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Q86XR7

- TCAM2_HUMAN

UniProt

Q86XR7 - TCAM2_HUMAN

Protein

TIR domain-containing adapter molecule 2

Gene

TICAM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
    Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.

    GO - Molecular functioni

    1. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to lipopolysaccharide Source: UniProtKB
    2. I-kappaB kinase/NF-kappaB signaling Source: Reactome
    3. inflammatory response Source: UniProtKB-KW
    4. innate immune response Source: Reactome
    5. MyD88-independent toll-like receptor signaling pathway Source: Reactome
    6. negative regulation of chemokine (C-C motif) ligand 5 production Source: UniProtKB
    7. negative regulation of toll-like receptor 4 signaling pathway Source: UniProtKB
    8. positive regulation of chemokine (C-C motif) ligand 5 production Source: UniProtKB
    9. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    10. positive regulation of interleukin-18-mediated signaling pathway Source: UniProtKB
    11. positive regulation of toll-like receptor 4 signaling pathway Source: UniProtKB
    12. toll-like receptor 3 signaling pathway Source: Reactome
    13. toll-like receptor 4 signaling pathway Source: Reactome
    14. toll-like receptor signaling pathway Source: Reactome
    15. TRAM-dependent toll-like receptor 4 signaling pathway Source: UniProtKB
    16. TRIF-dependent toll-like receptor signaling pathway Source: Reactome

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_150361. TRIF-mediated programmed cell death.
    REACT_25148. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
    REACT_25351. TRAF6 mediated induction of TAK1 complex.
    REACT_25374. IKK complex recruitment mediated by RIP1.
    REACT_6894. Toll Like Receptor 4 (TLR4) Cascade.
    SignaLinkiQ86XR7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TIR domain-containing adapter molecule 2
    Short name:
    TICAM-2
    Alternative name(s):
    Putative NF-kappa-B-activating protein 502
    TRIF-related adapter molecule
    Toll-like receptor adaptor protein 3
    Toll/interleukin-1 receptor domain-containing protein
    Short name:
    MyD88-4
    Gene namesi
    Name:TICAM2
    Synonyms:TIRAP3, TIRP, TRAM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:21354. TICAM2.

    Subcellular locationi

    Isoform 1 : Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane
    Note: Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform 2 in late endosomes.
    Isoform 2 : Endoplasmic reticulum. Early endosome membrane. Late endosome membrane
    Note: Translocates to late endosomes upon LPS stimulation where it colcoalizes with isoform 1.

    GO - Cellular componenti

    1. early endosome Source: UniProtKB
    2. early endosome membrane Source: UniProtKB-SubCell
    3. endoplasmic reticulum Source: UniProtKB
    4. endosome membrane Source: Reactome
    5. Golgi apparatus Source: UniProtKB-SubCell
    6. late endosome Source: UniProtKB
    7. late endosome membrane Source: UniProtKB-SubCell
    8. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi2 – 21G → A: Results in relocalization from membrane to cytosol; Loss of ability to transduce TLR4-signal. 1 Publication
    Mutagenesisi6 – 61S → A: Loss of phosphorylation. Significant reduction in the ability to activate IRF3 or NF-kappa-B. 1 Publication
    Mutagenesisi10 – 101S → A: No effect on phosphorylation and on the ability to activate IRF3 or NF-kappa-B. 1 Publication
    Mutagenesisi14 – 141S → A: No effect on phosphorylation and on the ability to activate IRF3 or NF-kappa-B. 1 Publication
    Mutagenesisi16 – 161S → A: Loss of phosphorylation. Abolishes ability to activate IRF3 or NF-kappa-B and to transduce TLR4 signal. 1 Publication
    Mutagenesisi16 – 161S → E: Significant decrease of localization in the membrane. 1 Publication
    Mutagenesisi116 – 1161P → H: Loss of ability to dimerize. Significant loss of RANTES-inducing activity. Loss of ability to induce NF-kappa-B activation. 2 Publications
    Mutagenesisi117 – 1171C → H: Loss of ability to dimerize. Loss of RANTES-inducing activity and ability to induce NF-kappa-B activation. Inhibition of TLR4-dependent activation of IRF3 and IRF7. Loss of interaction with TLR4. 2 Publications

    Organism-specific databases

    PharmGKBiPA134881157.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 235234TIR domain-containing adapter molecule 2PRO_0000317689Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycine1 Publication
    Modified residuei16 – 161Phosphoserine; by PKC/PRKCE1 Publication

    Post-translational modificationi

    Phosphorylated by PRKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.1 Publication
    Isoform 1 is myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.1 Publication

    Keywords - PTMi

    Lipoprotein, Myristate, Phosphoprotein

    Proteomic databases

    MaxQBiQ86XR7.
    PaxDbiQ86XR7.
    PRIDEiQ86XR7.

    PTM databases

    PhosphoSiteiQ86XR7.

    Expressioni

    Tissue specificityi

    Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).3 Publications

    Gene expression databases

    BgeeiQ86XR7.
    CleanExiHS_TICAM2.
    GenevestigatoriQ86XR7.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs in late endosomes and disrupts the interaction between isoform 1 and TICAM1. Interacts with MYD88; the interaction decreases after IL-18 stimulation in a time-dependent manner. Interacts with IL18R1 and IL18RAP.4 Publications

    Protein-protein interaction databases

    BioGridi131694. 9 interactions.
    970651. 1 interaction.
    IntActiQ86XR7. 10 interactions.
    STRINGi9606.ENSP00000386341.

    Structurei

    Secondary structure

    1
    235
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi80 – 845
    Beta strandi87 – 893
    Helixi90 – 10011
    Turni101 – 1044
    Beta strandi108 – 1114
    Turni112 – 1143
    Beta strandi118 – 1203
    Helixi125 – 1284
    Beta strandi130 – 1334
    Beta strandi135 – 1373
    Helixi141 – 15313
    Helixi155 – 1606
    Beta strandi166 – 1683
    Beta strandi176 – 1783
    Helixi182 – 1843
    Turni187 – 1915
    Beta strandi196 – 1994
    Helixi202 – 2098
    Helixi212 – 23221

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2M1WNMR-A75-235[»]
    ProteinModelPortaliQ86XR7.
    SMRiQ86XR7. Positions 75-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini73 – 232160TIRPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The TIR domain mediates the interaction with TRAF6 and MYD88.1 Publication

    Sequence similaritiesi

    Contains 1 TIR domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG43987.
    HOGENOMiHOG000068974.
    HOVERGENiHBG102133.
    KOiK05409.
    OMAiTRVAYCH.
    OrthoDBiEOG70ZZP7.
    PhylomeDBiQ86XR7.
    TreeFamiTF313000.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR000157. TIR_dom.
    IPR015720. TMP21-related.
    [Graphical view]
    PANTHERiPTHR22811. PTHR22811. 1 hit.
    PfamiPF13676. TIR_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS50104. TIR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86XR7-1) [UniParc]FASTAAdd to Basket

    Also known as: TRAM

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGIGKSKINS CPLSLSWGKR HSVDTSPGYH ESDSKKSEDL SLCNVAEHSN    50
    TTEGPTGKQE GAQSVEEMFE EEAEEEVFLK FVILHAEDDT DEALRVQNLL 100
    QDDFGIKPGI IFAEMPCGRQ HLQNLDDAVN GSAWTILLLT ENFLRDTWCN 150
    FQFYTSLMNS VNRQHKYNSV IPMRPLNNPL PRERTPFALQ TINALEEESR 200
    GFPTQVERIF QESVYKTQQT IWKETRNMVQ RQFIA 235
    Length:235
    Mass (Da):26,916
    Last modified:June 1, 2003 - v1
    Checksum:i2D1171F9B04D9C4C
    GO
    Isoform 2 (identifier: Q86XR7-2) [UniParc]FASTAAdd to Basket

