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Protein

Uncharacterized protein ZSWIM9

Gene

ZSWIM9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein ZSWIM9
Gene namesi
Name:ZSWIM9Imported
Synonyms:C19orf68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000185453.12
HGNCiHGNC:34495 ZSWIM9
neXtProtiNX_Q86XI8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi374920
OpenTargetsiENSG00000185453

Polymorphism and mutation databases

DMDMi189046910

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003225961 – 627Uncharacterized protein ZSWIM9Add BLAST627

Proteomic databases

EPDiQ86XI8
MaxQBiQ86XI8
PaxDbiQ86XI8
PeptideAtlasiQ86XI8
PRIDEiQ86XI8

PTM databases

iPTMnetiQ86XI8
PhosphoSitePlusiQ86XI8

Expressioni

Gene expression databases

BgeeiENSG00000185453
CleanExiHS_C19orf68
ExpressionAtlasiQ86XI8 baseline and differential
GenevisibleiQ86XI8 HS

Organism-specific databases

HPAiHPA061028

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
JUNBP172752EBI-2682158,EBI-748062

Protein-protein interaction databases

BioGridi131938, 3 interactors
IntActiQ86XI8, 8 interactors
STRINGi9606.ENSP00000331363

Structurei

3D structure databases

ProteinModelPortaliQ86XI8
SMRiQ86XI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IENB Eukaryota
ENOG410ZJVT LUCA
GeneTreeiENSGT00390000011694
HOGENOMiHOG000112000
HOVERGENiHBG107768
InParanoidiQ86XI8
OMAiERNWEPR
OrthoDBiEOG091G04MI
PhylomeDBiQ86XI8
TreeFamiTF337793

Family and domain databases

InterProiView protein in InterPro
IPR004162 SINA-like
PANTHERiPTHR10315 PTHR10315, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86XI8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERPEPPPGT AAGQEEQELR ERAFFSWAEF SRFFDAWCQQ RLALFFVKSS
60 70 80 90 100
MHLARCRWAS APPLYTLIDV LKYSYVRLVC KDVRAPSRPA VGPPQPGCPA
110 120 130 140 150
FIIVKLSPLR DRLVVTECQL THSHPACPLE FAYYFRPGHL LANACLPVRT
160 170 180 190 200
TNKISKQFVA PADVRRLLSY CKGRDHGVLD ALHVLEGLFR TDPEAKVKLV
210 220 230 240 250
FVEDQAVVET VFFLTSRTRA LLRRFPRMLL VDRLPGLQGA LDLLAVLCVD
260 270 280 290 300
GSGRARQAAC CVARPGTPSL LRFALASLLQ SAPDVKGRVR CLTAGPEVAA
310 320 330 340 350
QLPAVRQLLP CARVQICRAQ GLETLFSKAQ ELGGAGREDP GLWSRLCRLA
360 370 380 390 400
GASSPAAYDE ALAELHAHGP AAFVDYFERN WEPRRDMWVR FRAFEAARDL
410 420 430 440 450
DACALVRGHR RRLLRRLSPS RGVAQCLRDL VAMQWADAAG EAVPEGPDGG
460 470 480 490 500
GPWLEDEPGR GAQGENERVR GLETGDWGGA PKEGSIWRGA QMEKEWARAL
510 520 530 540 550
ETRDWGGAQF EGEKGRALQI RDWRGGRLEN QKPRGLEGGV LRGSKLEKGH
560 570 580 590 600
LRGPEIRDWR GPQLEGEKDW GLEGYVWRGS QLEDQALRGL EGYTWRVAQL
610 620
EDRRSTTDLR GTQFDYERGK GESTEDR
Length:627
Mass (Da):70,073
Last modified:February 26, 2008 - v2
Checksum:i84D0F5AFC0478DBD
GO
Isoform 2 (identifier: Q86XI8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     619-627: GKGESTEDR → VRSLEGSPWR...RDCWGRAPEP

Show »
Length:920
Mass (Da):101,681
Checksum:iCBB24074FC4046EA
GO

Sequence cautioni

The sequence AAH43386 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059340619 – 627GKGESTEDR → VRSLEGSPWRGAQLHDERAG GLRTAEWKGPQSEVEKGRGL EVRNLRGIPLEKSLELAPEN GDQRGPQWEDERRRGPEIAE ERGARVGVKRRRGLEDIVLV QLGDTRVTGMENGDGGGARS VGPKSRAGRGMEWGDAGGRC LGLGNGVVSGTPVGTVLEGS PEWAAARSEHLAAGDGLQEG GEDGPREPKRLCRPPGEEEV DWEPLAKFRAACGPELADLV AEELAFARQHGTRGFHWTGA GFALKDGTSDFFLDGALTRC SCSIHAARRLPCRHLFAARL LTGAALFHMDLLRDCWGRAP EP in isoform 2. 9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011466 Genomic DNA No translation available.
BC043386 mRNA Translation: AAH43386.1 Different initiation.
CCDSiCCDS74411.1 [Q86XI8-2]
RefSeqiNP_955373.3, NM_199341.3 [Q86XI8-2]
XP_006723268.1, XM_006723205.2 [Q86XI8-2]
UniGeneiHs.664054

Genome annotation databases

EnsembliENST00000328759; ENSP00000331363; ENSG00000185453 [Q86XI8-1]
ENST00000614654; ENSP00000480314; ENSG00000185453 [Q86XI8-2]
GeneIDi374920
KEGGihsa:374920
UCSCiuc061aqx.1 human [Q86XI8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZSWM9_HUMAN
AccessioniPrimary (citable) accession number: Q86XI8
Secondary accession number(s): A0A087WWL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health