Reviewed, UniProtKB/Swiss-Prot Q86XS5 (ANGL5_HUMAN)

Names and origin

Protein names

Recommended name:
    Angiopoietin-related protein 5
Alternative name(s):
    Angiopoietin-like 5

Gene names

Name:	ANGPTL5
ORF Names:	UNQ5795/PRO19600

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	SecretedPotential.
Tissue specificity	Mainly expressed in adult heart.
Sequence similarities	Contains 1 fibrinogen C-terminal domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Coiled coil Signal
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 388	363	Angiopoietin-related protein 5		PRO_0000009127
Regions
	Domain	141 – 383	243	Fibrinogen C-terminal
	Coiled coil	98 – 123	26	Potential
Amino acid modifications
	Glycosylation	53	1	N-linked (GlcNAc...) Potential
	Glycosylation	238	1	N-linked (GlcNAc...) Potential
	Glycosylation	329	1	N-linked (GlcNAc...) Potential
	Disulfide bond	310 ↔ 314		By similarity
	Disulfide bond	324 ↔ 338		By similarity
Experimental info
	Sequence conflict	281	1	N → S in AAO38749. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q86XS5-1 [UniParc]. Last modified May 10, 2005. Version 2. Checksum: 3433289CDA77229A	FASTA	388	44,174
	10 20 30 40 50 60 MMSPSQASLL FLNVCIFICG EAVQGNCVHH STDSSVVNIV EDGSNAKDES KSNDTVCKED 70 80 90 100 110 120 CEESCDVKTK ITREEKHFMC RNLQNSIVSY TRSTKKLLRN MMDEQQASLD YLSNQVNELM 130 140 150 160 170 180 NRVLLLTTEV FRKQLDPFPH RPVQSHGLDC TDIKDTIGSV TKTPSGLYII HPEGSSYPFE 190 200 210 220 230 240 VMCDMDYRGG GWTVIQKRID GIIDFQRLWC DYLDGFGDLL GEFWLGLKKI FYIVNQKNTS 250 260 270 280 290 300 FMLYVALESE DDTLAYASYD NFWLEDETRF FKMHLGRYSG NAGDAFRGLK KEDNQNAMPF 310 320 330 340 350 360 STSDVDNDGC RPACLVNGQS VKSCSHLHNK TGWWFNECGL ANLNGIHHFS GKLLATGIQW 370 380 GTWTKNNSPV KIKSVSMKIR RMYNPYFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel human angiopoietin-like gene expressed mainly in heart." Zeng L., Dai J., Ying K., Zhao E., Jin W., Ye Y., Dai J., Xu J., Xie Y., Mao Y. J. Hum. Genet. 48:159-162(2003) [PubMed: 12624729] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY169281 mRNA. Translation: AAO38749.1. AY358827 mRNA. Translation: AAQ89186.1. BC049170 mRNA. Translation: AAH49170.1.
RefSeq	NP_835228.2.
UniGene	Hs.318370
3D structure databases
HSSP	HSSP built from PDB template 1FIC based on UniProtKB P02679.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000187151. Homo sapiens. [Contig view]
GeneID	253935.
KEGG	hsa:253935.
Organism-specific databases
H-InvDB	HIX0026172.
HGNC	HGNC:19705. ANGPTL5.
MIM	607666. gene.
PharmGKB	PA134944139.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q86XS5.
HOVERGEN	Q86XS5.
Gene expression databases
CleanEx	HS_ANGPTL5.
Family and domain databases
InterPro	IPR002181. Fibrinogen_a/b/g_C. IPR014716. Fibrinogen_a/b/g_C_1. [Graphical view]
Gene3D	G3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit.
Pfam	PF00147. Fibrinogen_C. 1 hit. [Graphical view]
SMART	SM00186. FBG. 1 hit. [Graphical view]
PROSITE	PS00514. FIBRINOGEN_C_1. 1 hit. PS51406. FIBRINOGEN_C_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

ANGL5_HUMAN

Accession

Primary (citable) accession number: Q86XS5
Secondary accession number(s): Q86VR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	November 25, 2008
This is version 36 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)