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Q86XM0

- CTSRD_HUMAN

UniProt

Q86XM0 - CTSRD_HUMAN

Protein

Cation channel sperm-associated protein subunit delta

Gene

CATSPERD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 3 (15 May 2007)
      Previous versions | rss
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    Functioni

    Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane By similarity.By similarity

    GO - Biological processi

    1. cilium or flagellum-dependent cell motility Source: Ensembl
    2. multicellular organismal development Source: UniProtKB-KW
    3. multicellular organism reproduction Source: Reactome
    4. single fertilization Source: Reactome
    5. spermatogenesis Source: UniProtKB
    6. sperm capacitation Source: UniProtKB
    7. sperm-egg recognition Source: Reactome
    8. sperm motility Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Enzyme and pathway databases

    ReactomeiREACT_163875. Sperm Motility And Taxes.

    Protein family/group databases

    TCDBi1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cation channel sperm-associated protein subunit delta
    Short name:
    CatSper-delta
    Short name:
    CatSperdelta
    Alternative name(s):
    Transmembrane protein 146
    Gene namesi
    Name:CATSPERD
    Synonyms:TMEM146
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:28598. CATSPERD.

    Subcellular locationi

    Cell projectionciliumflagellum membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Specifically located in the principal piece of sperm tail.By similarity

    GO - Cellular componenti

    1. CatSper complex Source: UniProtKB
    2. ciliary membrane Source: Ensembl
    3. plasma membrane Source: Reactome
    4. sperm principal piece Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cilium, Flagellum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA144596254.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 798778Cation channel sperm-associated protein subunit deltaPRO_0000287150Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ86XM0.
    PRIDEiQ86XM0.

    PTM databases

    PhosphoSiteiQ86XM0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86XM0.
    BgeeiQ86XM0.
    CleanExiHS_TMEM146.
    GenevestigatoriQ86XM0.

    Organism-specific databases

    HPAiHPA024056.

    Interactioni

    Subunit structurei

    Component of the CatSper complex.By similarity

    Protein-protein interaction databases

    BioGridi129194. 1 interaction.
    STRINGi9606.ENSP00000371037.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86XM0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 718698ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini740 – 79859CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei719 – 73921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CATSPERD family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG68519.
    HOGENOMiHOG000081747.
    HOVERGENiHBG108576.
    InParanoidiQ86XM0.
    KOiK16895.
    OMAiEYVLLEV.
    OrthoDBiEOG7WHH8S.
    PhylomeDBiQ86XM0.
    TreeFamiTF337973.

    Family and domain databases

    InterProiIPR028751. CATSPERD.
    [Graphical view]
    PfamiPF15020. CATSPERD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86XM0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLMLMLVAAV TMWLRPLVTA QLCRSRTVRT GKVFNLIQDV QGDRLYFHPT    50
    TTRLIKHPCE KNIALYLGKQ VFFTMDNFET SLLPFTIPTS MQVGVPEVTS 100
    AHFAGSLLLL VVDQKVYIYD YENNSWSMSL GIKHPVTHVS GDNCCYTGSL 150
    FCVHVSNLVF AYFRGDQISQ TYIYYSNTGG FSFWKYHYDR QAEIIGSLGG 200
    IFHFFSLSQV AMLVVNQGKG MFKYSDHPLN RSFGLSFDYN GTLDILIAPG 250
    QRGILLLWFE NSLLFSHNAG QLVDTVRVKK GDQTLFSSIF EAKITIHNIA 300
    VTENELAVIT REDNLYYGNL GIVPSSIIKF ADQYIWSEDV ALMFRSPGTL 350
    EILTPLRDTA FPAFDFQKCL VNIQALLMDP ELHVGKCKIE FLTGEFIYRM 400
    YTIDMHSQLE LTASLIPQPG TSLIPLVMVS NPHSLGFQAT FYENGYTSDG 450
    NTKYKLDIFL KQQQHWGRTD SNFTSSLKKA TMSTLTVDIA NKEISCVDIK 500
    PLSTLISVGC DLDKKIVIQN KVSACSMGIL DPLTLQDNYS FIIEKEFYDP 550
    GFQGQQSSED LHVFYSYQQL GCPLLVYYDT LWKPVVELWR KDSFQEVIDA 600
    EYVLLEVNGQ FSYSYSLTAQ SAMCTSQPQN WTTMIKEFGG PFFWNRENYV 650
    SCHDPNNNAP LRWPDVQYQI LGGRTANQII FGHNGFYVFY ISIVDPYYSY 700
    CQLETIFSIY VYGAFPVQLV SAGVVILLII SSILGSVWLA YKTPKLLRTA 750
    RGRRIKKCAT QLCRRCKTVC QFRASATARA GTEPPGRHRT PHGGRSDH 798
    Length:798
    Mass (Da):90,468
    Last modified:May 15, 2007 - v3
    Checksum:i2BB506703AA9A417
    GO
    Isoform 2 (identifier: Q86XM0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-342: Missing.
         589-700: WRKDSFQEVI...ISIVDPYYSY → LECSGMNTVH...IFSRDRVSPC
         701-798: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:358
    Mass (Da):39,975
    Checksum:i1A789BDD1C406CF6
    GO

    Sequence cautioni

    The sequence AAH43005.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti212 – 2121M → T.
    Corresponds to variant rs57680462 [ dbSNP | Ensembl ].
    VAR_061714
    Natural varianti504 – 5041T → A.1 Publication
    Corresponds to variant rs17854252 [ dbSNP | Ensembl ].
    VAR_032270
    Natural varianti743 – 7431T → S.
    Corresponds to variant rs2305925 [ dbSNP | Ensembl ].
    VAR_032271

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 342342Missing in isoform 2. 1 PublicationVSP_025344Add
    BLAST
    Alternative sequencei589 – 700112WRKDS…PYYSY → LECSGMNTVHCSLNLPGSSG PPASASQVAGTAVAYHNARL IFFFFFFFFLRQSLALSPRL ECSGVILAHRKLRLPGSRHS PASASRVAGITGARHCARLI FFIFSRDRVSPC in isoform 2. 1 PublicationVSP_025345Add
    BLAST
    Alternative sequencei701 – 79898Missing in isoform 2. 1 PublicationVSP_025346Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK128088 mRNA. No translation available.
    AC011499 Genomic DNA. No translation available.
    BC043005 mRNA. Translation: AAH43005.2. Different initiation.
    CCDSiCCDS12149.2. [Q86XM0-1]
    RefSeqiNP_689997.3. NM_152784.3. [Q86XM0-1]
    UniGeneiHs.631842.

    Genome annotation databases

    EnsembliENST00000381624; ENSP00000371037; ENSG00000174898. [Q86XM0-1]
    GeneIDi257062.
    KEGGihsa:257062.
    UCSCiuc002mda.3. human. [Q86XM0-1]

    Polymorphism databases

    DMDMi147734568.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK128088 mRNA. No translation available.
    AC011499 Genomic DNA. No translation available.
    BC043005 mRNA. Translation: AAH43005.2 . Different initiation.
    CCDSi CCDS12149.2. [Q86XM0-1 ]
    RefSeqi NP_689997.3. NM_152784.3. [Q86XM0-1 ]
    UniGenei Hs.631842.

    3D structure databases

    ProteinModelPortali Q86XM0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129194. 1 interaction.
    STRINGi 9606.ENSP00000371037.

    Protein family/group databases

    TCDBi 1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei Q86XM0.

    Polymorphism databases

    DMDMi 147734568.

    Proteomic databases

    PaxDbi Q86XM0.
    PRIDEi Q86XM0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381624 ; ENSP00000371037 ; ENSG00000174898 . [Q86XM0-1 ]
    GeneIDi 257062.
    KEGGi hsa:257062.
    UCSCi uc002mda.3. human. [Q86XM0-1 ]

    Organism-specific databases

    CTDi 257062.
    GeneCardsi GC19P005720.
    HGNCi HGNC:28598. CATSPERD.
    HPAi HPA024056.
    neXtProti NX_Q86XM0.
    PharmGKBi PA144596254.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68519.
    HOGENOMi HOG000081747.
    HOVERGENi HBG108576.
    InParanoidi Q86XM0.
    KOi K16895.
    OMAi EYVLLEV.
    OrthoDBi EOG7WHH8S.
    PhylomeDBi Q86XM0.
    TreeFami TF337973.

    Enzyme and pathway databases

    Reactomei REACT_163875. Sperm Motility And Taxes.

    Miscellaneous databases

    GenomeRNAii 257062.
    NextBioi 92916.
    PROi Q86XM0.

    Gene expression databases

    ArrayExpressi Q86XM0.
    Bgeei Q86XM0.
    CleanExi HS_TMEM146.
    Genevestigatori Q86XM0.

    Family and domain databases

    InterProi IPR028751. CATSPERD.
    [Graphical view ]
    Pfami PF15020. CATSPERD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-504.
      Tissue: Testis.

    Entry informationi

    Entry nameiCTSRD_HUMAN
    AccessioniPrimary (citable) accession number: Q86XM0
    Secondary accession number(s): Q6ZRP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 79 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3