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Protein

Proline and serine-rich protein 1

Gene

PROSER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Proline and serine-rich protein 1
Gene namesi
Name:PROSER1
Synonyms:C13orf23, KIAA2032
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20291. PROSER1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134912550.

Polymorphism and mutation databases

DMDMi125950653.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 944944Proline and serine-rich protein 1PRO_0000274309Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ86XN7.
MaxQBiQ86XN7.
PaxDbiQ86XN7.
PRIDEiQ86XN7.

PTM databases

iPTMnetiQ86XN7.
PhosphoSiteiQ86XN7.

Expressioni

Gene expression databases

BgeeiQ86XN7.
CleanExiHS_C13orf23.
ExpressionAtlasiQ86XN7. baseline and differential.
GenevisibleiQ86XN7. HS.

Organism-specific databases

HPAiCAB034225.
HPA055687.

Interactioni

Protein-protein interaction databases

BioGridi123178. 3 interactions.
STRINGi9606.ENSP00000332034.

Structurei

3D structure databases

ProteinModelPortaliQ86XN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi185 – 386202Pro-richAdd
BLAST
Compositional biasi388 – 798411Ser-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IE75. Eukaryota.
ENOG410ZVUA. LUCA.
GeneTreeiENSGT00730000111188.
HOGENOMiHOG000113186.
HOVERGENiHBG081845.
InParanoidiQ86XN7.
OMAiPVKAINH.
OrthoDBiEOG7060Q8.
PhylomeDBiQ86XN7.
TreeFamiTF331494.

Family and domain databases

InterProiIPR028011. DUF4476.
[Graphical view]
PfamiPF14771. DUF4476. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86XN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKKSFEMVL DEIRKAVLTE YKLKAIEYVH GYFSSEQVVD LLRYFSWAEP
60 70 80 90 100
QLKAMKALQH KMVAVQPTEV VNILNCFTFS KDKLVALELL ASNIIDAQNS
110 120 130 140 150
RPIEDLFRVN MSEKKRCKRI LEQAFKGGCK APHAMISSCG TIPGNPYPKG
160 170 180 190 200
RPSRINGIFP GTPLKKDGEE CTNEGKGIAA RILGPSKPPP STYNPHKPVP
210 220 230 240 250
YPIPPCRPHA TIAPSAYNNA GLVPLANVIA PPPPPYTPNP VGTENEDLSN
260 270 280 290 300
PSKPIQNQTF STPASQLFSP HGSNPSTPAA TPVPTASPVK AINHPSASAA
310 320 330 340 350
ATVSGMNLLN TVLPVFPGQV SSAVHTPQPS IPNPTVIRTP SLPTAPVTSI
360 370 380 390 400
HSTTTTPVPS IFSGLVSLPG PSATPTAATP TPGPTPRSTL GSSEAFASTS
410 420 430 440 450
APFTSLPFST SSSAASTSNP NSASLSSVFA GLPLPLPPTS QGLSNPTPVI
460 470 480 490 500
AGGSTPSVAG PLGVNSPLLS ALKGFLTSND TNLINSSALS SAVTSGLASL
510 520 530 540 550
SSLTLQNSDS SASAPNKCYA PSAIPTPQRT STPGLALFPG LPSPVANSTS
560 570 580 590 600
TPLTLPVQSP LATAASASTS VPVSCGSSAS LLRGPHPGTS DLHISSTPAA
610 620 630 640 650
TTLPVMIKTE PTSPTPSAFK GPSHSGNPSH GTLGLSGTLG RAYTSTSVPI
660 670 680 690 700
SLSACLNPAL SGLSSLSTPL NGSNPLSSIS LPPHGSSTPI APVFTALPSF
710 720 730 740 750
TSLTNNFPLT GNPSLNPSVS LPGSLIATSS TAATSTSLPH PSSTAAVLSG
760 770 780 790 800
LSASAPVSAA PFPLNLSTAV PSLFSVTQGP LSSSNPSYPG FSVSNTPSVT
810 820 830 840 850
PALPSFPGLQ APSTVAAVTP LPVAATAPSP APVLPGFASA FSSNFNSALV
860 870 880 890 900
AQAGLSSGLQ AAGSSVFPGL LSLPGIPGFP QNPSQSSLQE LQHNAAAQSA
910 920 930 940
LLQQVHSASA LESYPAQPDG FPSYPSAPGT PFSLQPSLSQ SGWQ
Length:944
Mass (Da):95,698
Last modified:February 6, 2007 - v2
Checksum:iDC236EA48D320C2F
GO
Isoform 2 (identifier: Q86XN7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-37: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:922
Mass (Da):93,140
Checksum:i76F1A6A6618C8B53
GO

