Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Angiopoietin-related protein 5

Gene

ANGPTL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 5
Alternative name(s):
Angiopoietin-like protein 5
Gene namesi
Name:ANGPTL5
ORF Names:UNQ5795/PRO19600
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19705. ANGPTL5.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187151.
PharmGKBiPA134944139.

Polymorphism and mutation databases

BioMutaiANGPTL5.
DMDMi296439430.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000912726 – 388Angiopoietin-related protein 5Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi310 ↔ 314PROSITE-ProRule annotation
Disulfide bondi324 ↔ 338PROSITE-ProRule annotation
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86XS5.
PRIDEiQ86XS5.

PTM databases

iPTMnetiQ86XS5.
PhosphoSitePlusiQ86XS5.

Expressioni

Tissue specificityi

Mainly expressed in adult heart.1 Publication

Gene expression databases

BgeeiENSG00000187151.
CleanExiHS_ANGPTL5.
ExpressionAtlasiQ86XS5. baseline and differential.

Organism-specific databases

HPAiHPA038516.

Interactioni

Protein-protein interaction databases

DIPiDIP-59887N.
STRINGi9606.ENSP00000335255.

Structurei

3D structure databases

ProteinModelPortaliQ86XS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 383Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST243

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili98 – 123Sequence analysisAdd BLAST26

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00890000139379.
HOGENOMiHOG000168535.
HOVERGENiHBG050502.
InParanoidiQ86XS5.
OMAiSHGLDCT.
OrthoDBiEOG091G03M1.
PhylomeDBiQ86XS5.
TreeFamiTF351983.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiView protein in InterPro
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
PfamiView protein in Pfam
PF00147. Fibrinogen_C. 1 hit.
SMARTiView protein in SMART
SM00186. FBG. 1 hit.
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiView protein in PROSITE
PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86XS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSPSQASLL FLNVCIFICG EAVQGNCVHH STDSSVVNIV EDGSNAKDES
60 70 80 90 100
KSNDTVCKED CEESCDVKTK ITREEKHFMC RNLQNSIVSY TRSTKKLLRN
110 120 130 140 150
MMDEQQASLD YLSNQVNELM NRVLLLTTEV FRKQLDPFPH RPVQSHGLDC
160 170 180 190 200
TDIKDTIGSV TKTPSGLYII HPEGSSYPFE VMCDMDYRGG GRTVIQKRID
210 220 230 240 250
GIIDFQRLWC DYLDGFGDLL GEFWLGLKKI FYIVNQKNTS FMLYVALESE
260 270 280 290 300
DDTLAYASYD NFWLEDETRF FKMHLGRYSG NAGDAFRGLK KEDNQNAMPF
310 320 330 340 350
STSDVDNDGC RPACLVNGQS VKSCSHLHNK TGWWFNECGL ANLNGIHHFS
360 370 380
GKLLATGIQW GTWTKNNSPV KIKSVSMKIR RMYNPYFK
Length:388
Mass (Da):44,144
Last modified:May 18, 2010 - v3
Checksum:i4060C998885151BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192R → W in AAO38749 (PubMed:12624729).Curated1
Sequence conflicti192R → W in AAQ89186 (PubMed:12975309).Curated1
Sequence conflicti192R → W in BAF84212 (PubMed:14702039).Curated1
Sequence conflicti192R → W in AAH49170 (PubMed:15489334).Curated1
Sequence conflicti281N → S in AAO38749 (PubMed:12624729).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055803175S → P. Corresponds to variant dbSNP:rs7946238Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169281 mRNA. Translation: AAO38749.1.
AY358827 mRNA. Translation: AAQ89186.1.
AK291523 mRNA. Translation: BAF84212.1.
AP003383 Genomic DNA. No translation available.
BC049170 mRNA. Translation: AAH49170.1.
CCDSiCCDS8312.1.
RefSeqiNP_835228.2. NM_178127.4.
UniGeneiHs.318370.

Genome annotation databases

EnsembliENST00000334289; ENSP00000335255; ENSG00000187151.
GeneIDi253935.
KEGGihsa:253935.
UCSCiuc001pgl.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANGL5_HUMAN
AccessioniPrimary (citable) accession number: Q86XS5
Secondary accession number(s): A8K658, Q86VR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 18, 2010
Last modified: August 30, 2017
This is version 103 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot