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Protein

Zinc finger protein 761

Gene

ZNF761

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri215 – 237C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri690 – 712C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri718 – 740C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 761
Gene namesi
Name:ZNF761
Synonyms:KIAA2033
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000160336.14
HGNCiHGNC:23179 ZNF761
neXtProtiNX_Q86XN6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160336
PharmGKBiPA145149911

Polymorphism and mutation databases

BioMutaiZNF761
DMDMi158706491

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003068801 – 746Zinc finger protein 761Add BLAST746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ86XN6
MaxQBiQ86XN6
PeptideAtlasiQ86XN6
PRIDEiQ86XN6

PTM databases

iPTMnetiQ86XN6
PhosphoSitePlusiQ86XN6

Expressioni

Gene expression databases

CleanExiHS_ZNF761

Interactioni

Protein-protein interaction databases

BioGridi132744, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ86XN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 81KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri215 – 237C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri690 – 712C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri718 – 740C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00690000102079
HOVERGENiHBG018163
InParanoidiQ86XN6
KOiK09228
OMAiATKHACW
PhylomeDBiQ86XN6

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

Sequencei

Sequence statusi: Complete.

Q86XN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFSQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS
60 70 80 90 100
SKCTMKEFLS TAQGNREVFH AGTLQIHESH HNGDFCYQDV DKDIHDYEFQ
110 120 130 140 150
WQEDERNGHE APMTKIKKLT GITERYDQSH ARNKPIKDQL GSSFHSHLPE
160 170 180 190 200
MHIFQTEEKI DNQVVKSVHD ASLVSTAQRI SCRPKTHISN NHGNNFWNSS
210 220 230 240 250
LLTQKQEVHM REKSFQCNES GKAFNYSSLL RKHQIIHLAD KYKCDVCGKL
260 270 280 290 300
FNQKRNLACH RRCHTGENPY KCNECGKTFS QTSSLTCHRR LHTGEKPYKC
310 320 330 340 350
EECDKAFHFK SILERHRIIH TEEKPYKCNE CGKTFRQKSI LTRHHRLHTG
360 370 380 390 400
EKPYKCNECG KTFSHKSSLT CHHRLHTGEK PYKCNECGKT FSHKSSLTCH
410 420 430 440 450
RRLHTGEKPY KCEECDKAYS FRSNFEIHRK IHTEDNAYKC NECGKTFSRT
460 470 480 490 500
SSLTCHRRRH TGEQPYKCEE CDKAFRFKSN LERHRRIHTG EKPYKCNECG
510 520 530 540 550
KTFSRKSYLT CHHRLHTGEK AYKCNECGKT FSWKSSLTCH RRLHSGEKPY
560 570 580 590 600
KCKECGKTFN QQLTLKRHRR LHSGENPYKC EDSDKAYSFK SNLEIHQKIH
610 620 630 640 650
TEENPYKCNE CGKTFSRTSS LTCHRRLHTG EKPYKCEECD KAFRVKSNLE
660 670 680 690 700
GHRRIHTGEK PYKCNECGKT FSRKSYFICH HRLHTGEKPY KCNECGKNFS
710 720 730 740
QKSSLICHHR LHTGEKPYKC NECGKTFSQK SNLTCHRRLH TGEKQV
Length:746
Mass (Da):87,716
Last modified:March 28, 2018 - v3
Checksum:i7DE0524FF2673CA0
GO

Sequence cautioni

The sequence BAC67660 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAD18456 differs from that shown. Aberrant splicing in the N-terminal part.Curated
The sequence BAD18456 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317R → S in BAD18456 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035335122I → S2 PublicationsCorresponds to variant dbSNP:rs2708743Ensembl.1
Natural variantiVAR_035336168V → I2 PublicationsCorresponds to variant dbSNP:rs1984432Ensembl.1
Natural variantiVAR_035337528G → S1 PublicationCorresponds to variant dbSNP:rs2708742Ensembl.1
Natural variantiVAR_035338603E → Q1 PublicationCorresponds to variant dbSNP:rs2617726Ensembl.1
Natural variantiVAR_080210678I → V1 PublicationCorresponds to variant dbSNP:rs139713552Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB107355 mRNA Translation: BAC67660.2 Different initiation.
AC022137 Genomic DNA No translation available.
KF495723 Genomic DNA No translation available.
AK131281 mRNA Translation: BAD18456.1 Sequence problems.
RefSeqiNP_001008401.3, NM_001008401.3
NP_001276880.1, NM_001289951.1
NP_001276881.1, NM_001289952.1
UniGeneiHs.433293

Genome annotation databases

EnsembliENST00000432094; ENSP00000480218; ENSG00000160336
ENST00000454407; ENSP00000481272; ENSG00000160336
GeneIDi388561
KEGGihsa:388561

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN761_HUMAN
AccessioniPrimary (citable) accession number: Q86XN6
Secondary accession number(s): A0A087WXT7, Q6ZNB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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