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Protein

GAS2-like protein 3

Gene

GAS2L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • microtubule binding Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • microtubule cytoskeleton organization Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GAS2-like protein 3
Alternative name(s):
Growth arrest-specific protein 2-like 3
Gene namesi
Name:GAS2L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:27475. GAS2L3.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cytoplasmcytoskeleton 1 Publication

  • Note: Localizes to microtubule and actin cytoskeletons.

GO - Cellular componenti

  • actin cytoskeleton Source: UniProtKB
  • cytoplasm Source: UniProtKB-SubCell
  • microtubule Source: UniProtKB-KW
  • microtubule cytoskeleton Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139354.
PharmGKBiPA134979032.

Polymorphism and mutation databases

BioMutaiGAS2L3.
DMDMi73919616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904461 – 694GAS2-like protein 3Add BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei441PhosphothreonineCombined sources1
Modified residuei570PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86XJ1.
MaxQBiQ86XJ1.
PaxDbiQ86XJ1.
PeptideAtlasiQ86XJ1.
PRIDEiQ86XJ1.

PTM databases

iPTMnetiQ86XJ1.
PhosphoSitePlusiQ86XJ1.

Expressioni

Tissue specificityi

Expressed in the pancreas, heart, liver, placenta, brain, skeletal muscle, kidney and lung.1 Publication

Gene expression databases

BgeeiENSG00000139354.
CleanExiHS_GAS2L3.
ExpressionAtlasiQ86XJ1. baseline and differential.
GenevisibleiQ86XJ1. HS.

Organism-specific databases

HPAiHPA048593.

Interactioni

Subunit structurei

Interacts (via CH domain) with F-actin. Interacts (via C terminus) with microtubules.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AURKBQ96GD44EBI-9248152,EBI-624291
BIRC5O153924EBI-9248152,EBI-518823
CDCA8Q53HL22EBI-9248152,EBI-979174

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • microtubule binding Source: UniProtKB

Protein-protein interaction databases

BioGridi129559. 14 interactors.
IntActiQ86XJ1. 6 interactors.
MINTiMINT-4994683.
STRINGi9606.ENSP00000266754.

Structurei

3D structure databases

ProteinModelPortaliQ86XJ1.
SMRiQ86XJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 168CHPROSITE-ProRule annotationAdd BLAST121
Domaini208 – 281GARPROSITE-ProRule annotationAdd BLAST74

Domaini

The GAR domain modulates the binding strength to each cytoskeletal network.1 Publication

Sequence similaritiesi

Belongs to the GAS2 family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 GAR domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQBS. Eukaryota.
ENOG410Z7C5. LUCA.
GeneTreeiENSGT00390000002205.
HOGENOMiHOG000059643.
HOVERGENiHBG005805.
InParanoidiQ86XJ1.
OMAiCRILQFA.
OrthoDBiEOG091G0PJ6.
PhylomeDBiQ86XJ1.
TreeFamiTF323754.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
3.30.920.20. 1 hit.
InterProiIPR001715. CH-domain.
IPR029932. GAS2L3.
IPR003108. GAS_dom.
[Graphical view]
PANTHERiPTHR11915:SF256. PTHR11915:SF256. 1 hit.
PfamiPF00307. CH. 1 hit.
PF02187. GAS2. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00243. GAS2. 1 hit.
[Graphical view]
SUPFAMiSSF143575. SSF143575. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51460. GAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86XJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPAIQVWFG EDLPLSPRSP LTPRHGPGLA NVCQYDEWIA VRHEATLLPM
60 70 80 90 100
QEDLSIWLSG LLGIKVKAEK LLEELDNGVL LCQLIDVLQN MVKTCNSEES
110 120 130 140 150
GNFPMRKVPC KKDAASGSFF ARDNTANFLH WCRDIGVDET YLFESEGLVL
160 170 180 190 200
HKDPRQVYLC LLEIGRIVSR YGVEPPVLVK LEKEIELEET LLNTSGPEDS
210 220 230 240 250
ISIPKSCCRH EELHEAVKHI AEDPPCSCSH RFSIEYLSEG RYRLGDKILF
260 270 280 290 300
IRMLHGKHVM VRVGGGWDTL QGFLLKYDPC RILQFATLEQ KILAFQKGVS
310 320 330 340 350
NESVPDSPAR TPQPPEMNPL SAVNMFQKQN SKPSVPVSIP KSKEKQGRPP
360 370 380 390 400
GALVPASSLK GGNLGSMSVR SKLPNSPAAS SHPKLKSSKG ITKKPQAPSN
410 420 430 440 450
NASSSLASLN PVGKNTSSPA LPRTAPCISE SPRKCISSPN TPKAKVIPAQ
460 470 480 490 500
NSADLPESTL LPNKCSGKTQ PKYLKHNHIS SRDNAVSHLA AHSNSSSKCP
510 520 530 540 550
KLPKANIPVR PKPSFQSSAK MTKTSSKTIA TGLGTQSQPS DGAPQAKPVP
560 570 580 590 600
AQKLKSALNL NQPVSVSSVS PVKATQKSKD KNIVSATKKQ PQNKSAFQKT
610 620 630 640 650
GPSSLKSPGR TPLSIVSLPQ SSTKTQTAPK SAQTVAKSQH STKGPPRSGK
660 670 680 690
TPASIRKPPS SVKDADSGDK KPTAKKKEDD DHYFVMTGSK KPRK
Length:694
Mass (Da):75,214
Last modified:June 1, 2003 - v1
Checksum:iFF20533B5A0D4844
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033944461L → S.Corresponds to variant rs11834625dbSNPEnsembl.1
Natural variantiVAR_033945500P → T.Corresponds to variant rs17030365dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315189 mRNA. Translation: BAG37629.1.
CH471054 Genomic DNA. Translation: EAW97641.1.
BC043366 mRNA. Translation: AAH43366.1.
CCDSiCCDS9079.1.
RefSeqiNP_001290059.1. NM_001303130.1.
NP_777602.1. NM_174942.2.
XP_005268861.1. XM_005268804.3.
XP_011536521.1. XM_011538219.2.
XP_011536522.1. XM_011538220.2.
XP_011536523.1. XM_011538221.2.
XP_016874695.1. XM_017019206.1.
UniGeneiHs.20575.
Hs.547389.

Genome annotation databases

EnsembliENST00000266754; ENSP00000266754; ENSG00000139354.
ENST00000539410; ENSP00000439672; ENSG00000139354.
ENST00000547754; ENSP00000448955; ENSG00000139354.
GeneIDi283431.
KEGGihsa:283431.
UCSCiuc001thu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315189 mRNA. Translation: BAG37629.1.
CH471054 Genomic DNA. Translation: EAW97641.1.
BC043366 mRNA. Translation: AAH43366.1.
CCDSiCCDS9079.1.
RefSeqiNP_001290059.1. NM_001303130.1.
NP_777602.1. NM_174942.2.
XP_005268861.1. XM_005268804.3.
XP_011536521.1. XM_011538219.2.
XP_011536522.1. XM_011538220.2.
XP_011536523.1. XM_011538221.2.
XP_016874695.1. XM_017019206.1.
UniGeneiHs.20575.
Hs.547389.

3D structure databases

ProteinModelPortaliQ86XJ1.
SMRiQ86XJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129559. 14 interactors.
IntActiQ86XJ1. 6 interactors.
MINTiMINT-4994683.
STRINGi9606.ENSP00000266754.

PTM databases

iPTMnetiQ86XJ1.
PhosphoSitePlusiQ86XJ1.

Polymorphism and mutation databases

BioMutaiGAS2L3.
DMDMi73919616.

Proteomic databases

EPDiQ86XJ1.
MaxQBiQ86XJ1.
PaxDbiQ86XJ1.
PeptideAtlasiQ86XJ1.
PRIDEiQ86XJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266754; ENSP00000266754; ENSG00000139354.
ENST00000539410; ENSP00000439672; ENSG00000139354.
ENST00000547754; ENSP00000448955; ENSG00000139354.
GeneIDi283431.
KEGGihsa:283431.
UCSCiuc001thu.4. human.

Organism-specific databases

CTDi283431.
GeneCardsiGAS2L3.
H-InvDBHIX0018956.
HGNCiHGNC:27475. GAS2L3.
HPAiHPA048593.
neXtProtiNX_Q86XJ1.
OpenTargetsiENSG00000139354.
PharmGKBiPA134979032.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQBS. Eukaryota.
ENOG410Z7C5. LUCA.
GeneTreeiENSGT00390000002205.
HOGENOMiHOG000059643.
HOVERGENiHBG005805.
InParanoidiQ86XJ1.
OMAiCRILQFA.
OrthoDBiEOG091G0PJ6.
PhylomeDBiQ86XJ1.
TreeFamiTF323754.

Miscellaneous databases

ChiTaRSiGAS2L3. human.
GenomeRNAii283431.
PROiQ86XJ1.

Gene expression databases

BgeeiENSG00000139354.
CleanExiHS_GAS2L3.
ExpressionAtlasiQ86XJ1. baseline and differential.
GenevisibleiQ86XJ1. HS.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
3.30.920.20. 1 hit.
InterProiIPR001715. CH-domain.
IPR029932. GAS2L3.
IPR003108. GAS_dom.
[Graphical view]
PANTHERiPTHR11915:SF256. PTHR11915:SF256. 1 hit.
PfamiPF00307. CH. 1 hit.
PF02187. GAS2. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00243. GAS2. 1 hit.
[Graphical view]
SUPFAMiSSF143575. SSF143575. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51460. GAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGA2L3_HUMAN
AccessioniPrimary (citable) accession number: Q86XJ1
Secondary accession number(s): B2RCN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.