PRNP

Functionⁱ

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein homooligomerization Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	PrionUniRule annotationImported
Ligand	CopperSAAS annotation, Metal-bindingSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Major prion proteinUniRule annotation
Gene namesⁱ	Name:PRNPImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	97 – 116	HelicalSequence analysisAdd BLAST		20
Transmembraneⁱ	217 – 237	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Amyloid, Cell membraneUniRule annotationSAAS annotation, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 15	Sequence analysisAdd BLAST		15
ChainⁱPRO_5012881304	16 – 238	Major prion proteinSequence analysisAdd BLAST		223

Keywords - PTMⁱ

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q86XR1.
PRIDEⁱ	Q86XR1.

Interactionⁱ

Subunit structureⁱ

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization.SAAS annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86XR1.
SMRⁱ	Q86XR1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	98 – 113	Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST		16
Domainⁱ	185 – 203	Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST		19

Sequence similaritiesⁱ

Belongs to the prion family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IJMM. Eukaryota. ENOG410YXUU. LUCA.
HOVERGENⁱ	HBG008260.

Family and domain databases

Gene3Dⁱ	1.10.790.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000817. Prion. IPR036924. Prion/Doppel_b-ribbon_dom_sf. IPR022416. Prion/Doppel_prot_b-ribbon_dom. IPR025860. Prion_N_dom.
PANTHERⁱ	PTHR10502:SF134. PTHR10502:SF134. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00377. Prion. 1 hit. PF11587. Prion_bPrPp. 1 hit.
PRINTSⁱ	PR00341. PRION.
SMARTⁱ	View protein in SMART SM00157. PRP. 1 hit.
SUPFAMⁱ	SSF54098. SSF54098. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00291. PRION_1. 1 hit. PS00706. PRION_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q86XR1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLVLFVATWS DLGLCKKRPK PGGWNTGGSR YPGQGSPGGN RYPPQGGGGW 
        60         70         80         90        100
GQPHGGGWGQ PHGGGWGQPH GGGWGQGGGT HSQWNKPSKP KTNMKHMAGA 
       110        120        130        140        150
AAAGAVVGGL GGYMLGSAMS RPIIHFGSDY EDRYYRENMH RYPNQVYYRP 
       160        170        180        190        200
MDEYSNQNNF VHDCVNITIK QHTVTTTTKG ENFTETDVKM MERVVEQMCI 
       210        220        230 
TQYERESQAY YQRGSSMVLF SSPPVILLIS FLIFLIVG

Length:238

Mass (Da):26,108

Last modified:June 1, 2003 - v1

Checksum:ⁱEC9FA42623F3BBAE

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1
Non-terminal residueⁱ	238	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY219882 Genomic DNA. Translation: AAO83635.1.
UniGeneⁱ	Hs.472010. Hs.610285. Hs.721670.

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q86XR1	P04156 Q53YK7 P04156-2 A2A2V1 X6RKS3 UPI0005F419F8 P40258 G8IPQ7 UPI000533EDF0 C1K4U9 +408	Homo sapiens (Human) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Saimiri sciureus (Common squirrel monkey) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Cervus elaphus (Red deer) Capreolus capreolus (Roe deer) Rangifer tarandus granti Cervus elaphus elaphus Cervus nippon (Sika deer) Odocoileus hemionus hemionus And more	253	UniRef90_P04156	Cluster: Major prion protein	419

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q86XR1	P04156 Q53YK7 P04156-2 A2A2V1 X6RKS3 UPI0005F419F8 P40258 G8IPQ7 UPI000533EDF0 C1K4U9 +486	Homo sapiens (Human) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Saimiri sciureus (Common squirrel monkey) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Ovis aries (Sheep) Rangifer tarandus granti Ovis canadensis (Bighorn sheep) Procapra gutturosa (Mongolian gazelle) Odocoileus virginianus (White-tailed deer) Rangifer tarandus tarandus And more	253	UniRef50_P04156	Cluster: Major prion protein	497

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY219882 Genomic DNA. Translation: AAO83635.1.
UniGeneⁱ	Hs.472010. Hs.610285. Hs.721670.

3D structure databases

ProteinModelPortalⁱ	Q86XR1.
SMRⁱ	Q86XR1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q86XR1.
PRIDEⁱ	Q86XR1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJMM. Eukaryota. ENOG410YXUU. LUCA.
HOVERGENⁱ	HBG008260.

Miscellaneous databases

ChiTaRSⁱ	PRNP. human.

ChiTaRSⁱ

PRNP. human.

Family and domain databases

Gene3Dⁱ	1.10.790.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000817. Prion. IPR036924. Prion/Doppel_b-ribbon_dom_sf. IPR022416. Prion/Doppel_prot_b-ribbon_dom. IPR025860. Prion_N_dom.
PANTHERⁱ	PTHR10502:SF134. PTHR10502:SF134. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00377. Prion. 1 hit. PF11587. Prion_bPrPp. 1 hit.
PRINTSⁱ	PR00341. PRION.
SMARTⁱ	View protein in SMART SM00157. PRP. 1 hit.
SUPFAMⁱ	SSF54098. SSF54098. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00291. PRION_1. 1 hit. PS00706. PRION_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q86XR1_HUMAN
Accessionⁱ	Q86XR1Primary (citable) accession number: Q86XR1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 1, 2003
	Last sequence update:	June 1, 2003
	Last modified:	January 31, 2018
	This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q86XR1 (Q86XR1_HUMAN)

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Major prion protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