Sequence cautioni

The sequence BAB14204.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC67659.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti541 – 5411L → P in BAB14204 (PubMed:14702039).Curated
Sequence conflicti666 – 6661L → S in BAB14204 (PubMed:14702039).Curated
Sequence conflicti786 – 7861P → L in BAB14204 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti571 – 5711V → A.2 Publications
Corresponds to variant rs3751379 [ dbSNP | Ensembl ].
VAR_030253
Natural varianti847 – 8471S → T.
Corresponds to variant rs17058955 [ dbSNP | Ensembl ].
VAR_030254

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei16 – 3722Missing in isoform 2. CuratedVSP_055641Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB107354 mRNA. Translation: BAC67659.1. Different initiation.
AL833854 mRNA. Translation: CAD38713.1.
AL834435 mRNA. Translation: CAD39095.1.
BX647471 mRNA. Translation: CAH56138.1.
AL445590 Genomic DNA. Translation: CAI40975.1.
CH471075 Genomic DNA. Translation: EAX08610.1.
BC053566 mRNA. Translation: AAH53566.1.
BC064348 mRNA. Translation: AAH64348.1.
AK022723 mRNA. Translation: BAB14204.1. Different initiation.
CCDSiCCDS9368.2. [Q86XN7-1]
RefSeqiNP_079414.3. NM_025138.4. [Q86XN7-1]
XP_005266602.1. XM_005266545.2. [Q86XN7-2]
UniGeneiHs.318526.

Genome annotation databases

EnsembliENST00000352251; ENSP00000332034; ENSG00000120685. [Q86XN7-1]
ENST00000625998; ENSP00000486159; ENSG00000120685. [Q86XN7-2]
GeneIDi80209.
KEGGihsa:80209.
UCSCiuc001uwy.5. human. [Q86XN7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB107354 mRNA. Translation: BAC67659.1. Different initiation.
AL833854 mRNA. Translation: CAD38713.1.
AL834435 mRNA. Translation: CAD39095.1.
BX647471 mRNA. Translation: CAH56138.1.
AL445590 Genomic DNA. Translation: CAI40975.1.
CH471075 Genomic DNA. Translation: EAX08610.1.
BC053566 mRNA. Translation: AAH53566.1.
BC064348 mRNA. Translation: AAH64348.1.
AK022723 mRNA. Translation: BAB14204.1. Different initiation.
CCDSiCCDS9368.2. [Q86XN7-1]
RefSeqiNP_079414.3. NM_025138.4. [Q86XN7-1]
XP_005266602.1. XM_005266545.2. [Q86XN7-2]
UniGeneiHs.318526.

3D structure databases

ProteinModelPortaliQ86XN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123178. 3 interactions.
STRINGi9606.ENSP00000332034.

PTM databases

iPTMnetiQ86XN7.
PhosphoSiteiQ86XN7.

Polymorphism and mutation databases

DMDMi125950653.

Proteomic databases

EPDiQ86XN7.
MaxQBiQ86XN7.
PaxDbiQ86XN7.
PRIDEiQ86XN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352251; ENSP00000332034; ENSG00000120685. [Q86XN7-1]
ENST00000625998; ENSP00000486159; ENSG00000120685. [Q86XN7-2]
GeneIDi80209.
KEGGihsa:80209.
UCSCiuc001uwy.5. human. [Q86XN7-1]

Organism-specific databases

CTDi80209.
GeneCardsiPROSER1.
H-InvDBHIX0011252.
HGNCiHGNC:20291. PROSER1.
HPAiCAB034225.
HPA055687.
neXtProtiNX_Q86XN7.
PharmGKBiPA134912550.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE75. Eukaryota.
ENOG410ZVUA. LUCA.
GeneTreeiENSGT00730000111188.
HOGENOMiHOG000113186.
HOVERGENiHBG081845.
InParanoidiQ86XN7.
OMAiPVKAINH.
OrthoDBiEOG7060Q8.
PhylomeDBiQ86XN7.
TreeFamiTF331494.

Miscellaneous databases

ChiTaRSiPROSER1. human.
GenomeRNAii80209.
NextBioi70594.
PROiQ86XN7.

Gene expression databases

BgeeiQ86XN7.
CleanExiHS_C13orf23.
ExpressionAtlasiQ86XN7. baseline and differential.
GenevisibleiQ86XN7. HS.

Family and domain databases

InterProiIPR028011. DUF4476.
[Graphical view]
PfamiPF14771. DUF4476. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The nucleotide sequence of a long cDNA clone isolated from human."
    Nagase T., Kikuno R., Ohara O.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala, Colon endothelium and Melanoma.
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-571.
    Tissue: Brain and PNS.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-944 (ISOFORMS 1/2), VARIANT ALA-571.
    Tissue: Teratocarcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPRSR1_HUMAN
AccessioniPrimary (citable) accession number: Q86XN7
Secondary accession number(s): A6NJ97
, Q6P2S2, Q7Z3X5, Q8N3D2, Q8N3P1, Q9H9M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: April 13, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.