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Protein

Major prion protein

Gene

PRNP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

PrionUniRule annotationImported

Keywords - Ligandi

CopperSAAS annotation, Metal-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Major prion proteinUniRule annotation
Gene namesi
Name:PRNPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cell membrane SAAS annotation; Lipid-anchorGPI-anchor SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei97 – 11620HelicalSequence analysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Cell membraneUniRule annotationSAAS annotation, Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ86XR1.
PeptideAtlasiQ86XR1.
PRIDEiQ86XR1.

Expressioni

Gene expression databases

BgeeiENSG00000171867.

Interactioni

Subunit structurei

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization.SAAS annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000368752.

Structurei

3D structure databases

ProteinModelPortaliQ86XR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 11316Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd
BLAST
Domaini185 – 20319Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the prion family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IJMM. Eukaryota.
ENOG410YXUU. LUCA.
HOVERGENiHBG008260.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR000817. Prion.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
IPR025860. Prion_N_dom.
[Graphical view]
PANTHERiPTHR10502:SF11. PTHR10502:SF11. 1 hit.
PfamiPF00377. Prion. 1 hit.
PF11587. Prion_bPrPp. 1 hit.
[Graphical view]
PRINTSiPR00341. PRION.
SMARTiSM00157. PRP. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.
PROSITEiPS00291. PRION_1. 1 hit.
PS00706. PRION_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q86XR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVLFVATWS DLGLCKKRPK PGGWNTGGSR YPGQGSPGGN RYPPQGGGGW
60 70 80 90 100
GQPHGGGWGQ PHGGGWGQPH GGGWGQGGGT HSQWNKPSKP KTNMKHMAGA
110 120 130 140 150
AAAGAVVGGL GGYMLGSAMS RPIIHFGSDY EDRYYRENMH RYPNQVYYRP
160 170 180 190 200
MDEYSNQNNF VHDCVNITIK QHTVTTTTKG ENFTETDVKM MERVVEQMCI
210 220 230
TQYERESQAY YQRGSSMVLF SSPPVILLIS FLIFLIVG
Length:238
Mass (Da):26,108
Last modified:June 1, 2003 - v1
Checksum:iEC9FA42623F3BBAE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei238 – 2381Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY219882 Genomic DNA. Translation: AAO83635.1.
UniGeneiHs.472010.
Hs.610285.
Hs.721670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY219882 Genomic DNA. Translation: AAO83635.1.
UniGeneiHs.472010.
Hs.610285.
Hs.721670.

3D structure databases

ProteinModelPortaliQ86XR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368752.

Proteomic databases

PaxDbiQ86XR1.
PeptideAtlasiQ86XR1.
PRIDEiQ86XR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IJMM. Eukaryota.
ENOG410YXUU. LUCA.
HOVERGENiHBG008260.

Miscellaneous databases

ChiTaRSiPRNP. human.

Gene expression databases

BgeeiENSG00000171867.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR000817. Prion.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
IPR025860. Prion_N_dom.
[Graphical view]
PANTHERiPTHR10502:SF11. PTHR10502:SF11. 1 hit.
PfamiPF00377. Prion. 1 hit.
PF11587. Prion_bPrPp. 1 hit.
[Graphical view]
PRINTSiPR00341. PRION.
SMARTiSM00157. PRP. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.
PROSITEiPS00291. PRION_1. 1 hit.
PS00706. PRION_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ86XR1_HUMAN
AccessioniPrimary (citable) accession number: Q86XR1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.