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Q86XR8

- CEP57_HUMAN

UniProt

Q86XR8 - CEP57_HUMAN

Protein

Centrosomal protein of 57 kDa

Gene

CEP57

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.1 Publication

    GO - Molecular functioni

    1. fibroblast growth factor binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. fibroblast growth factor receptor signaling pathway Source: UniProtKB
    2. G2/M transition of mitotic cell cycle Source: Reactome
    3. microtubule anchoring Source: InterPro
    4. mitotic cell cycle Source: Reactome
    5. protein homooligomerization Source: Ensembl
    6. protein import into nucleus, translocation Source: UniProtKB
    7. spermatid development Source: HGNC

    Enzyme and pathway databases

    ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15364. Loss of Nlp from mitotic centrosomes.
    REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
    REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centrosomal protein of 57 kDa
    Short name:
    Cep57
    Alternative name(s):
    FGF2-interacting protein
    Testis-specific protein 57
    Translokin
    Gene namesi
    Name:CEP57
    Synonyms:KIAA0092, TSP57
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:30794. CEP57.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: HPA
    3. cytosol Source: Reactome
    4. Golgi apparatus Source: UniProtKB
    5. microtubule Source: UniProtKB
    6. microtubule cytoskeleton Source: HPA
    7. nucleus Source: HGNC

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Mosaic variegated aneuploidy syndrome 2 (MVA2) [MIM:614114]: A severe developmental disorder characterized by mosaic aneuploidies, predominantly trisomies and monosomies, involving multiple different chromosomes and tissues. Affected individuals typically present with severe intrauterine growth retardation and microcephaly. Eye anomalies, mild dysmorphism, variable developmental delay, and a broad spectrum of additional congenital abnormalities and medical conditions may also occur. The risk of malignancy is high, with rhabdomyosarcoma, Wilms tumor and leukemia reported in several cases.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi614114. phenotype.
    Orphaneti1052. Mosaic variegated aneuploidy syndrome.
    PharmGKBiPA142672123.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Centrosomal protein of 57 kDaPRO_0000189532Add
    BLAST

    Proteomic databases

    MaxQBiQ86XR8.
    PaxDbiQ86XR8.
    PRIDEiQ86XR8.

    PTM databases

    PhosphoSiteiQ86XR8.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ86XR8.
    BgeeiQ86XR8.
    CleanExiHS_CEP57.
    GenevestigatoriQ86XR8.

    Organism-specific databases

    HPAiHPA018315.

    Interactioni

    Subunit structurei

    Homodimer and homooligomer. Interacts with microtubules. Interacts with FGF2 and RAP80. Does not interact with FGF1 or FGF2 isoform 24 kDa.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MYCP011063EBI-308614,EBI-447544

    Protein-protein interaction databases

    BioGridi115054. 7 interactions.
    IntActiQ86XR8. 8 interactions.
    MINTiMINT-4989031.
    STRINGi9606.ENSP00000317902.

    Structurei

    Secondary structure

    1
    500
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi356 – 38631
    Helixi391 – 42636

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4L0RX-ray2.49A/B334-433[»]
    ProteinModelPortaliQ86XR8.
    SMRiQ86XR8. Positions 355-428.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni58 – 239182centrosome localization domain (CLD)By similarityAdd
    BLAST
    Regioni277 – 491215Mediates interaction with microtubulesBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili63 – 242180Sequence AnalysisAdd
    BLAST
    Coiled coili392 – 492101Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi260 – 2656Poly-Lys

    Domaini

    The C-terminal region mediates the interaction with microtubules and is able to nucleate and bundles microtubules in vitro.By similarity
    The centrosome localization domain (CLD) region mediates the localization to centrosomes and homooligomerization.By similarity

    Sequence similaritiesi

    Belongs to the translokin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG19004.
    HOVERGENiHBG050917.
    InParanoidiQ86XR8.
    KOiK16762.
    OMAiRERQHDQ.
    PhylomeDBiQ86XR8.
    TreeFamiTF329178.

    Family and domain databases

    InterProiIPR010597. Centrosomal_protein_57kDa.
    IPR025913. Cep57_CLD.
    IPR024957. Cep57_MT-bd_dom.
    [Graphical view]
    PANTHERiPTHR19336. PTHR19336. 1 hit.
    PfamiPF14073. Cep57_CLD. 1 hit.
    PF06657. Cep57_MT_bd. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86XR8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAASVSAAS GSHLSNSFAE PSRSNGSMVR HSSSPYVVYP SDKPFLNSDL    50
    RRSPSKPTLA YPESNSRAIF SALKNLQDKI RRLELERIQA EESVKTLSRE 100
    TIEYKKVLDE QIQERENSKN EESKHNQELT SQLLAAENKC NLLEKQLEYM 150
    RNMIKHAEME RTSVLEKQVS LERERQHDQT HVQSQLEKLD LLEQEYNKLT 200
    TMQALAEKKM QELEAKLHEE EQERKRMQAK AAELQTGLET NRLIFEDKAT 250
    PCVPNARRIK KKKSKPPEKK SSRNYFGAQP HYRLCLGDMP FVAGKSTSPS 300
    HAVVANVQLV LHLMKQHSKA LCNDRVINSI PLAKQVSSRG GKSKKLSVTP 350
    PSSNGINEEL SEVLQTLQDE FGQMSFDHQQ LAKLIQESPT VELKDKLECE 400
    LEALVGRMEA KANQITKVRK YQAQLEKQKL EKQKKELKAT KKTLDEERNS 450
    SSRSGITGTT NKKDFMKLRP GEKRRKNLQL LKDMQSIQNS LQSSSLCWDY 500
    Length:500
    Mass (Da):57,089
    Last modified:December 21, 2004 - v2
    Checksum:i88FC47E7B33CE328
    GO
    Isoform 2 (identifier: Q86XR8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         270-295: Missing.

    Show »
    Length:474
    Mass (Da):54,164
    Checksum:iFC5DCDF19948F496
    GO
    Isoform 3 (identifier: Q86XR8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         270-270: K → V
         271-500: Missing.

    Show »
    Length:270
    Mass (Da):31,147
    Checksum:iDA552E20AB2A6648
    GO
    Isoform 4 (identifier: Q86XR8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-15: MAAASVSAASGSHLS → MLTRID
         498-500: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:488
    Mass (Da):56,026
    Checksum:iFF8621FE703DB0F6
    GO
    Isoform 5 (identifier: Q86XR8-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-15: MAAASVSAASGSHLS → MLTRID

    Note: No experimental confirmation available.

    Show »
    Length:491
    Mass (Da):56,490
    Checksum:i5C5F2F4F8621FE70
    GO

    Sequence cautioni

    The sequence AAH29385.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAA07654.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti45 – 451F → S in BAF83934. (PubMed:14702039)Curated
    Sequence conflicti182 – 1821V → A in BAG56806. (PubMed:14702039)Curated
    Sequence conflicti188 – 1881K → E in BAF83934. (PubMed:14702039)Curated
    Sequence conflicti468 – 4681L → Q in BAA07654. (PubMed:7788527)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti448 – 4481R → G.2 Publications
    Corresponds to variant rs644799 [ dbSNP | Ensembl ].
    VAR_059839

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1515MAAAS…GSHLS → MLTRID in isoform 4 and isoform 5. 1 PublicationVSP_037839Add
    BLAST
    Alternative sequencei270 – 29526Missing in isoform 2. 1 PublicationVSP_012262Add
    BLAST
    Alternative sequencei270 – 2701K → V in isoform 3. 1 PublicationVSP_012263
    Alternative sequencei271 – 500230Missing in isoform 3. 1 PublicationVSP_012264Add
    BLAST
    Alternative sequencei498 – 5003Missing in isoform 4. 1 PublicationVSP_037840

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY225092 mRNA. Translation: AAO73938.1.
    AY239292 mRNA. Translation: AAP72184.1.
    D42054 mRNA. Translation: BAA07654.2. Different initiation.
    AK291245 mRNA. Translation: BAF83934.1.
    AK293277 mRNA. Translation: BAG56806.1.
    AP001877 Genomic DNA. No translation available.
    BC001233 mRNA. Translation: AAH01233.1.
    BC029385 mRNA. Translation: AAH29385.1. Sequence problems.
    BC039711 mRNA. Translation: AAH39711.1.
    CCDSiCCDS58166.1. [Q86XR8-2]
    CCDS58167.1. [Q86XR8-5]
    CCDS8304.1. [Q86XR8-1]
    RefSeqiNP_001230705.1. NM_001243776.1. [Q86XR8-5]
    NP_001230706.1. NM_001243777.1. [Q86XR8-2]
    NP_055494.2. NM_014679.4. [Q86XR8-1]
    UniGeneiHs.101014.

