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Protein

F-box only protein 11

Gene

FBXO11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.6 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri833 – 904UBR-typePROSITE-ProRule annotationAdd BLAST72

GO - Molecular functioni

  • protein-arginine N-methyltransferase activity Source: BHF-UCL
  • ubiquitin-protein transferase activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cellular protein modification process Source: HGNC
  • protein ubiquitination Source: UniProtKB
  • sensory perception of sound Source: Ensembl
  • ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ86XK2.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 11
Alternative name(s):
Protein arginine N-methyltransferase 9
Vitiligo-associated protein 1
Short name:
VIT-1
Gene namesi
Name:FBXO11
Synonyms:FBX11, PRMT9, VIT1
ORF Names:UG063H01
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:13590. FBXO11.

Subcellular locationi

GO - Cellular componenti

  • chromosome Source: UniProtKB-SubCell
  • cytoplasm Source: HGNC
  • nucleolus Source: HPA
  • nucleus Source: HGNC
  • ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in FBXO11 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL6, an oncoprotein that has a critical role in lymphomas.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi575Q → L: Greatly reduced ability to bind PRDM1 and reduced proteolysis of PRDM1. 1 Publication1

Organism-specific databases

DisGeNETi80204.
OpenTargetsiENSG00000138081.
Orphaneti3435. Vitiligo.
PharmGKBiPA28031.

Polymorphism and mutation databases

BioMutaiFBXO11.
DMDMi124012093.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002735741 – 927F-box only protein 11Add BLAST927

Proteomic databases

MaxQBiQ86XK2.
PaxDbiQ86XK2.
PeptideAtlasiQ86XK2.
PRIDEiQ86XK2.

PTM databases

iPTMnetiQ86XK2.
PhosphoSitePlusiQ86XK2.

Expressioni

Tissue specificityi

Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.1 Publication

Developmental stagei

Protein levels increase during G1 and S phases to decline as cells progress through G2 to enter in G1 phase of the next cell cycle.1 Publication

Gene expression databases

BgeeiENSG00000138081.
ExpressionAtlasiQ86XK2. baseline and differential.
GenevisibleiQ86XK2. HS.

Organism-specific databases

HPAiHPA002690.

Interactioni

Subunit structurei

Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with p53/TP53, BCL6 and DTL (when not phosphorylated). Interacts with PRMD1.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632086EBI-1047804,EBI-307486
SNAI1O958636EBI-1047804,EBI-1045459
TP53P046374EBI-1047804,EBI-366083

Protein-protein interaction databases

BioGridi123173. 51 interactors.
DIPiDIP-35680N.
IntActiQ86XK2. 14 interactors.
STRINGi9606.ENSP00000384823.

Structurei

3D structure databases

ProteinModelPortaliQ86XK2.
SMRiQ86XK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 199F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati395 – 417PbH1 1Add BLAST23
Repeati418 – 440PbH1 2Add BLAST23
Repeati441 – 463PbH1 3Add BLAST23
Repeati464 – 486PbH1 4Add BLAST23
Repeati487 – 509PbH1 5Add BLAST23
Repeati510 – 532PbH1 6Add BLAST23
Repeati533 – 555PbH1 7Add BLAST23
Repeati556 – 578PbH1 8Add BLAST23
Repeati579 – 601PbH1 9Add BLAST23
Repeati602 – 624PbH1 10Add BLAST23
Repeati625 – 647PbH1 11Add BLAST23
Repeati648 – 670PbH1 12Add BLAST23
Repeati671 – 693PbH1 13Add BLAST23
Repeati694 – 716PbH1 14Add BLAST23
Repeati717 – 739PbH1 15Add BLAST23
Repeati740 – 762PbH1 16Add BLAST23
Repeati763 – 785PbH1 17Add BLAST23
Repeati786 – 808PbH1 18Add BLAST23
Repeati809 – 830PbH1 19Add BLAST22

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 19 PbH1 repeats.Curated
Contains 1 UBR-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri833 – 904UBR-typePROSITE-ProRule annotationAdd BLAST72

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1777. Eukaryota.
ENOG410YP8C. LUCA.
GeneTreeiENSGT00530000063425.
HOGENOMiHOG000020584.
HOVERGENiHBG051565.
InParanoidiQ86XK2.
KOiK10297.
OMAiSHHKHYC.
OrthoDBiEOG091G01YS.
PhylomeDBiQ86XK2.
TreeFamiTF313602.

Family and domain databases

Gene3Di2.160.20.10. 4 hits.
InterProiIPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR029799. FBX11/DRE-1.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
IPR003126. Znf_UBR.
[Graphical view]
PANTHERiPTHR22990:SF20. PTHR22990:SF20. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
PF05048. NosD. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 19 hits.
SM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 3 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR03804. para_beta_helix. 4 hits.
PROSITEiPS50181. FBOX. 1 hit.
PS51157. ZF_UBR. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86XK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSVRAANRR PRRVSRPRPV QQQQQQPPQQ PPPQPPQQQP PQQQPPPPPQ
60 70 80 90 100
QQQQQQPPPP PPPPPPLPQE RNNVGERDDD VPADMVAEES GPGAQNSPYQ
110 120 130 140 150
LRRKTLLPKR TACPTKNSME GASTSTTENF GHRAKRARVS GKSQDLSAAP
160 170 180 190 200
AEQYLQEKLP DEVVLKIFSY LLEQDLCRAA CVCKRFSELA NDPILWKRLY
210 220 230 240 250
MEVFEYTRPM MHPEPGKFYQ INPEEYEHPN PWKESFQQLY KGAHVKPGFA
260 270 280 290 300
EHFYSNPARY KGRENMLYYD TIEDALGGVQ EAHFDGLIFV HSGIYTDEWI
310 320 330 340 350
YIESPITMIG AAPGKVADKV IIENTRDSTF VFMEGSEDAY VGYMTIRFNP
360 370 380 390 400
DDKSAQHHNA HHCLEITVNC SPIIDHCIIR STCTVGSAVC VSGQGACPTI
410 420 430 440 450
KHCNISDCEN VGLYITDHAQ GIYEDNEISN NALAGIWVKN HGNPIIRRNH
460 470 480 490 500
IHHGRDVGVF TFDHGMGYFE SCNIHRNRIA GFEVKAYANP TVVRCEIHHG
510 520 530 540 550
QTGGIYVHEK GRGQFIENKI YANNFAGVWI TSNSDPTIRG NSIFNGNQGG
560 570 580 590 600
VYIFGDGRGL IEGNDIYGNA LAGIQIRTNS CPIVRHNKIH DGQHGGIYVH
610 620 630 640 650
EKGQGVIEEN EVYSNTLAGV WVTTGSTPVL RRNRIHSGKQ VGVYFYDNGH
660 670 680 690 700
GVLEDNDIYN HMYSGVQIRT GSNPKIRRNK IWGGQNGGIL VYNSGLGCIE
710 720 730 740 750
DNEIFDNAMA GVWIKTDSNP TLRRNKIHDG RDGGICIFNG GRGLLEENDI
760 770 780 790 800
FRNAQAGVLI STNSHPILRK NRIFDGFAAG IEITNHATAT LEGNQIFNNR
810 820 830 840 850
FGGLFLASGV NVTMKDNKIM NNQDAIEKAV SRGQCLYKIS SYTSYPMHDF
860 870 880 890 900
YRCHTCNTTD RNAICVNCIK KCHQGHDVEF IRHDRFFCDC GAGTLSNPCT
910 920
LAGEPTHDTD TLYDSAPPIE SNTLQHN
Length:927
Mass (Da):103,585
Last modified:January 23, 2007 - v3
Checksum:iCADBD23A6B892A78
GO
Isoform 2 (identifier: Q86XK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.
     744-770: LLEENDIFRNAQAGVLISTNSHPILRK → IVVNFALVKNPVFHYSSISLMINDIAN
     771-927: Missing.

Show »
Length:561
Mass (Da):62,418
Checksum:i53E2FF0C642059C6
GO
Isoform 6 (identifier: Q86XK2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:843
Mass (Da):94,056
Checksum:i242712732406F8FA
GO
Isoform 3 (identifier: Q86XK2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     670-927: Missing.

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):65,559
Checksum:i319A266C66D541B6
GO
Isoform 4 (identifier: Q86XK2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-211: KRLYMEVFEYTRPMM → LGEVAHAYNPSTLGG
     212-927: Missing.

