Q86XL3 (ANKL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat and LEM domain-containing protein 2

Alternative name(s):
LEM domain-containing protein 4

Gene names

Name:	ANKLE2
Synonyms:	KIAA0692, LEM4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	938 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Ref.11
Subunit structure	Interacts with BAF/BANF1. Interacts with protein phosphatase 2A (PP2A) components PPP2C (PPP2CA or PPP2CB) and PPP2R1A. Ref.11
Subcellular location	Endoplasmic reticulum membrane; Single-pass type III membrane protein Ref.11.
Sequence similarities	Belongs to the ANKLE2 family. Contains 1 ANK repeat. Contains 1 LEM domain.
Sequence caution	The sequence BAG51259.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Signal-anchor Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW mitotic nuclear envelope reassembly Inferred from mutant phenotype Ref.11. Source: UniProtKB negative regulation of phosphorylation Inferred from direct assay Ref.11. Source: UniProtKB positive regulation of protein dephosphorylation Inferred from direct assay Ref.11. Source: UniProtKB
Cellular_component	integral to endoplasmic reticulum membrane Inferred from direct assay Ref.11. Source: UniProtKB
Molecular_function	protein phosphatase 2A binding Inferred from direct assay Ref.11. Source: UniProtKB protein phosphatase type 2A regulator activity Traceable author statement Ref.11. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
vrk-1	Q19848	2	EBI-1773621,EBI-2414048	From a different organism.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86XL3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86XL3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     631-648: GSNSISVRAFLDEDDMSL → VEMRFHRIDQAGLELLTS
     649-938: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q86XL3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-645: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 938	938	Ankyrin repeat and LEM domain-containing protein 2		PRO_0000280242
Regions
	Topological domain	1 – 12	12	Lumenal Potential
	Transmembrane	13 – 32	20	Helical; Signal-anchor for type III membrane protein; Potential
	Topological domain	33 – 938	906	Cytoplasmic Potential
	Domain	69 – 113	45	LEM
	Repeat	411 – 440	30	ANK
Amino acid modifications
	Modified residue	259	1	Phosphoserine Ref.6
	Modified residue	268	1	Phosphoserine Ref.6
	Modified residue	488	1	Phosphoserine Ref.6
	Modified residue	496	1	Phosphoserine Ref.6 Ref.8
	Modified residue	512	1	Phosphoserine Ref.6
	Modified residue	662	1	Phosphoserine Ref.6 Ref.8 Ref.10
	Modified residue	896	1	Phosphoserine Ref.6
	Modified residue	914	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	1 – 645	645	Missing in isoform 3.		VSP_044173
	Alternative sequence	631 – 648	18	GSNSI…DDMSL → VEMRFHRIDQAGLELLTS in isoform 2.		VSP_023574
	Alternative sequence	649 – 938	290	Missing in isoform 2.		VSP_023575
	Natural variant	122	1	H → Y. Ref.3 Corresponds to variant rs1132375 [ dbSNP | Ensembl ].		VAR_031097
	Natural variant	148	1	Q → E. Corresponds to variant rs7968520 [ dbSNP | Ensembl ].		VAR_031098
	Natural variant	720	1	R → H. Ref.3 Ref.4 Corresponds to variant rs10781634 [ dbSNP | Ensembl ].		VAR_031099
Experimental info
	Sequence conflict	266	1	P → Q in AAH43157. Ref.3
	Sequence conflict	481	1	L → V in AAH43157. Ref.3
	Sequence conflict	647	1	S → N in AAH43157. Ref.3
	Sequence conflict	662	1	S → I in BAG52720. Ref.1
	Sequence conflict	680	1	E → K in BAG52720. Ref.1
	Sequence conflict	863	1	L → P in BAG51259. Ref.1
	Sequence conflict	891	1	G → A in BAG52720. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 24, 2009. Version 4. Checksum: ED2F25F05E8106F2	FASTA	938	104,114
	10 20 30 40 50 60 MLWPRLAAAE WAALAWELLG ASVLLIAVRW LVRRLGPRPG GLGRSGTPVP PPSAAAAPAS 70 80 90 100 110 120 GEMTMDALLA RLKLLNPDDL REEIVKAGLK CGPITSTTRF IFEKKLAQAL LEQGGRLSSF 130 140 150 160 170 180 YHHEAGVTAL SQDPQRILKP AEGNPTDQAG FSEDRDFGYS VGLNPPEEEA VTSKTCSVPP 190 200 210 220 230 240 SDTDTYRAGA TASKEPPLYY GVCPVYEDVP ARNERIYVYE NKKEALQAVK MIKGSRFKAF 250 260 270 280 290 300 STREDAEKFA RGICDYFPSP SKTSLPLSPV KTAPLFSNDR LKDGLCLSES ETVNKERANS 310 320 330 340 350 360 YKNPRTQDLT AKLRKAVEKG EEDTFSDLIW SNPRYLIGSG DNPTIVQEGC RYNVMHVAAK 370 380 390 400 410 420 ENQASICQLT LDVLENPDFM RLMYPDDDEA MLQKRIRYVV DLYLNTPDKM GYDTPLHFAC 430 440 450 460 470 480 KFGNADVVNV LSSHHLIVKN SRNKYDKTPE DVICERSKNK SVELKERIRE YLKGHYYVPL 490 500 510 520 530 540 LRAEETSSPV IGELWSPDQT AEASHVSRYG GSPRDPVLTL RAFAGPLSPA KAEDFRKLWK 550 560 570 580 590 600 TPPREKAGFL HHVKKSDPER GFERVGRELA HELGYPWVEY WEFLGCFVDL SSQEGLQRLE 610 620 630 640 650 660 EYLTQQEIGK KAQQETGERE ASCRDKATTS GSNSISVRAF LDEDDMSLEE IKNRQNAARN 670 680 690 700 710 720 NSPPTVGAFG HTRCSAFPLE QEADLIEAAE PGGPHSSRNG LCHPLNHSRT LAGKRPKAPR 730 740 750 760 770 780 GEEAHLPPVS DLTVEFDKLN LQNIGRSVSK TPDESTKTKD QILTSRINAV ERDLLEPSPA 790 800 810 820 830 840 DQLGNGHRRT ESEMSARIAK MSLSPSSPRH EDQLEVTREP ARRLFLFGEE PSKLDQDVLA 850 860 870 880 890 900 ALECADVDPH QFPAVHRWKS AVLCYSPSDR QSWPSPAVKG RFKSQLPDLS GPHSYSPGRN 910 920 930 SVAGSNPAKP GLGSPGRYSP VHGSQLRRMA RLAELAAL
	Isoform 2 [UniParc]. Checksum: A98712EBEE04E982	FASTA	648	72,641
	10 20 30 40 50 60 MLWPRLAAAE WAALAWELLG ASVLLIAVRW LVRRLGPRPG GLGRSGTPVP PPSAAAAPAS 70 80 90 100 110 120 GEMTMDALLA RLKLLNPDDL REEIVKAGLK CGPITSTTRF IFEKKLAQAL LEQGGRLSSF 130 140 150 160 170 180 YHHEAGVTAL SQDPQRILKP AEGNPTDQAG FSEDRDFGYS VGLNPPEEEA VTSKTCSVPP 190 200 210 220 230 240 SDTDTYRAGA TASKEPPLYY GVCPVYEDVP ARNERIYVYE NKKEALQAVK MIKGSRFKAF 250 260 270 280 290 300 STREDAEKFA RGICDYFPSP SKTSLPLSPV KTAPLFSNDR LKDGLCLSES ETVNKERANS 310 320 330 340 350 360 YKNPRTQDLT AKLRKAVEKG EEDTFSDLIW SNPRYLIGSG DNPTIVQEGC RYNVMHVAAK 370 380 390 400 410 420 ENQASICQLT LDVLENPDFM RLMYPDDDEA MLQKRIRYVV DLYLNTPDKM GYDTPLHFAC 430 440 450 460 470 480 KFGNADVVNV LSSHHLIVKN SRNKYDKTPE DVICERSKNK SVELKERIRE YLKGHYYVPL 490 500 510 520 530 540 LRAEETSSPV IGELWSPDQT AEASHVSRYG GSPRDPVLTL RAFAGPLSPA KAEDFRKLWK 550 560 570 580 590 600 TPPREKAGFL HHVKKSDPER GFERVGRELA HELGYPWVEY WEFLGCFVDL SSQEGLQRLE 610 620 630 640 EYLTQQEIGK KAQQETGERE ASCRDKATTS VEMRFHRIDQ AGLELLTS
	Isoform 3 [UniParc]. Checksum: 018D51B5FEA0E877	FASTA	293	31,982
	10 20 30 40 50 60 MSLEEIKNRQ NAARNNSPPT VGAFGHTRCS AFPLEQEADL IEAAEPGGPH SSRNGLCHPL 70 80 90 100 110 120 NHSRTLAGKR PKAPRGEEAH LPPVSDLTVE FDKLNLQNIG RSVSKTPDES TKTKDQILTS 130 140 150 160 170 180 RINAVERDLL EPSPADQLGN GHRRTESEMS ARIAKMSLSP SSPRHEDQLE VTREPARRLF 190 200 210 220 230 240 LFGEEPSKLD QDVLAALECA DVDPHQFPAV HRWKSAVLCY SPSDRQSWPS PAVKGRFKSQ 250 260 270 280 290 LPDLSGPHSY SPGRNSVAGS NPAKPGLGSP GRYSPVHGSQ LRRMARLAEL AAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 409-938 (ISOFORM 1). Tissue: Testis and Uterus.
[2]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 208-938 (ISOFORM 2), VARIANTS TYR-122 AND HIS-720. Tissue: Brain and Skin.