    Genome annotation databases

    EnsembliENST00000325486; ENSP00000317487; ENSG00000166037. [Q86XR8-2]
    ENST00000325542; ENSP00000317902; ENSG00000166037. [Q86XR8-1]
    ENST00000538658; ENSP00000445706; ENSG00000166037. [Q86XR8-3]
    ENST00000541150; ENSP00000443436; ENSG00000166037. [Q86XR8-5]
    GeneIDi9702.
    KEGGihsa:9702.
    UCSCiuc001pfo.2. human. [Q86XR8-3]
    uc001pfp.2. human. [Q86XR8-1]
    uc001pfq.2. human. [Q86XR8-2]

    Polymorphism databases

    DMDMi56748768.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY225092 mRNA. Translation: AAO73938.1 .
    AY239292 mRNA. Translation: AAP72184.1 .
    D42054 mRNA. Translation: BAA07654.2 . Different initiation.
    AK291245 mRNA. Translation: BAF83934.1 .
    AK293277 mRNA. Translation: BAG56806.1 .
    AP001877 Genomic DNA. No translation available.
    BC001233 mRNA. Translation: AAH01233.1 .
    BC029385 mRNA. Translation: AAH29385.1 . Sequence problems.
    BC039711 mRNA. Translation: AAH39711.1 .
    CCDSi CCDS58166.1. [Q86XR8-2 ]
    CCDS58167.1. [Q86XR8-5 ]
    CCDS8304.1. [Q86XR8-1 ]
    RefSeqi NP_001230705.1. NM_001243776.1. [Q86XR8-5 ]
    NP_001230706.1. NM_001243777.1. [Q86XR8-2 ]
    NP_055494.2. NM_014679.4. [Q86XR8-1 ]
    UniGenei Hs.101014.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4L0R X-ray 2.49 A/B 334-433 [» ]
    ProteinModelPortali Q86XR8.
    SMRi Q86XR8. Positions 355-428.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115054. 7 interactions.
    IntActi Q86XR8. 8 interactions.
    MINTi MINT-4989031.
    STRINGi 9606.ENSP00000317902.

    PTM databases

    PhosphoSitei Q86XR8.

    Polymorphism databases

    DMDMi 56748768.

    Proteomic databases

    MaxQBi Q86XR8.
    PaxDbi Q86XR8.
    PRIDEi Q86XR8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325486 ; ENSP00000317487 ; ENSG00000166037 . [Q86XR8-2 ]
    ENST00000325542 ; ENSP00000317902 ; ENSG00000166037 . [Q86XR8-1 ]
    ENST00000538658 ; ENSP00000445706 ; ENSG00000166037 . [Q86XR8-3 ]
    ENST00000541150 ; ENSP00000443436 ; ENSG00000166037 . [Q86XR8-5 ]
    GeneIDi 9702.
    KEGGi hsa:9702.
    UCSCi uc001pfo.2. human. [Q86XR8-3 ]
    uc001pfp.2. human. [Q86XR8-1 ]
    uc001pfq.2. human. [Q86XR8-2 ]

    Organism-specific databases

    CTDi 9702.
    GeneCardsi GC11P095523.
    HGNCi HGNC:30794. CEP57.
    HPAi HPA018315.
    MIMi 607951. gene.
    614114. phenotype.
    neXtProti NX_Q86XR8.
    Orphaneti 1052. Mosaic variegated aneuploidy syndrome.
    PharmGKBi PA142672123.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG19004.
    HOVERGENi HBG050917.
    InParanoidi Q86XR8.
    KOi K16762.
    OMAi RERQHDQ.
    PhylomeDBi Q86XR8.
    TreeFami TF329178.

    Enzyme and pathway databases

    Reactomei REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15364. Loss of Nlp from mitotic centrosomes.
    REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
    REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

    Miscellaneous databases

    GeneWikii CEP57.
    GenomeRNAii 9702.
    NextBioi 36461.
    PROi Q86XR8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86XR8.
    Bgeei Q86XR8.
    CleanExi HS_CEP57.
    Genevestigatori Q86XR8.

    Family and domain databases

    InterProi IPR010597. Centrosomal_protein_57kDa.
    IPR025913. Cep57_CLD.
    IPR024957. Cep57_MT-bd_dom.
    [Graphical view ]
    PANTHERi PTHR19336. PTHR19336. 1 hit.
    Pfami PF14073. Cep57_CLD. 1 hit.
    PF06657. Cep57_MT_bd. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, SUBUNIT, INTERACTION WITH FGF2, VARIANT GLY-448.
      Tissue: Placenta.
    2. Kim J.W.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
      DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Bone marrow.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT GLY-448.
      Tissue: Teratocarcinoma.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Kidney, Mammary gland and Placenta.
    7. "Proteomic characterization of the human centrosome by protein correlation profiling."
      Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
      Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Lymphoblast.
    8. Cited for: INVOLVEMENT IN MVA2.
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1."
      Zhen Y., Sorensen V., Skjerpen C.S., Haugsten E.M., Jin Y., Walchli S., Olsnes S., Wiedlocha A.
      Traffic 13:650-664(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCEP57_HUMAN
    AccessioniPrimary (citable) accession number: Q86XR8
    Secondary accession number(s): A0PJH1
    , A8K5D0, B4DDP5, F5H5F7, Q14704, Q5JB46, Q8IXP0, Q9BVF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3