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Q86XP3

- DDX42_HUMAN

UniProt

Q86XP3 - DDX42_HUMAN

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Protein

ATP-dependent RNA helicase DDX42

Gene
DDX42
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.2 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi297 – 3048ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. poly(A) RNA binding Source: UniProtKB
  4. protein binding Source: UniProtKB

GO - Biological processi

  1. protein localization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX42 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 42
RNA helicase-like protein
Short name:
RHELP
RNA helicase-related protein
Short name:
RNAHP
SF3b DEAD box protein
Splicing factor 3B-associated 125 kDa protein
Short name:
SF3b125
Gene namesi
Name:DDX42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:18676. DDX42.

Subcellular locationi

Cytoplasm. Nucleus speckle. NucleusCajal body
Note: Isoform 2 is present in Cajal bodies (CBs) and nuclear speckles.3 Publications

GO - Cellular componenti

  1. Cajal body Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB
  3. nuclear speck Source: UniProtKB-SubCell
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134875761.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 938938ATP-dependent RNA helicase DDX42PRO_0000280058Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei5 – 51N6-acetyllysine1 Publication
Modified residuei104 – 1041Phosphoserine1 Publication
Modified residuei109 – 1091Phosphoserine4 Publications
Modified residuei111 – 1111Phosphoserine4 Publications
Modified residuei185 – 1851Phosphoserine1 Publication
Modified residuei754 – 7541Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ86XP3.
PaxDbiQ86XP3.
PRIDEiQ86XP3.

PTM databases

PhosphoSiteiQ86XP3.

Expressioni

Tissue specificityi

Expressed in several cell lines (at protein level). Expressed in liver, lung, tonsil, thymus, muscle and pancreatic islets.2 Publications

Gene expression databases

ArrayExpressiQ86XP3.
BgeeiQ86XP3.
CleanExiHS_DDX42.
GenevestigatoriQ86XP3.

Organism-specific databases

HPAiHPA023447.
HPA023571.
HPA025941.

Interactioni

Subunit structurei

Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A/SF3B14B, and DDX42/SF3B125. Interacts (via the C-terminus) with TP53BP2; the interaction is not inhibitied by TP53BP2 ubiquitination and is independent of p53/TP53.2 Publications

Protein-protein interaction databases

BioGridi116454. 35 interactions.
IntActiQ86XP3. 15 interactions.
MINTiMINT-1427725.
STRINGi9606.ENSP00000352308.

Structurei

3D structure databases

ProteinModelPortaliQ86XP3.
SMRiQ86XP3. Positions 211-624.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini284 – 459176Helicase ATP-bindingAdd
BLAST
Domaini487 – 632146Helicase C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni738 – 83396Necessary for interaction with TP53BP2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili116 – 15742 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi253 – 28129Q motifAdd
BLAST
Motifi407 – 4104DEAD box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi43 – 464Poly-Ser
Compositional biasi175 – 1784Poly-Glu
Compositional biasi654 – 6596Poly-Gly
Compositional biasi762 – 883122Gly-richAdd
BLAST
Compositional biasi819 – 87153His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0513.
HOVERGENiHBG081425.
InParanoidiQ86XP3.
KOiK12835.
OMAiQGVNNTA.
OrthoDBiEOG7TMZR2.
PhylomeDBiQ86XP3.
TreeFamiTF300351.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86XP3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNWNKGGPGT KRGFGFGGFA ISAGKKEEPK LPQQSHSAFG ATSSSSGFGK    50
SAPPQLPSFY KIGSKRANFD EENAYFEDEE EDSSNVDLPY IPAENSPTRQ 100
QFHSKPVDSD SDDDPLEAFM AEVEDQAARD MKRLEEKDKE RKNVKGIRDD 150
IEEEDDQEAY FRYMAENPTA GVVQEEEEDN LEYDSDGNPI APTKKIIDPL 200
PPIDHSEIDY PPFEKNFYNE HEEITNLTPQ QLIDLRHKLN LRVSGAAPPR 250
PGSSFAHFGF DEQLMHQIRK SEYTQPTPIQ CQGVPVALSG RDMIGIAKTG 300
SGKTAAFIWP MLIHIMDQKE LEPGDGPIAV IVCPTRELCQ QIHAECKRFG 350
KAYNLRSVAV YGGGSMWEQA KALQEGAEIV VCTPGRLIDH VKKKATNLQR 400
VSYLVFDEAD RMFDMGFEYQ VRSIASHVRP DRQTLLFSAT FRKKIEKLAR 450
DILIDPIRVV QGDIGEANED VTQIVEILHS GPSKWNWLTR RLVEFTSSGS 500
VLLFVTKKAN AEELANNLKQ EGHNLGLLHG DMDQSERNKV ISDFKKKDIP 550
VLVATDVAAR GLDIPSIKTV INYDVARDID THTHRIGRTG RAGEKGVAYT 600
LLTPKDSNFA GDLVRNLEGA NQHVSKELLD LAMQNAWFRK SRFKGGKGKK 650
LNIGGGGLGY RERPGLGSEN MDRGNNNVMS NYEAYKPSTG AMGDRLTAMK 700
AAFQSQYKSH FVAASLSNQK AGSSAAGASG WTSAGSLNSV PTNSAQQGHN 750
SPDSPVTSAA KGIPGFGNTG NISGAPVTYP SAGAQGVNNT ASGNNSREGT 800
GGSNGKRERY TENRGSSRHS HGETGNRHSD SPRHGDGGRH GDGYRHPESS 850
SRHTDGHRHG ENRHGGSAGR HGENRGANDG RNGESRKEAF NRESKMEPKM 900
EPKVDSSKMD KVDSKTDKTA DGFAVPEPPK RKKSRWDS 938
Length:938
Mass (Da):102,975
Last modified:June 1, 2003 - v1
Checksum:iD89A252E095D8913
GO
Isoform 2 (identifier: Q86XP3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Show »
Length:819
Mass (Da):90,068
Checksum:iF1EED814DA44F42C
GO

Sequence cautioni

The sequence AAC32396.1 differs from that shown. Reason: Frameshift at position 818.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 119119Missing in isoform 2. VSP_023518Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083255 mRNA. Translation: AAC32396.1. Frameshift.
AB036090 mRNA. Translation: BAC66466.1.
AK292908 mRNA. Translation: BAF85597.1.
AC015651 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94277.1.
BC008208 mRNA. Translation: AAH08208.1.
BC015505 mRNA. Translation: AAH15505.1.
BC078667 mRNA. Translation: AAH78667.1.
BC093081 mRNA. Translation: AAH93081.1.
AL050096 mRNA. Translation: CAB43268.1.
BK000566 mRNA. Translation: DAA00077.1.
CCDSiCCDS32704.1. [Q86XP3-1]
PIRiT08745.
RefSeqiNP_031398.2. NM_007372.3. [Q86XP3-1]
NP_987095.1. NM_203499.2. [Q86XP3-1]
XP_006721720.1. XM_006721657.1. [Q86XP3-1]
UniGeneiHs.702010.

Genome annotation databases

EnsembliENST00000359353; ENSP00000352308; ENSG00000198231. [Q86XP3-2]
ENST00000389924; ENSP00000374574; ENSG00000198231. [Q86XP3-1]
ENST00000457800; ENSP00000390121; ENSG00000198231. [Q86XP3-1]
ENST00000578681; ENSP00000464050; ENSG00000198231. [Q86XP3-1]
ENST00000583590; ENSP00000463561; ENSG00000198231. [Q86XP3-1]
GeneIDi11325.
KEGGihsa:11325.
UCSCiuc002jbu.3. human. [Q86XP3-1]

Polymorphism databases

DMDMi74750541.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083255 mRNA. Translation: AAC32396.1 . Frameshift.
AB036090 mRNA. Translation: BAC66466.1 .
AK292908 mRNA. Translation: BAF85597.1 .
AC015651 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94277.1 .
BC008208 mRNA. Translation: AAH08208.1 .
BC015505 mRNA. Translation: AAH15505.1 .
BC078667 mRNA. Translation: AAH78667.1 .
BC093081 mRNA. Translation: AAH93081.1 .
AL050096 mRNA. Translation: CAB43268.1 .
BK000566 mRNA. Translation: DAA00077.1 .
CCDSi CCDS32704.1. [Q86XP3-1 ]
PIRi T08745.
RefSeqi NP_031398.2. NM_007372.3. [Q86XP3-1 ]
NP_987095.1. NM_203499.2. [Q86XP3-1 ]
XP_006721720.1. XM_006721657.1. [Q86XP3-1 ]
UniGenei Hs.702010.

