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Q86XP1

- DGKH_HUMAN

UniProt

Q86XP1 - DGKH_HUMAN

Protein

Diacylglycerol kinase eta

Gene

DGKH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.2 Publications

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri175 – 22551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri247 – 29852Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. diacylglycerol kinase activity Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. intracellular signal transduction Source: InterPro
    3. platelet activation Source: Reactome
    4. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    5. protein oligomerization Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_2202. Effects of PIP2 hydrolysis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase eta (EC:2.7.1.107)
    Short name:
    DAG kinase eta
    Alternative name(s):
    Diglyceride kinase eta
    Short name:
    DGK-eta
    Gene namesi
    Name:DGKH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:2854. DGKH.

    Subcellular locationi

    Cytoplasm. Cell membrane
    Note: Translocated from the cytoplasm to endosomes in response to stress stimuli. Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association. Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endosome Source: UniProtKB
    3. nuclear membrane Source: HPA
    4. nucleus Source: HPA
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1151 – 11511W → G: Abolishes homo and heterooligomerization but not its catalytic activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA27315.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12201220Diacylglycerol kinase etaPRO_0000239367Add
    BLAST

    Post-translational modificationi

    Phosphorylated; does not inhibit catalytic activity.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ86XP1.
    PaxDbiQ86XP1.
    PRIDEiQ86XP1.

    PTM databases

    PhosphoSiteiQ86XP1.

    Expressioni

    Tissue specificityi

    Isoform 2 is ubiquitously expressed. Isoform 1 is expressed only in testis, kidney and colon.1 Publication

    Gene expression databases

    ArrayExpressiQ86XP1.
    BgeeiQ86XP1.
    CleanExiHS_DGKH.
    GenevestigatoriQ86XP1.

    Organism-specific databases

    HPAiHPA039533.
    HPA040355.

    Interactioni

    Subunit structurei

    Isoform 1 forms homooligomers through the SAM domain. Isoform 1 is also able to form heterooligomers with SAM domain-containing isoforms of DGKD. Oligomerization of isoform 1 inhibits its catalytic activity. Interacts with RAF1 and BRAF.2 Publications

    Protein-protein interaction databases

    BioGridi127768. 5 interactions.
    IntActiQ86XP1. 2 interactions.
    STRINGi9606.ENSP00000337572.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86XP1.
    SMRiQ86XP1. Positions 68-154, 228-292, 1147-1214.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 15894PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini328 – 463136DAGKcPROSITE-ProRule annotationAdd
    BLAST
    Domaini1151 – 121464SAMPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1218 – 12203PDZ-binding

    Sequence similaritiesi

    Contains 1 DAGKc domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri175 – 22551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri247 – 29852Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG328046.
    HOVERGENiHBG051346.
    InParanoidiQ86XP1.
    KOiK00901.
    OMAiYEVAQFN.
    OrthoDBiEOG7DVD9B.
    PhylomeDBiQ86XP1.
    TreeFamiTF313104.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    [Graphical view]
    PfamiPF00130. C1_1. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF00169. PH. 1 hit.
    PF07647. SAM_2. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 2 hits.
    SSF47769. SSF47769. 1 hit.
    PROSITEiPS50146. DAGK. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86XP1-1) [UniParc]FASTAAdd to Basket

    Also known as: DAG kinase eta-2, DGKH-2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGAGGQHHP PGAAGGAAAG AGAAVTSAAA SAGPGEDSSD SEAEQEGPQK     50
    LIRKVSTSGQ IRTKTSIKEG QLLKQTSSFQ RWKKRYFKLR GRTLYYAKDS 100
    KSLIFDEVDL SDASVAEAST KNANNSFTII TPFRRLMLCA ENRKEMEDWI 150
    SSLKSVQTRE PYEVAQFNVE HFSGMHNWYA CSHARPTFCN VCRESLSGVT 200
    SHGLSCEVCK FKAHKRCAVR ATNNCKWTTL ASIGKDIIED EDGVAMPHQW 250
    LEGNLPVSAK CAVCDKTCGS VLRLQDWKCL WCKTMVHTAC KDLYHPICPL 300
    GQCKVSIIPP IALNSTDSDG FCRATFSFCV SPLLVFVNSK SGDNQGVKFL 350
    RRFKQLLNPA QVFDLMNGGP HLGLRLFQKF DNFRILVCGG DGSVGWVLSE 400
    IDKLNLNKQC QLGVLPLGTG NDLARVLGWG GSYDDDTQLP QILEKLERAS 450
    TKMLDRWSIM TYELKLPPKA SLLPGPPEAS EEFYMTIYED SVATHLTKIL 500
    NSDEHAVVIS SAKTLCETVK DFVAKVEKTY DKTLENAVVA DAVASKCSVL 550
    NEKLEQLLQA LHTDSQAAPV LPGLSPLIVE EDAVESSSEE SLGESKEQLG 600
    DDVTKPSSQK AVKPREIMLR ANSLKKAVRQ VIEEAGKVMD DPTVHPCEPA 650
    NQSSDYDSTE TDESKEEAKD DGAKESITVK TAPRSPDARA SYGHSQTDSV 700
    PGPAVAASKE NLPVLNTRII CPGLRAGLAA SIAGSSIINK MLLANIDPFG 750
    ATPFIDPDLD SVDGYSEKCV MNNYFGIGLD AKISLEFNNK REEHPEKCRS 800
    RTKNLMWYGV LGTRELLQRS YKNLEQRVQL ECDGQYIPLP SLQGIAVLNI 850
    PSYAGGTNFW GGTKEDDIFA APSFDDKILE VVAIFDSMQM AVSRVIKLQH 900
    HRIAQCRTVK ITIFGDEGVP VQVDGEAWVQ PPGIIKIVHK NRAQMLTRDR 950
    AFESTLKSWE DKQKCDSGKP VLRTHLYIHH AIDLATEEVS QMQLCSQAAE 1000
    ELITRICDAA TIHCLLEQEL AHAVNACSHA LNKANPRCPE SLTRDTATEI 1050
    AINVKALYNE TESLLVGRVP LQLESPHEER VSNALHSVEV ELQKLTEIPW 1100
    LYYILHPNED EEPPMDCTKR NNRSTVFRIV PKFKKEKVQK QKTSSQPVQK 1150
    WGTEEVAAWL DLLNLGEYKD IFIRHDIRGA ELLHLERRDL KDLGIPKVGH 1200
    VKRILQGIKE LGRSTPQSEV 1220
    Length:1,220
    Mass (Da):134,866
    Last modified:June 1, 2003 - v1
    Checksum:iF1BBF5B7FA582C97
    GO
    Isoform 2 (identifier: Q86XP1-2) [UniParc]FASTAAdd to Basket

    Also known as: DAG kinase eta-1, DGKH-1

    The sequence of this isoform differs from the canonical sequence as follows:
         1148-1220: VQKWGTEEVA...LGRSTPQSEV → GSGDTESGSCEANSPGN

    Show »
    Length:1,164
    Mass (Da):128,035
    Checksum:iDF39B04BECC0B629
    GO
    Isoform 3 (identifier: Q86XP1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-136: Missing.
         1191-1191: K → KNTVGEKRDTKENGKHM

    Note: No experimental confirmation available.

    Show »
    Length:1,100
    Mass (Da):122,392
    Checksum:i0D36C1FA1E7C1A43
    GO
    Isoform 4 (identifier: Q86XP1-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-136: Missing.

    Show »
    Length:1,084
    Mass (Da):120,566
    Checksum:i8994FBC10F6DB99D
    GO

    Sequence cautioni

    The sequence BAC05280.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti677 – 6771I → M in BAC05280. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1201 – 12011V → A.
    Corresponds to variant rs17646069 [ dbSNP | Ensembl ].
    VAR_033867

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 136136Missing in isoform 3 and isoform 4. 2 PublicationsVSP_019183Add
    BLAST
    Alternative sequencei1148 – 122073VQKWG…PQSEV → GSGDTESGSCEANSPGN in isoform 2. 2 PublicationsVSP_019185Add
    BLAST
    Alternative sequencei1191 – 11911K → KNTVGEKRDTKENGKHM in isoform 3. 1 PublicationVSP_019186

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB078967 mRNA. Translation: BAC66960.1.
    AB078968 mRNA. Translation: BAC66961.1.
    AK302727 mRNA. Translation: BAG63946.1.
    AL136527, AL139328, AL157932 Genomic DNA. Translation: CAH71399.2.
    AL136527, AL139328, AL157932 Genomic DNA. Translation: CAM14245.1.
    AL139328, AL136527, AL157932 Genomic DNA. Translation: CAI16894.2.
    AL139328, AL136527, AL157932 Genomic DNA. Translation: CAM23676.1.
    AL157932, AL136527, AL139328 Genomic DNA. Translation: CAH71062.2.
    AL157932, AL136527, AL139328 Genomic DNA. Translation: CAM13770.1.
    BC043292 mRNA. Translation: AAH43292.1.
    AL833883 mRNA. Translation: CAD38739.1.
    AK098302 mRNA. Translation: BAC05280.1. Different initiation.
    CCDSiCCDS55898.1. [Q86XP1-3]
    CCDS55899.1. [Q86XP1-5]
    CCDS9381.1. [Q86XP1-1]
    CCDS9382.1. [Q86XP1-2]
    RefSeqiNP_001191433.1. NM_001204504.1. [Q86XP1-2]
    NP_001191434.1. NM_001204505.1. [Q86XP1-3]
    NP_001191435.1. NM_001204506.1. [Q86XP1-5]
    NP_690874.2. NM_152910.4. [Q86XP1-2]
    NP_821077.1. NM_178009.3. [Q86XP1-1]
    UniGeneiHs.733239.

    Genome annotation databases

    EnsembliENST00000261491; ENSP00000261491; ENSG00000102780. [Q86XP1-2]
    ENST00000337343; ENSP00000337572; ENSG00000102780. [Q86XP1-1]
    ENST00000379274; ENSP00000368576; ENSG00000102780. [Q86XP1-3]
    ENST00000536612; ENSP00000445114; ENSG00000102780. [Q86XP1-5]
    GeneIDi160851.
    KEGGihsa:160851.
    UCSCiuc001uyl.2. human. [Q86XP1-1]
    uc001uym.2. human. [Q86XP1-2]
    uc001uyo.2. human. [Q86XP1-3]

    Polymorphism databases

    DMDMi74762463.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB078967 mRNA. Translation: BAC66960.1 .
    AB078968 mRNA. Translation: BAC66961.1 .
    AK302727 mRNA. Translation: BAG63946.1 .
    AL136527 , AL139328 , AL157932 Genomic DNA. Translation: CAH71399.2 .
    AL136527 , AL139328 , AL157932 Genomic DNA. Translation: CAM14245.1 .
    AL139328 , AL136527 , AL157932 Genomic DNA. Translation: CAI16894.2 .
    AL139328 , AL136527 , AL157932 Genomic DNA. Translation: CAM23676.1 .
    AL157932 , AL136527 , AL139328 Genomic DNA. Translation: CAH71062.2 .
    AL157932 , AL136527 , AL139328 Genomic DNA. Translation: CAM13770.1 .
    BC043292 mRNA. Translation: AAH43292.1 .
    AL833883 mRNA. Translation: CAD38739.1 .
    AK098302 mRNA. Translation: BAC05280.1 . Different initiation.
    CCDSi CCDS55898.1. [Q86XP1-3 ]
    CCDS55899.1. [Q86XP1-5 ]
    CCDS9381.1. [Q86XP1-1 ]
    CCDS9382.1. [Q86XP1-2 ]
    RefSeqi NP_001191433.1. NM_001204504.1. [Q86XP1-2 ]
    NP_001191434.1. NM_001204505.1. [Q86XP1-3 ]
    NP_001191435.1. NM_001204506.1. [Q86XP1-5 ]
    NP_690874.2. NM_152910.4. [Q86XP1-2 ]
    NP_821077.1. NM_178009.3. [Q86XP1-1 ]
    UniGenei Hs.733239.

