UniProtKB - Q86XR1 (Q86XR1_HUMAN)
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Protein
Major prion protein
Gene
PRNP
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- protein homooligomerization Source: InterPro
Keywordsi
Molecular function | PrionUniRule annotationImported |
Ligand | CopperSAAS annotation, Metal-bindingSAAS annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Major prion proteinUniRule annotation |
Gene namesi | Name:PRNPImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 97 – 116 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 217 – 237 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Amyloid, Cell membraneUniRule annotationSAAS annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
ChainiPRO_5012881304 | 16 – 238 | Major prion proteinSequence analysisAdd BLAST | 223 |
Keywords - PTMi
Disulfide bondSAAS annotationProteomic databases
PeptideAtlasi | Q86XR1. |
PRIDEi | Q86XR1. |
Interactioni
Subunit structurei
Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization.SAAS annotation
Structurei
3D structure databases
ProteinModelPortali | Q86XR1. |
SMRi | Q86XR1. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 98 – 113 | Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST | 16 | |
Domaini | 185 – 203 | Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST | 19 |
Sequence similaritiesi
Keywords - Domaini
RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG410IJMM. Eukaryota. ENOG410YXUU. LUCA. |
HOVERGENi | HBG008260. |
Family and domain databases
Gene3Di | 1.10.790.10. 1 hit. |
InterProi | View protein in InterPro IPR000817. Prion. IPR036924. Prion/Doppel_b-ribbon_dom_sf. IPR022416. Prion/Doppel_prot_b-ribbon_dom. IPR025860. Prion_N_dom. |
PANTHERi | PTHR10502:SF134. PTHR10502:SF134. 1 hit. |
Pfami | View protein in Pfam PF00377. Prion. 1 hit. PF11587. Prion_bPrPp. 1 hit. |
PRINTSi | PR00341. PRION. |
SMARTi | View protein in SMART SM00157. PRP. 1 hit. |
SUPFAMi | SSF54098. SSF54098. 1 hit. |
PROSITEi | View protein in PROSITE PS00291. PRION_1. 1 hit. PS00706. PRION_2. 1 hit. |
i Sequence
Sequence statusi: Fragment.
Q86XR1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVLFVATWS DLGLCKKRPK PGGWNTGGSR YPGQGSPGGN RYPPQGGGGW
60 70 80 90 100
GQPHGGGWGQ PHGGGWGQPH GGGWGQGGGT HSQWNKPSKP KTNMKHMAGA
110 120 130 140 150
AAAGAVVGGL GGYMLGSAMS RPIIHFGSDY EDRYYRENMH RYPNQVYYRP
160 170 180 190 200
MDEYSNQNNF VHDCVNITIK QHTVTTTTKG ENFTETDVKM MERVVEQMCI
210 220 230
TQYERESQAY YQRGSSMVLF SSPPVILLIS FLIFLIVG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 238 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY219882 Genomic DNA. Translation: AAO83635.1. |
UniGenei | Hs.472010. Hs.610285. Hs.721670. |
Similar proteinsi
Entry informationi
Entry namei | Q86XR1_HUMAN | |
Accessioni | Q86XR1Primary (citable) accession number: Q86XR1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2003 |
Last sequence update: | June 1, 2003 | |
Last modified: | January 31, 2018 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |