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Protein

Gastrokine-2

Gene

GKN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrokine-2
Alternative name(s):
Blottin
Down-regulated in gastric cancer
Trefoil factor interactions(z) 1
Gene namesi
Name:GKN2
Synonyms:BLOT, GDDR, TFIZ1
ORF Names:UNQ465/PRO813
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24588. GKN2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi200504.
OpenTargetsiENSG00000183607.
PharmGKBiPA162389760.

Polymorphism and mutation databases

BioMutaiGKN2.
DMDMi74750542.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025210421 – 184Gastrokine-2Add BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi81 ↔ 143By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ86XP6.
PeptideAtlasiQ86XP6.
PRIDEiQ86XP6.
TopDownProteomicsiQ86XP6.

PTM databases

iPTMnetiQ86XP6.
PhosphoSitePlusiQ86XP6.

Expressioni

Tissue specificityi

Expressed in gastric mucosa.1 Publication

Gene expression databases

BgeeiENSG00000183607.
CleanExiHS_GKN2.
ExpressionAtlasiQ86XP6. baseline and differential.
GenevisibleiQ86XP6. HS.

Organism-specific databases

HPAiHPA057765.

Interactioni

Subunit structurei

Interacts with TFF2 (By similarity). Heterodimer with TFF1; disulfide linked.By similarity1 Publication

Protein-protein interaction databases

IntActiQ86XP6. 1 interactor.
STRINGi9606.ENSP00000329292.

Structurei

3D structure databases

ProteinModelPortaliQ86XP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 151BRICHOSPROSITE-ProRule annotationAdd BLAST98

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJBR. Eukaryota.
ENOG41118P5. LUCA.
GeneTreeiENSGT00530000063697.
HOGENOMiHOG000112729.
HOVERGENiHBG099667.
InParanoidiQ86XP6.
OMAiDWFLFGS.
OrthoDBiEOG091G0NX5.
PhylomeDBiQ86XP6.
TreeFamiTF335950.

Family and domain databases

InterProiView protein in InterPro
IPR007084. BRICHOS_dom.
PfamiView protein in Pfam
PF04089. BRICHOS. 1 hit.
SMARTiView protein in SMART
SM01039. BRICHOS. 1 hit.
PROSITEiView protein in PROSITE
PS50869. BRICHOS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86XP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILVAFLVV LTIFGIQSHG YEVFNIISPS NNGGNVQETV TIDNEKNTAI
60 70 80 90 100
INIHAGSCSS TTIFDYKHGY IASRVLSRRA CFILKMDHQN IPPLNNLQWY
110 120 130 140 150
IYEKQALDNM FSSKYTWVKY NPLESLIKDV DWFLLGSPIE KLCKHIPLYK
160 170 180
GEVVENTHNV GAGGCAKAGL LGILGISICA DIHV
Length:184
Mass (Da):20,487
Last modified:March 15, 2005 - v2
Checksum:i84B08AF978173AA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9V → M in AAQ89027 (PubMed:12975309).Curated1
Sequence conflicti51I → V in AAQ89027 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051012113S → N1 PublicationCorresponds to variant dbSNP:rs1128272Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494509 mRNA. Translation: AAO85515.2.
AJ966788 mRNA. Translation: CAI85014.1.
AY943908 mRNA. Translation: AAY24521.1.
AY358664 mRNA. Translation: AAQ89027.1.
CCDSiCCDS33215.1.
RefSeqiNP_872342.2. NM_182536.2.
UniGeneiHs.16757.

Genome annotation databases

EnsembliENST00000328895; ENSP00000329292; ENSG00000183607.
GeneIDi200504.
KEGGihsa:200504.
UCSCiuc002sfa.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGKN2_HUMAN
AccessioniPrimary (citable) accession number: Q86XP6
Secondary accession number(s): Q6UWS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 15, 2005
Last modified: March 15, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations