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Q86XQ3

- CTSR3_HUMAN

UniProt

Q86XQ3 - CTSR3_HUMAN

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Protein
Cation channel sperm-associated protein 3
Gene
CATSPER3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.2 Publications

GO - Molecular functioni

  1. calcium activated cation channel activity Source: Ensembl
  2. voltage-gated calcium channel activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. calcium ion import Source: RefGenome
  2. cell differentiation Source: UniProtKB-KW
  3. cilium or flagellum-dependent cell motility Source: Ensembl
  4. membrane depolarization during action potential Source: RefGenome
  5. multicellular organism reproduction Source: Reactome
  6. multicellular organismal development Source: UniProtKB-KW
  7. single fertilization Source: Reactome
  8. sodium ion transport Source: Ensembl
  9. sperm motility Source: RefGenome
  10. sperm-egg recognition Source: Reactome
  11. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Developmental protein, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Differentiation, Ion transport, Spermatogenesis, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_163875. Sperm Motility And Taxes.

Protein family/group databases

TCDBi1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein 3
Short name:
CatSper3
Alternative name(s):
Ca(v)-like protein
One-repeat calcium channel-like protein
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:20819. CATSPER3.

Subcellular locationi

Cell projectionciliumflagellum membrane; Multi-pass membrane protein
Note: Specifically located in the principal piece of sperm tail.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei51 – 7121Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Topological domaini72 – 787Extracellular Reviewed prediction
Transmembranei79 – 10022Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini101 – 11515Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei116 – 13621Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Topological domaini137 – 1415Extracellular Reviewed prediction
Transmembranei142 – 16120Helical; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini162 – 17918Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei180 – 20021Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Topological domaini201 – 2099Extracellular Reviewed prediction
Intramembranei210 – 23021Helical; Pore-forming; Reviewed prediction
Add
BLAST
Topological domaini231 – 24818Extracellular Reviewed prediction
Add
BLAST
Transmembranei249 – 26921Helical; Name=Segment S6; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. CatSper complex Source: UniProtKB
  2. acrosomal vesicle Source: Ensembl
  3. cilium Source: UniProtKB-KW
  4. endoplasmic reticulum Source: Ensembl
  5. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134911185.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Cation channel sperm-associated protein 3
PRO_0000295679Add
BLAST

Proteomic databases

PaxDbiQ86XQ3.
PRIDEiQ86XQ3.

PTM databases

PhosphoSiteiQ86XQ3.

Expressioni

Tissue specificityi

Testis-specific.3 Publications

Gene expression databases

BgeeiQ86XQ3.
CleanExiHS_CATSPER3.
GenevestigatoriQ86XQ3.

Interactioni

Subunit structurei

Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 Reviewed prediction. Component of the CatSper complex. Interacts with CATSPER1 By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000282611.

Structurei

3D structure databases

ProteinModelPortaliQ86XQ3.
SMRiQ86XQ3. Positions 43-315.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG117719.
HOGENOMiHOG000112052.
HOVERGENiHBG099875.
InParanoidiQ86XQ3.
KOiK16891.
OMAiYWKDGYN.
OrthoDBiEOG7PVWQD.
PhylomeDBiQ86XQ3.
TreeFamiTF343841.

Family and domain databases

InterProiIPR028739. Cat_Sper_3.
IPR005821. Ion_trans_dom.
[Graphical view]
PANTHERiPTHR10037:SF197. PTHR10037:SF197. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86XQ3-1 [UniParc]FASTAAdd to Basket

« Hide

MSQHRHQRHS RVISSSPVDT TSVGFCPTFK KFKRNDDECR AFVKRVIMSR    50
FFKIIMISTV TSNAFFMALW TSYDIRYRLF RLLEFSEIFF VSICTSELSM 100
KVYVDPINYW KNGYNLLDVI IIIVMFLPYA LRQLMGKQFT YLYIADGMQS 150
LRILKLIGYS QGIRTLITAV GQTVYTVASV LLLLFLLMYI FAILGFCLFG 200
SPDNGDHDNW GNLAAAFFTL FSLATVDGWT DLQKQLDNRE FALSRAFTII 250
FILLASFIFL NMFVGVMIMH TEDSIRKFER ELMLEQQEML MGEKQVILQR 300
QQEEISRLMH IQKNADCTSF SELVENFKKT LSHTDPMVLD DFGTSLPFID 350
IYFSTLDYQD TTVHKLQELY YEIVHVLSLM LEDLPQEKPQ SLEKVDEK 398
Length:398
Mass (Da):46,422
Last modified:June 1, 2003 - v1
Checksum:iFB460F66F367DB69
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti204 – 2041N → K.
Corresponds to variant rs3896260 [ dbSNP | Ensembl ].
VAR_033309

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF432876 mRNA. Translation: AAO85416.1.
AY156951 mRNA. Translation: AAO13012.1.
BC101692 mRNA. Translation: AAI01693.1.
BC110384 mRNA. Translation: AAI10385.1.
BN000272 mRNA. Translation: CAE30476.1.
CCDSiCCDS4181.1.
RefSeqiNP_821138.1. NM_178019.2.
UniGeneiHs.631804.

Genome annotation databases

EnsembliENST00000282611; ENSP00000282611; ENSG00000152705.
GeneIDi347732.
KEGGihsa:347732.
UCSCiuc003lag.3. human.

Polymorphism databases

DMDMi74714131.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF432876 mRNA. Translation: AAO85416.1 .
AY156951 mRNA. Translation: AAO13012.1 .
BC101692 mRNA. Translation: AAI01693.1 .
BC110384 mRNA. Translation: AAI10385.1 .
BN000272 mRNA. Translation: CAE30476.1 .
CCDSi CCDS4181.1.
RefSeqi NP_821138.1. NM_178019.2.
UniGenei Hs.631804.

3D structure databases

ProteinModelPortali Q86XQ3.
SMRi Q86XQ3. Positions 43-315.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000282611.

Chemistry

GuidetoPHARMACOLOGYi 390.

Protein family/group databases

TCDBi 1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q86XQ3.

Polymorphism databases

DMDMi 74714131.

Proteomic databases

PaxDbi Q86XQ3.
PRIDEi Q86XQ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000282611 ; ENSP00000282611 ; ENSG00000152705 .
GeneIDi 347732.
KEGGi hsa:347732.
UCSCi uc003lag.3. human.

Organism-specific databases

CTDi 347732.
GeneCardsi GC05P134331.
HGNCi HGNC:20819. CATSPER3.
MIMi 609120. gene.
neXtProti NX_Q86XQ3.
PharmGKBi PA134911185.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG117719.
HOGENOMi HOG000112052.
HOVERGENi HBG099875.
InParanoidi Q86XQ3.
KOi K16891.
OMAi YWKDGYN.
OrthoDBi EOG7PVWQD.
PhylomeDBi Q86XQ3.
TreeFami TF343841.

Enzyme and pathway databases

Reactomei REACT_163875. Sperm Motility And Taxes.

Miscellaneous databases

GeneWikii CatSper3.
GenomeRNAii 347732.
NextBioi 99258.
PROi Q86XQ3.
SOURCEi Search...

Gene expression databases

Bgeei Q86XQ3.
CleanExi HS_CATSPER3.
Genevestigatori Q86XQ3.

Family and domain databases

InterProi IPR028739. Cat_Sper_3.
IPR005821. Ion_trans_dom.
[Graphical view ]
PANTHERi PTHR10037:SF197. PTHR10037:SF197. 1 hit.
Pfami PF00520. Ion_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Cerebellum.
  3. "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis."
    Lobley A., Pierron V., Reynolds L., Allen L., Michalovich D.
    Reprod. Biol. Endocrinol. 1:53-53(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  4. "Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility."
    Li H.-G., Ding X.-F., Liao A.-H., Kong X.-B., Xiong C.-L.
    Mol. Hum. Reprod. 13:299-306(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm."
    Strunker T., Goodwin N., Brenker C., Kashikar N.D., Weyand I., Seifert R., Kaupp U.B.
    Nature 471:382-386(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ACTIVATION BY PROGESTERONE.
  6. "Progesterone activates the principal Ca2+ channel of human sperm."
    Lishko P.V., Botchkina I.L., Kirichok Y.
    Nature 471:387-391(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ACTIVATION BY PROGESTERONE.

Entry informationi

Entry nameiCTSR3_HUMAN
AccessioniPrimary (citable) accession number: Q86XQ3
Secondary accession number(s): Q86XS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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