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Q86XP3

- DDX42_HUMAN

UniProt

Q86XP3 - DDX42_HUMAN

Protein

ATP-dependent RNA helicase DDX42

Gene

DDX42

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.2 Publications

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi297 – 3048ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent helicase activity Source: InterPro
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. protein localization Source: UniProtKB

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent RNA helicase DDX42 (EC:3.6.4.13)
    Alternative name(s):
    DEAD box protein 42
    RNA helicase-like protein
    Short name:
    RHELP
    RNA helicase-related protein
    Short name:
    RNAHP
    SF3b DEAD box protein
    Splicing factor 3B-associated 125 kDa protein
    Short name:
    SF3b125
    Gene namesi
    Name:DDX42
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:18676. DDX42.

    Subcellular locationi

    Cytoplasm. Nucleus speckle. NucleusCajal body
    Note: Isoform 2 is present in Cajal bodies (CBs) and nuclear speckles.

    GO - Cellular componenti

    1. Cajal body Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB
    3. membrane Source: UniProtKB
    4. nuclear speck Source: UniProtKB-SubCell
    5. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134875761.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 938938ATP-dependent RNA helicase DDX42PRO_0000280058Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei5 – 51N6-acetyllysine1 Publication
    Modified residuei104 – 1041Phosphoserine1 Publication
    Modified residuei109 – 1091Phosphoserine4 Publications
    Modified residuei111 – 1111Phosphoserine4 Publications
    Modified residuei185 – 1851Phosphoserine1 Publication
    Modified residuei754 – 7541Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ86XP3.
    PaxDbiQ86XP3.
    PRIDEiQ86XP3.

    PTM databases

    PhosphoSiteiQ86XP3.

    Expressioni

    Tissue specificityi

    Expressed in several cell lines (at protein level). Expressed in liver, lung, tonsil, thymus, muscle and pancreatic islets.2 Publications

    Gene expression databases

    ArrayExpressiQ86XP3.
    BgeeiQ86XP3.
    CleanExiHS_DDX42.
    GenevestigatoriQ86XP3.

    Organism-specific databases

    HPAiHPA023447.
    HPA023571.
    HPA025941.

    Interactioni

    Subunit structurei

    Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A/SF3B14B, and DDX42/SF3B125. Interacts (via the C-terminus) with TP53BP2; the interaction is not inhibitied by TP53BP2 ubiquitination and is independent of p53/TP53.2 Publications

    Protein-protein interaction databases

    BioGridi116454. 35 interactions.
    IntActiQ86XP3. 14 interactions.
    MINTiMINT-1427725.
    STRINGi9606.ENSP00000352308.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86XP3.
    SMRiQ86XP3. Positions 211-624.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini284 – 459176Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini487 – 632146Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni738 – 83396Necessary for interaction with TP53BP2Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili116 – 15742Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi253 – 28129Q motifAdd
    BLAST
    Motifi407 – 4104DEAD box

