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Q86XR8

- CEP57_HUMAN

UniProt

Q86XR8 - CEP57_HUMAN

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Protein

Centrosomal protein of 57 kDa

Gene
CEP57, KIAA0092, TSP57
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.1 Publication

GO - Molecular functioni

  1. fibroblast growth factor binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. fibroblast growth factor receptor signaling pathway Source: UniProtKB
  2. G2/M transition of mitotic cell cycle Source: Reactome
  3. microtubule anchoring Source: InterPro
  4. mitotic cell cycle Source: Reactome
  5. protein homooligomerization Source: Ensembl
  6. protein import into nucleus, translocation Source: UniProtKB
  7. spermatid development Source: HGNC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 57 kDa
Short name:
Cep57
Alternative name(s):
FGF2-interacting protein
Testis-specific protein 57
Translokin
Gene namesi
Name:CEP57
Synonyms:KIAA0092, TSP57
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:30794. CEP57.

Subcellular locationi

Nucleus By similarity. Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 2 Publications

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: HPA
  3. cytosol Source: Reactome
  4. Golgi apparatus Source: UniProtKB
  5. microtubule Source: UniProtKB
  6. microtubule cytoskeleton Source: HPA
  7. nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Involvement in diseasei

Mosaic variegated aneuploidy syndrome 2 (MVA2) [MIM:614114]: A severe developmental disorder characterized by mosaic aneuploidies, predominantly trisomies and monosomies, involving multiple different chromosomes and tissues. Affected individuals typically present with severe intrauterine growth retardation and microcephaly. Eye anomalies, mild dysmorphism, variable developmental delay, and a broad spectrum of additional congenital abnormalities and medical conditions may also occur. The risk of malignancy is high, with rhabdomyosarcoma, Wilms tumor and leukemia reported in several cases.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Organism-specific databases

MIMi614114. phenotype.
Orphaneti1052. Mosaic variegated aneuploidy syndrome.
PharmGKBiPA142672123.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Centrosomal protein of 57 kDaPRO_0000189532Add
BLAST

Proteomic databases

MaxQBiQ86XR8.
PaxDbiQ86XR8.
PRIDEiQ86XR8.

PTM databases

PhosphoSiteiQ86XR8.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ArrayExpressiQ86XR8.
BgeeiQ86XR8.
CleanExiHS_CEP57.
GenevestigatoriQ86XR8.

Organism-specific databases

HPAiHPA018315.

Interactioni

Subunit structurei

Homodimer and homooligomer. Interacts with microtubules. Interacts with FGF2 and RAP80. Does not interact with FGF1 or FGF2 isoform 24 kDa.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MYCP011063EBI-308614,EBI-447544

Protein-protein interaction databases

BioGridi115054. 7 interactions.
IntActiQ86XR8. 8 interactions.
MINTiMINT-4989031.
STRINGi9606.ENSP00000317902.

Structurei

Secondary structure

1
500
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi356 – 38631
Helixi391 – 42636

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4L0RX-ray2.49A/B334-433[»]
ProteinModelPortaliQ86XR8.
SMRiQ86XR8. Positions 355-428.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 239182centrosome localization domain (CLD) By similarityAdd
BLAST
Regioni277 – 491215Mediates interaction with microtubules By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili63 – 242180 Reviewed predictionAdd
BLAST
Coiled coili392 – 492101 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi260 – 2656Poly-Lys

Domaini

The C-terminal region mediates the interaction with microtubules and is able to nucleate and bundles microtubules in vitro By similarity.
The centrosome localization domain (CLD) region mediates the localization to centrosomes and homooligomerization By similarity.

Sequence similaritiesi

Belongs to the translokin family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG19004.
HOVERGENiHBG050917.
InParanoidiQ86XR8.
KOiK16762.
OMAiRERQHDQ.
PhylomeDBiQ86XR8.
TreeFamiTF329178.

