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Protein

Cation channel sperm-associated protein 3

Gene

CATSPER3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.2 Publications

Enzyme regulationi

The CatSper calcium channel is indirectly activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2 (PubMed:21412338, PubMed:21412339, PubMed:26989199). The CatSper calcium channel is directly inhibited by endocannabinoid 2-arachidonoylglycerol (2AG) (PubMed:26989199). Indirect activation by progesterone takes place via the following mechanism: progesterone binds and activates the acylglycerol lipase ABHD2, which in turn mediates hydrolysis of 2AG inhibitor, relieving inhibition of the CatSper channel (PubMed:26989199). The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers (PubMed:21412338, PubMed:21412339). Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH (PubMed:21412338, PubMed:21412339).3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Developmental protein, Ion channel, Voltage-gated channel
Biological processCalcium transport, Differentiation, Ion transport, Spermatogenesis, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-1300642 Sperm Motility And Taxes

Protein family/group databases

TCDBi1.A.1.19.1 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein 3
Short name:
CatSper3
Alternative name(s):
Ca(v)-like protein
One-repeat calcium channel-like protein
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000152705.7
HGNCiHGNC:20819 CATSPER3
MIMi609120 gene
neXtProtiNX_Q86XQ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 50CytoplasmicSequence analysisAdd BLAST50
Transmembranei51 – 71Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini72 – 78ExtracellularSequence analysis7
Transmembranei79 – 100Helical; Name=Segment S2Sequence analysisAdd BLAST22
Topological domaini101 – 115CytoplasmicSequence analysisAdd BLAST15
Transmembranei116 – 136Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini137 – 141ExtracellularSequence analysis5
Transmembranei142 – 161Helical; Name=Segment S4Sequence analysisAdd BLAST20
Topological domaini162 – 179CytoplasmicSequence analysisAdd BLAST18
Transmembranei180 – 200Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini201 – 209ExtracellularSequence analysis9
Intramembranei210 – 230Helical; Pore-formingSequence analysisAdd BLAST21
Topological domaini231 – 248ExtracellularSequence analysisAdd BLAST18
Transmembranei249 – 269Helical; Name=Segment S6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000152705
PharmGKBiPA134911185

Chemistry databases

GuidetoPHARMACOLOGYi390

Polymorphism and mutation databases

BioMutaiCATSPER3
DMDMi74714131

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002956791 – 398Cation channel sperm-associated protein 3Add BLAST398

Proteomic databases

PaxDbiQ86XQ3
PeptideAtlasiQ86XQ3
PRIDEiQ86XQ3

PTM databases

iPTMnetiQ86XQ3
PhosphoSitePlusiQ86XQ3

Expressioni

Tissue specificityi

Testis-specific.3 Publications

Gene expression databases

BgeeiENSG00000152705
CleanExiHS_CATSPER3
GenevisibleiQ86XQ3 HS

Interactioni

Subunit structurei

Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with CATSPER1 (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi9606.ENSP00000282611

Structurei

3D structure databases

ProteinModelPortaliQ86XQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9A Eukaryota
ENOG4111SVN LUCA
GeneTreeiENSGT00760000119325
HOGENOMiHOG000112052
HOVERGENiHBG099875
InParanoidiQ86XQ3
KOiK16891
OMAiYWKDGYN
OrthoDBiEOG091G0D3H
PhylomeDBiQ86XQ3
TreeFamiTF343841

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit

Sequencei

Sequence statusi: Complete.

Q86XQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQHRHQRHS RVISSSPVDT TSVGFCPTFK KFKRNDDECR AFVKRVIMSR
60 70 80 90 100
FFKIIMISTV TSNAFFMALW TSYDIRYRLF RLLEFSEIFF VSICTSELSM
110 120 130 140 150
KVYVDPINYW KNGYNLLDVI IIIVMFLPYA LRQLMGKQFT YLYIADGMQS
160 170 180 190 200
LRILKLIGYS QGIRTLITAV GQTVYTVASV LLLLFLLMYI FAILGFCLFG
210 220 230 240 250
SPDNGDHDNW GNLAAAFFTL FSLATVDGWT DLQKQLDNRE FALSRAFTII
260 270 280 290 300
FILLASFIFL NMFVGVMIMH TEDSIRKFER ELMLEQQEML MGEKQVILQR
310 320 330 340 350
QQEEISRLMH IQKNADCTSF SELVENFKKT LSHTDPMVLD DFGTSLPFID
360 370 380 390
IYFSTLDYQD TTVHKLQELY YEIVHVLSLM LEDLPQEKPQ SLEKVDEK
Length:398
Mass (Da):46,422
Last modified:June 1, 2003 - v1
Checksum:iFB460F66F367DB69
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033309204N → K. Corresponds to variant dbSNP:rs3896260Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF432876 mRNA Translation: AAO85416.1
AY156951 mRNA Translation: AAO13012.1
BC101692 mRNA Translation: AAI01693.1
BC110384 mRNA Translation: AAI10385.1
BN000272 mRNA Translation: CAE30476.1
CCDSiCCDS4181.1
RefSeqiNP_821138.1, NM_178019.2
UniGeneiHs.631804

Genome annotation databases

EnsembliENST00000282611; ENSP00000282611; ENSG00000152705
GeneIDi347732
KEGGihsa:347732
UCSCiuc003lag.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCTSR3_HUMAN
AccessioniPrimary (citable) accession number: Q86XQ3
Secondary accession number(s): Q86XS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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