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Protein

Uncharacterized protein C19orf68

Gene

C19orf68

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. multicellular organismal development Source: InterPro
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C19orf68
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:34495. C19orf68.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Uncharacterized protein C19orf68PRO_0000322596Add
BLAST

Proteomic databases

MaxQBiQ86XI8.
PaxDbiQ86XI8.
PRIDEiQ86XI8.

PTM databases

PhosphoSiteiQ86XI8.

Expressioni

Gene expression databases

BgeeiQ86XI8.
CleanExiHS_C19orf68.
GenevestigatoriQ86XI8.

Organism-specific databases

HPAiHPA061028.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
JUNBP172752EBI-2682158,EBI-748062

Protein-protein interaction databases

IntActiQ86XI8. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ86XI8.
SMRiQ86XI8. Positions 442-503, 538-616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG86879.
GeneTreeiENSGT00390000011694.
HOGENOMiHOG000112000.
HOVERGENiHBG107768.
InParanoidiQ86XI8.
OMAiNQISKQF.
OrthoDBiEOG70GMDX.
PhylomeDBiQ86XI8.
TreeFamiTF337793.

Family and domain databases

InterProiIPR004162. SINA_like.
[Graphical view]
PANTHERiPTHR10315. PTHR10315. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86XI8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERPEPPPGT AAGQEEQELR ERAFFSWAEF SRFFDAWCQQ RLALFFVKSS
60 70 80 90 100
MHLARCRWAS APPLYTLIDV LKYSYVRLVC KDVRAPSRPA VGPPQPGCPA
110 120 130 140 150
FIIVKLSPLR DRLVVTECQL THSHPACPLE FAYYFRPGHL LANACLPVRT
160 170 180 190 200
TNKISKQFVA PADVRRLLSY CKGRDHGVLD ALHVLEGLFR TDPEAKVKLV
210 220 230 240 250
FVEDQAVVET VFFLTSRTRA LLRRFPRMLL VDRLPGLQGA LDLLAVLCVD
260 270 280 290 300
GSGRARQAAC CVARPGTPSL LRFALASLLQ SAPDVKGRVR CLTAGPEVAA
310 320 330 340 350
QLPAVRQLLP CARVQICRAQ GLETLFSKAQ ELGGAGREDP GLWSRLCRLA
360 370 380 390 400
GASSPAAYDE ALAELHAHGP AAFVDYFERN WEPRRDMWVR FRAFEAARDL
410 420 430 440 450
DACALVRGHR RRLLRRLSPS RGVAQCLRDL VAMQWADAAG EAVPEGPDGG
460 470 480 490 500
GPWLEDEPGR GAQGENERVR GLETGDWGGA PKEGSIWRGA QMEKEWARAL
510 520 530 540 550
ETRDWGGAQF EGEKGRALQI RDWRGGRLEN QKPRGLEGGV LRGSKLEKGH
560 570 580 590 600
LRGPEIRDWR GPQLEGEKDW GLEGYVWRGS QLEDQALRGL EGYTWRVAQL
610 620
EDRRSTTDLR GTQFDYERGK GESTEDR
Length:627
Mass (Da):70,073
Last modified:February 26, 2008 - v2
Checksum:i84D0F5AFC0478DBD
GO

Sequence cautioni

The sequence AAH43386.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011466 Genomic DNA. No translation available.
BC043386 mRNA. Translation: AAH43386.1. Different initiation.
RefSeqiNP_955373.3. NM_199341.3.
UniGeneiHs.664054.

Genome annotation databases

EnsembliENST00000328759; ENSP00000331363; ENSG00000185453.
GeneIDi374920.
KEGGihsa:374920.
UCSCiuc002pic.3. human.

Polymorphism databases

DMDMi189046910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011466 Genomic DNA. No translation available.
BC043386 mRNA. Translation: AAH43386.1. Different initiation.
RefSeqiNP_955373.3. NM_199341.3.
UniGeneiHs.664054.

3D structure databases

ProteinModelPortaliQ86XI8.
SMRiQ86XI8. Positions 442-503, 538-616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ86XI8. 3 interactions.

PTM databases

PhosphoSiteiQ86XI8.

Polymorphism databases

DMDMi189046910.

Proteomic databases

MaxQBiQ86XI8.
PaxDbiQ86XI8.
PRIDEiQ86XI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328759; ENSP00000331363; ENSG00000185453.
GeneIDi374920.
KEGGihsa:374920.
UCSCiuc002pic.3. human.

Organism-specific databases

CTDi374920.
GeneCardsiGC19P048673.
HGNCiHGNC:34495. C19orf68.
HPAiHPA061028.
neXtProtiNX_Q86XI8.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG86879.
GeneTreeiENSGT00390000011694.
HOGENOMiHOG000112000.
HOVERGENiHBG107768.
InParanoidiQ86XI8.
OMAiNQISKQF.
OrthoDBiEOG70GMDX.
PhylomeDBiQ86XI8.
TreeFamiTF337793.

Miscellaneous databases

ChiTaRSiC19orf68. human.
GenomeRNAii374920.

Gene expression databases

BgeeiQ86XI8.
CleanExiHS_C19orf68.
GenevestigatoriQ86XI8.

Family and domain databases

InterProiIPR004162. SINA_like.
[Graphical view]
PANTHERiPTHR10315. PTHR10315. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiCS068_HUMAN
AccessioniPrimary (citable) accession number: Q86XI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: January 7, 2015
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.