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Q86XM0

- CTSRD_HUMAN

UniProt

Q86XM0 - CTSRD_HUMAN

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Protein

Cation channel sperm-associated protein subunit delta

Gene
CATSPERD, TMEM146
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane By similarity.

GO - Biological processi

  1. cilium or flagellum-dependent cell motility Source: Ensembl
  2. multicellular organismal development Source: UniProtKB-KW
  3. multicellular organism reproduction Source: Reactome
  4. single fertilization Source: Reactome
  5. spermatogenesis Source: UniProtKB
  6. sperm capacitation Source: UniProtKB
  7. sperm-egg recognition Source: Reactome
  8. sperm motility Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiREACT_163875. Sperm Motility And Taxes.

Protein family/group databases

TCDBi1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein subunit delta
Short name:
CatSper-delta
Short name:
CatSperdelta
Alternative name(s):
Transmembrane protein 146
Gene namesi
Synonyms:TMEM146
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:28598. CATSPERD.

Subcellular locationi

Cell projectionciliumflagellum membrane; Single-pass type I membrane protein By similarity
Note: Specifically located in the principal piece of sperm tail By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 718698Extracellular Reviewed predictionAdd
BLAST
Transmembranei719 – 73921Helical; Reviewed predictionAdd
BLAST
Topological domaini740 – 79859Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. CatSper complex Source: UniProtKB
  2. ciliary membrane Source: Ensembl
  3. plasma membrane Source: Reactome
  4. sperm principal piece Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596254.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 798778Cation channel sperm-associated protein subunit deltaPRO_0000287150Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi240 – 2401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi472 – 4721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi538 – 5381N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86XM0.
PRIDEiQ86XM0.

PTM databases

PhosphoSiteiQ86XM0.

Expressioni

Gene expression databases

ArrayExpressiQ86XM0.
BgeeiQ86XM0.
CleanExiHS_TMEM146.
GenevestigatoriQ86XM0.

Organism-specific databases

HPAiHPA024056.

Interactioni

Subunit structurei

Component of the CatSper complex By similarity.

Protein-protein interaction databases

BioGridi129194. 1 interaction.
STRINGi9606.ENSP00000371037.

Structurei

3D structure databases

ProteinModelPortaliQ86XM0.

Family & Domainsi

Sequence similaritiesi

Belongs to the CATSPERD family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG68519.
HOGENOMiHOG000081747.
HOVERGENiHBG108576.
InParanoidiQ86XM0.
KOiK16895.
OMAiEYVLLEV.
OrthoDBiEOG7WHH8S.
PhylomeDBiQ86XM0.
TreeFamiTF337973.

Family and domain databases

InterProiIPR028751. CATSPERD.
[Graphical view]
PfamiPF15020. CATSPERD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86XM0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLMLMLVAAV TMWLRPLVTA QLCRSRTVRT GKVFNLIQDV QGDRLYFHPT    50
TTRLIKHPCE KNIALYLGKQ VFFTMDNFET SLLPFTIPTS MQVGVPEVTS 100
AHFAGSLLLL VVDQKVYIYD YENNSWSMSL GIKHPVTHVS GDNCCYTGSL 150
FCVHVSNLVF AYFRGDQISQ TYIYYSNTGG FSFWKYHYDR QAEIIGSLGG 200
IFHFFSLSQV AMLVVNQGKG MFKYSDHPLN RSFGLSFDYN GTLDILIAPG 250
QRGILLLWFE NSLLFSHNAG QLVDTVRVKK GDQTLFSSIF EAKITIHNIA 300
VTENELAVIT REDNLYYGNL GIVPSSIIKF ADQYIWSEDV ALMFRSPGTL 350
EILTPLRDTA FPAFDFQKCL VNIQALLMDP ELHVGKCKIE FLTGEFIYRM 400
YTIDMHSQLE LTASLIPQPG TSLIPLVMVS NPHSLGFQAT FYENGYTSDG 450
NTKYKLDIFL KQQQHWGRTD SNFTSSLKKA TMSTLTVDIA NKEISCVDIK 500
PLSTLISVGC DLDKKIVIQN KVSACSMGIL DPLTLQDNYS FIIEKEFYDP 550
GFQGQQSSED LHVFYSYQQL GCPLLVYYDT LWKPVVELWR KDSFQEVIDA 600
EYVLLEVNGQ FSYSYSLTAQ SAMCTSQPQN WTTMIKEFGG PFFWNRENYV 650
SCHDPNNNAP LRWPDVQYQI LGGRTANQII FGHNGFYVFY ISIVDPYYSY 700
CQLETIFSIY VYGAFPVQLV SAGVVILLII SSILGSVWLA YKTPKLLRTA 750
RGRRIKKCAT QLCRRCKTVC QFRASATARA GTEPPGRHRT PHGGRSDH 798
Length:798
Mass (Da):90,468
Last modified:May 15, 2007 - v3
Checksum:i2BB506703AA9A417
GO
Isoform 2 (identifier: Q86XM0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-342: Missing.
     589-700: WRKDSFQEVI...ISIVDPYYSY → LECSGMNTVH...IFSRDRVSPC
     701-798: Missing.

Note: No experimental confirmation available.

Show »
Length:358
Mass (Da):39,975
Checksum:i1A789BDD1C406CF6
GO

Sequence cautioni

The sequence AAH43005.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti212 – 2121M → T.
Corresponds to variant rs57680462 [ dbSNP | Ensembl ].
VAR_061714
Natural varianti504 – 5041T → A.1 Publication
Corresponds to variant rs17854252 [ dbSNP | Ensembl ].
VAR_032270
Natural varianti743 – 7431T → S.
Corresponds to variant rs2305925 [ dbSNP | Ensembl ].
VAR_032271

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 342342Missing in isoform 2. VSP_025344Add
BLAST
Alternative sequencei589 – 700112WRKDS…PYYSY → LECSGMNTVHCSLNLPGSSG PPASASQVAGTAVAYHNARL IFFFFFFFFLRQSLALSPRL ECSGVILAHRKLRLPGSRHS PASASRVAGITGARHCARLI FFIFSRDRVSPC in isoform 2. VSP_025345Add
BLAST
Alternative sequencei701 – 79898Missing in isoform 2. VSP_025346Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK128088 mRNA. No translation available.
AC011499 Genomic DNA. No translation available.
BC043005 mRNA. Translation: AAH43005.2. Different initiation.
CCDSiCCDS12149.2. [Q86XM0-1]
RefSeqiNP_689997.3. NM_152784.3. [Q86XM0-1]
UniGeneiHs.631842.

Genome annotation databases

EnsembliENST00000381624; ENSP00000371037; ENSG00000174898. [Q86XM0-1]
GeneIDi257062.
KEGGihsa:257062.
UCSCiuc002mda.3. human. [Q86XM0-1]

Polymorphism databases

DMDMi147734568.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK128088 mRNA. No translation available.
AC011499 Genomic DNA. No translation available.
BC043005 mRNA. Translation: AAH43005.2 . Different initiation.
CCDSi CCDS12149.2. [Q86XM0-1 ]
RefSeqi NP_689997.3. NM_152784.3. [Q86XM0-1 ]
UniGenei Hs.631842.

3D structure databases

ProteinModelPortali Q86XM0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129194. 1 interaction.
STRINGi 9606.ENSP00000371037.

Protein family/group databases

TCDBi 1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q86XM0.

Polymorphism databases

DMDMi 147734568.

Proteomic databases

PaxDbi Q86XM0.
PRIDEi Q86XM0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381624 ; ENSP00000371037 ; ENSG00000174898 . [Q86XM0-1 ]
GeneIDi 257062.
KEGGi hsa:257062.
UCSCi uc002mda.3. human. [Q86XM0-1 ]

Organism-specific databases

CTDi 257062.
GeneCardsi GC19P005720.
HGNCi HGNC:28598. CATSPERD.
HPAi HPA024056.
neXtProti NX_Q86XM0.
PharmGKBi PA144596254.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68519.
HOGENOMi HOG000081747.
HOVERGENi HBG108576.
InParanoidi Q86XM0.
KOi K16895.
OMAi EYVLLEV.
OrthoDBi EOG7WHH8S.
PhylomeDBi Q86XM0.
TreeFami TF337973.

Enzyme and pathway databases

Reactomei REACT_163875. Sperm Motility And Taxes.

Miscellaneous databases

GenomeRNAii 257062.
NextBioi 92916.
PROi Q86XM0.

Gene expression databases

ArrayExpressi Q86XM0.
Bgeei Q86XM0.
CleanExi HS_TMEM146.
Genevestigatori Q86XM0.

Family and domain databases

InterProi IPR028751. CATSPERD.
[Graphical view ]
Pfami PF15020. CATSPERD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-504.
    Tissue: Testis.

Entry informationi

Entry nameiCTSRD_HUMAN
AccessioniPrimary (citable) accession number: Q86XM0
Secondary accession number(s): Q6ZRP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: September 3, 2014
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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