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Q86XP1

- DGKH_HUMAN

UniProt

Q86XP1 - DGKH_HUMAN

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Protein

Diacylglycerol kinase eta

Gene
DGKH
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.2 Publications

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 22551Phorbol-ester/DAG-type 1Add
BLAST
Zinc fingeri247 – 29852Phorbol-ester/DAG-type 2Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. intracellular signal transduction Source: InterPro
  3. platelet activation Source: Reactome
  4. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  5. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_2202. Effects of PIP2 hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase eta (EC:2.7.1.107)
Short name:
DAG kinase eta
Alternative name(s):
Diglyceride kinase eta
Short name:
DGK-eta
Gene namesi
Name:DGKH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:2854. DGKH.

Subcellular locationi

Cytoplasm. Cell membrane
Note: Translocated from the cytoplasm to endosomes in response to stress stimuli. Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association. Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS.2 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
  3. nuclear membrane Source: HPA
  4. nucleus Source: HPA
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1151 – 11511W → G: Abolishes homo and heterooligomerization but not its catalytic activity. 1 Publication

Organism-specific databases

PharmGKBiPA27315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12201220Diacylglycerol kinase etaPRO_0000239367Add
BLAST

Post-translational modificationi

Phosphorylated; does not inhibit catalytic activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86XP1.
PaxDbiQ86XP1.
PRIDEiQ86XP1.

PTM databases

PhosphoSiteiQ86XP1.

Expressioni

Tissue specificityi

Isoform 2 is ubiquitously expressed. Isoform 1 is expressed only in testis, kidney and colon.1 Publication

Gene expression databases

ArrayExpressiQ86XP1.
BgeeiQ86XP1.
CleanExiHS_DGKH.
GenevestigatoriQ86XP1.

Organism-specific databases

HPAiHPA039533.
HPA040355.

Interactioni

Subunit structurei

Isoform 1 forms homooligomers through the SAM domain. Isoform 1 is also able to form heterooligomers with SAM domain-containing isoforms of DGKD. Oligomerization of isoform 1 inhibits its catalytic activity. Interacts with RAF1 and BRAF.2 Publications

Protein-protein interaction databases

BioGridi127768. 5 interactions.
IntActiQ86XP1. 2 interactions.
STRINGi9606.ENSP00000337572.

Structurei

3D structure databases

ProteinModelPortaliQ86XP1.
SMRiQ86XP1. Positions 68-154, 228-292, 1147-1214.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 15894PHAdd
BLAST
Domaini328 – 463136DAGKcAdd
BLAST
Domaini1151 – 121464SAMAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1218 – 12203PDZ-binding

Sequence similaritiesi

Contains 1 DAGKc domain.
Contains 1 PH domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 22551Phorbol-ester/DAG-type 1Add
BLAST
Zinc fingeri247 – 29852Phorbol-ester/DAG-type 2Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG328046.
HOVERGENiHBG051346.
InParanoidiQ86XP1.
KOiK00901.
OMAiYEVAQFN.
OrthoDBiEOG7DVD9B.
PhylomeDBiQ86XP1.
TreeFamiTF313104.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86XP1-1) [UniParc]FASTAAdd to Basket

Also known as: DAG kinase eta-2, DGKH-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAGAGGQHHP PGAAGGAAAG AGAAVTSAAA SAGPGEDSSD SEAEQEGPQK     50
LIRKVSTSGQ IRTKTSIKEG QLLKQTSSFQ RWKKRYFKLR GRTLYYAKDS 100
KSLIFDEVDL SDASVAEAST KNANNSFTII TPFRRLMLCA ENRKEMEDWI 150
SSLKSVQTRE PYEVAQFNVE HFSGMHNWYA CSHARPTFCN VCRESLSGVT 200
SHGLSCEVCK FKAHKRCAVR ATNNCKWTTL ASIGKDIIED EDGVAMPHQW 250
LEGNLPVSAK CAVCDKTCGS VLRLQDWKCL WCKTMVHTAC KDLYHPICPL 300
GQCKVSIIPP IALNSTDSDG FCRATFSFCV SPLLVFVNSK SGDNQGVKFL 350
RRFKQLLNPA QVFDLMNGGP HLGLRLFQKF DNFRILVCGG DGSVGWVLSE 400
IDKLNLNKQC QLGVLPLGTG NDLARVLGWG GSYDDDTQLP QILEKLERAS 450
TKMLDRWSIM TYELKLPPKA SLLPGPPEAS EEFYMTIYED SVATHLTKIL 500
NSDEHAVVIS SAKTLCETVK DFVAKVEKTY DKTLENAVVA DAVASKCSVL 550
NEKLEQLLQA LHTDSQAAPV LPGLSPLIVE EDAVESSSEE SLGESKEQLG 600
DDVTKPSSQK AVKPREIMLR ANSLKKAVRQ VIEEAGKVMD DPTVHPCEPA 650
NQSSDYDSTE TDESKEEAKD DGAKESITVK TAPRSPDARA SYGHSQTDSV 700
PGPAVAASKE NLPVLNTRII CPGLRAGLAA SIAGSSIINK MLLANIDPFG 750
ATPFIDPDLD SVDGYSEKCV MNNYFGIGLD AKISLEFNNK REEHPEKCRS 800
RTKNLMWYGV LGTRELLQRS YKNLEQRVQL ECDGQYIPLP SLQGIAVLNI 850
PSYAGGTNFW GGTKEDDIFA APSFDDKILE VVAIFDSMQM AVSRVIKLQH 900
HRIAQCRTVK ITIFGDEGVP VQVDGEAWVQ PPGIIKIVHK NRAQMLTRDR 950
AFESTLKSWE DKQKCDSGKP VLRTHLYIHH AIDLATEEVS QMQLCSQAAE 1000
ELITRICDAA TIHCLLEQEL AHAVNACSHA LNKANPRCPE SLTRDTATEI 1050
AINVKALYNE TESLLVGRVP LQLESPHEER VSNALHSVEV ELQKLTEIPW 1100
LYYILHPNED EEPPMDCTKR NNRSTVFRIV PKFKKEKVQK QKTSSQPVQK 1150
WGTEEVAAWL DLLNLGEYKD IFIRHDIRGA ELLHLERRDL KDLGIPKVGH 1200
VKRILQGIKE LGRSTPQSEV 1220
Length:1,220
Mass (Da):134,866
Last modified:June 1, 2003 - v1
Checksum:iF1BBF5B7FA582C97
GO
Isoform 2 (identifier: Q86XP1-2) [UniParc]FASTAAdd to Basket

Also known as: DAG kinase eta-1, DGKH-1

The sequence of this isoform differs from the canonical sequence as follows:
     1148-1220: VQKWGTEEVA...LGRSTPQSEV → GSGDTESGSCEANSPGN

Show »
Length:1,164
Mass (Da):128,035
Checksum:iDF39B04BECC0B629
GO
Isoform 3 (identifier: Q86XP1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.
     1191-1191: K → KNTVGEKRDTKENGKHM

Note: No experimental confirmation available.

Show »
Length:1,100
Mass (Da):122,392
Checksum:i0D36C1FA1E7C1A43
GO
Isoform 4 (identifier: Q86XP1-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.

Show »
Length:1,084
Mass (Da):120,566
Checksum:i8994FBC10F6DB99D
GO

Sequence cautioni

The sequence BAC05280.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1201 – 12011V → A.
Corresponds to variant rs17646069 [ dbSNP | Ensembl ].
VAR_033867

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 136136Missing in isoform 3 and isoform 4. VSP_019183Add
BLAST
Alternative sequencei1148 – 122073VQKWG…PQSEV → GSGDTESGSCEANSPGN in isoform 2. VSP_019185Add
BLAST
Alternative sequencei1191 – 11911K → KNTVGEKRDTKENGKHM in isoform 3. VSP_019186

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti677 – 6771I → M in BAC05280. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB078967 mRNA. Translation: BAC66960.1.
AB078968 mRNA. Translation: BAC66961.1.
AK302727 mRNA. Translation: BAG63946.1.
AL136527, AL139328, AL157932 Genomic DNA. Translation: CAH71399.2.
AL136527, AL139328, AL157932 Genomic DNA. Translation: CAM14245.1.
AL139328, AL136527, AL157932 Genomic DNA. Translation: CAI16894.2.
AL139328, AL136527, AL157932 Genomic DNA. Translation: CAM23676.1.
AL157932, AL136527, AL139328 Genomic DNA. Translation: CAH71062.2.
AL157932, AL136527, AL139328 Genomic DNA. Translation: CAM13770.1.
BC043292 mRNA. Translation: AAH43292.1.
AL833883 mRNA. Translation: CAD38739.1.
AK098302 mRNA. Translation: BAC05280.1. Different initiation.
CCDSiCCDS55898.1. [Q86XP1-3]
CCDS55899.1. [Q86XP1-5]
CCDS9381.1. [Q86XP1-1]
CCDS9382.1. [Q86XP1-2]
RefSeqiNP_001191433.1. NM_001204504.1. [Q86XP1-2]
NP_001191434.1. NM_001204505.1. [Q86XP1-3]
NP_001191435.1. NM_001204506.1. [Q86XP1-5]
NP_690874.2. NM_152910.4. [Q86XP1-2]
NP_821077.1. NM_178009.3. [Q86XP1-1]
UniGeneiHs.733239.

