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Q86XQ3

- CTSR3_HUMAN

UniProt

Q86XQ3 - CTSR3_HUMAN

Protein

Cation channel sperm-associated protein 3

Gene

CATSPER3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.2 Publications

    GO - Molecular functioni

    1. calcium activated cation channel activity Source: Ensembl
    2. voltage-gated calcium channel activity Source: RefGenome

    GO - Biological processi

    1. calcium ion import Source: RefGenome
    2. cell differentiation Source: UniProtKB-KW
    3. cilium or flagellum-dependent cell motility Source: Ensembl
    4. membrane depolarization during action potential Source: RefGenome
    5. multicellular organismal development Source: UniProtKB-KW
    6. multicellular organism reproduction Source: Reactome
    7. single fertilization Source: Reactome
    8. sodium ion transport Source: Ensembl
    9. spermatogenesis Source: UniProtKB-KW
    10. sperm-egg recognition Source: Reactome
    11. sperm motility Source: RefGenome

    Keywords - Molecular functioni

    Calcium channel, Developmental protein, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Differentiation, Ion transport, Spermatogenesis, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_163875. Sperm Motility And Taxes.

    Protein family/group databases

    TCDBi1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cation channel sperm-associated protein 3
    Short name:
    CatSper3
    Alternative name(s):
    Ca(v)-like protein
    One-repeat calcium channel-like protein
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:20819. CATSPER3.

    Subcellular locationi

    Cell projectionciliumflagellum membrane; Multi-pass membrane protein
    Note: Specifically located in the principal piece of sperm tail.

    GO - Cellular componenti

    1. acrosomal vesicle Source: Ensembl
    2. CatSper complex Source: UniProtKB
    3. cilium Source: UniProtKB-KW
    4. endoplasmic reticulum Source: Ensembl
    5. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cilium, Flagellum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134911185.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Cation channel sperm-associated protein 3PRO_0000295679Add
    BLAST

    Proteomic databases

    PaxDbiQ86XQ3.
    PRIDEiQ86XQ3.

    PTM databases

    PhosphoSiteiQ86XQ3.

    Expressioni

    Tissue specificityi

    Testis-specific.3 Publications

    Gene expression databases

    BgeeiQ86XQ3.
    CleanExiHS_CATSPER3.
    GenevestigatoriQ86XQ3.

    Interactioni

    Subunit structurei

    Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 Potential. Component of the CatSper complex. Interacts with CATSPER1 By similarity.By similarityCurated

    Protein-protein interaction databases

    STRINGi9606.ENSP00000282611.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86XQ3.
    SMRiQ86XQ3. Positions 43-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5050CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini72 – 787ExtracellularSequence Analysis
    Topological domaini101 – 11515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini137 – 1415ExtracellularSequence Analysis
    Topological domaini162 – 17918CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini201 – 2099ExtracellularSequence Analysis
    Topological domaini231 – 24818ExtracellularSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei210 – 23021Helical; Pore-formingSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei51 – 7121Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei79 – 10022Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16120Helical; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei249 – 26921Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG117719.
    HOGENOMiHOG000112052.
    HOVERGENiHBG099875.
    InParanoidiQ86XQ3.
    KOiK16891.
    OMAiYWKDGYN.
    OrthoDBiEOG7PVWQD.
    PhylomeDBiQ86XQ3.
    TreeFamiTF343841.

    Family and domain databases

    InterProiIPR028739. Cat_Sper_3.
    IPR005821. Ion_trans_dom.
    [Graphical view]
    PANTHERiPTHR10037:SF197. PTHR10037:SF197. 1 hit.
    PfamiPF00520. Ion_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86XQ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQHRHQRHS RVISSSPVDT TSVGFCPTFK KFKRNDDECR AFVKRVIMSR    50
    FFKIIMISTV TSNAFFMALW TSYDIRYRLF RLLEFSEIFF VSICTSELSM 100
    KVYVDPINYW KNGYNLLDVI IIIVMFLPYA LRQLMGKQFT YLYIADGMQS 150
    LRILKLIGYS QGIRTLITAV GQTVYTVASV LLLLFLLMYI FAILGFCLFG 200
    SPDNGDHDNW GNLAAAFFTL FSLATVDGWT DLQKQLDNRE FALSRAFTII 250
    FILLASFIFL NMFVGVMIMH TEDSIRKFER ELMLEQQEML MGEKQVILQR 300
    QQEEISRLMH IQKNADCTSF SELVENFKKT LSHTDPMVLD DFGTSLPFID 350
    IYFSTLDYQD TTVHKLQELY YEIVHVLSLM LEDLPQEKPQ SLEKVDEK 398
    Length:398
    Mass (Da):46,422
    Last modified:June 1, 2003 - v1
    Checksum:iFB460F66F367DB69
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti204 – 2041N → K.
    Corresponds to variant rs3896260 [ dbSNP | Ensembl ].
    VAR_033309

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF432876 mRNA. Translation: AAO85416.1.
    AY156951 mRNA. Translation: AAO13012.1.
    BC101692 mRNA. Translation: AAI01693.1.
    BC110384 mRNA. Translation: AAI10385.1.
    BN000272 mRNA. Translation: CAE30476.1.
    CCDSiCCDS4181.1.
    RefSeqiNP_821138.1. NM_178019.2.
    UniGeneiHs.631804.

    Genome annotation databases

    EnsembliENST00000282611; ENSP00000282611; ENSG00000152705.
    GeneIDi347732.
    KEGGihsa:347732.
    UCSCiuc003lag.3. human.

    Polymorphism databases

    DMDMi74714131.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF432876 mRNA. Translation: AAO85416.1 .
    AY156951 mRNA. Translation: AAO13012.1 .
    BC101692 mRNA. Translation: AAI01693.1 .
    BC110384 mRNA. Translation: AAI10385.1 .
    BN000272 mRNA. Translation: CAE30476.1 .
    CCDSi CCDS4181.1.
    RefSeqi NP_821138.1. NM_178019.2.
    UniGenei Hs.631804.

    3D structure databases

    ProteinModelPortali Q86XQ3.
    SMRi Q86XQ3. Positions 43-315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000282611.

    Chemistry

    GuidetoPHARMACOLOGYi 390.

    Protein family/group databases

    TCDBi 1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei Q86XQ3.

    Polymorphism databases

    DMDMi 74714131.

    Proteomic databases

    PaxDbi Q86XQ3.
    PRIDEi Q86XQ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282611 ; ENSP00000282611 ; ENSG00000152705 .
    GeneIDi 347732.
    KEGGi hsa:347732.
    UCSCi uc003lag.3. human.

    Organism-specific databases

    CTDi 347732.
    GeneCardsi GC05P134331.
    HGNCi HGNC:20819. CATSPER3.
    MIMi 609120. gene.
    neXtProti NX_Q86XQ3.
    PharmGKBi PA134911185.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG117719.
    HOGENOMi HOG000112052.
    HOVERGENi HBG099875.
    InParanoidi Q86XQ3.
    KOi K16891.
    OMAi YWKDGYN.
    OrthoDBi EOG7PVWQD.
    PhylomeDBi Q86XQ3.
    TreeFami TF343841.

    Enzyme and pathway databases

    Reactomei REACT_163875. Sperm Motility And Taxes.

    Miscellaneous databases

    GeneWikii CatSper3.
    GenomeRNAii 347732.
    NextBioi 99258.
    PROi Q86XQ3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86XQ3.
    CleanExi HS_CATSPER3.
    Genevestigatori Q86XQ3.

    Family and domain databases

    InterProi IPR028739. Cat_Sper_3.
    IPR005821. Ion_trans_dom.
    [Graphical view ]
    PANTHERi PTHR10037:SF197. PTHR10037:SF197. 1 hit.
    Pfami PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Cerebellum.
    3. "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis."
      Lobley A., Pierron V., Reynolds L., Allen L., Michalovich D.
      Reprod. Biol. Endocrinol. 1:53-53(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    4. "Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility."
      Li H.-G., Ding X.-F., Liao A.-H., Kong X.-B., Xiong C.-L.
      Mol. Hum. Reprod. 13:299-306(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm."
      Strunker T., Goodwin N., Brenker C., Kashikar N.D., Weyand I., Seifert R., Kaupp U.B.
      Nature 471:382-386(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ACTIVATION BY PROGESTERONE.
    6. "Progesterone activates the principal Ca2+ channel of human sperm."
      Lishko P.V., Botchkina I.L., Kirichok Y.
      Nature 471:387-391(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ACTIVATION BY PROGESTERONE.

    Entry informationi

    Entry nameiCTSR3_HUMAN
    AccessioniPrimary (citable) accession number: Q86XQ3
    Secondary accession number(s): Q86XS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3