Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q86XL3

- ANKL2_HUMAN

UniProt

Q86XL3 - ANKL2_HUMAN

Protein

Ankyrin repeat and LEM domain-containing protein 2

Gene

ANKLE2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 4 (24 Nov 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein phosphatase 2A binding Source: UniProtKB
    3. protein phosphatase type 2A regulator activity Source: UniProtKB

    GO - Biological processi

    1. mitotic cell cycle Source: Reactome
    2. mitotic nuclear division Source: UniProtKB-KW
    3. mitotic nuclear envelope reassembly Source: UniProtKB
    4. negative regulation of phosphorylation Source: UniProtKB
    5. positive regulation of protein dephosphorylation Source: UniProtKB
    6. regulation of catalytic activity Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Enzyme and pathway databases

    ReactomeiREACT_160242. Initiation of Nuclear Envelope Reformation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat and LEM domain-containing protein 2
    Alternative name(s):
    LEM domain-containing protein 4
    Gene namesi
    Name:ANKLE2
    Synonyms:KIAA0692, LEM4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:29101. ANKLE2.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Single-pass type III membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. integral component of endoplasmic reticulum membrane Source: UniProtKB
    3. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162376532.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 938938Ankyrin repeat and LEM domain-containing protein 2PRO_0000280242Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei259 – 2591Phosphoserine1 Publication
    Modified residuei268 – 2681Phosphoserine1 Publication
    Modified residuei488 – 4881Phosphoserine1 Publication
    Modified residuei496 – 4961Phosphoserine2 Publications
    Modified residuei512 – 5121Phosphoserine1 Publication
    Modified residuei662 – 6621Phosphoserine3 Publications
    Modified residuei896 – 8961Phosphoserine1 Publication
    Modified residuei914 – 9141Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ86XL3.
    PaxDbiQ86XL3.
    PRIDEiQ86XL3.

    PTM databases

    PhosphoSiteiQ86XL3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86XL3.
    BgeeiQ86XL3.
    CleanExiHS_ANKLE2.
    GenevestigatoriQ86XL3.

    Organism-specific databases

    HPAiHPA003602.

    Interactioni

    Subunit structurei

    Interacts with BAF/BANF1. Interacts with protein phosphatase 2A (PP2A) components PPP2C (PPP2CA or PPP2CB) and PPP2R1A.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    vrk-1Q198482EBI-1773621,EBI-2414048From a different organism.

    Protein-protein interaction databases

    BioGridi116758. 7 interactions.
    IntActiQ86XL3. 8 interactions.
    MINTiMINT-1187128.
    STRINGi9606.ENSP00000350686.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86XL3.
    SMRiQ86XL3. Positions 412-456.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212LumenalSequence AnalysisAdd
    BLAST
    Topological domaini33 – 938906CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3220Helical; Signal-anchor for type III membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini69 – 11345LEMPROSITE-ProRule annotationAdd
    BLAST
    Repeati411 – 44030ANKAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ANKLE2 family.Curated
    Contains 1 ANK repeat.Curated
    Contains 1 LEM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG83459.
    HOGENOMiHOG000234326.
    HOVERGENiHBG096073.
    InParanoidiQ86XL3.
    OMAiCYIVDLY.
    OrthoDBiEOG7RBZ81.
    PhylomeDBiQ86XL3.
    TreeFamiTF317729.