Genome annotation databases

EnsembliENST00000261491; ENSP00000261491; ENSG00000102780. [Q86XP1-2]
ENST00000337343; ENSP00000337572; ENSG00000102780. [Q86XP1-1]
ENST00000379274; ENSP00000368576; ENSG00000102780. [Q86XP1-3]
ENST00000536612; ENSP00000445114; ENSG00000102780. [Q86XP1-5]
ENST00000540693; ENSP00000440823; ENSG00000102780. [Q86XP1-2]
GeneIDi160851.
KEGGihsa:160851.
UCSCiuc001uyl.2. human. [Q86XP1-1]
uc001uym.2. human. [Q86XP1-2]
uc001uyo.2. human. [Q86XP1-3]

Polymorphism databases

DMDMi74762463.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB078967 mRNA. Translation: BAC66960.1 .
AB078968 mRNA. Translation: BAC66961.1 .
AK302727 mRNA. Translation: BAG63946.1 .
AL136527 , AL139328 , AL157932 Genomic DNA. Translation: CAH71399.2 .
AL136527 , AL139328 , AL157932 Genomic DNA. Translation: CAM14245.1 .
AL139328 , AL136527 , AL157932 Genomic DNA. Translation: CAI16894.2 .
AL139328 , AL136527 , AL157932 Genomic DNA. Translation: CAM23676.1 .
AL157932 , AL136527 , AL139328 Genomic DNA. Translation: CAH71062.2 .
AL157932 , AL136527 , AL139328 Genomic DNA. Translation: CAM13770.1 .
BC043292 mRNA. Translation: AAH43292.1 .
AL833883 mRNA. Translation: CAD38739.1 .
AK098302 mRNA. Translation: BAC05280.1 . Different initiation.
CCDSi CCDS55898.1. [Q86XP1-3 ]
CCDS55899.1. [Q86XP1-5 ]
CCDS9381.1. [Q86XP1-1 ]
CCDS9382.1. [Q86XP1-2 ]
RefSeqi NP_001191433.1. NM_001204504.1. [Q86XP1-2 ]
NP_001191434.1. NM_001204505.1. [Q86XP1-3 ]
NP_001191435.1. NM_001204506.1. [Q86XP1-5 ]
NP_690874.2. NM_152910.4. [Q86XP1-2 ]
NP_821077.1. NM_178009.3. [Q86XP1-1 ]
UniGenei Hs.733239.

3D structure databases

ProteinModelPortali Q86XP1.
SMRi Q86XP1. Positions 68-154, 228-292, 1147-1214.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127768. 5 interactions.
IntActi Q86XP1. 2 interactions.
STRINGi 9606.ENSP00000337572.

PTM databases

PhosphoSitei Q86XP1.

Polymorphism databases

DMDMi 74762463.

Proteomic databases

MaxQBi Q86XP1.
PaxDbi Q86XP1.
PRIDEi Q86XP1.

Protocols and materials databases

DNASUi 160851.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261491 ; ENSP00000261491 ; ENSG00000102780 . [Q86XP1-2 ]
ENST00000337343 ; ENSP00000337572 ; ENSG00000102780 . [Q86XP1-1 ]
ENST00000379274 ; ENSP00000368576 ; ENSG00000102780 . [Q86XP1-3 ]
ENST00000536612 ; ENSP00000445114 ; ENSG00000102780 . [Q86XP1-5 ]
ENST00000540693 ; ENSP00000440823 ; ENSG00000102780 . [Q86XP1-2 ]
GeneIDi 160851.
KEGGi hsa:160851.
UCSCi uc001uyl.2. human. [Q86XP1-1 ]
uc001uym.2. human. [Q86XP1-2 ]
uc001uyo.2. human. [Q86XP1-3 ]

Organism-specific databases

CTDi 160851.
GeneCardsi GC13P042622.
HGNCi HGNC:2854. DGKH.
HPAi HPA039533.
HPA040355.
MIMi 604071. gene.
neXtProti NX_Q86XP1.
PharmGKBi PA27315.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG328046.
HOVERGENi HBG051346.
InParanoidi Q86XP1.
KOi K00901.
OMAi YEVAQFN.
OrthoDBi EOG7DVD9B.
PhylomeDBi Q86XP1.
TreeFami TF313104.

Enzyme and pathway databases

Reactomei REACT_2202. Effects of PIP2 hydrolysis.

Miscellaneous databases

ChiTaRSi DGKH. human.
GenomeRNAii 160851.
NextBioi 88001.
PROi Q86XP1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q86XP1.
Bgeei Q86XP1.
CleanExi HS_DGKH.
Genevestigatori Q86XP1.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of two splice variants of human diacylglycerol kinase eta."
    Murakami T., Sakane F., Imai S., Houkin K., Kanoh H.
    J. Biol. Chem. 278:34364-34372(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, CATALYTIC ACTIVITY, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION, MUTAGENESIS OF TRP-1151.
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 640-1220 (ISOFORM 2).
    Tissue: Testis and Uterus.
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-1220 (ISOFORM 1).
    Tissue: Amygdala.
  6. "Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization."
    Yasuda S., Kai M., Imai S., Takeishi K., Taketomi A., Toyota M., Kanoh H., Sakane F.
    J. Biol. Chem. 284:29559-29570(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RAF1 AND BRAF.

Entry informationi

Entry nameiDGKH_HUMAN
AccessioniPrimary (citable) accession number: Q86XP1
Secondary accession number(s): A2A2W7
, A6NFX7, B4DZ34, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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