Q86XS5 (ANGL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Angiopoietin-related protein 5

Alternative name(s):
Angiopoietin-like protein 5

Gene names

Name:	ANGPTL5
ORF Names:	UNQ5795/PRO19600

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Tissue specificity	Mainly expressed in adult heart. Ref.1
Sequence similarities	Contains 1 fibrinogen C-terminal domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Coiled coil Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from electronic annotation. Source: InterPro
Molecular function	receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 388	363	Angiopoietin-related protein 5		PRO_0000009127
Regions
	Domain	141 – 383	243	Fibrinogen C-terminal
	Coiled coil	98 – 123	26	Potential
Amino acid modifications
	Glycosylation	53	1	N-linked (GlcNAc...) Potential
	Glycosylation	238	1	N-linked (GlcNAc...) Potential
	Glycosylation	329	1	N-linked (GlcNAc...) Potential
	Disulfide bond	310 ↔ 314		By similarity
	Disulfide bond	324 ↔ 338		By similarity
Natural variations
	Natural variant	175	1	S → P. Corresponds to variant rs7946238 [ dbSNP | Ensembl ].		VAR_055803
Experimental info
	Sequence conflict	192	1	R → W in AAO38749. Ref.1
	Sequence conflict	192	1	R → W in AAQ89186. Ref.2
	Sequence conflict	192	1	R → W in BAF84212. Ref.3
	Sequence conflict	192	1	R → W in AAH49170. Ref.5
	Sequence conflict	281	1	N → S in AAO38749. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q86XS5 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 4060C998885151BF	FASTA	388	44,144
	10 20 30 40 50 60 MMSPSQASLL FLNVCIFICG EAVQGNCVHH STDSSVVNIV EDGSNAKDES KSNDTVCKED 70 80 90 100 110 120 CEESCDVKTK ITREEKHFMC RNLQNSIVSY TRSTKKLLRN MMDEQQASLD YLSNQVNELM 130 140 150 160 170 180 NRVLLLTTEV FRKQLDPFPH RPVQSHGLDC TDIKDTIGSV TKTPSGLYII HPEGSSYPFE 190 200 210 220 230 240 VMCDMDYRGG GRTVIQKRID GIIDFQRLWC DYLDGFGDLL GEFWLGLKKI FYIVNQKNTS 250 260 270 280 290 300 FMLYVALESE DDTLAYASYD NFWLEDETRF FKMHLGRYSG NAGDAFRGLK KEDNQNAMPF 310 320 330 340 350 360 STSDVDNDGC RPACLVNGQS VKSCSHLHNK TGWWFNECGL ANLNGIHHFS GKLLATGIQW 370 380 GTWTKNNSPV KIKSVSMKIR RMYNPYFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel human angiopoietin-like gene expressed mainly in heart." Zeng L., Dai J., Ying K., Zhao E., Jin W., Ye Y., Dai J., Xu J., Xie Y., Mao Y. J. Hum. Genet. 48:159-162(2003) [PubMed: 12624729] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pericardium.
[4]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY169281 mRNA. Translation: AAO38749.1. AY358827 mRNA. Translation: AAQ89186.1. AK291523 mRNA. Translation: BAF84212.1. AP003383 Genomic DNA. No translation available. BC049170 mRNA. Translation: AAH49170.1.
IPI	IPI00328963.
RefSeq	NP_835228.2. NM_178127.4.
UniGene	Hs.318370.
3D structure databases
ProteinModelPortal	Q86XS5.
SMR	Q86XS5. Positions 103-385.
ModBase	Search...
Protein-protein interaction databases
STRING	Q86XS5.
Polymorphism databases
DMDM	296439430.
Proteomic databases
PRIDE	Q86XS5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334289; ENSP00000335255; ENSG00000187151.
GeneID	253935.
KEGG	hsa:253935.
UCSC	uc001pgl.3. human.
Organism-specific databases
CTD	253935.
GeneCards	GC11M101795.
H-InvDB	HIX0026172.
HGNC	HGNC:19705. ANGPTL5.
HPA	HPA038516.
MIM	607666. gene.
neXtProt	NX_Q86XS5.
PharmGKB	PA134944139.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG263069.
GeneTree	ENSGT00650000093127.
HOGENOM	HOG000168535.
HOVERGEN	HBG050502.
InParanoid	Q86XS5.
OMA	ICGEAVQ.
OrthoDB	EOG4QFWD7.
PhylomeDB	Q86XS5.
Gene expression databases
Bgee	Q86XS5.
CleanEx	HS_ANGPTL5.
Genevestigator	Q86XS5.
Family and domain databases
Gene3D	G3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit. G3DSA:4.10.530.10. Fibrinogen_a/b/g_C_2. 1 hit.
InterPro	IPR002181. Fibrinogen_a/b/g_C. IPR014716. Fibrinogen_a/b/g_C_1. IPR014715. Fibrinogen_a/b/g_C_2. IPR020837. Fibrinogen_CS. [Graphical view]
Pfam	PF00147. Fibrinogen_C. 1 hit. [Graphical view]
SMART	SM00186. FBG. 1 hit. [Graphical view]
SUPFAM	SSF56496. Fibrinogen_a/b/g_C. 1 hit.
PROSITE	PS00514. FIBRINOGEN_C_1. 1 hit. PS51406. FIBRINOGEN_C_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	92194.
SOURCE	Search...

Entry information

Entry name

ANGL5_HUMAN

Accession

Primary (citable) accession number: Q86XS5
Secondary accession number(s): A8K658, Q86VR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	May 18, 2010
Last modified:	May 16, 2012
This is version 64 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.