOIETIN-RELATED PROTEIN 5; 1.
DR   PANTHER; PTHR19143; FIBRINOGEN/TENASCIN/ANGIOPOEITIN; 1.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..388
FT                   /note="Angiopoietin-related protein 5"
FT                   /id="PRO_0000009127"
FT   DOMAIN          141..383
FT                   /note="Fibrinogen C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT   COILED          98..123
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        238
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        329
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        310..314
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT   DISULFID        324..338
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT   VARIANT         175
FT                   /note="S -> P (in dbSNP:rs7946238)"
FT                   /id="VAR_055803"
FT   CONFLICT        192
FT                   /note="R -> W (in Ref. 1; AAO38749, 2; AAQ89186, 3;
FT                   BAF84212 and 5; AAH49170)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        281
FT                   /note="N -> S (in Ref. 1; AAO38749)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   388 AA;  44144 MW;  4060C998885151BF CRC64;
     MMSPSQASLL FLNVCIFICG EAVQGNCVHH STDSSVVNIV EDGSNAKDES KSNDTVCKED
     CEESCDVKTK ITREEKHFMC RNLQNSIVSY TRSTKKLLRN MMDEQQASLD YLSNQVNELM
     NRVLLLTTEV FRKQLDPFPH RPVQSHGLDC TDIKDTIGSV TKTPSGLYII HPEGSSYPFE
     VMCDMDYRGG GRTVIQKRID GIIDFQRLWC DYLDGFGDLL GEFWLGLKKI FYIVNQKNTS
     FMLYVALESE DDTLAYASYD NFWLEDETRF FKMHLGRYSG NAGDAFRGLK KEDNQNAMPF
     STSDVDNDGC RPACLVNGQS VKSCSHLHNK TGWWFNECGL ANLNGIHHFS GKLLATGIQW
     GTWTKNNSPV KIKSVSMKIR RMYNPYFK
//