Q86XN7 (PRSR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proline and serine-rich protein 1

Gene names

Name:	PROSER1
Synonyms:	C13orf23, KIAA2032

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	944 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence caution

The sequence BAB14204.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC67659.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 944	944	Proline and serine-rich protein 1		PRO_0000274309
Regions
	Compositional bias	185 – 386	202	Pro-rich
	Compositional bias	388 – 798	411	Ser-rich
Natural variations
	Natural variant	571	1	V → A. Ref.4 Ref.5 Corresponds to variant rs3751379 [ dbSNP | Ensembl ].		VAR_030253
	Natural variant	847	1	S → T. Corresponds to variant rs17058955 [ dbSNP | Ensembl ].		VAR_030254
Experimental info
	Sequence conflict	541	1	L → P in BAB14204. Ref.5
	Sequence conflict	666	1	L → S in BAB14204. Ref.5
	Sequence conflict	786	1	P → L in BAB14204. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q86XN7 [UniParc]. Last modified February 6, 2007. Version 2. Checksum: DC236EA48D320C2F	FASTA	944	95,698
	10 20 30 40 50 60 MDKKSFEMVL DEIRKAVLTE YKLKAIEYVH GYFSSEQVVD LLRYFSWAEP QLKAMKALQH 70 80 90 100 110 120 KMVAVQPTEV VNILNCFTFS KDKLVALELL ASNIIDAQNS RPIEDLFRVN MSEKKRCKRI 130 140 150 160 170 180 LEQAFKGGCK APHAMISSCG TIPGNPYPKG RPSRINGIFP GTPLKKDGEE CTNEGKGIAA 190 200 210 220 230 240 RILGPSKPPP STYNPHKPVP YPIPPCRPHA TIAPSAYNNA GLVPLANVIA PPPPPYTPNP 250 260 270 280 290 300 VGTENEDLSN PSKPIQNQTF STPASQLFSP HGSNPSTPAA TPVPTASPVK AINHPSASAA 310 320 330 340 350 360 ATVSGMNLLN TVLPVFPGQV SSAVHTPQPS IPNPTVIRTP SLPTAPVTSI HSTTTTPVPS 370 380 390 400 410 420 IFSGLVSLPG PSATPTAATP TPGPTPRSTL GSSEAFASTS APFTSLPFST SSSAASTSNP 430 440 450 460 470 480 NSASLSSVFA GLPLPLPPTS QGLSNPTPVI AGGSTPSVAG PLGVNSPLLS ALKGFLTSND 490 500 510 520 530 540 TNLINSSALS SAVTSGLASL SSLTLQNSDS SASAPNKCYA PSAIPTPQRT STPGLALFPG 550 560 570 580 590 600 LPSPVANSTS TPLTLPVQSP LATAASASTS VPVSCGSSAS LLRGPHPGTS DLHISSTPAA 610 620 630 640 650 660 TTLPVMIKTE PTSPTPSAFK GPSHSGNPSH GTLGLSGTLG RAYTSTSVPI SLSACLNPAL 670 680 690 700 710 720 SGLSSLSTPL NGSNPLSSIS LPPHGSSTPI APVFTALPSF TSLTNNFPLT GNPSLNPSVS 730 740 750 760 770 780 LPGSLIATSS TAATSTSLPH PSSTAAVLSG LSASAPVSAA PFPLNLSTAV PSLFSVTQGP 790 800 810 820 830 840 LSSSNPSYPG FSVSNTPSVT PALPSFPGLQ APSTVAAVTP LPVAATAPSP APVLPGFASA 850 860 870 880 890 900 FSSNFNSALV AQAGLSSGLQ AAGSSVFPGL LSLPGIPGFP QNPSQSSLQE LQHNAAAQSA 910 920 930 940 LLQQVHSASA LESYPAQPDG FPSYPSAPGT PFSLQPSLSQ SGWQ

References

[1]	"The nucleotide sequence of a long cDNA clone isolated from human." Nagase T., Kikuno R., Ohara O. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Amygdala, Colon endothelium and Melanoma.
[3]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-571. Tissue: Brain and PNS.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-944, VARIANT ALA-571. Tissue: Teratocarcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB107354 mRNA. Translation: BAC67659.1. Different initiation. AL833854 mRNA. Translation: CAD38713.1. AL834435 mRNA. Translation: CAD39095.1. BX647471 mRNA. Translation: CAH56138.1. AL445590 Genomic DNA. Translation: CAI40975.1. BC053566 mRNA. Translation: AAH53566.1. BC064348 mRNA. Translation: AAH64348.1. AK022723 mRNA. Translation: BAB14204.1. Different initiation.
IPI	IPI00329260.
RefSeq	NP_079414.3. NM_025138.4.
UniGene	Hs.318526.
3D structure databases
ProteinModelPortal	Q86XN7.
ModBase	Search...
PTM databases
PhosphoSite	Q86XN7.
Polymorphism databases
DMDM	125950653.
Proteomic databases
PaxDb	Q86XN7.
PRIDE	Q86XN7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000352251; ENSP00000332034; ENSG00000120685.
GeneID	80209.
KEGG	hsa:80209.
UCSC	uc001uwy.3. human.
Organism-specific databases
CTD	80209.
GeneCards	GC13M039585.
H-InvDB	HIX0011252.
HGNC	HGNC:20291. PROSER1.
HPA	CAB034225.
neXtProt	NX_Q86XN7.
PharmGKB	PA134912550.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000113186.
HOVERGEN	HBG081845.
InParanoid	Q86XN7.
OMA	FLTSNDT.
OrthoDB	EOG44QT29.
Gene expression databases
ArrayExpress	Q86XN7.
Bgee	Q86XN7.
CleanEx	HS_C13orf23.
Genevestigator	Q86XN7.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	PROSER1. human.
GenomeRNAi	80209.
NextBio	70594.

Entry information

Entry name

PRSR1_HUMAN

Accession

Primary (citable) accession number: Q86XN7
Secondary accession number(s): Q6P2S2 , Q7Z3X5, Q8N3D2, Q8N3P1, Q9H9M1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	March 6, 2013
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.