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Q86XM0 (CTSRD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cation channel sperm-associated protein subunit delta

Short name=CatSper-delta
Short name=CatSperdelta
Alternative name(s):
Transmembrane protein 146
Gene names
Name:CATSPERD
Synonyms:TMEM146
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length798 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane By similarity.

Subunit structure

Component of the CatSper complex By similarity.

Subcellular location

Cell projectionciliumflagellum membrane; Single-pass type I membrane protein By similarity. Note: Specifically located in the principal piece of sperm tail By similarity.

Sequence similarities

Belongs to the CATSPERD family.

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.

Sequence caution

The sequence AAH43005.2 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86XM0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86XM0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-342: Missing.
     589-700: WRKDSFQEVI...ISIVDPYYSY → LECSGMNTVH...IFSRDRVSPC
     701-798: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 798778Cation channel sperm-associated protein subunit delta
PRO_0000287150

Regions

Topological domain21 – 718698Extracellular Potential
Transmembrane719 – 73921Helical; Potential
Topological domain740 – 79859Cytoplasmic Potential

Amino acid modifications

Glycosylation2401N-linked (GlcNAc...) Potential
Glycosylation4721N-linked (GlcNAc...) Potential
Glycosylation5381N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 342342Missing in isoform 2.
VSP_025344
Alternative sequence589 – 700112WRKDS…PYYSY → LECSGMNTVHCSLNLPGSSG PPASASQVAGTAVAYHNARL IFFFFFFFFLRQSLALSPRL ECSGVILAHRKLRLPGSRHS PASASRVAGITGARHCARLI FFIFSRDRVSPC in isoform 2.
VSP_025345
Alternative sequence701 – 79898Missing in isoform 2.
VSP_025346
Natural variant2121M → T.
Corresponds to variant rs57680462 [ dbSNP | Ensembl ].
VAR_061714
Natural variant5041T → A. Ref.3
Corresponds to variant rs17854252 [ dbSNP | Ensembl ].
VAR_032270
Natural variant7431T → S.
Corresponds to variant rs2305925 [ dbSNP | Ensembl ].
VAR_032271

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 15, 2007. Version 3.
Checksum: 2BB506703AA9A417

FASTA79890,468
        10         20         30         40         50         60 
MLMLMLVAAV TMWLRPLVTA QLCRSRTVRT GKVFNLIQDV QGDRLYFHPT TTRLIKHPCE 

        70         80         90        100        110        120 
KNIALYLGKQ VFFTMDNFET SLLPFTIPTS MQVGVPEVTS AHFAGSLLLL VVDQKVYIYD 

       130        140        150        160        170        180 
YENNSWSMSL GIKHPVTHVS GDNCCYTGSL FCVHVSNLVF AYFRGDQISQ TYIYYSNTGG 

       190        200        210        220        230        240 
FSFWKYHYDR QAEIIGSLGG IFHFFSLSQV AMLVVNQGKG MFKYSDHPLN RSFGLSFDYN 

       250        260        270        280        290        300 
GTLDILIAPG QRGILLLWFE NSLLFSHNAG QLVDTVRVKK GDQTLFSSIF EAKITIHNIA 

       310        320        330        340        350        360 
VTENELAVIT REDNLYYGNL GIVPSSIIKF ADQYIWSEDV ALMFRSPGTL EILTPLRDTA 

       370        380        390        400        410        420 
FPAFDFQKCL VNIQALLMDP ELHVGKCKIE FLTGEFIYRM YTIDMHSQLE LTASLIPQPG 

       430        440        450        460        470        480 
TSLIPLVMVS NPHSLGFQAT FYENGYTSDG NTKYKLDIFL KQQQHWGRTD SNFTSSLKKA 

       490        500        510        520        530        540 
TMSTLTVDIA NKEISCVDIK PLSTLISVGC DLDKKIVIQN KVSACSMGIL DPLTLQDNYS 

       550        560        570        580        590        600 
FIIEKEFYDP GFQGQQSSED LHVFYSYQQL GCPLLVYYDT LWKPVVELWR KDSFQEVIDA 

       610        620        630        640        650        660 
EYVLLEVNGQ FSYSYSLTAQ SAMCTSQPQN WTTMIKEFGG PFFWNRENYV SCHDPNNNAP 

       670        680        690        700        710        720 
LRWPDVQYQI LGGRTANQII FGHNGFYVFY ISIVDPYYSY CQLETIFSIY VYGAFPVQLV 

       730        740        750        760        770        780 
SAGVVILLII SSILGSVWLA YKTPKLLRTA RGRRIKKCAT QLCRRCKTVC QFRASATARA 

       790 
GTEPPGRHRT PHGGRSDH 

« Hide

Isoform 2 [UniParc].

Checksum: 1A789BDD1C406CF6
Show »

FASTA35839,975

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-504.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK128088 mRNA. No translation available.
AC011499 Genomic DNA. No translation available.
BC043005 mRNA. Translation: AAH43005.2. Different initiation.
CCDSCCDS12149.2. [Q86XM0-1]
RefSeqNP_689997.3. NM_152784.3. [Q86XM0-1]
UniGeneHs.631842.

3D structure databases

ProteinModelPortalQ86XM0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129194. 1 interaction.
STRING9606.ENSP00000371037.

Protein family/group databases

TCDB1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSiteQ86XM0.

Polymorphism databases

DMDM147734568.

Proteomic databases

PaxDbQ86XM0.
PRIDEQ86XM0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381624; ENSP00000371037; ENSG00000174898. [Q86XM0-1]
GeneID257062.
KEGGhsa:257062.
UCSCuc002mda.3. human. [Q86XM0-1]

Organism-specific databases

CTD257062.
GeneCardsGC19P005720.
HGNCHGNC:28598. CATSPERD.
HPAHPA024056.
neXtProtNX_Q86XM0.
PharmGKBPA144596254.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG68519.
HOGENOMHOG000081747.
HOVERGENHBG108576.
InParanoidQ86XM0.
KOK16895.
OMAEYVLLEV.
OrthoDBEOG7WHH8S.
PhylomeDBQ86XM0.
TreeFamTF337973.

Enzyme and pathway databases

ReactomeREACT_163848. Reproduction.

Gene expression databases

ArrayExpressQ86XM0.
BgeeQ86XM0.
CleanExHS_TMEM146.
GenevestigatorQ86XM0.

Family and domain databases

InterProIPR028751. CATSPERD.
[Graphical view]
PfamPF15020. CATSPERD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi257062.
NextBio92916.
PROQ86XM0.

Entry information

Entry nameCTSRD_HUMAN
AccessionPrimary (citable) accession number: Q86XM0
Secondary accession number(s): Q6ZRP1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: July 9, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM