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Q86XP0

- PA24D_HUMAN

UniProt

Q86XP0 - PA24D_HUMAN

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Protein

Cytosolic phospholipase A2 delta

Gene
PLA2G4D
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.1 Publication

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Enzyme regulationi

Stimulated by cytosolic Ca2+.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei361 – 3611Nucleophile By similarity
Active sitei647 – 6471Proton acceptor By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phospholipase A2 activity Source: UniProtKB-EC

GO - Biological processi

  1. glycerophospholipid biosynthetic process Source: Reactome
  2. phosphatidic acid biosynthetic process Source: Reactome
  3. phosphatidylcholine acyl-chain remodeling Source: Reactome
  4. phosphatidylethanolamine acyl-chain remodeling Source: Reactome
  5. phosphatidylglycerol acyl-chain remodeling Source: Reactome
  6. phosphatidylinositol acyl-chain remodeling Source: Reactome
  7. phosphatidylserine acyl-chain remodeling Source: Reactome
  8. phospholipid catabolic process Source: InterPro
  9. phospholipid metabolic process Source: Reactome
  10. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_120722. Acyl chain remodelling of PI.
REACT_120829. Acyl chain remodelling of PC.
REACT_120906. Synthesis of PA.
REACT_120977. Hydrolysis of LPC.
REACT_121324. Acyl chain remodelling of PG.
REACT_121369. Acyl chain remodelling of PE.
REACT_121384. Acyl chain remodelling of PS.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic phospholipase A2 delta (EC:3.1.1.4)
Short name:
cPLA2-delta
Alternative name(s):
Phospholipase A2 group IVD
Gene namesi
Name:PLA2G4D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:30038. PLA2G4D.

Subcellular locationi

Cytoplasmcytosol. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: Translocates to membrane vesicles in a calcium-dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation By similarity.

GO - Cellular componenti

  1. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  2. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134974074.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 818818Cytosolic phospholipase A2 deltaPRO_0000247023Add
BLAST

Proteomic databases

MaxQBiQ86XP0.
PaxDbiQ86XP0.
PRIDEiQ86XP0.

PTM databases

PhosphoSiteiQ86XP0.

Expressioni

Tissue specificityi

Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin.1 Publication

Gene expression databases

BgeeiQ86XP0.
CleanExiHS_PLA2G4D.
GenevestigatoriQ86XP0.

Organism-specific databases

HPAiHPA039489.

Interactioni

Protein-protein interaction databases

BioGridi129664. 1 interaction.
STRINGi9606.ENSP00000290472.

Structurei

3D structure databases

ProteinModelPortaliQ86XP0.
SMRiQ86XP0. Positions 23-166, 234-807.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 120112C2Add
BLAST
Domaini273 – 818546PLA2cAdd
BLAST

Domaini

The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+ By similarity.

Sequence similaritiesi

Contains 1 C2 domain.
Contains 1 PLA2c domain.

Phylogenomic databases

eggNOGiNOG300348.
HOGENOMiHOG000231788.
HOVERGENiHBG080412.
InParanoidiQ86XP0.
KOiK16342.
OMAiTYKEEDF.
OrthoDBiEOG70CR62.
PhylomeDBiQ86XP0.
TreeFamiTF325228.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR000008. C2_dom.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS51210. PLA2C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86XP0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MESLSPGGPP GHPYQGEAST CWQLTVRVLE ARNLRWADLL SEADPYVILQ    50
LSTAPGMKFK TKTLTDTSHP VWNEAFRFLI QSQVKNVLEL SIYDEDSVTE 100
DDICFKVLYD ISEVLPGKLL RKTFSQSPQG EEELDVEFLM EETSDRPENL 150
ITNKVIVARE LSCLDVHLDS TGSTAVVADQ DKLELELVLK GSYEDTQTSF 200
LGTASAFRFH YMAALETELS GRLRSSRSNG WNGDNSAGYL TVPLRPLTIG 250
KEVTMDVPAP NAPGVRLQLK AEGCPEELAV HLGFNLCAEE QAFLSRRKQV 300
VAKALKQALQ LDRDLQEDEV PVVGIMATGG GARAMTSLYG HLLALQKLGL 350
LDCVTYFSGI SGSTWTMAHL YGDPEWSQRD LEGPIRYARE HLAKSKLEVF 400
SPERLASYRR ELELRAEQGH PTTFVDLWAL VLESMLHGQV MDQKLSGQRA 450
ALERGQNPLP LYLSLNVKEN NLETLDFKEW VEFSPYEVGF LKYGAFVPPE 500
LFGSEFFMGR LMRRIPEPRI CFLEAIWSNI FSLNLLDAWY DLTSSGESWK 550
QHIKDKTRSL EKEPLTTSGT SSRLEASWLQ PGTALAQAFK GFLTGRPLHQ 600
RSPNFLQGLQ LHQDYCSHKD FSTWADYQLD SMPSQLTPKE PRLCLVDAAY 650
FINTSSPSMF RPGRRLDLIL SFDYSLSAPF EALQQTELYC RARGLPFPRV 700
EPSPQDQHQP RECHLFSDPA CPEAPILLHF PLVNASFKDH SAPGVQRSPA 750
ELQGGQVDLT GATCPYTLSN MTYKEEDFER LLRLSDYNVQ TSQGAILQAL 800
RTALKHRTLE ARPPRAQT 818
Length:818
Mass (Da):91,952
Last modified:November 24, 2009 - v2
Checksum:i06187324748A4C21
GO
Isoform 2 (identifier: Q86XP0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     682-723: ALQQTELYCR...HLFSDPACPE → VPWSPQGNPS...VPKGRRGVRP
     724-818: Missing.

Note: May be due to an intron retention.

Show »
Length:723
Mass (Da):80,930
Checksum:i0C385309D4BAB085
GO

Sequence cautioni

The sequence AAH34571.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti275 – 2751P → R.
Corresponds to variant rs11635685 [ dbSNP | Ensembl ].
VAR_057676
Natural varianti434 – 4341S → T.
Corresponds to variant rs4924618 [ dbSNP | Ensembl ].
VAR_057677
Natural varianti573 – 5731R → W.
Corresponds to variant rs17747505 [ dbSNP | Ensembl ].
VAR_027049
Natural varianti649 – 6491A → G.
Corresponds to variant rs17690899 [ dbSNP | Ensembl ].
VAR_027050
Natural varianti747 – 7471R → G.1 Publication
Corresponds to variant rs2459692 [ dbSNP | Ensembl ].
VAR_027051
Natural varianti783 – 7831R → Q.
Corresponds to variant rs750052 [ dbSNP | Ensembl ].
VAR_057678
Natural varianti807 – 8071R → Q.
Corresponds to variant rs750051 [ dbSNP | Ensembl ].
VAR_057679

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei682 – 72342ALQQT…PACPE → VPWSPQGNPSAQPGQAPEAS SRATEPLPHTAGVPKGRRGV RP in isoform 2. VSP_019881Add
BLAST
Alternative sequencei724 – 81895Missing in isoform 2. VSP_019882Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101P → T in BAC67158. 1 Publication
Isoform 2 (identifier: Q86XP0-2)
Sequence conflicti713 – 7131G → R in AAH34571. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB090876 mRNA. Translation: BAC67158.1.
AC084693 Genomic DNA. No translation available.
BC034571 mRNA. Translation: AAH34571.1. Different initiation.
CCDSiCCDS32203.1. [Q86XP0-1]
RefSeqiNP_828848.3. NM_178034.3. [Q86XP0-1]
UniGeneiHs.380225.

Genome annotation databases

EnsembliENST00000290472; ENSP00000290472; ENSG00000159337. [Q86XP0-1]
GeneIDi283748.
KEGGihsa:283748.
UCSCiuc001zox.3. human. [Q86XP0-1]

Polymorphism databases

DMDMi269849641.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB090876 mRNA. Translation: BAC67158.1 .
AC084693 Genomic DNA. No translation available.
BC034571 mRNA. Translation: AAH34571.1 . Different initiation.
CCDSi CCDS32203.1. [Q86XP0-1 ]
RefSeqi NP_828848.3. NM_178034.3. [Q86XP0-1 ]
UniGenei Hs.380225.

3D structure databases

ProteinModelPortali Q86XP0.
SMRi Q86XP0. Positions 23-166, 234-807.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129664. 1 interaction.
STRINGi 9606.ENSP00000290472.

PTM databases

PhosphoSitei Q86XP0.

Polymorphism databases

DMDMi 269849641.

Proteomic databases

MaxQBi Q86XP0.
PaxDbi Q86XP0.
PRIDEi Q86XP0.

Protocols and materials databases

DNASUi 283748.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000290472 ; ENSP00000290472 ; ENSG00000159337 . [Q86XP0-1 ]
GeneIDi 283748.
KEGGi hsa:283748.
UCSCi uc001zox.3. human. [Q86XP0-1 ]

Organism-specific databases

CTDi 283748.
GeneCardsi GC15M042359.
H-InvDB HIX0026772.
HGNCi HGNC:30038. PLA2G4D.
HPAi HPA039489.
MIMi 612864. gene.
neXtProti NX_Q86XP0.
PharmGKBi PA134974074.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300348.
HOGENOMi HOG000231788.
HOVERGENi HBG080412.
InParanoidi Q86XP0.
KOi K16342.
OMAi TYKEEDF.
OrthoDBi EOG70CR62.
PhylomeDBi Q86XP0.
TreeFami TF325228.

Enzyme and pathway databases

Reactomei REACT_120722. Acyl chain remodelling of PI.
REACT_120829. Acyl chain remodelling of PC.
REACT_120906. Synthesis of PA.
REACT_120977. Hydrolysis of LPC.
REACT_121324. Acyl chain remodelling of PG.
REACT_121369. Acyl chain remodelling of PE.
REACT_121384. Acyl chain remodelling of PS.

Miscellaneous databases

GenomeRNAii 283748.
NextBioi 94215.
PROi Q86XP0.
SOURCEi Search...

Gene expression databases

Bgeei Q86XP0.
CleanExi HS_PLA2G4D.
Genevestigatori Q86XP0.

Family and domain databases

Gene3Di 2.60.40.150. 1 hit.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR000008. C2_dom.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF00168. C2. 1 hit.
PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50004. C2. 1 hit.
PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin."
    Chiba H., Michibata H., Wakimoto K., Seishima M., Kawasaki S., Okubo K., Mitsui H., Torii H., Imai Y.
    J. Biol. Chem. 279:12890-12897(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, TISSUE SPECIFICITY.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 491-818 (ISOFORM 2).
    Tissue: Brain.
  4. "A family based study of the genetic association between the PLA2G4D gene and schizophrenia."
    Tao R., Yu Y., Zhang X., Shi J., Guo Y., Wang C., Han B., Xu Q., Shang H., Zhang X., Xie L., Liu S., Ju G., Shen Y., Wei J.
    Prostaglandins Leukot. Essent. Fatty Acids 73:419-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLY-747.

Entry informationi

Entry nameiPA24D_HUMAN
AccessioniPrimary (citable) accession number: Q86XP0
Secondary accession number(s): Q8N176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 24, 2009
Last modified: September 3, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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