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Reviewed, UniProtKB/Swiss-Prot Q86XS5 (ANGL5_HUMAN)

Last modified November 25, 2008. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Angiopoietin-related protein 5
Alternative name(s):
    Angiopoietin-like 5
Gene names
Name: ANGPTL5
ORF Names: UNQ5795/PRO19600
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Subcellular location

SecretedPotential.

Tissue specificity

Mainly expressed in adult heart.

Sequence similarities

Contains 1 fibrinogen C-terminal domain.

Ontologies

Keywords

   Cellular componentSecreted
   DomainCoiled coil
Signal
   PTMGlycoprotein

Gene Ontology (GO)

   Biological processsignal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionreceptor binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 388363Angiopoietin-related protein 5
PRO_0000009127

Regions

Domain141 – 383243Fibrinogen C-terminal
Coiled coil98 – 12326 Potential

Amino acid modifications

Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation2381N-linked (GlcNAc...) Potential
Glycosylation3291N-linked (GlcNAc...) Potential
Disulfide bond310 ↔ 314 By similarity
Disulfide bond324 ↔ 338 By similarity

Experimental info

Sequence conflict2811N → S in AAO38749. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q86XS5-1 [UniParc].

Last modified May 10, 2005. Version 2.
Checksum: 3433289CDA77229A

FASTA38844,174
        10         20         30         40         50         60 
MMSPSQASLL FLNVCIFICG EAVQGNCVHH STDSSVVNIV EDGSNAKDES KSNDTVCKED 

        70         80         90        100        110        120 
CEESCDVKTK ITREEKHFMC RNLQNSIVSY TRSTKKLLRN MMDEQQASLD YLSNQVNELM 

       130        140        150        160        170        180 
NRVLLLTTEV FRKQLDPFPH RPVQSHGLDC TDIKDTIGSV TKTPSGLYII HPEGSSYPFE 

       190        200        210        220        230        240 
VMCDMDYRGG GWTVIQKRID GIIDFQRLWC DYLDGFGDLL GEFWLGLKKI FYIVNQKNTS 

       250        260        270        280        290        300 
FMLYVALESE DDTLAYASYD NFWLEDETRF FKMHLGRYSG NAGDAFRGLK KEDNQNAMPF 

       310        320        330        340        350        360 
STSDVDNDGC RPACLVNGQS VKSCSHLHNK TGWWFNECGL ANLNGIHHFS GKLLATGIQW 

       370        380 
GTWTKNNSPV KIKSVSMKIR RMYNPYFK 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel human angiopoietin-like gene expressed mainly in heart."
Zeng L., Dai J., Ying K., Zhao E., Jin W., Ye Y., Dai J., Xu J., Xie Y., Mao Y.
J. Hum. Genet. 48:159-162(2003) [PubMed: 12624729] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

AY169281 mRNA. Translation: AAO38749.1.
AY358827 mRNA. Translation: AAQ89186.1.
BC049170 mRNA. Translation: AAH49170.1.
RefSeqNP_835228.2.
UniGeneHs.318370

3D structure databases

HSSPHSSP built from PDB template 1FIC based on UniProtKB P02679.
ModBaseSearch...

Genome annotation databases

EnsemblENSG00000187151. Homo sapiens. [Contig view]
GeneID253935.
KEGGhsa:253935.

Organism-specific databases

H-InvDBHIX0026172.
HGNCHGNC:19705. ANGPTL5.
MIM607666. gene.
PharmGKBPA134944139.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ86XS5.
HOVERGENQ86XS5.

Gene expression databases

CleanExHS_ANGPTL5.

Family and domain databases

InterProIPR002181. Fibrinogen_a/b/g_C.
IPR014716. Fibrinogen_a/b/g_C_1.
[Graphical view]
Gene3DG3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit.
PfamPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTSM00186. FBG. 1 hit.
[Graphical view]
PROSITEPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Entry information

Entry nameANGL5_HUMAN
AccessionPrimary (citable) accession number: Q86XS5
Secondary accession number(s): Q86VR9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 25, 2008
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents