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Protein

Zinc finger protein 761

Gene

ZNF761

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri215 – 23723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri578 – 60023C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri606 – 62823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri634 – 65623C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri662 – 68423C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri690 – 71223C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri718 – 74023C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 761
Gene namesi
Name:ZNF761
Synonyms:KIAA2033
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:23179. ZNF761.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145149911.

Polymorphism and mutation databases

BioMutaiZNF761.
DMDMi158706491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 746746Zinc finger protein 761PRO_0000306880Add
BLAST

Proteomic databases

EPDiQ86XN6.
MaxQBiQ86XN6.
PRIDEiQ86XN6.

PTM databases

iPTMnetiQ86XN6.
PhosphoSiteiQ86XN6.

Expressioni

Gene expression databases

CleanExiHS_ZNF761.

Interactioni

Protein-protein interaction databases

BioGridi132744. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ86XN6.
SMRiQ86XN6. Positions 166-744.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8174KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri215 – 23723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri578 – 60023C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri606 – 62823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri634 – 65623C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri662 – 68423C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri690 – 71223C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri718 – 74023C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG018163.
InParanoidiQ86XN6.
KOiK09228.
PhylomeDBiQ86XN6.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86XN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFSQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS
60 70 80 90 100
SKCTMKEFLS TAQGNREVFH AGTLQIHESH HNGDFCYQDV DKDIHDYEFQ
110 120 130 140 150
WQEDERNGHE APMTKIKKLT GSTERYDQSH ARNKPIKDQL GSSFHSHLPE
160 170 180 190 200
MHIFQTEEKI DNQVVKSIHD ASLVSTAQRI SCRPKTHISN NHGNNFWNSS
210 220 230 240 250
LLTQKQEVHM REKSFQCNES GKAFNYSSLL RKHQIIHLAD KYKCDVCGKL
260 270 280 290 300
FNQKRNLACH RRCHTGENPY KCNECGKTFS QTSSLTCHRR LHTGEKPYKC
310 320 330 340 350
EECDKAFHFK SILERHRIIH TEEKPYKCNE CGKTFRQKSI LTRHHRLHTG
360 370 380 390 400
EKPYKCNECG KTFSHKSSLT CHHRLHTGEK PYKCNECGKT FSHKSSLTCH
410 420 430 440 450
RRLHTGEKPY KCEECDKAYS FRSNFEIHRK IHTEDNAYKC NECGKTFSRT
460 470 480 490 500
SSLTCHRRRH TGEQPYKCEE CDKAFRFKSN LERHRRIHTG EKPYKCNECG
510 520 530 540 550
KTFSRKSYLT CHHRLHTGEK AYKCNECSKT FSWKSSLTCH RRLHSGEKPY
560 570 580 590 600
KCKECGKTFN QQLTLKRHRR LHSGENPYKC EDSDKAYSFK SNLEIHQKIH
610 620 630 640 650
TEQNPYKCNE CGKTFSRTSS LTCHRRLHTG EKPYKCEECD KAFRVKSNLE
660 670 680 690 700
GHRRIHTGEK PYKCNECGKT FSRKSYFVCH HRLHTGEKPY KCNECGKNFS
710 720 730 740
QKSSLICHHR LHTGEKPYKC NECGKTFSQK SNLTCHRRLH TGEKQV
Length:746
Mass (Da):87,719
Last modified:October 2, 2007 - v2
Checksum:i03A3FAE4E805ABAB
GO
Isoform 2 (identifier: Q86XN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     699-726: Missing.

Note: No experimental confirmation available.
Show »
Length:718
Mass (Da):84,504
Checksum:iF5621E6663E1E780
GO
Isoform 3 (identifier: Q86XN6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Note: No experimental confirmation available.
Show »
Length:692
Mass (Da):81,404
Checksum:i89C61F795ADD7451
GO

Sequence cautioni

The sequence BAC67660.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti317 – 3171R → S in BAD18456 (PubMed:14702039).Curated
Sequence conflicti678 – 6781V → I in BAD18456 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221S → I.
Corresponds to variant rs2708743 [ dbSNP | Ensembl ].
VAR_035335
Natural varianti168 – 1681I → V.
Corresponds to variant rs1984432 [ dbSNP | Ensembl ].
VAR_035336
Natural varianti528 – 5281S → G.1 Publication
Corresponds to variant rs2708742 [ dbSNP | Ensembl ].
VAR_035337
Natural varianti603 – 6031Q → E.1 Publication
Corresponds to variant rs2617726 [ dbSNP | Ensembl ].
VAR_035338

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5454Missing in isoform 3. 1 PublicationVSP_028557Add
BLAST
Alternative sequencei699 – 72628Missing in isoform 2. 1 PublicationVSP_028558Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB107355 mRNA. Translation: BAC67660.2. Different initiation.
AK131281 mRNA. Translation: BAD18456.1.
AC022137 Genomic DNA. No translation available.
RefSeqiNP_001008401.3. NM_001008401.3.
NP_001276881.1. NM_001289952.1.
UniGeneiHs.433293.

Genome annotation databases

GeneIDi388561.
KEGGihsa:388561.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB107355 mRNA. Translation: BAC67660.2. Different initiation.
AK131281 mRNA. Translation: BAD18456.1.
AC022137 Genomic DNA. No translation available.
RefSeqiNP_001008401.3. NM_001008401.3.
NP_001276881.1. NM_001289952.1.
UniGeneiHs.433293.

3D structure databases

ProteinModelPortaliQ86XN6.
SMRiQ86XN6. Positions 166-744.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132744. 2 interactions.

PTM databases

iPTMnetiQ86XN6.
PhosphoSiteiQ86XN6.

Polymorphism and mutation databases

BioMutaiZNF761.
DMDMi158706491.

Proteomic databases

EPDiQ86XN6.
MaxQBiQ86XN6.
PRIDEiQ86XN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi388561.
KEGGihsa:388561.

Organism-specific databases

CTDi388561.
GeneCardsiZNF761.
HGNCiHGNC:23179. ZNF761.
neXtProtiNX_Q86XN6.
PharmGKBiPA145149911.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG018163.
InParanoidiQ86XN6.
KOiK09228.
PhylomeDBiQ86XN6.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF761. human.
GenomeRNAii388561.
NextBioi102159.
PROiQ86XN6.

Gene expression databases

CleanExiHS_ZNF761.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The nucleotide sequence of a long cDNA clone isolated from human."
    Nagase T., Kikuno R., Ohara O.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS GLY-528 AND GLU-603.
    Tissue: Brain.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZN761_HUMAN
AccessioniPrimary (citable) accession number: Q86XN6
Secondary accession number(s): Q6ZNB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 16, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.