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Q86XN8 (MEX3D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-binding protein MEX3D
Alternative name(s):
RING finger and KH domain-containing protein 1
RING finger protein 193
TINO
Gene names
Name:MEX3D
Synonyms:KIAA2031, RKHD1, RNF193
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length651 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

RNA binding protein, may be involved in post-transcriptional regulatory mechanisms By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway By similarity.

Tissue specificity

Ubiquitously expressed in all the cell lines and tissues tested. Ref.1

Domain

Binds RNA through its KH domains By similarity.

Post-translational modification

Phosphorylated By similarity.

Sequence similarities

Contains 2 KH domains.

Contains 1 RING-type zinc finger.

Sequence caution

The sequence AAQ04763.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86XN8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86XN8-2)

Also known as: TINO;

The sequence of this isoform differs from the canonical sequence as follows:
     648-651: HIFS → RVETPQPGGASALQRQY
Isoform 3 (identifier: Q86XN8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     648-651: HIFS → RVETETPQPGGASALQRQY
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 651651RNA-binding protein MEX3D
PRO_0000050123

Regions

Domain179 – 24062KH 1
Domain273 – 33462KH 2
Zinc finger600 – 64041RING-type

Natural variations

Alternative sequence648 – 6514HIFS → RVETPQPGGASALQRQY in isoform 2.
VSP_024019
Alternative sequence648 – 6514HIFS → RVETETPQPGGASALQRQY in isoform 3.
VSP_047662

Secondary structure

................. 651
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 20, 2007. Version 3.
Checksum: 5E056EE2D08BC4CD

FASTA65164,883
        10         20         30         40         50         60 
MPSSLGQPDG GGGGGGGGGG VGAAGEDPGP GPAPPPEGAQ EAAPAPRPPP EPDDAAAALR 

        70         80         90        100        110        120 
LALDQLSALG LGGAGDTDEE GAAGDGAAAA GGADGGAAPE PVPPDGPEAG APPTLAPAVA 

       130        140        150        160        170        180 
PGSLPLLDPN ASPPPPPPPR PSPPDVFAGF APHPAALGPP TLLADQMSVI GSRKKSVNMT 

       190        200        210        220        230        240 
ECVPVPSSEH VAEIVGRQGC KIKALRAKTN TYIKTPVRGE EPVFIVTGRK EDVEMAKREI 

       250        260        270        280        290        300 
LSAAEHFSII RATRSKAGGL PGAAQGPPNL PGQTTIQVRV PYRVVGLVVG PKGATIKRIQ 

       310        320        330        340        350        360 
QRTHTYIVTP GRDKEPVFAV TGMPENVDRA REEIEAHITL RTGAFTDAGP DSDFHANGTD 

       370        380        390        400        410        420 
VCLDLLGAAA SLWAKTPNQG RRPPTATAGL RGDTALGAPS APEAFYAGSR GGPSVPDPGP 

       430        440        450        460        470        480 
ASPYSGSGNG GFAFGAEGPG APVGTAAPDD CDFGFDFDFL ALDLTVPAAA TIWAPFERAA 

       490        500        510        520        530        540 
PLPAFSGCST VNGAPGPPAA GARRSSGAGT PRHSPTLPEP GGLRLELPLS RRGAPDPVGA 

       550        560        570        580        590        600 
LSWRPPQGPV SFPGGAAFST ATSLPSSPAA AACAPLDSGA SENSRKPPSA SSAPALAREC 

       610        620        630        640        650 
VVCAEGEVMA ALVPCGHNLF CMDCAVRICG KSEPECPACR TPATQAIHIF S 

« Hide

Isoform 2 (TINO) [UniParc].

Checksum: CA8D41D3EEFD3A48
Show »

FASTA66466,238
Isoform 3 [UniParc].

Checksum: 498479459CECBD6C
Show »

FASTA66666,469

References

« Hide 'large scale' references
[1]"Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies."
Buchet-Poyau K., Courchet J., Le Hir H., Seraphin B., Scoazec J.-Y., Duret L., Domon-Dell C., Freund J.-N., Billaud M.
Nucleic Acids Res. 35:1289-1300(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The nucleotide sequence of a long cDNA clone isolated from human."
Nagase T., Kikuno R., Ohara O.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-651 (ISOFORM 1).
Tissue: Brain.
[4]"Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein."
Donnini M., Lapucci A., Papucci L., Witort E., Jacquier A., Brewer G., Nicolin A., Capaccioli S., Schiavone N.
J. Biol. Chem. 279:20154-20166(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 177-651 (ISOFORM 2).
Tissue: Placenta.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 178-651 (ISOFORM 2).
[6]"Solution structure of the second KH domain in RING finger and KH domain-containing protein 1."
RIKEN structural genomics initiative (RSGI)
Submitted (SEP-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 272-343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY950680 mRNA. Translation: AAY34148.1.
AC005943 Genomic DNA. No translation available.
AC027307 Genomic DNA. No translation available.
AB107353 mRNA. Translation: BAC67658.1.
AF458084 mRNA. Translation: AAQ04763.1. Different initiation.
BC113384 mRNA. Translation: AAI13385.1.
BC113741 mRNA. Translation: AAI13742.2.
CCDSCCDS32865.2. [Q86XN8-1]
RefSeqNP_001167589.1. NM_001174118.1. [Q86XN8-3]
NP_976049.3. NM_203304.3. [Q86XN8-1]
UniGeneHs.436495.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DGRNMR-A272-341[»]
ProteinModelPortalQ86XN8.
SMRQ86XN8. Positions 273-343, 598-644.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid134376. 6 interactions.
STRING9606.ENSP00000384398.

PTM databases

PhosphoSiteQ86XN8.

Polymorphism databases

DMDM134047829.

Proteomic databases

MaxQBQ86XN8.
PaxDbQ86XN8.
PRIDEQ86XN8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000388824; ENSP00000373476; ENSG00000181588. [Q86XN8-3]
ENST00000402693; ENSP00000384398; ENSG00000181588. [Q86XN8-1]
GeneID399664.
KEGGhsa:399664.

Organism-specific databases

CTD399664.
GeneCardsGC19M001554.
HGNCHGNC:16734. MEX3D.
MIM611009. gene.
neXtProtNX_Q86XN8.
PharmGKBPA162395829.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG260228.
HOGENOMHOG000236282.
HOVERGENHBG071698.
KOK15686.
OMASLWAKTP.
OrthoDBEOG7D85WG.
PhylomeDBQ86XN8.
TreeFamTF315107.

Gene expression databases

ArrayExpressQ86XN8.
BgeeQ86XN8.
CleanExHS_MEX3D.
GenevestigatorQ86XN8.

Family and domain databases

Gene3D3.30.1370.10. 2 hits.
3.30.40.10. 1 hit.
InterProIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF00013. KH_1. 2 hits.
[Graphical view]
SMARTSM00322. KH. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMSSF54791. SSF54791. 2 hits.
PROSITEPS50084. KH_TYPE_1. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ86XN8.
GeneWikiMEX3D.
GenomeRNAi399664.
NextBio105463.
PROQ86XN8.
SOURCESearch...

Entry information

Entry nameMEX3D_HUMAN
AccessionPrimary (citable) accession number: Q86XN8
Secondary accession number(s): A0PJL8 expand/collapse secondary AC list , A1L023, E9PAL6, Q71M49
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 20, 2007
Last modified: July 9, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM