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Protein

F-box only protein 11

Gene

FBXO11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.6 Publications

Caution

Isoform 2: Has been initially named PRMT9 and reported to act as an arginine methyltransferase that can catalyze the formation of omega-N monomethylarginine (MMA) as well as symmetrical and asymmetrical dimethylarginine (sDMA and aDMA), however no further works support these observations (PubMed:16487488). It should not be confused with official PRMT9 (AC Q6P2P2).1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri833 – 904UBR-typePROSITE-ProRule annotationAdd BLAST72

GO - Molecular functioni

GO - Biological processi

  • cellular protein modification process Source: HGNC
  • post-translational protein modification Source: Reactome
  • protein polyubiquitination Source: Reactome
  • protein ubiquitination Source: UniProtKB
  • sensory perception of sound Source: Ensembl
  • ubiquitin-dependent protein catabolic process Source: UniProtKB

Keywordsi

Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORiQ86XK2
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 11
Alternative name(s):
Protein arginine N-methyltransferase 9
Vitiligo-associated protein 1
Short name:
VIT-1
Gene namesi
Name:FBXO11
Synonyms:FBX11, PRMT9, VIT1
ORF Names:UG063H01
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138081.19
HGNCiHGNC:13590 FBXO11
MIMi607871 gene
neXtProtiNX_Q86XK2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in FBXO11 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL6, an oncoprotein that has a critical role in lymphomas.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi575Q → L: Greatly reduced ability to bind PRDM1 and reduced proteolysis of PRDM1. 1 Publication1

Organism-specific databases

DisGeNETi80204
OpenTargetsiENSG00000138081
Orphaneti3435 Vitiligo
PharmGKBiPA28031

Polymorphism and mutation databases

BioMutaiFBXO11
DMDMi124012093

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002735741 – 927F-box only protein 11Add BLAST927

Proteomic databases

MaxQBiQ86XK2
PaxDbiQ86XK2
PeptideAtlasiQ86XK2
PRIDEiQ86XK2
ProteomicsDBi70286
70287 [Q86XK2-2]
70288 [Q86XK2-3]
70289 [Q86XK2-4]
70290 [Q86XK2-5]

PTM databases

iPTMnetiQ86XK2
PhosphoSitePlusiQ86XK2

Expressioni

Tissue specificityi

Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.1 Publication

Developmental stagei

Protein levels increase during G1 and S phases to decline as cells progress through G2 to enter in G1 phase of the next cell cycle.1 Publication

Gene expression databases

BgeeiENSG00000138081
ExpressionAtlasiQ86XK2 baseline and differential
GenevisibleiQ86XK2 HS

Organism-specific databases

HPAiHPA002690

Interactioni

Subunit structurei

Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with p53/TP53, BCL6 and DTL (when not phosphorylated). Interacts with PRMD1.6 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123173, 63 interactors
CORUMiQ86XK2
DIPiDIP-35680N
IntActiQ86XK2, 16 interactors
MINTiQ86XK2
STRINGi9606.ENSP00000384823

Structurei

Secondary structure

1927
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi839 – 844Combined sources6
Beta strandi845 – 856Combined sources12
Helixi866 – 872Combined sources7
Beta strandi878 – 884Combined sources7
Turni889 – 893Combined sources5
Beta strandi895 – 897Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VMDX-ray2.20A/B/C/D833-904[»]
ProteinModelPortaliQ86XK2
SMRiQ86XK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 199F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati395 – 417PbH1 1Add BLAST23
Repeati418 – 440PbH1 2Add BLAST23
Repeati441 – 463PbH1 3Add BLAST23
Repeati464 – 486PbH1 4Add BLAST23
Repeati487 – 509PbH1 5Add BLAST23
Repeati510 – 532PbH1 6Add BLAST23
Repeati533 – 555PbH1 7Add BLAST23
Repeati556 – 578PbH1 8Add BLAST23
Repeati579 – 601PbH1 9Add BLAST23
Repeati602 – 624PbH1 10Add BLAST23
Repeati625 – 647PbH1 11Add BLAST23
Repeati648 – 670PbH1 12Add BLAST23
Repeati671 – 693PbH1 13Add BLAST23
Repeati694 – 716PbH1 14Add BLAST23
Repeati717 – 739PbH1 15Add BLAST23
Repeati740 – 762PbH1 16Add BLAST23
Repeati763 – 785PbH1 17Add BLAST23
Repeati786 – 808PbH1 18Add BLAST23
Repeati809 – 830PbH1 19Add BLAST22

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri833 – 904UBR-typePROSITE-ProRule annotationAdd BLAST72

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1777 Eukaryota
ENOG410YP8C LUCA
GeneTreeiENSGT00530000063425
HOGENOMiHOG000020584
HOVERGENiHBG051565
InParanoidiQ86XK2
KOiK10297
OMAiLMEQDLC
OrthoDBiEOG091G01YS
PhylomeDBiQ86XK2
TreeFamiTF313602

Family and domain databases

Gene3Di2.160.20.10, 3 hits
InterProiView protein in InterPro
IPR006633 Carb-bd_sugar_hydrolysis-dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR029799 FBX11/DRE-1
IPR007742 NosD_dom
IPR022441 Para_beta_helix_rpt-2
IPR006626 PbH1
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR003126 Znf_UBR
PANTHERiPTHR22990:SF20 PTHR22990:SF20, 1 hit
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF05048 NosD, 1 hit
PF02207 zf-UBR, 1 hit
SMARTiView protein in SMART
SM00722 CASH, 3 hits
SM00256 FBOX, 1 hit
SM00710 PbH1, 19 hits
SM00396 ZnF_UBR1, 1 hit
SUPFAMiSSF51126 SSF51126, 3 hits
SSF81383 SSF81383, 1 hit
TIGRFAMsiTIGR03804 para_beta_helix, 4 hits
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS51157 ZF_UBR, 1 hit

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86XK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSVRAANRR PRRVSRPRPV QQQQQQPPQQ PPPQPPQQQP PQQQPPPPPQ
60 70 80 90 100
QQQQQQPPPP PPPPPPLPQE RNNVGERDDD VPADMVAEES GPGAQNSPYQ
110 120 130 140 150
LRRKTLLPKR TACPTKNSME GASTSTTENF GHRAKRARVS GKSQDLSAAP
160 170 180 190 200
AEQYLQEKLP DEVVLKIFSY LLEQDLCRAA CVCKRFSELA NDPILWKRLY
210 220 230 240 250
MEVFEYTRPM MHPEPGKFYQ INPEEYEHPN PWKESFQQLY KGAHVKPGFA
260 270 280 290 300
EHFYSNPARY KGRENMLYYD TIEDALGGVQ EAHFDGLIFV HSGIYTDEWI
310 320 330 340 350
YIESPITMIG AAPGKVADKV IIENTRDSTF VFMEGSEDAY VGYMTIRFNP
360 370 380 390 400
DDKSAQHHNA HHCLEITVNC SPIIDHCIIR STCTVGSAVC VSGQGACPTI
410 420 430 440 450
KHCNISDCEN VGLYITDHAQ GIYEDNEISN NALAGIWVKN HGNPIIRRNH
460 470 480 490 500
IHHGRDVGVF TFDHGMGYFE SCNIHRNRIA GFEVKAYANP TVVRCEIHHG
510 520 530 540 550
QTGGIYVHEK GRGQFIENKI YANNFAGVWI TSNSDPTIRG NSIFNGNQGG
560 570 580 590 600
VYIFGDGRGL IEGNDIYGNA LAGIQIRTNS CPIVRHNKIH DGQHGGIYVH
610 620 630 640 650
EKGQGVIEEN EVYSNTLAGV WVTTGSTPVL RRNRIHSGKQ VGVYFYDNGH
660 670 680 690 700
GVLEDNDIYN HMYSGVQIRT GSNPKIRRNK IWGGQNGGIL VYNSGLGCIE
710 720 730 740 750
DNEIFDNAMA GVWIKTDSNP TLRRNKIHDG RDGGICIFNG GRGLLEENDI
760 770 780 790 800
FRNAQAGVLI STNSHPILRK NRIFDGFAAG IEITNHATAT LEGNQIFNNR
810 820 830 840 850
FGGLFLASGV NVTMKDNKIM NNQDAIEKAV SRGQCLYKIS SYTSYPMHDF
860 870 880 890 900
YRCHTCNTTD RNAICVNCIK KCHQGHDVEF IRHDRFFCDC GAGTLSNPCT
910 920
LAGEPTHDTD TLYDSAPPIE SNTLQHN
Length:927
Mass (Da):103,585
Last modified:January 23, 2007 - v3
Checksum:iCADBD23A6B892A78
GO
Isoform 2 (identifier: Q86XK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.
     744-770: LLEENDIFRNAQAGVLISTNSHPILRK → IVVNFALVKNPVFHYSSISLMINDIAN
     771-927: Missing.

Show »
Length:561
Mass (Da):62,418
Checksum:i53E2FF0C642059C6
GO
Isoform 6 (identifier: Q86XK2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:843
Mass (Da):94,056
Checksum:i242712732406F8FA
GO
Isoform 3 (identifier: Q86XK2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     670-927: Missing.

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):65,559
Checksum:i319A266C66D541B6
GO
Isoform 4 (identifier: Q86XK2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-211: KRLYMEVFEYTRPMM → LGEVAHAYNPSTLGG
     212-927: Missing.

Show »
Length:211
Mass (Da):23,441
Checksum:iEA62852C6C1C91E3
GO
Isoform 5 (identifier: Q86XK2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     885-885: R → RYVAHLLDILPNYFPPHFSNIWVSFCFR

Note: No experimental confirmation available.
Show »
Length:954
Mass (Da):106,864
Checksum:i1F8E7073B253AC2D
GO

Sequence cautioni

The sequence AAF76888 differs from that shown. Intron retention.Curated
The sequence AAN76518 differs from that shown. Reason: Frameshift at position 141.Curated
The sequence AAY24083 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB15143 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239L → S in BAB14214 (PubMed:14702039).Curated1
Sequence conflicti577R → G in AAN76518 (Ref. 2) Curated1
Sequence conflicti632R → G in BAD97312 (Ref. 3) Curated1
Sequence conflicti903G → S in AAV87312 (PubMed:17098746).Curated1
Sequence conflicti903G → S in AAH43258 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024441126T → S. Corresponds to variant dbSNP:rs17036993Ensembl.1
Natural variantiVAR_070073206Y → C Found in a patient with lymphoma. 1 Publication1
Natural variantiVAR_070074644Y → C Found in a lymphoma cell line; diminishes ubiquitin-mediated degradation of BCL6. 1 Publication1
Natural variantiVAR_070075684G → E Found in a patient with lymphoma; strongly diminishes ubiquitin-mediated degradation of BCL6. 1 Publication1
Natural variantiVAR_070076715K → N Found in a patient with lymphoma; strongly diminishes ubiquitin-mediated degradation of BCL6. 1 Publication1
Natural variantiVAR_070077715K → Q Found in a patient with lymphoma; almost abolishes ubiquitin-mediated degradation of BCL6. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0225741 – 209Missing in isoform 2. 1 PublicationAdd BLAST209
Alternative sequenceiVSP_0225731 – 84Missing in isoform 3 and isoform 6. 4 PublicationsAdd BLAST84
Alternative sequenceiVSP_008860197 – 211KRLYM…TRPMM → LGEVAHAYNPSTLGG in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_008861212 – 927Missing in isoform 4. 1 PublicationAdd BLAST716
Alternative sequenceiVSP_008862670 – 927Missing in isoform 3. 1 PublicationAdd BLAST258
Alternative sequenceiVSP_008863744 – 770LLEEN…PILRK → IVVNFALVKNPVFHYSSISL MINDIAN in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_008864771 – 927Missing in isoform 2. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_008865885R → RYVAHLLDILPNYFPPHFSN IWVSFCFR in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY827075 mRNA Translation: AAV87312.1
AF351618 mRNA Translation: AAN76518.1 Sequence problems.
AK223592 mRNA Translation: BAD97312.1
AK022735 mRNA Translation: BAB14214.1
AK025477 mRNA Translation: BAB15143.1 Different initiation.
AK292877 mRNA Translation: BAF85566.1
AC006509 Genomic DNA No translation available.
AC079807 Genomic DNA Translation: AAY24083.1 Sequence problems.
CH471053 Genomic DNA Translation: EAX00205.1
BC012728 mRNA Translation: AAH12728.2
BC043258 mRNA Translation: AAH43258.2
BC130445 mRNA Translation: AAI30446.1
BC136480 mRNA Translation: AAI36481.1
AF174599 mRNA Translation: AAF04520.1
AF176706 mRNA Translation: AAF17611.1
AL117620 mRNA Translation: CAB56019.1
AF264714 mRNA Translation: AAF76888.1 Sequence problems.
CCDSiCCDS1837.1 [Q86XK2-6]
CCDS54357.1 [Q86XK2-1]
PIRiT17329
RefSeqiNP_001177203.1, NM_001190274.1 [Q86XK2-1]
NP_079409.3, NM_025133.4 [Q86XK2-6]
XP_005264629.1, XM_005264572.4 [Q86XK2-5]
XP_016860506.1, XM_017005017.1 [Q86XK2-6]
UniGeneiHs.352677

Genome annotation databases

EnsembliENST00000402508; ENSP00000385398; ENSG00000138081 [Q86XK2-6]
ENST00000403359; ENSP00000384823; ENSG00000138081 [Q86XK2-1]
GeneIDi80204
KEGGihsa:80204
UCSCiuc002rwe.3 human [Q86XK2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFBX11_HUMAN
AccessioniPrimary (citable) accession number: Q86XK2
Secondary accession number(s): A1L491
, Q52ZP1, Q53EP7, Q53RT5, Q8IXG3, Q96E90, Q9H6V8, Q9H9L1, Q9NR14, Q9UFK1, Q9UHI1, Q9UKC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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