    Family and domain databases

    Gene3Di1.10.720.40. 1 hit.
    1.25.40.20. 1 hit.
    3.40.970.10. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011015. LEM/LEM-like_dom.
    IPR003887. LEM_dom.
    IPR011320. RNase_H1_N.
    [Graphical view]
    PfamiPF13606. Ank_3. 1 hit.
    PF03020. LEM. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 2 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 2 hits.
    SSF63451. SSF63451. 1 hit.
    PROSITEiPS50954. LEM. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86XL3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLWPRLAAAE WAALAWELLG ASVLLIAVRW LVRRLGPRPG GLGRSGTPVP    50
    PPSAAAAPAS GEMTMDALLA RLKLLNPDDL REEIVKAGLK CGPITSTTRF 100
    IFEKKLAQAL LEQGGRLSSF YHHEAGVTAL SQDPQRILKP AEGNPTDQAG 150
    FSEDRDFGYS VGLNPPEEEA VTSKTCSVPP SDTDTYRAGA TASKEPPLYY 200
    GVCPVYEDVP ARNERIYVYE NKKEALQAVK MIKGSRFKAF STREDAEKFA 250
    RGICDYFPSP SKTSLPLSPV KTAPLFSNDR LKDGLCLSES ETVNKERANS 300
    YKNPRTQDLT AKLRKAVEKG EEDTFSDLIW SNPRYLIGSG DNPTIVQEGC 350
    RYNVMHVAAK ENQASICQLT LDVLENPDFM RLMYPDDDEA MLQKRIRYVV 400
    DLYLNTPDKM GYDTPLHFAC KFGNADVVNV LSSHHLIVKN SRNKYDKTPE 450
    DVICERSKNK SVELKERIRE YLKGHYYVPL LRAEETSSPV IGELWSPDQT 500
    AEASHVSRYG GSPRDPVLTL RAFAGPLSPA KAEDFRKLWK TPPREKAGFL 550
    HHVKKSDPER GFERVGRELA HELGYPWVEY WEFLGCFVDL SSQEGLQRLE 600
    EYLTQQEIGK KAQQETGERE ASCRDKATTS GSNSISVRAF LDEDDMSLEE 650
    IKNRQNAARN NSPPTVGAFG HTRCSAFPLE QEADLIEAAE PGGPHSSRNG 700
    LCHPLNHSRT LAGKRPKAPR GEEAHLPPVS DLTVEFDKLN LQNIGRSVSK 750
    TPDESTKTKD QILTSRINAV ERDLLEPSPA DQLGNGHRRT ESEMSARIAK 800
    MSLSPSSPRH EDQLEVTREP ARRLFLFGEE PSKLDQDVLA ALECADVDPH 850
    QFPAVHRWKS AVLCYSPSDR QSWPSPAVKG RFKSQLPDLS GPHSYSPGRN 900
    SVAGSNPAKP GLGSPGRYSP VHGSQLRRMA RLAELAAL 938
    Length:938
    Mass (Da):104,114
    Last modified:November 24, 2009 - v4
    Checksum:iED2F25F05E8106F2
    GO
    Isoform 2 (identifier: Q86XL3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         631-648: GSNSISVRAFLDEDDMSL → VEMRFHRIDQAGLELLTS
         649-938: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:648
    Mass (Da):72,641
    Checksum:iA98712EBEE04E982
    GO
    Isoform 3 (identifier: Q86XL3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-645: Missing.

    Show »
    Length:293
    Mass (Da):31,982
    Checksum:i018D51B5FEA0E877
    GO

    Sequence cautioni

    The sequence BAG51259.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti266 – 2661P → Q in AAH43157. (PubMed:15489334)Curated
    Sequence conflicti481 – 4811L → V in AAH43157. (PubMed:15489334)Curated
    Sequence conflicti647 – 6471S → N in AAH43157. (PubMed:15489334)Curated
    Sequence conflicti662 – 6621S → I in BAG52720. (PubMed:14702039)Curated
    Sequence conflicti680 – 6801E → K in BAG52720. (PubMed:14702039)Curated
    Sequence conflicti863 – 8631L → P in BAG51259. (PubMed:14702039)Curated
    Sequence conflicti891 – 8911G → A in BAG52720. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti122 – 1221H → Y.1 Publication
    Corresponds to variant rs1132375 [ dbSNP | Ensembl ].
    VAR_031097
    Natural varianti148 – 1481Q → E.
    Corresponds to variant rs7968520 [ dbSNP | Ensembl ].
    VAR_031098
    Natural varianti720 – 7201R → H.2 Publications
    Corresponds to variant rs10781634 [ dbSNP | Ensembl ].
    VAR_031099

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 645645Missing in isoform 3. 1 PublicationVSP_044173Add
    BLAST
    Alternative sequencei631 – 64818GSNSI…DDMSL → VEMRFHRIDQAGLELLTS in isoform 2. 1 PublicationVSP_023574Add
    BLAST
    Alternative sequencei649 – 938290Missing in isoform 2. 1 PublicationVSP_023575Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024061 mRNA. Translation: BAG51259.1. Different initiation.
    AK093451 mRNA. Translation: BAG52720.1.
    AK293028 mRNA. Translation: BAF85717.1.
    AC135586 Genomic DNA. No translation available.
    AC136467 Genomic DNA. No translation available.
    BC001530 mRNA. Translation: AAH01530.2.
    BC025347 mRNA. Translation: AAH25347.1.
    BC043157 mRNA. Translation: AAH43157.2.
    BC062373 mRNA. Translation: AAH62373.1.
    BC082962 mRNA. Translation: AAH82962.1.
    AB014592 mRNA. Translation: BAA31667.1.
    CCDSiCCDS41869.1. [Q86XL3-1]
    PIRiT00354.
    RefSeqiNP_055929.1. NM_015114.2. [Q86XL3-1]
    UniGeneiHs.654628.

    Genome annotation databases

    EnsembliENST00000357997; ENSP00000350686; ENSG00000176915. [Q86XL3-1]
    ENST00000542282; ENSP00000437807; ENSG00000176915. [Q86XL3-3]
    ENST00000542657; ENSP00000438551; ENSG00000176915. [Q86XL3-3]
    GeneIDi23141.
    KEGGihsa:23141.
    UCSCiuc001ukx.2. human. [Q86XL3-1]
    uc001uky.3. human. [Q86XL3-2]
    uc009zyw.1. human. [Q86XL3-3]

    Polymorphism databases

    DMDMi269849748.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024061 mRNA. Translation: BAG51259.1 . Different initiation.
    AK093451 mRNA. Translation: BAG52720.1 .
    AK293028 mRNA. Translation: BAF85717.1 .
    AC135586 Genomic DNA. No translation available.
    AC136467 Genomic DNA. No translation available.
    BC001530 mRNA. Translation: AAH01530.2 .
    BC025347 mRNA. Translation: AAH25347.1 .
    BC043157 mRNA. Translation: AAH43157.2 .
    BC062373 mRNA. Translation: AAH62373.1 .
    BC082962 mRNA. Translation: AAH82962.1 .
    AB014592 mRNA. Translation: BAA31667.1 .
    CCDSi CCDS41869.1. [Q86XL3-1 ]
    PIRi T00354.
    RefSeqi NP_055929.1. NM_015114.2. [Q86XL3-1 ]
    UniGenei Hs.654628.

    3D structure databases

    ProteinModelPortali Q86XL3.
    SMRi Q86XL3. Positions 412-456.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116758. 7 interactions.
    IntActi Q86XL3. 8 interactions.
    MINTi MINT-1187128.
    STRINGi 9606.ENSP00000350686.

    PTM databases

    PhosphoSitei Q86XL3.

    Polymorphism databases

    DMDMi 269849748.

    Proteomic databases

    MaxQBi Q86XL3.
    PaxDbi Q86XL3.
    PRIDEi Q86XL3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357997 ; ENSP00000350686 ; ENSG00000176915 . [Q86XL3-1 ]
    ENST00000542282 ; ENSP00000437807 ; ENSG00000176915 . [Q86XL3-3 ]
    ENST00000542657 ; ENSP00000438551 ; ENSG00000176915 . [Q86XL3-3 ]
    GeneIDi 23141.
    KEGGi hsa:23141.
    UCSCi uc001ukx.2. human. [Q86XL3-1 ]
    uc001uky.3. human. [Q86XL3-2 ]
    uc009zyw.1. human. [Q86XL3-3 ]

    Organism-specific databases

    CTDi 23141.
    GeneCardsi GC12M133302.
    H-InvDB HIX0020726.
    HGNCi HGNC:29101. ANKLE2.
    HPAi HPA003602.
    neXtProti NX_Q86XL3.
    PharmGKBi PA162376532.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83459.
    HOGENOMi HOG000234326.
    HOVERGENi HBG096073.
    InParanoidi Q86XL3.
    OMAi CYIVDLY.
    OrthoDBi EOG7RBZ81.
    PhylomeDBi Q86XL3.
    TreeFami TF317729.

    Enzyme and pathway databases

    Reactomei REACT_160242. Initiation of Nuclear Envelope Reformation.

    Miscellaneous databases

    ChiTaRSi ANKLE2. human.
    GenomeRNAii 23141.
    NextBioi 44418.
    PROi Q86XL3.

    Gene expression databases

    ArrayExpressi Q86XL3.
    Bgeei Q86XL3.
    CleanExi HS_ANKLE2.
    Genevestigatori Q86XL3.

    Family and domain databases

    Gene3Di 1.10.720.40. 1 hit.
    1.25.40.20. 1 hit.
    3.40.970.10. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011015. LEM/LEM-like_dom.
    IPR003887. LEM_dom.
    IPR011320. RNase_H1_N.
    [Graphical view ]
    Pfami PF13606. Ank_3. 1 hit.
    PF03020. LEM. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 2 hits.
    SSF63451. SSF63451. 1 hit.
    PROSITEi PS50954. LEM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 409-938 (ISOFORM 1).
      Tissue: Testis and Uterus.
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 208-938 (ISOFORM 2), VARIANTS TYR-122 AND HIS-720.
      Tissue: Brain and Skin.
    4. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 156-938 (ISOFORM 1), VARIANT HIS-720.
      Tissue: Brain.
    5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259; SER-268; SER-488; SER-496; SER-512; SER-662; SER-896 AND SER-914, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496 AND SER-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-662, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis."
      Asencio C., Davidson I.F., Santarella-Mellwig R., Ly-Hartig T.B., Mall M., Wallenfang M.R., Mattaj I.W., Gorjanacz M.
      Cell 150:122-135(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH BANF1 AND PROTEIN PHOSPHATASE 2A.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiANKL2_HUMAN
    AccessioniPrimary (citable) accession number: Q86XL3
    Secondary accession number(s): A8KAG3
    , B3KN97, B3KSF8, O75176, Q6P6A5, Q8TAZ9, Q96DH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 101 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3