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi43 – 464Poly-Ser
    Compositional biasi175 – 1784Poly-Glu
    Compositional biasi654 – 6596Poly-Gly
    Compositional biasi762 – 883122Gly-richAdd
    BLAST
    Compositional biasi819 – 87153His-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0513.
    HOVERGENiHBG081425.
    InParanoidiQ86XP3.
    KOiK12835.
    OMAiQGVNNTA.
    OrthoDBiEOG7TMZR2.
    PhylomeDBiQ86XP3.
    TreeFamiTF300351.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86XP3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNWNKGGPGT KRGFGFGGFA ISAGKKEEPK LPQQSHSAFG ATSSSSGFGK    50
    SAPPQLPSFY KIGSKRANFD EENAYFEDEE EDSSNVDLPY IPAENSPTRQ 100
    QFHSKPVDSD SDDDPLEAFM AEVEDQAARD MKRLEEKDKE RKNVKGIRDD 150
    IEEEDDQEAY FRYMAENPTA GVVQEEEEDN LEYDSDGNPI APTKKIIDPL 200
    PPIDHSEIDY PPFEKNFYNE HEEITNLTPQ QLIDLRHKLN LRVSGAAPPR 250
    PGSSFAHFGF DEQLMHQIRK SEYTQPTPIQ CQGVPVALSG RDMIGIAKTG 300
    SGKTAAFIWP MLIHIMDQKE LEPGDGPIAV IVCPTRELCQ QIHAECKRFG 350
    KAYNLRSVAV YGGGSMWEQA KALQEGAEIV VCTPGRLIDH VKKKATNLQR 400
    VSYLVFDEAD RMFDMGFEYQ VRSIASHVRP DRQTLLFSAT FRKKIEKLAR 450
    DILIDPIRVV QGDIGEANED VTQIVEILHS GPSKWNWLTR RLVEFTSSGS 500
    VLLFVTKKAN AEELANNLKQ EGHNLGLLHG DMDQSERNKV ISDFKKKDIP 550
    VLVATDVAAR GLDIPSIKTV INYDVARDID THTHRIGRTG RAGEKGVAYT 600
    LLTPKDSNFA GDLVRNLEGA NQHVSKELLD LAMQNAWFRK SRFKGGKGKK 650
    LNIGGGGLGY RERPGLGSEN MDRGNNNVMS NYEAYKPSTG AMGDRLTAMK 700
    AAFQSQYKSH FVAASLSNQK AGSSAAGASG WTSAGSLNSV PTNSAQQGHN 750
    SPDSPVTSAA KGIPGFGNTG NISGAPVTYP SAGAQGVNNT ASGNNSREGT 800
    GGSNGKRERY TENRGSSRHS HGETGNRHSD SPRHGDGGRH GDGYRHPESS 850
    SRHTDGHRHG ENRHGGSAGR HGENRGANDG RNGESRKEAF NRESKMEPKM 900
    EPKVDSSKMD KVDSKTDKTA DGFAVPEPPK RKKSRWDS 938
    Length:938
    Mass (Da):102,975
    Last modified:June 1, 2003 - v1
    Checksum:iD89A252E095D8913
    GO
    Isoform 2 (identifier: Q86XP3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-119: Missing.

    Show »
    Length:819
    Mass (Da):90,068
    Checksum:iF1EED814DA44F42C
    GO

    Sequence cautioni

    The sequence AAC32396.1 differs from that shown. Reason: Frameshift at position 818.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 119119Missing in isoform 2. 4 PublicationsVSP_023518Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083255 mRNA. Translation: AAC32396.1. Frameshift.
    AB036090 mRNA. Translation: BAC66466.1.
    AK292908 mRNA. Translation: BAF85597.1.
    AC015651 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94277.1.
    BC008208 mRNA. Translation: AAH08208.1.
    BC015505 mRNA. Translation: AAH15505.1.
    BC078667 mRNA. Translation: AAH78667.1.
    BC093081 mRNA. Translation: AAH93081.1.
    AL050096 mRNA. Translation: CAB43268.1.
    BK000566 mRNA. Translation: DAA00077.1.
    CCDSiCCDS32704.1. [Q86XP3-1]
    PIRiT08745.
    RefSeqiNP_031398.2. NM_007372.3. [Q86XP3-1]
    NP_987095.1. NM_203499.2. [Q86XP3-1]
    XP_006721720.1. XM_006721657.1. [Q86XP3-1]
    UniGeneiHs.702010.

    Genome annotation databases

    EnsembliENST00000359353; ENSP00000352308; ENSG00000198231. [Q86XP3-2]
    ENST00000389924; ENSP00000374574; ENSG00000198231. [Q86XP3-1]
    ENST00000457800; ENSP00000390121; ENSG00000198231. [Q86XP3-1]
    ENST00000578681; ENSP00000464050; ENSG00000198231. [Q86XP3-1]
    ENST00000583590; ENSP00000463561; ENSG00000198231. [Q86XP3-1]
    GeneIDi11325.
    KEGGihsa:11325.
    UCSCiuc002jbu.3. human. [Q86XP3-1]

    Polymorphism databases

    DMDMi74750541.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083255 mRNA. Translation: AAC32396.1 . Frameshift.
    AB036090 mRNA. Translation: BAC66466.1 .
    AK292908 mRNA. Translation: BAF85597.1 .
    AC015651 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94277.1 .
    BC008208 mRNA. Translation: AAH08208.1 .
    BC015505 mRNA. Translation: AAH15505.1 .
    BC078667 mRNA. Translation: AAH78667.1 .
    BC093081 mRNA. Translation: AAH93081.1 .
    AL050096 mRNA. Translation: CAB43268.1 .
    BK000566 mRNA. Translation: DAA00077.1 .
    CCDSi CCDS32704.1. [Q86XP3-1 ]
    PIRi T08745.
    RefSeqi NP_031398.2. NM_007372.3. [Q86XP3-1 ]
    NP_987095.1. NM_203499.2. [Q86XP3-1 ]
    XP_006721720.1. XM_006721657.1. [Q86XP3-1 ]
    UniGenei Hs.702010.

