ID   ZSWM9_HUMAN             Reviewed;         627 AA.
AC   Q86XI8; A0A087WWL5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   27-MAR-2024, entry version 127.
DE   RecName: Full=Uncharacterized protein ZSWIM9;
GN   Name=ZSWIM9 {ECO:0000312|HGNC:HGNC:34495}; Synonyms=C19orf68;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-807 (ISOFORM 2), AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=28112733; DOI=10.1038/nsmb.3366;
RA   Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA   Nielsen M.L.;
RT   "Site-specific mapping of the human SUMO proteome reveals co-modification
RT   with phosphorylation.";
RL   Nat. Struct. Mol. Biol. 24:325-336(2017).
CC   -!- INTERACTION:
CC       Q86XI8; P17275: JUNB; NbExp=2; IntAct=EBI-2682158, EBI-748062;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q86XI8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q86XI8-2; Sequence=VSP_059340;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH43386.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AC011466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC043386; AAH43386.1; ALT_INIT; mRNA.
DR   CCDS; CCDS74411.1; -. [Q86XI8-2]
DR   RefSeq; NP_955373.3; NM_199341.3. [Q86XI8-2]
DR   RefSeq; XP_006723268.1; XM_006723205.2. [Q86XI8-2]
DR   AlphaFoldDB; Q86XI8; -.
DR   BioGRID; 131938; 20.
DR   IntAct; Q86XI8; 10.
DR   MINT; Q86XI8; -.
DR   STRING; 9606.ENSP00000480314; -.
DR   iPTMnet; Q86XI8; -.
DR   PhosphoSitePlus; Q86XI8; -.
DR   BioMuta; ZSWIM9; -.
DR   DMDM; 189046910; -.
DR   EPD; Q86XI8; -.
DR   jPOST; Q86XI8; -.
DR   MassIVE; Q86XI8; -.
DR   MaxQB; Q86XI8; -.
DR   PaxDb; 9606-ENSP00000480314; -.
DR   PeptideAtlas; Q86XI8; -.
DR   ProteomicsDB; 70282; -.
DR   Antibodypedia; 68326; 16 antibodies from 8 providers.
DR   DNASU; 374920; -.
DR   Ensembl; ENST00000328759.11; ENSP00000331363.7; ENSG00000185453.13. [Q86XI8-1]
DR   Ensembl; ENST00000614654.2; ENSP00000480314.1; ENSG00000185453.13. [Q86XI8-2]
DR   GeneID; 374920; -.
DR   KEGG; hsa:374920; -.
DR   MANE-Select; ENST00000614654.2; ENSP00000480314.1; NM_199341.4; NP_955373.3. [Q86XI8-2]
DR   UCSC; uc061aqx.1; human. [Q86XI8-1]
DR   AGR; HGNC:34495; -.
DR   CTD; 374920; -.
DR   DisGeNET; 374920; -.
DR   GeneCards; ZSWIM9; -.
DR   HGNC; HGNC:34495; ZSWIM9.
DR   HPA; ENSG00000185453; Tissue enhanced (brain).
DR   neXtProt; NX_Q86XI8; -.
DR   OpenTargets; ENSG00000185453; -.
DR   VEuPathDB; HostDB:ENSG00000185453; -.
DR   eggNOG; ENOG502QUUY; Eukaryota.
DR   GeneTree; ENSGT00390000011694; -.
DR   HOGENOM; CLU_450996_0_0_1; -.
DR   InParanoid; Q86XI8; -.
DR   OMA; RIWPLLC; -.
DR   OrthoDB; 5314578at2759; -.
DR   PhylomeDB; Q86XI8; -.
DR   TreeFam; TF337793; -.
DR   PathwayCommons; Q86XI8; -.
DR   SignaLink; Q86XI8; -.
DR   BioGRID-ORCS; 374920; 7 hits in 295 CRISPR screens.
DR   ChiTaRS; C19orf68; human.
DR   GenomeRNAi; 374920; -.
DR   Pharos; Q86XI8; Tdark.
DR   PRO; PR:Q86XI8; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q86XI8; Protein.
DR   Bgee; ENSG00000185453; Expressed in tendon of biceps brachii and 186 other cell types or tissues.
DR   InterPro; IPR049218; DUF5575_C.
DR   InterPro; IPR049217; DUF5575_N.
DR   InterPro; IPR040854; ZSWIM9.
DR   InterPro; IPR048315; ZSWIM9_RNaseH-like.
DR   PANTHER; PTHR47086; BTB DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47086:SF1; ZINC FINGER SWIM-TYPE-CONTAINING 9; 1.
DR   Pfam; PF17738; DUF5575; 1.
DR   Pfam; PF20784; DUF5575_C; 1.
DR   Pfam; PF20783; DUF5575_N; 1.
DR   Genevisible; Q86XI8; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Isopeptide bond; Reference proteome; Ubl conjugation.
FT   CHAIN           1..627
FT                   /note="Uncharacterized protein ZSWIM9"
FT                   /id="PRO_0000322596"
FT   REGION          441..466
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          608..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         619..627
FT                   /note="GKGESTEDR -> VRSLEGSPWRGAQLHDERAGGLRTAEWKGPQSEVEKGRG
FT                   LEVRNLRGIPLEKSLELAPENGDQRGPQWEDERRRGPEIAEERGARVGVKRRRGLEDIV
FT                   LVQLGDTRVTGMENGDGGGARSVGPKSRAGRGMEWGDAGGRCLGLGNGVVSGTPVGTVL
FT                   EGSPEWAAARSEHLAAGDGLQEGGEDGPREPKRLCRPPGEEEVDWEPLAKFRAACGPEL
FT                   ADLVAEELAFARQHGTRGFHWTGAGFALKDGTSDFFLDGALTRCSCSIHAARRLPCRHL
FT                   FAARLLTGAALFHMDLLRDCWGRAPEP (in isoform 2)"
FT                   /id="VSP_059340"
FT   CROSSLNK        Q86XI8-2:807
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:28112733"
SQ   SEQUENCE   627 AA;  70073 MW;  84D0F5AFC0478DBD CRC64;
     MERPEPPPGT AAGQEEQELR ERAFFSWAEF SRFFDAWCQQ RLALFFVKSS MHLARCRWAS
     APPLYTLIDV LKYSYVRLVC KDVRAPSRPA VGPPQPGCPA FIIVKLSPLR DRLVVTECQL
     THSHPACPLE FAYYFRPGHL LANACLPVRT TNKISKQFVA PADVRRLLSY CKGRDHGVLD
     ALHVLEGLFR TDPEAKVKLV FVEDQAVVET VFFLTSRTRA LLRRFPRMLL VDRLPGLQGA
     LDLLAVLCVD GSGRARQAAC CVARPGTPSL LRFALASLLQ SAPDVKGRVR CLTAGPEVAA
     QLPAVRQLLP CARVQICRAQ GLETLFSKAQ ELGGAGREDP GLWSRLCRLA GASSPAAYDE
     ALAELHAHGP AAFVDYFERN WEPRRDMWVR FRAFEAARDL DACALVRGHR RRLLRRLSPS
     RGVAQCLRDL VAMQWADAAG EAVPEGPDGG GPWLEDEPGR GAQGENERVR GLETGDWGGA
     PKEGSIWRGA QMEKEWARAL ETRDWGGAQF EGEKGRALQI RDWRGGRLEN QKPRGLEGGV
     LRGSKLEKGH LRGPEIRDWR GPQLEGEKDW GLEGYVWRGS QLEDQALRGL EGYTWRVAQL
     EDRRSTTDLR GTQFDYERGK GESTEDR
//