    Also known as: TAG, TRAM adaptor with GOLD domain

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: MGIGKSKINSCPLSLSWGKR → MPRPGSAQRW...EDLNTRVAYW

    Show »
    Length:404
    Mass (Da):46,173
    Checksum:iC539E6D9B8185764
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2020MGIGK…SWGKR → MPRPGSAQRWAAVAGRWGCR LLALLLLVPGPGGASEITFE LPDNAKQCFYEDIAQGTKCT LEFQVITGGHYDVDCRLEDP DGKVLYKEMKKQYDSFTFTA SKNGTYKFCFSNEFSTFTHK TVYFDFQVGEDPPLFPSENR VSALTQMESACVSIHEALKS VIDYQTHFRLREAQGRSRAE DLNTRVAYW in isoform 2. 1 PublicationVSP_047437Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY275836 mRNA. Translation: AAP81748.1.
    AB109098 mRNA. Translation: BAC98399.1.
    AB091054 mRNA. Translation: BAC98397.1.
    AY232653 mRNA. Translation: AAO74498.1.
    AY304581 mRNA. Translation: AAQ97430.1.
    AY304582 mRNA. Translation: AAQ97431.1.
    AY304583 mRNA. Translation: AAQ97432.1.
    AY304584 mRNA. Translation: AAQ97433.1.
    AB446491 mRNA. Translation: BAG55268.1.
    AB097022 mRNA. Translation: BAC77375.1.
    AC010226 Genomic DNA. No translation available.
    CH471086 Genomic DNA. Translation: EAW48960.1.
    CH471086 Genomic DNA. Translation: EAW48961.1.
    BC109265 mRNA. Translation: AAI09266.1.
    BC109266 mRNA. Translation: AAI09267.1.
    CCDSiCCDS4119.1. [Q86XR7-1]
    RefSeqiNP_001157940.1. NM_001164468.3. [Q86XR7-2]
    NP_001157941.1. NM_001164469.3.
    NP_067681.1. NM_021649.7. [Q86XR7-1]
    UniGeneiHs.718838.

    Genome annotation databases

    EnsembliENST00000427199; ENSP00000415139; ENSG00000243414. [Q86XR7-1]
    GeneIDi100302736.
    353376.
    KEGGihsa:100302736.
    hsa:353376.
    UCSCiuc003krc.3. human. [Q86XR7-1]
    uc003kre.3. human.

    Polymorphism databases

    DMDMi74727858.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY275836 mRNA. Translation: AAP81748.1 .
    AB109098 mRNA. Translation: BAC98399.1 .
    AB091054 mRNA. Translation: BAC98397.1 .
    AY232653 mRNA. Translation: AAO74498.1 .
    AY304581 mRNA. Translation: AAQ97430.1 .
    AY304582 mRNA. Translation: AAQ97431.1 .
    AY304583 mRNA. Translation: AAQ97432.1 .
    AY304584 mRNA. Translation: AAQ97433.1 .
    AB446491 mRNA. Translation: BAG55268.1 .
    AB097022 mRNA. Translation: BAC77375.1 .
    AC010226 Genomic DNA. No translation available.
    CH471086 Genomic DNA. Translation: EAW48960.1 .
    CH471086 Genomic DNA. Translation: EAW48961.1 .
    BC109265 mRNA. Translation: AAI09266.1 .
    BC109266 mRNA. Translation: AAI09267.1 .
    CCDSi CCDS4119.1. [Q86XR7-1 ]
    RefSeqi NP_001157940.1. NM_001164468.3. [Q86XR7-2 ]
    NP_001157941.1. NM_001164469.3.
    NP_067681.1. NM_021649.7. [Q86XR7-1 ]
    UniGenei Hs.718838.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2M1W NMR - A 75-235 [» ]
    ProteinModelPortali Q86XR7.
    SMRi Q86XR7. Positions 75-235.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131694. 9 interactions.
    970651. 1 interaction.
    IntActi Q86XR7. 10 interactions.
    STRINGi 9606.ENSP00000386341.

    PTM databases

    PhosphoSitei Q86XR7.

    Polymorphism databases

    DMDMi 74727858.

    Proteomic databases

    MaxQBi Q86XR7.
    PaxDbi Q86XR7.
    PRIDEi Q86XR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000427199 ; ENSP00000415139 ; ENSG00000243414 . [Q86XR7-1 ]
    GeneIDi 100302736.
    353376.
    KEGGi hsa:100302736.
    hsa:353376.
    UCSCi uc003krc.3. human. [Q86XR7-1 ]
    uc003kre.3. human.

    Organism-specific databases

    CTDi 100302736.
    353376.
    GeneCardsi GC05M114942.
    HGNCi HGNC:21354. TICAM2.
    MIMi 608321. gene.
    neXtProti NX_Q86XR7.
    PharmGKBi PA134881157.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43987.
    HOGENOMi HOG000068974.
    HOVERGENi HBG102133.
    KOi K05409.
    OMAi TRVAYCH.
    OrthoDBi EOG70ZZP7.
    PhylomeDBi Q86XR7.
    TreeFami TF313000.

    Enzyme and pathway databases

    Reactomei REACT_150361. TRIF-mediated programmed cell death.
    REACT_25148. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
    REACT_25351. TRAF6 mediated induction of TAK1 complex.
    REACT_25374. IKK complex recruitment mediated by RIP1.
    REACT_6894. Toll Like Receptor 4 (TLR4) Cascade.
    SignaLinki Q86XR7.

    Miscellaneous databases

    GeneWikii TICAM2.
    NextBioi 20796124.
    PROi Q86XR7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86XR7.
    CleanExi HS_TICAM2.
    Genevestigatori Q86XR7.

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR000157. TIR_dom.
    IPR015720. TMP21-related.
    [Graphical view ]
    PANTHERi PTHR22811. PTHR22811. 1 hit.
    Pfami PF13676. TIR_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling."
      Bin L.-H., Xu L.-G., Shu H.-B.
      J. Biol. Chem. 278:24526-24532(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DOMAIN, INTERACTION WITH TRAF6; IL1R1; IL1RAP; IRAK1; IRAK2; IRAK3; IRAK4; TIRAP AND TICAM1, TISSUE SPECIFICITY.
    2. "TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta."
      Oshiumi H., Sasai M., Shida K., Fujita T., Matsumoto M., Seya T.
      J. Biol. Chem. 278:49751-49762(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, INTERACTION WITH TICAM1 AND TLR4, TISSUE SPECIFICITY, MUTAGENESIS OF PRO-116 AND CYS-117.
    3. "LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF."
      Fitzgerald K.A., Rowe D.C., Barnes B.J., Caffrey D.R., Visintin A., Latz E., Monks B., Pitha P.M., Golenbock D.T.
      J. Exp. Med. 198:1043-1055(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH TICAM1; TIRAP; TLR4; IRF3 AND IRF7, MUTAGENESIS OF PRO-116 AND CYS-117.
    4. "Natural selection in the TLR-related genes in the course of primate evolution."
      Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
      Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway."
      Palsson-McDermott E.M., Doyle S.L., McGettrick A.F., Hardy M., Husebye H., Banahan K., Gong M., Golenbock D., Espevik T., O'Neill L.A.
      Nat. Immunol. 10:579-586(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    6. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
      Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
      Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    7. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    10. "The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction."
      Rowe D.C., McGettrick A.F., Latz E., Monks B.G., Gay N.J., Yamamoto M., Akira S., O'Neill L.A., Fitzgerald K.A., Golenbock D.T.
      Proc. Natl. Acad. Sci. U.S.A. 103:6299-6304(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, MYRISTOYLATION AT GLY-2, MUTAGENESIS OF GLY-2.
    11. "Trif-related adapter molecule is phosphorylated by PKCepsilon during Toll-like receptor 4 signaling."
      McGettrick A.F., Brint E.K., Palsson-McDermott E.M., Rowe D.C., Golenbock D.T., Gay N.J., Fitzgerald K.A., O'Neill L.A.J.
      Proc. Natl. Acad. Sci. U.S.A. 103:9196-9201(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-16, MUTAGENESIS OF SER-6; SER-10; SER-14 AND SER-16.
    12. "TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88."
      Ohnishi H., Tochio H., Kato Z., Kawamoto N., Kimura T., Kubota K., Yamamoto T., Funasaka T., Nakano H., Wong R.W., Shirakawa M., Kondo N.
      PLoS ONE 7:E38423-E38423(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MYD88; IL18R1 AND IL18RAP.

    Entry informationi

    Entry nameiTCAM2_HUMAN
    AccessioniPrimary (citable) accession number: Q86XR7
    Secondary accession number(s): B3Y698, Q6JUT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3