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Protein

Gastrokine-2

Gene

GKN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrokine-2
Alternative name(s):
Blottin
Down-regulated in gastric cancer
Trefoil factor interactions(z) 1
Gene namesi
Name:GKN2
Synonyms:BLOT, GDDR, TFIZ1
ORF Names:UNQ465/PRO813
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24588. GKN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389760.

Polymorphism and mutation databases

BioMutaiGKN2.
DMDMi74750542.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 184164Gastrokine-2PRO_0000252104Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi81 ↔ 143By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ86XP6.
PeptideAtlasiQ86XP6.
PRIDEiQ86XP6.
TopDownProteomicsiQ86XP6.

PTM databases

iPTMnetiQ86XP6.
PhosphoSiteiQ86XP6.

Expressioni

Tissue specificityi

Expressed in gastric mucosa.1 Publication

Gene expression databases

BgeeiQ86XP6.
CleanExiHS_GKN2.
ExpressionAtlasiQ86XP6. baseline and differential.
GenevisibleiQ86XP6. HS.

Organism-specific databases

HPAiHPA057765.

Interactioni

Subunit structurei

Interacts with TFF2 (By similarity). Heterodimer with TFF1; disulfide linked.By similarity1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000329292.

Structurei

3D structure databases

ProteinModelPortaliQ86XP6.
SMRiQ86XP6. Positions 48-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 15198BRICHOSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BRICHOS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJBR. Eukaryota.
ENOG41118P5. LUCA.
GeneTreeiENSGT00530000063697.
HOGENOMiHOG000112729.
HOVERGENiHBG099667.
InParanoidiQ86XP6.
OMAiRRACYIL.
OrthoDBiEOG7P2XTD.
PhylomeDBiQ86XP6.
TreeFamiTF335950.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86XP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILVAFLVV LTIFGIQSHG YEVFNIISPS NNGGNVQETV TIDNEKNTAI
60 70 80 90 100
INIHAGSCSS TTIFDYKHGY IASRVLSRRA CFILKMDHQN IPPLNNLQWY
110 120 130 140 150
IYEKQALDNM FSSKYTWVKY NPLESLIKDV DWFLLGSPIE KLCKHIPLYK
160 170 180
GEVVENTHNV GAGGCAKAGL LGILGISICA DIHV
Length:184
Mass (Da):20,487
Last modified:March 15, 2005 - v2
Checksum:i84B08AF978173AA5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91V → M in AAQ89027 (PubMed:12975309).Curated
Sequence conflicti51 – 511I → V in AAQ89027 (PubMed:12975309).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131S → N.1 Publication
Corresponds to variant rs1128272 [ dbSNP | Ensembl ].
VAR_051012

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494509 mRNA. Translation: AAO85515.2.
AJ966788 mRNA. Translation: CAI85014.1.
AY943908 mRNA. Translation: AAY24521.1.
AY358664 mRNA. Translation: AAQ89027.1.
CCDSiCCDS33215.1.
RefSeqiNP_872342.2. NM_182536.2.
UniGeneiHs.16757.

Genome annotation databases

EnsembliENST00000328895; ENSP00000329292; ENSG00000183607.
GeneIDi200504.
KEGGihsa:200504.
UCSCiuc002sfa.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494509 mRNA. Translation: AAO85515.2.
AJ966788 mRNA. Translation: CAI85014.1.
AY943908 mRNA. Translation: AAY24521.1.
AY358664 mRNA. Translation: AAQ89027.1.
CCDSiCCDS33215.1.
RefSeqiNP_872342.2. NM_182536.2.
UniGeneiHs.16757.

3D structure databases

ProteinModelPortaliQ86XP6.
SMRiQ86XP6. Positions 48-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000329292.

PTM databases

iPTMnetiQ86XP6.
PhosphoSiteiQ86XP6.

Polymorphism and mutation databases

BioMutaiGKN2.
DMDMi74750542.

Proteomic databases

PaxDbiQ86XP6.
PeptideAtlasiQ86XP6.
PRIDEiQ86XP6.
TopDownProteomicsiQ86XP6.

Protocols and materials databases

DNASUi200504.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328895; ENSP00000329292; ENSG00000183607.
GeneIDi200504.
KEGGihsa:200504.
UCSCiuc002sfa.3. human.

Organism-specific databases

CTDi200504.
GeneCardsiGKN2.
HGNCiHGNC:24588. GKN2.
HPAiHPA057765.
neXtProtiNX_Q86XP6.
PharmGKBiPA162389760.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJBR. Eukaryota.
ENOG41118P5. LUCA.
GeneTreeiENSGT00530000063697.
HOGENOMiHOG000112729.
HOVERGENiHBG099667.
InParanoidiQ86XP6.
OMAiRRACYIL.
OrthoDBiEOG7P2XTD.
PhylomeDBiQ86XP6.
TreeFamiTF335950.

Miscellaneous databases

GenomeRNAii200504.
PROiQ86XP6.

Gene expression databases

BgeeiQ86XP6.
CleanExiHS_GKN2.
ExpressionAtlasiQ86XP6. baseline and differential.
GenevisibleiQ86XP6. HS.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Down-regulated full-length novel gene GDDR and its effect on gastric cancer."
    Du J.J., Dou K.F., Zhong M., Xiao H.S., Wang W.Z., Wang Z.H., Gao Z.Q.
    Zhonghua Yi Xue Za Zhi 83:1166-1168(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Stomach.
  2. "Study on novel gene GDDR related to gastric cancer."
    Du J.J., Dou K.F., Peng S.Y., Li J.T., Liu Y.B., Wang W.Z., Guan W.X., Gao Z.Q.
    Zhonghua Wai Ke Za Zhi 43:10-13(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Stomach.
  3. "Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a Brichos domain-containing protein with homology to SP-C."
    Westley B.R., Griffin S.M., May F.E.B.
    Biochemistry 44:7967-7975(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-33, TISSUE SPECIFICITY, INTERACTION WITH TFF1.
    Tissue: Stomach.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-184, VARIANT ASN-113.

Entry informationi

Entry nameiGKN2_HUMAN
AccessioniPrimary (citable) accession number: Q86XP6
Secondary accession number(s): Q6UWS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 15, 2005
Last modified: July 6, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.