Show »
Length:211
Mass (Da):23,441
Checksum:iEA62852C6C1C91E3
GO
Isoform 5 (identifier: Q86XK2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     885-885: R → RYVAHLLDILPNYFPPHFSNIWVSFCFR

Note: No experimental confirmation available.
Show »
Length:954
Mass (Da):106,864
Checksum:i1F8E7073B253AC2D
GO

Sequence cautioni

The sequence AAF76888 differs from that shown. Intron retention.Curated
The sequence AAN76518 differs from that shown. Reason: Frameshift at position 141.Curated
The sequence AAY24083 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB15143 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239L → S in BAB14214 (PubMed:14702039).Curated1
Sequence conflicti577R → G in AAN76518 (Ref. 2) Curated1
Sequence conflicti632R → G in BAD97312 (Ref. 3) Curated1
Sequence conflicti903G → S in AAV87312 (PubMed:17098746).Curated1
Sequence conflicti903G → S in AAH43258 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024441126T → S.Corresponds to variant rs17036993dbSNPEnsembl.1
Natural variantiVAR_070073206Y → C Found in a patient with lymphoma. 1 Publication1
Natural variantiVAR_070074644Y → C Found in a lymphoma cell line; diminishes ubiquitin-mediated degradation of BCL6. 1 Publication1
Natural variantiVAR_070075684G → E Found in a patient with lymphoma; strongly diminishes ubiquitin-mediated degradation of BCL6. 1 Publication1
Natural variantiVAR_070076715K → N Found in a patient with lymphoma; strongly diminishes ubiquitin-mediated degradation of BCL6. 1 Publication1
Natural variantiVAR_070077715K → Q Found in a patient with lymphoma; almost abolishes ubiquitin-mediated degradation of BCL6. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0225741 – 209Missing in isoform 2. 1 PublicationAdd BLAST209
Alternative sequenceiVSP_0225731 – 84Missing in isoform 3 and isoform 6. 4 PublicationsAdd BLAST84
Alternative sequenceiVSP_008860197 – 211KRLYM…TRPMM → LGEVAHAYNPSTLGG in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_008861212 – 927Missing in isoform 4. 1 PublicationAdd BLAST716
Alternative sequenceiVSP_008862670 – 927Missing in isoform 3. 1 PublicationAdd BLAST258
Alternative sequenceiVSP_008863744 – 770LLEEN…PILRK → IVVNFALVKNPVFHYSSISL MINDIAN in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_008864771 – 927Missing in isoform 2. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_008865885R → RYVAHLLDILPNYFPPHFSN IWVSFCFR in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY827075 mRNA. Translation: AAV87312.1.
AF351618 mRNA. Translation: AAN76518.1. Sequence problems.
AK223592 mRNA. Translation: BAD97312.1.
AK022735 mRNA. Translation: BAB14214.1.
AK025477 mRNA. Translation: BAB15143.1. Different initiation.
AK292877 mRNA. Translation: BAF85566.1.
AC006509 Genomic DNA. No translation available.
AC079807 Genomic DNA. Translation: AAY24083.1. Sequence problems.
CH471053 Genomic DNA. Translation: EAX00205.1.
BC012728 mRNA. Translation: AAH12728.2.
BC043258 mRNA. Translation: AAH43258.2.
BC130445 mRNA. Translation: AAI30446.1.
BC136480 mRNA. Translation: AAI36481.1.
AF174599 mRNA. Translation: AAF04520.1.
AF176706 mRNA. Translation: AAF17611.1.
AL117620 mRNA. Translation: CAB56019.1.
AF264714 mRNA. Translation: AAF76888.1. Sequence problems.
CCDSiCCDS1837.1. [Q86XK2-6]
CCDS54357.1. [Q86XK2-1]
PIRiT17329.
RefSeqiNP_001177203.1. NM_001190274.1. [Q86XK2-1]
NP_079409.3. NM_025133.4. [Q86XK2-6]
XP_005264629.1. XM_005264572.4. [Q86XK2-5]
XP_016860506.1. XM_017005017.1. [Q86XK2-6]
UniGeneiHs.352677.

Genome annotation databases

EnsembliENST00000402508; ENSP00000385398; ENSG00000138081. [Q86XK2-6]
ENST00000403359; ENSP00000384823; ENSG00000138081. [Q86XK2-1]
GeneIDi80204.
KEGGihsa:80204.
UCSCiuc002rwe.3. human. [Q86XK2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY827075 mRNA. Translation: AAV87312.1.
AF351618 mRNA. Translation: AAN76518.1. Sequence problems.
AK223592 mRNA. Translation: BAD97312.1.
AK022735 mRNA. Translation: BAB14214.1.
AK025477 mRNA. Translation: BAB15143.1. Different initiation.
AK292877 mRNA. Translation: BAF85566.1.
AC006509 Genomic DNA. No translation available.
AC079807 Genomic DNA. Translation: AAY24083.1. Sequence problems.
CH471053 Genomic DNA. Translation: EAX00205.1.
BC012728 mRNA. Translation: AAH12728.2.
BC043258 mRNA. Translation: AAH43258.2.
BC130445 mRNA. Translation: AAI30446.1.
BC136480 mRNA. Translation: AAI36481.1.
AF174599 mRNA. Translation: AAF04520.1.
AF176706 mRNA. Translation: AAF17611.1.
AL117620 mRNA. Translation: CAB56019.1.
AF264714 mRNA. Translation: AAF76888.1. Sequence problems.
CCDSiCCDS1837.1. [Q86XK2-6]
CCDS54357.1. [Q86XK2-1]
PIRiT17329.
RefSeqiNP_001177203.1. NM_001190274.1. [Q86XK2-1]
NP_079409.3. NM_025133.4. [Q86XK2-6]
XP_005264629.1. XM_005264572.4. [Q86XK2-5]
XP_016860506.1. XM_017005017.1. [Q86XK2-6]
UniGeneiHs.352677.

3D structure databases

ProteinModelPortaliQ86XK2.
SMRiQ86XK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123173. 51 interactors.
DIPiDIP-35680N.
IntActiQ86XK2. 14 interactors.
STRINGi9606.ENSP00000384823.

PTM databases

iPTMnetiQ86XK2.
PhosphoSitePlusiQ86XK2.

Polymorphism and mutation databases

BioMutaiFBXO11.
DMDMi124012093.

Proteomic databases

MaxQBiQ86XK2.
PaxDbiQ86XK2.
PeptideAtlasiQ86XK2.
PRIDEiQ86XK2.

Protocols and materials databases

DNASUi80204.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402508; ENSP00000385398; ENSG00000138081. [Q86XK2-6]
ENST00000403359; ENSP00000384823; ENSG00000138081. [Q86XK2-1]
GeneIDi80204.
KEGGihsa:80204.
UCSCiuc002rwe.3. human. [Q86XK2-1]

Organism-specific databases

CTDi80204.
DisGeNETi80204.
GeneCardsiFBXO11.
H-InvDBHIX0002044.
HGNCiHGNC:13590. FBXO11.
HPAiHPA002690.
MIMi607871. gene.
neXtProtiNX_Q86XK2.
OpenTargetsiENSG00000138081.
Orphaneti3435. Vitiligo.
PharmGKBiPA28031.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1777. Eukaryota.
ENOG410YP8C. LUCA.
GeneTreeiENSGT00530000063425.
HOGENOMiHOG000020584.
HOVERGENiHBG051565.
InParanoidiQ86XK2.
KOiK10297.
OMAiSHHKHYC.
OrthoDBiEOG091G01YS.
PhylomeDBiQ86XK2.
TreeFamiTF313602.

Enzyme and pathway databases

UniPathwayiUPA00143.
SIGNORiQ86XK2.

Miscellaneous databases

ChiTaRSiFBXO11. human.
GeneWikiiFBXO11.
GenomeRNAii80204.
PROiQ86XK2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138081.
ExpressionAtlasiQ86XK2. baseline and differential.
GenevisibleiQ86XK2. HS.

Family and domain databases

Gene3Di2.160.20.10. 4 hits.
InterProiIPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR029799. FBX11/DRE-1.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
IPR003126. Znf_UBR.
[Graphical view]
PANTHERiPTHR22990:SF20. PTHR22990:SF20. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
PF05048. NosD. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 19 hits.
SM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 3 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR03804. para_beta_helix. 4 hits.
PROSITEiPS50181. FBOX. 1 hit.
PS51157. ZF_UBR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX11_HUMAN
AccessioniPrimary (citable) accession number: Q86XK2
Secondary accession number(s): A1L491
, Q52ZP1, Q53EP7, Q53RT5, Q8IXG3, Q96E90, Q9H6V8, Q9H9L1, Q9NR14, Q9UFK1, Q9UHI1, Q9UKC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Isoform 2: Has been initially named PRMT9 and reported to act as an arginine methyltransferase that can catalyze the formation of omega-N monomethylarginine (MMA) as well as symmetrical and asymmetrical dimethylarginine (sDMA and aDMA), however no further works support these observations (PubMed:16487488). It should not be confused with official PRMT9 (AC Q6P2P2).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.