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Protein

Angiopoietin-related protein 5

Gene

ANGPTL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 5
Alternative name(s):
Angiopoietin-like protein 5
Gene namesi
Name:ANGPTL5
ORF Names:UNQ5795/PRO19600
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19705. ANGPTL5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944139.

Polymorphism and mutation databases

BioMutaiANGPTL5.
DMDMi296439430.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 388363Angiopoietin-related protein 5PRO_0000009127Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence analysis
Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi310 ↔ 314PROSITE-ProRule annotation
Disulfide bondi324 ↔ 338PROSITE-ProRule annotation
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86XS5.
PRIDEiQ86XS5.

PTM databases

iPTMnetiQ86XS5.

Expressioni

Tissue specificityi

Mainly expressed in adult heart.1 Publication

Gene expression databases

BgeeiQ86XS5.
CleanExiHS_ANGPTL5.
ExpressionAtlasiQ86XS5. baseline and differential.

Organism-specific databases

HPAiHPA038516.

Interactioni

Protein-protein interaction databases

DIPiDIP-59887N.
STRINGi9606.ENSP00000335255.

Structurei

3D structure databases

ProteinModelPortaliQ86XS5.
SMRiQ86XS5. Positions 105-380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini141 – 383243Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili98 – 12326Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00840000129899.
HOGENOMiHOG000168535.
HOVERGENiHBG050502.
InParanoidiQ86XS5.
OMAiFCEMDYM.
OrthoDBiEOG7X9G60.
PhylomeDBiQ86XS5.
TreeFamiTF351983.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86XS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSPSQASLL FLNVCIFICG EAVQGNCVHH STDSSVVNIV EDGSNAKDES
60 70 80 90 100
KSNDTVCKED CEESCDVKTK ITREEKHFMC RNLQNSIVSY TRSTKKLLRN
110 120 130 140 150
MMDEQQASLD YLSNQVNELM NRVLLLTTEV FRKQLDPFPH RPVQSHGLDC
160 170 180 190 200
TDIKDTIGSV TKTPSGLYII HPEGSSYPFE VMCDMDYRGG GRTVIQKRID
210 220 230 240 250
GIIDFQRLWC DYLDGFGDLL GEFWLGLKKI FYIVNQKNTS FMLYVALESE
260 270 280 290 300
DDTLAYASYD NFWLEDETRF FKMHLGRYSG NAGDAFRGLK KEDNQNAMPF
310 320 330 340 350
STSDVDNDGC RPACLVNGQS VKSCSHLHNK TGWWFNECGL ANLNGIHHFS
360 370 380
GKLLATGIQW GTWTKNNSPV KIKSVSMKIR RMYNPYFK
Length:388
Mass (Da):44,144
Last modified:May 18, 2010 - v3
Checksum:i4060C998885151BF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921R → W in AAO38749 (PubMed:12624729).Curated
Sequence conflicti192 – 1921R → W in AAQ89186 (PubMed:12975309).Curated
Sequence conflicti192 – 1921R → W in BAF84212 (PubMed:14702039).Curated
Sequence conflicti192 – 1921R → W in AAH49170 (PubMed:15489334).Curated
Sequence conflicti281 – 2811N → S in AAO38749 (PubMed:12624729).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti175 – 1751S → P.
Corresponds to variant rs7946238 [ dbSNP | Ensembl ].
VAR_055803

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169281 mRNA. Translation: AAO38749.1.
AY358827 mRNA. Translation: AAQ89186.1.
AK291523 mRNA. Translation: BAF84212.1.
AP003383 Genomic DNA. No translation available.
BC049170 mRNA. Translation: AAH49170.1.
CCDSiCCDS8312.1.
RefSeqiNP_835228.2. NM_178127.4.
UniGeneiHs.318370.

Genome annotation databases

EnsembliENST00000334289; ENSP00000335255; ENSG00000187151.
GeneIDi253935.
KEGGihsa:253935.
UCSCiuc001pgl.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169281 mRNA. Translation: AAO38749.1.
AY358827 mRNA. Translation: AAQ89186.1.
AK291523 mRNA. Translation: BAF84212.1.
AP003383 Genomic DNA. No translation available.
BC049170 mRNA. Translation: AAH49170.1.
CCDSiCCDS8312.1.
RefSeqiNP_835228.2. NM_178127.4.
UniGeneiHs.318370.

3D structure databases

ProteinModelPortaliQ86XS5.
SMRiQ86XS5. Positions 105-380.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59887N.
STRINGi9606.ENSP00000335255.

PTM databases

iPTMnetiQ86XS5.

Polymorphism and mutation databases

BioMutaiANGPTL5.
DMDMi296439430.

Proteomic databases

PaxDbiQ86XS5.
PRIDEiQ86XS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334289; ENSP00000335255; ENSG00000187151.
GeneIDi253935.
KEGGihsa:253935.
UCSCiuc001pgl.3. human.

Organism-specific databases

CTDi253935.
GeneCardsiANGPTL5.
H-InvDBHIX0026172.
HGNCiHGNC:19705. ANGPTL5.
HPAiHPA038516.
MIMi607666. gene.
neXtProtiNX_Q86XS5.
PharmGKBiPA134944139.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00840000129899.
HOGENOMiHOG000168535.
HOVERGENiHBG050502.
InParanoidiQ86XS5.
OMAiFCEMDYM.
OrthoDBiEOG7X9G60.
PhylomeDBiQ86XS5.
TreeFamiTF351983.

Miscellaneous databases

GenomeRNAii253935.
PROiQ86XS5.
SOURCEiSearch...

Gene expression databases

BgeeiQ86XS5.
CleanExiHS_ANGPTL5.
ExpressionAtlasiQ86XS5. baseline and differential.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel human angiopoietin-like gene expressed mainly in heart."
    Zeng L., Dai J., Ying K., Zhao E., Jin W., Ye Y., Dai J., Xu J., Xie Y., Mao Y.
    J. Hum. Genet. 48:159-162(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pericardium.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiANGL5_HUMAN
AccessioniPrimary (citable) accession number: Q86XS5
Secondary accession number(s): A8K658, Q86VR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.