Family and domain databases

InterProiIPR010597. Centrosomal_protein_57kDa.
IPR025913. Cep57_CLD.
IPR024957. Cep57_MT-bd_dom.
[Graphical view]
PANTHERiPTHR19336. PTHR19336. 1 hit.
PfamiPF14073. Cep57_CLD. 1 hit.
PF06657. Cep57_MT_bd. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86XR8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAASVSAAS GSHLSNSFAE PSRSNGSMVR HSSSPYVVYP SDKPFLNSDL    50
RRSPSKPTLA YPESNSRAIF SALKNLQDKI RRLELERIQA EESVKTLSRE 100
TIEYKKVLDE QIQERENSKN EESKHNQELT SQLLAAENKC NLLEKQLEYM 150
RNMIKHAEME RTSVLEKQVS LERERQHDQT HVQSQLEKLD LLEQEYNKLT 200
TMQALAEKKM QELEAKLHEE EQERKRMQAK AAELQTGLET NRLIFEDKAT 250
PCVPNARRIK KKKSKPPEKK SSRNYFGAQP HYRLCLGDMP FVAGKSTSPS 300
HAVVANVQLV LHLMKQHSKA LCNDRVINSI PLAKQVSSRG GKSKKLSVTP 350
PSSNGINEEL SEVLQTLQDE FGQMSFDHQQ LAKLIQESPT VELKDKLECE 400
LEALVGRMEA KANQITKVRK YQAQLEKQKL EKQKKELKAT KKTLDEERNS 450
SSRSGITGTT NKKDFMKLRP GEKRRKNLQL LKDMQSIQNS LQSSSLCWDY 500
Length:500
Mass (Da):57,089
Last modified:December 21, 2004 - v2
Checksum:i88FC47E7B33CE328
GO
Isoform 2 (identifier: Q86XR8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-295: Missing.

Show »
Length:474
Mass (Da):54,164
Checksum:iFC5DCDF19948F496
GO
Isoform 3 (identifier: Q86XR8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-270: K → V
     271-500: Missing.

Show »
Length:270
Mass (Da):31,147
Checksum:iDA552E20AB2A6648
GO
Isoform 4 (identifier: Q86XR8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MAAASVSAASGSHLS → MLTRID
     498-500: Missing.

Note: No experimental confirmation available.

Show »
Length:488
Mass (Da):56,026
Checksum:iFF8621FE703DB0F6
GO
Isoform 5 (identifier: Q86XR8-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MAAASVSAASGSHLS → MLTRID

Note: No experimental confirmation available.

Show »
Length:491
Mass (Da):56,490
Checksum:i5C5F2F4F8621FE70
GO

Sequence cautioni

The sequence AAH29385.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence BAA07654.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti448 – 4481R → G.2 Publications
Corresponds to variant rs644799 [ dbSNP | Ensembl ].
VAR_059839

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1515MAAAS…GSHLS → MLTRID in isoform 4 and isoform 5. VSP_037839Add
BLAST
Alternative sequencei270 – 29526Missing in isoform 2. VSP_012262Add
BLAST
Alternative sequencei270 – 2701K → V in isoform 3. VSP_012263
Alternative sequencei271 – 500230Missing in isoform 3. VSP_012264Add
BLAST
Alternative sequencei498 – 5003Missing in isoform 4. VSP_037840

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451F → S in BAF83934. 1 Publication
Sequence conflicti182 – 1821V → A in BAG56806. 1 Publication
Sequence conflicti188 – 1881K → E in BAF83934. 1 Publication
Sequence conflicti468 – 4681L → Q in BAA07654. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY225092 mRNA. Translation: AAO73938.1.
AY239292 mRNA. Translation: AAP72184.1.
D42054 mRNA. Translation: BAA07654.2. Different initiation.
AK291245 mRNA. Translation: BAF83934.1.
AK293277 mRNA. Translation: BAG56806.1.
AP001877 Genomic DNA. No translation available.
BC001233 mRNA. Translation: AAH01233.1.
BC029385 mRNA. Translation: AAH29385.1. Sequence problems.
BC039711 mRNA. Translation: AAH39711.1.
CCDSiCCDS58166.1. [Q86XR8-2]
CCDS58167.1. [Q86XR8-5]
CCDS8304.1. [Q86XR8-1]
RefSeqiNP_001230705.1. NM_001243776.1. [Q86XR8-5]
NP_001230706.1. NM_001243777.1. [Q86XR8-2]
NP_055494.2. NM_014679.4. [Q86XR8-1]
UniGeneiHs.101014.