    3D structure databases

    ProteinModelPortali Q86XP1.
    SMRi Q86XP1. Positions 68-154, 228-292, 1147-1214.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127768. 5 interactions.
    IntActi Q86XP1. 2 interactions.
    STRINGi 9606.ENSP00000337572.

    PTM databases

    PhosphoSitei Q86XP1.

    Polymorphism databases

    DMDMi 74762463.

    Proteomic databases

    MaxQBi Q86XP1.
    PaxDbi Q86XP1.
    PRIDEi Q86XP1.

    Protocols and materials databases

    DNASUi 160851.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261491 ; ENSP00000261491 ; ENSG00000102780 . [Q86XP1-2 ]
    ENST00000337343 ; ENSP00000337572 ; ENSG00000102780 . [Q86XP1-1 ]
    ENST00000379274 ; ENSP00000368576 ; ENSG00000102780 . [Q86XP1-3 ]
    ENST00000536612 ; ENSP00000445114 ; ENSG00000102780 . [Q86XP1-5 ]
    GeneIDi 160851.
    KEGGi hsa:160851.
    UCSCi uc001uyl.2. human. [Q86XP1-1 ]
    uc001uym.2. human. [Q86XP1-2 ]
    uc001uyo.2. human. [Q86XP1-3 ]

    Organism-specific databases

    CTDi 160851.
    GeneCardsi GC13P042622.
    HGNCi HGNC:2854. DGKH.
    HPAi HPA039533.
    HPA040355.
    MIMi 604071. gene.
    neXtProti NX_Q86XP1.
    PharmGKBi PA27315.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG328046.
    HOVERGENi HBG051346.
    InParanoidi Q86XP1.
    KOi K00901.
    OMAi YEVAQFN.
    OrthoDBi EOG7DVD9B.
    PhylomeDBi Q86XP1.
    TreeFami TF313104.

    Enzyme and pathway databases

    Reactomei REACT_2202. Effects of PIP2 hydrolysis.

    Miscellaneous databases

    ChiTaRSi DGKH. human.
    GenomeRNAii 160851.
    NextBioi 88001.
    PROi Q86XP1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86XP1.
    Bgeei Q86XP1.
    CleanExi HS_DGKH.
    Genevestigatori Q86XP1.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    [Graphical view ]
    Pfami PF00130. C1_1. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF00169. PH. 1 hit.
    PF07647. SAM_2. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 2 hits.
    SSF47769. SSF47769. 1 hit.
    PROSITEi PS50146. DAGK. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of two splice variants of human diacylglycerol kinase eta."
      Murakami T., Sakane F., Imai S., Houkin K., Kanoh H.
      J. Biol. Chem. 278:34364-34372(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, CATALYTIC ACTIVITY, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION, MUTAGENESIS OF TRP-1151.
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 640-1220 (ISOFORM 2).
      Tissue: Testis and Uterus.
    3. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-1220 (ISOFORM 1).
      Tissue: Amygdala.
    6. "Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization."
      Yasuda S., Kai M., Imai S., Takeishi K., Taketomi A., Toyota M., Kanoh H., Sakane F.
      J. Biol. Chem. 284:29559-29570(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RAF1 AND BRAF.

    Entry informationi

    Entry nameiDGKH_HUMAN
    AccessioniPrimary (citable) accession number: Q86XP1
    Secondary accession number(s): A2A2W7
    , A6NFX7, B4DZ34, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3