[4]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 156-938 (ISOFORM 1), VARIANT HIS-720. Tissue: Brain.
[5]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259; SER-268; SER-488; SER-496; SER-512; SER-662; SER-896 AND SER-914, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496 AND SER-662, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-662, MASS SPECTROMETRY.
[11]	"Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis." Asencio C., Davidson I.F., Santarella-Mellwig R., Ly-Hartig T.B., Mall M., Wallenfang M.R., Mattaj I.W., Gorjanacz M. Cell 150:122-135(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH BANF1 AND PROTEIN PHOSPHATASE 2A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK024061 mRNA. Translation: BAG51259.1. Different initiation. AK093451 mRNA. Translation: BAG52720.1. AK293028 mRNA. Translation: BAF85717.1. AC135586 Genomic DNA. No translation available. AC136467 Genomic DNA. No translation available. BC001530 mRNA. Translation: AAH01530.2. BC025347 mRNA. Translation: AAH25347.1. BC043157 mRNA. Translation: AAH43157.2. BC062373 mRNA. Translation: AAH62373.1. BC082962 mRNA. Translation: AAH82962.1. AB014592 mRNA. Translation: BAA31667.1.
IPI	IPI00329245. IPI00829741.
PIR	T00354.
RefSeq	NP_055929.1. NM_015114.1.
UniGene	Hs.654628.
3D structure databases
ProteinModelPortal	Q86XL3.
SMR	Q86XL3. Positions 412-456.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86XL3. 6 interactions.
MINT	MINT-1187128.
STRING	9606.ENSP00000350686.
PTM databases
PhosphoSite	Q86XL3.
Polymorphism databases
DMDM	269849748.
Proteomic databases
PaxDb	Q86XL3.
PRIDE	Q86XL3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000337516; ENSP00000337651; ENSG00000176915. ENST00000357997; ENSP00000350686; ENSG00000176915. ENST00000542282; ENSP00000437807; ENSG00000176915. ENST00000542657; ENSP00000438551; ENSG00000176915.
GeneID	23141.
KEGG	hsa:23141.
UCSC	uc001ukx.2. human. uc001uky.3. human.
Organism-specific databases
CTD	23141.
GeneCards	GC12M133302.
H-InvDB	HIX0020726.
HGNC	HGNC:29101. ANKLE2.
HPA	HPA003602.
neXtProt	NX_Q86XL3.
PharmGKB	PA162376532.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG83459.
HOGENOM	HOG000234326.
HOVERGEN	HBG096073.
InParanoid	Q86XL3.
OMA	HNVRKSD.
OrthoDB	EOG42JNQT.
Gene expression databases
ArrayExpress	Q86XL3.
Bgee	Q86XL3.
CleanEx	HS_ANKLE2.
Genevestigator	Q86XL3.
Family and domain databases
Gene3D	1.10.720.40. 1 hit. 1.25.40.20. 1 hit. 3.40.970.10. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR011015. LEM/LEM-like_dom. IPR003887. LEM_dom. IPR011320. RNase_H1_N. [Graphical view]
Pfam	PF13606. Ank_3. 1 hit. PF03020. LEM. 1 hit. [Graphical view]
SMART	SM00248. ANK. 2 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit. SSF63451. LEM_like. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. False negative. PS50088. ANK_REPEAT. False negative. PS50954. LEM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ANKLE2. human.
GenomeRNAi	23141.
NextBio	44418.

Entry information

Entry name

ANKL2_HUMAN

Accession

Primary (citable) accession number: Q86XL3
Secondary accession number(s): A8KAG3 , B3KN97, B3KSF8, O75176, Q6P6A5, Q8TAZ9, Q96DH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	November 24, 2009
Last modified:	May 1, 2013
This is version 87 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.