PRNP

Functionⁱ

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW

GO - Biological processⁱ

protein homooligomerization Source: InterPro

Keywordsⁱ

Molecular function	PrionUniRule annotationImported
Ligand	CopperSAAS annotation, Metal-bindingSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Major prion proteinUniRule annotation
Gene namesⁱ	Name:PRNPImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

Cell membrane
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00541856
; Lipid-anchor › GPI-anchor
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00541856

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	97 – 116	HelicalSequence analysisAdd BLAST		20
Transmembraneⁱ	217 – 237	HelicalSequence analysisAdd BLAST		21

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
plasma membrane Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Amyloid, Cell membraneUniRule annotationSAAS annotation, Membrane

PTM / Processingⁱ

Keywords - PTMⁱ

Disulfide bondSAAS annotation

Proteomic databases

PaxDbⁱ	Q86XR1.
PeptideAtlas More...PeptideAtlasⁱ	Q86XR1.
PRIDEⁱ	Q86XR1.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171867.

Bgeeⁱ

ENSG00000171867.

Interactionⁱ

Subunit structureⁱ

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization.SAAS annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86XR1.
SMRⁱ	Q86XR1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	98 – 113	Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST		16
Domainⁱ	185 – 203	Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST		19

Sequence similaritiesⁱ

Belongs to the prion family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IJMM. Eukaryota. ENOG410YXUU. LUCA.
HOVERGENⁱ	HBG008260.

Family and domain databases

Gene3Dⁱ	1.10.790.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000817. Prion. IPR022416. Prion/Doppel_prot_b-ribbon_dom. IPR025860. Prion_N_dom.
PANTHERⁱ	PTHR10502:SF163. PTHR10502:SF163. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00377. Prion. 1 hit. PF11587. Prion_bPrPp. 1 hit.
PRINTSⁱ	PR00341. PRION.
SMARTⁱ	View protein in SMART SM00157. PRP. 1 hit.
SUPFAMⁱ	SSF54098. SSF54098. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00291. PRION_1. 1 hit. PS00706. PRION_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q86XR1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLVLFVATWS DLGLCKKRPK PGGWNTGGSR YPGQGSPGGN RYPPQGGGGW 
        60         70         80         90        100
GQPHGGGWGQ PHGGGWGQPH GGGWGQGGGT HSQWNKPSKP KTNMKHMAGA 
       110        120        130        140        150
AAAGAVVGGL GGYMLGSAMS RPIIHFGSDY EDRYYRENMH RYPNQVYYRP 
       160        170        180        190        200
MDEYSNQNNF VHDCVNITIK QHTVTTTTKG ENFTETDVKM MERVVEQMCI 
       210        220        230 
TQYERESQAY YQRGSSMVLF SSPPVILLIS FLIFLIVG

Length:238

Mass (Da):26,108

Last modified:June 1, 2003 - v1

Checksum:ⁱEC9FA42623F3BBAE

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1
Non-terminal residueⁱ	238	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY219882 Genomic DNA. Translation: AAO83635.1.
UniGeneⁱ	Hs.472010. Hs.610285. Hs.721670.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY219882 Genomic DNA. Translation: AAO83635.1.
UniGeneⁱ	Hs.472010. Hs.610285. Hs.721670.

3D structure databases

ProteinModelPortalⁱ	Q86XR1.
SMRⁱ	Q86XR1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	Q86XR1.
PeptideAtlas More...PeptideAtlasⁱ	Q86XR1.
PRIDEⁱ	Q86XR1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJMM. Eukaryota. ENOG410YXUU. LUCA.
HOVERGENⁱ	HBG008260.

Miscellaneous databases

ChiTaRSⁱ	PRNP. human.

ChiTaRSⁱ

PRNP. human.

Gene expression databases

Bgeeⁱ	ENSG00000171867.

Bgeeⁱ

ENSG00000171867.

Family and domain databases

Gene3Dⁱ	1.10.790.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000817. Prion. IPR022416. Prion/Doppel_prot_b-ribbon_dom. IPR025860. Prion_N_dom.
PANTHERⁱ	PTHR10502:SF163. PTHR10502:SF163. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00377. Prion. 1 hit. PF11587. Prion_bPrPp. 1 hit.
PRINTSⁱ	PR00341. PRION.
SMARTⁱ	View protein in SMART SM00157. PRP. 1 hit.
SUPFAMⁱ	SSF54098. SSF54098. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00291. PRION_1. 1 hit. PS00706. PRION_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q86XR1_HUMAN
Accessionⁱ	Q86XR1Primary (citable) accession number: Q86XR1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 1, 2003
	Last sequence update:	June 1, 2003
	Last modified:	July 5, 2017
	This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q86XR1 (Q86XR1_HUMAN)

Your basket is currently empty.

Major prion protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