    3D structure databases

    ProteinModelPortali Q86XP3.
    SMRi Q86XP3. Positions 211-624.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116454. 35 interactions.
    IntActi Q86XP3. 14 interactions.
    MINTi MINT-1427725.
    STRINGi 9606.ENSP00000352308.

    PTM databases

    PhosphoSitei Q86XP3.

    Polymorphism databases

    DMDMi 74750541.

    Proteomic databases

    MaxQBi Q86XP3.
    PaxDbi Q86XP3.
    PRIDEi Q86XP3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359353 ; ENSP00000352308 ; ENSG00000198231 . [Q86XP3-2 ]
    ENST00000389924 ; ENSP00000374574 ; ENSG00000198231 . [Q86XP3-1 ]
    ENST00000457800 ; ENSP00000390121 ; ENSG00000198231 . [Q86XP3-1 ]
    ENST00000578681 ; ENSP00000464050 ; ENSG00000198231 . [Q86XP3-1 ]
    ENST00000583590 ; ENSP00000463561 ; ENSG00000198231 . [Q86XP3-1 ]
    GeneIDi 11325.
    KEGGi hsa:11325.
    UCSCi uc002jbu.3. human. [Q86XP3-1 ]

    Organism-specific databases

    CTDi 11325.
    GeneCardsi GC17P061851.
    HGNCi HGNC:18676. DDX42.
    HPAi HPA023447.
    HPA023571.
    HPA025941.
    MIMi 613369. gene.
    neXtProti NX_Q86XP3.
    PharmGKBi PA134875761.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0513.
    HOVERGENi HBG081425.
    InParanoidi Q86XP3.
    KOi K12835.
    OMAi QGVNNTA.
    OrthoDBi EOG7TMZR2.
    PhylomeDBi Q86XP3.
    TreeFami TF300351.

    Miscellaneous databases

    ChiTaRSi DDX42. human.
    GeneWikii DDX42.
    GenomeRNAii 11325.
    NextBioi 43019.
    PROi Q86XP3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86XP3.
    Bgeei Q86XP3.
    CleanExi HS_DDX42.
    Genevestigatori Q86XP3.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel human member of the DEAD box protein family."
      Suk K., Kim S., Kim Y.-H., Oh S.-H., Lee M.-K., Kim K.-W., Kim H.-D., Seo Y.-S., Lee M.-S.
      Biochim. Biophys. Acta 1501:63-69(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    2. "Expression of RNA helicase-related protein in human hair follicle."
      Ikeda A., Tsuritani K.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Trachea.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Eye, Pancreas and Uterus.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 574-938 (ISOFORMS 1/2).
      Tissue: Uterus.
    8. "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein."
      Will C.L., Urlaub H., Achsel T., Gentzel M., Wilm M., Luehrmann R.
      EMBO J. 21:4978-4988(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY (ISOFORM 2), SUBCELLULAR LOCATION, IDENTIFICATION IN THE SF3B COMPLEX.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109 AND SER-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Ddx42p -- a human DEAD box protein with RNA chaperone activities."
      Uhlmann-Schiffler H., Jalal C., Stahl H.
      Nucleic Acids Res. 34:10-22(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, RNA-BINDING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104; SER-109; SER-111; SER-185 AND SER-754, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis."
      Uhlmann-Schiffler H., Kiermayer S., Stahl H.
      Oncogene 28:2065-2073(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TP53BP2, SUBCELLULAR LOCATION.
    14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109 AND SER-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND LYS-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109 AND SER-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDDX42_HUMAN
    AccessioniPrimary (citable) accession number: Q86XP3
    Secondary accession number(s): A6NML1
    , A8KA43, O75619, Q68G51, Q96BK1, Q96HR7, Q9Y3V8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3