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Protein

Gastrokine-2

Gene

GKN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrokine-2
Alternative name(s):
Blottin
Down-regulated in gastric cancer
Trefoil factor interactions(z) 1
Gene namesi
Name:GKN2
Synonyms:BLOT, GDDR, TFIZ1
ORF Names:UNQ465/PRO813
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000183607.9
HGNCiHGNC:24588 GKN2
neXtProtiNX_Q86XP6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi200504
OpenTargetsiENSG00000183607
PharmGKBiPA162389760

Polymorphism and mutation databases

BioMutaiGKN2
DMDMi74750542

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025210421 – 184Gastrokine-2Add BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi81 ↔ 143By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ86XP6
PeptideAtlasiQ86XP6
PRIDEiQ86XP6
TopDownProteomicsiQ86XP6

PTM databases

iPTMnetiQ86XP6
PhosphoSitePlusiQ86XP6

Expressioni

Tissue specificityi

Expressed in gastric mucosa.1 Publication

Gene expression databases

BgeeiENSG00000183607
CleanExiHS_GKN2
ExpressionAtlasiQ86XP6 baseline and differential
GenevisibleiQ86XP6 HS

Organism-specific databases

HPAiHPA057765

Interactioni

Subunit structurei

Interacts with TFF2 (By similarity). Heterodimer with TFF1; disulfide linked.By similarity1 Publication

Protein-protein interaction databases

IntActiQ86XP6, 1 interactor
STRINGi9606.ENSP00000329292

Structurei

3D structure databases

ProteinModelPortaliQ86XP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 151BRICHOSPROSITE-ProRule annotationAdd BLAST98

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJBR Eukaryota
ENOG41118P5 LUCA
GeneTreeiENSGT00530000063697
HOGENOMiHOG000112729
HOVERGENiHBG099667
InParanoidiQ86XP6
OMAiDWFLFGS
OrthoDBiEOG091G0NX5
PhylomeDBiQ86XP6
TreeFamiTF335950

Family and domain databases

InterProiView protein in InterPro
IPR007084 BRICHOS_dom
PfamiView protein in Pfam
PF04089 BRICHOS, 1 hit
SMARTiView protein in SMART
SM01039 BRICHOS, 1 hit
PROSITEiView protein in PROSITE
PS50869 BRICHOS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86XP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILVAFLVV LTIFGIQSHG YEVFNIISPS NNGGNVQETV TIDNEKNTAI
60 70 80 90 100
INIHAGSCSS TTIFDYKHGY IASRVLSRRA CFILKMDHQN IPPLNNLQWY
110 120 130 140 150
IYEKQALDNM FSSKYTWVKY NPLESLIKDV DWFLLGSPIE KLCKHIPLYK
160 170 180
GEVVENTHNV GAGGCAKAGL LGILGISICA DIHV
Length:184
Mass (Da):20,487
Last modified:March 15, 2005 - v2
Checksum:i84B08AF978173AA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9V → M in AAQ89027 (PubMed:12975309).Curated1
Sequence conflicti51I → V in AAQ89027 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051012113S → N1 PublicationCorresponds to variant dbSNP:rs1128272Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494509 mRNA Translation: AAO85515.2
AJ966788 mRNA Translation: CAI85014.1
AY943908 mRNA Translation: AAY24521.1
AY358664 mRNA Translation: AAQ89027.1
CCDSiCCDS33215.1
RefSeqiNP_872342.2, NM_182536.2
UniGeneiHs.16757

Genome annotation databases

EnsembliENST00000328895; ENSP00000329292; ENSG00000183607
GeneIDi200504
KEGGihsa:200504
UCSCiuc002sfa.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGKN2_HUMAN
AccessioniPrimary (citable) accession number: Q86XP6
Secondary accession number(s): Q6UWS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 15, 2005
Last modified: February 28, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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