3D structure databases

ProteinModelPortali Q86XP3.
SMRi Q86XP3. Positions 211-624.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116454. 35 interactions.
IntActi Q86XP3. 15 interactions.
MINTi MINT-1427725.
STRINGi 9606.ENSP00000352308.

PTM databases

PhosphoSitei Q86XP3.

Polymorphism databases

DMDMi 74750541.

Proteomic databases

MaxQBi Q86XP3.
PaxDbi Q86XP3.
PRIDEi Q86XP3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359353 ; ENSP00000352308 ; ENSG00000198231 . [Q86XP3-2 ]
ENST00000389924 ; ENSP00000374574 ; ENSG00000198231 . [Q86XP3-1 ]
ENST00000457800 ; ENSP00000390121 ; ENSG00000198231 . [Q86XP3-1 ]
ENST00000578681 ; ENSP00000464050 ; ENSG00000198231 . [Q86XP3-1 ]
ENST00000583590 ; ENSP00000463561 ; ENSG00000198231 . [Q86XP3-1 ]
GeneIDi 11325.
KEGGi hsa:11325.
UCSCi uc002jbu.3. human. [Q86XP3-1 ]

Organism-specific databases

CTDi 11325.
GeneCardsi GC17P061851.
HGNCi HGNC:18676. DDX42.
HPAi HPA023447.
HPA023571.
HPA025941.
MIMi 613369. gene.
neXtProti NX_Q86XP3.
PharmGKBi PA134875761.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0513.
HOVERGENi HBG081425.
InParanoidi Q86XP3.
KOi K12835.
OMAi QGVNNTA.
OrthoDBi EOG7TMZR2.
PhylomeDBi Q86XP3.
TreeFami TF300351.

Miscellaneous databases

ChiTaRSi DDX42. human.
GeneWikii DDX42.
GenomeRNAii 11325.
NextBioi 43019.
PROi Q86XP3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q86XP3.
Bgeei Q86XP3.
CleanExi HS_DDX42.
Genevestigatori Q86XP3.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel human member of the DEAD box protein family."
    Suk K., Kim S., Kim Y.-H., Oh S.-H., Lee M.-K., Kim K.-W., Kim H.-D., Seo Y.-S., Lee M.-S.
    Biochim. Biophys. Acta 1501:63-69(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "Expression of RNA helicase-related protein in human hair follicle."
    Ikeda A., Tsuritani K.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Trachea.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye, Pancreas and Uterus.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 574-938 (ISOFORMS 1/2).
    Tissue: Uterus.
  8. "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein."
    Will C.L., Urlaub H., Achsel T., Gentzel M., Wilm M., Luehrmann R.
    EMBO J. 21:4978-4988(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY (ISOFORM 2), SUBCELLULAR LOCATION, IDENTIFICATION IN THE SF3B COMPLEX.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109 AND SER-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Ddx42p -- a human DEAD box protein with RNA chaperone activities."
    Uhlmann-Schiffler H., Jalal C., Stahl H.
    Nucleic Acids Res. 34:10-22(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, RNA-BINDING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104; SER-109; SER-111; SER-185 AND SER-754, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis."
    Uhlmann-Schiffler H., Kiermayer S., Stahl H.
    Oncogene 28:2065-2073(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TP53BP2, SUBCELLULAR LOCATION.
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109 AND SER-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND LYS-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109 AND SER-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDDX42_HUMAN
AccessioniPrimary (citable) accession number: Q86XP3
Secondary accession number(s): A6NML1
, A8KA43, O75619, Q68G51, Q96BK1, Q96HR7, Q9Y3V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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