Genome annotation databases

EnsembliENST00000325486; ENSP00000317487; ENSG00000166037. [Q86XR8-2]
ENST00000325542; ENSP00000317902; ENSG00000166037. [Q86XR8-1]
ENST00000538658; ENSP00000445706; ENSG00000166037. [Q86XR8-3]
ENST00000541150; ENSP00000443436; ENSG00000166037. [Q86XR8-5]
GeneIDi9702.
KEGGihsa:9702.
UCSCiuc001pfo.2. human. [Q86XR8-3]
uc001pfp.2. human. [Q86XR8-1]
uc001pfq.2. human. [Q86XR8-2]

Polymorphism databases

DMDMi56748768.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY225092 mRNA. Translation: AAO73938.1 .
AY239292 mRNA. Translation: AAP72184.1 .
D42054 mRNA. Translation: BAA07654.2 . Different initiation.
AK291245 mRNA. Translation: BAF83934.1 .
AK293277 mRNA. Translation: BAG56806.1 .
AP001877 Genomic DNA. No translation available.
BC001233 mRNA. Translation: AAH01233.1 .
BC029385 mRNA. Translation: AAH29385.1 . Sequence problems.
BC039711 mRNA. Translation: AAH39711.1 .
CCDSi CCDS58166.1. [Q86XR8-2 ]
CCDS58167.1. [Q86XR8-5 ]
CCDS8304.1. [Q86XR8-1 ]
RefSeqi NP_001230705.1. NM_001243776.1. [Q86XR8-5 ]
NP_001230706.1. NM_001243777.1. [Q86XR8-2 ]
NP_055494.2. NM_014679.4. [Q86XR8-1 ]
UniGenei Hs.101014.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4L0R X-ray 2.49 A/B 334-433 [» ]
ProteinModelPortali Q86XR8.
SMRi Q86XR8. Positions 355-428.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115054. 7 interactions.
IntActi Q86XR8. 8 interactions.
MINTi MINT-4989031.
STRINGi 9606.ENSP00000317902.

PTM databases

PhosphoSitei Q86XR8.

Polymorphism databases

DMDMi 56748768.

Proteomic databases

MaxQBi Q86XR8.
PaxDbi Q86XR8.
PRIDEi Q86XR8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000325486 ; ENSP00000317487 ; ENSG00000166037 . [Q86XR8-2 ]
ENST00000325542 ; ENSP00000317902 ; ENSG00000166037 . [Q86XR8-1 ]
ENST00000538658 ; ENSP00000445706 ; ENSG00000166037 . [Q86XR8-3 ]
ENST00000541150 ; ENSP00000443436 ; ENSG00000166037 . [Q86XR8-5 ]
GeneIDi 9702.
KEGGi hsa:9702.
UCSCi uc001pfo.2. human. [Q86XR8-3 ]
uc001pfp.2. human. [Q86XR8-1 ]
uc001pfq.2. human. [Q86XR8-2 ]

Organism-specific databases

CTDi 9702.
GeneCardsi GC11P095523.
HGNCi HGNC:30794. CEP57.
HPAi HPA018315.
MIMi 607951. gene.
614114. phenotype.
neXtProti NX_Q86XR8.
Orphaneti 1052. Mosaic variegated aneuploidy syndrome.
PharmGKBi PA142672123.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG19004.
HOVERGENi HBG050917.
InParanoidi Q86XR8.
KOi K16762.
OMAi RERQHDQ.
PhylomeDBi Q86XR8.
TreeFami TF329178.

Enzyme and pathway databases

Reactomei REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

GeneWikii CEP57.
GenomeRNAii 9702.
NextBioi 36461.
PROi Q86XR8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q86XR8.
Bgeei Q86XR8.
CleanExi HS_CEP57.
Genevestigatori Q86XR8.

Family and domain databases

InterProi IPR010597. Centrosomal_protein_57kDa.
IPR025913. Cep57_CLD.
IPR024957. Cep57_MT-bd_dom.
[Graphical view ]
PANTHERi PTHR19336. PTHR19336. 1 hit.
Pfami PF14073. Cep57_CLD. 1 hit.
PF06657. Cep57_MT_bd. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, SUBUNIT, INTERACTION WITH FGF2, VARIANT GLY-448.
    Tissue: Placenta.
  2. Kim J.W.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
    DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone marrow.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT GLY-448.
    Tissue: Teratocarcinoma.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Kidney, Mammary gland and Placenta.
  7. "Proteomic characterization of the human centrosome by protein correlation profiling."
    Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
    Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Lymphoblast.
  8. Cited for: INVOLVEMENT IN MVA2.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1."
    Zhen Y., Sorensen V., Skjerpen C.S., Haugsten E.M., Jin Y., Walchli S., Olsnes S., Wiedlocha A.
    Traffic 13:650-664(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCEP57_HUMAN
AccessioniPrimary (citable) accession number: Q86XR8
Secondary accession number(s): A0PJH1
, A8K5D0, B4DDP5, F5H5F7, Q14704, Q5JB46, Q8IXP0, Q9BVF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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