PRNP

Functionⁱ

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein homooligomerization Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	PrionUniRule annotationImported
Ligand	CopperSAAS annotation, Metal-bindingSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Major prion proteinUniRule annotation
Gene namesⁱ	Name:PRNPImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	97 – 116	HelicalSequence analysisAdd BLAST		20
Transmembraneⁱ	217 – 237	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Amyloid, Cell membraneUniRule annotationSAAS annotation, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 15	Sequence analysisAdd BLAST		15
ChainⁱPRO_5012881304	16 – 238	Major prion proteinSequence analysisAdd BLAST		223

Keywords - PTMⁱ

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q86XR1

PeptideAtlasⁱ

Q86XR1

Interactionⁱ

Subunit structureⁱ

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization.SAAS annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86XR1
SMRⁱ	Q86XR1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	98 – 113	Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST		16
Domainⁱ	185 – 203	Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST		19

Sequence similaritiesⁱ

Belongs to the prion family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IJMM Eukaryota ENOG410YXUU LUCA
HOVERGENⁱ	HBG008260

Family and domain databases

Gene3Dⁱ	1.10.790.10, 1 hit
InterProⁱ	View protein in InterPro IPR000817 Prion IPR036924 Prion/Doppel_b-ribbon_dom_sf IPR022416 Prion/Doppel_prot_b-ribbon_dom IPR025860 Prion_N_dom
PANTHERⁱ	PTHR10502:SF134 PTHR10502:SF134, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00377 Prion, 1 hit PF11587 Prion_bPrPp, 1 hit
PRINTSⁱ	PR00341 PRION
SMARTⁱ	View protein in SMART SM00157 PRP, 1 hit
SUPFAMⁱ	SSF54098 SSF54098, 1 hit
PROSITEⁱ	View protein in PROSITE PS00291 PRION_1, 1 hit PS00706 PRION_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q86XR1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLVLFVATWS DLGLCKKRPK PGGWNTGGSR YPGQGSPGGN RYPPQGGGGW 
        60         70         80         90        100
GQPHGGGWGQ PHGGGWGQPH GGGWGQGGGT HSQWNKPSKP KTNMKHMAGA 
       110        120        130        140        150
AAAGAVVGGL GGYMLGSAMS RPIIHFGSDY EDRYYRENMH RYPNQVYYRP 
       160        170        180        190        200
MDEYSNQNNF VHDCVNITIK QHTVTTTTKG ENFTETDVKM MERVVEQMCI 
       210        220        230 
TQYERESQAY YQRGSSMVLF SSPPVILLIS FLIFLIVG

Length:238

Mass (Da):26,108

Last modified:June 1, 2003 - v1

Checksum:ⁱEC9FA42623F3BBAE

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1
Non-terminal residueⁱ	238	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY219882 Genomic DNA Translation: AAO83635.1
UniGeneⁱ	Hs.472010 Hs.610285 Hs.721670

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q86XR1	Major prion protein	)	HUMAN		253
UPI0005F419F8		MANLE		261
Major prion protein		SAISC		260
UPI000533EDF0		SAIBB		271
Major prion protein		Eastern wapiti		256
+413

Protein	Similar proteins		Species	Score	Length
Q86XR1	Major prion protein	)	HUMAN		253
UPI0005F419F8		MANLE		261
Major prion protein		SAISC		260
UPI000533EDF0		SAIBB		271
Major prion protein		Rangifer tarandus granti		256
+496

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY219882 Genomic DNA Translation: AAO83635.1
UniGeneⁱ	Hs.472010 Hs.610285 Hs.721670

3D structure databases

ProteinModelPortalⁱ	Q86XR1
SMRⁱ	Q86XR1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q86XR1

PeptideAtlasⁱ

Q86XR1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJMM Eukaryota ENOG410YXUU LUCA
HOVERGENⁱ	HBG008260

Miscellaneous databases

ChiTaRSⁱ	PRNP human

ChiTaRSⁱ

PRNP human

Family and domain databases

Gene3Dⁱ	1.10.790.10, 1 hit
InterProⁱ	View protein in InterPro IPR000817 Prion IPR036924 Prion/Doppel_b-ribbon_dom_sf IPR022416 Prion/Doppel_prot_b-ribbon_dom IPR025860 Prion_N_dom
PANTHERⁱ	PTHR10502:SF134 PTHR10502:SF134, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00377 Prion, 1 hit PF11587 Prion_bPrPp, 1 hit
PRINTSⁱ	PR00341 PRION
SMARTⁱ	View protein in SMART SM00157 PRP, 1 hit
SUPFAMⁱ	SSF54098 SSF54098, 1 hit
PROSITEⁱ	View protein in PROSITE PS00291 PRION_1, 1 hit PS00706 PRION_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q86XR1_HUMAN
Accessionⁱ	Q86XR1Primary (citable) accession number: Q86XR1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 1, 2003
	Last sequence update:	June 1, 2003
	Last modified:	May 23, 2018
	This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q86XR1 (Q86XR1_HUMAN)

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Major prion protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