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Q86XI2

- CNDG2_HUMAN

UniProt

Q86XI2 - CNDG2_HUMAN

Protein

Condensin-2 complex subunit G2

Gene

NCAPG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.1 Publication

    GO - Molecular functioni

    1. methylated histone binding Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. chromosome condensation Source: UniProtKB-KW
    2. inner cell mass cell proliferation Source: Ensembl
    3. mitotic cell cycle Source: Reactome
    4. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, DNA condensation, Mitosis

    Enzyme and pathway databases

    ReactomeiREACT_172744. Condensation of Prophase Chromosomes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Condensin-2 complex subunit G2
    Alternative name(s):
    Chromosome-associated protein G2
    Short name:
    CAP-G2
    Short name:
    hCAP-G2
    Leucine zipper protein 5
    Non-SMC condensin II complex subunit G2
    Gene namesi
    Name:NCAPG2
    Synonyms:LUZP5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21904. NCAPG2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. nucleoplasm Source: Reactome
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162397212.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11431143Condensin-2 complex subunit G2PRO_0000255942Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei30 – 301Phosphoserine2 Publications
    Modified residuei805 – 8051Phosphothreonine2 Publications
    Modified residuei1119 – 11191Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ86XI2.
    PaxDbiQ86XI2.
    PRIDEiQ86XI2.

    PTM databases

    PhosphoSiteiQ86XI2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86XI2.
    BgeeiQ86XI2.
    CleanExiHS_NCAPG2.
    GenevestigatoriQ86XI2.

    Organism-specific databases

    HPAiHPA026631.
    HPA049637.

    Interactioni

    Subunit structurei

    Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NCAPH2Q6IBW42EBI-1047404,EBI-2548296

    Protein-protein interaction databases

    BioGridi120239. 6 interactions.
    DIPiDIP-43902N.
    IntActiQ86XI2. 2 interactions.
    MINTiMINT-4329936.
    STRINGi9606.ENSP00000348657.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86XI2.
    SMRiQ86XI2. Positions 380-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati460 – 49839HEATAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HEAT repeat.Curated

    Phylogenomic databases

    eggNOGiNOG261934.
    HOVERGENiHBG074124.
    KOiK11492.
    OMAiTSKYWEM.
    OrthoDBiEOG73V6N3.
    PhylomeDBiQ86XI2.
    TreeFamiTF101163.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR024741. Condensin2_G2.
    [Graphical view]
    PfamiPF12422. Condensin2nSMC. 2 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86XI2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEKRETFVQA VSKELVGEFL QFVQLDKEAS DPFSLNELLD ELSRKQKEEL     50
    WQRLKNLLTD VLLESPVDGW QVVEAQGEDN METEHGSKMR KSIEIIYAIT 100
    SVILASVSVI NESENYEALL ECVIILNGIL YALPESERKL QSSIQDLCVT 150
    WWEKGLPAKE DTGKTAFVML LRRSLETKTG ADVCRLWRIH QALYCFDYDL 200
    EESGEIKDML LECFININYI KKEEGRRFLS CLFNWNINFI KMIHGTIKNQ 250
    LQGLQKSLMV YIAEIYFRAW KKASGKILEA IENDCIQDFM FHGIHLPRRS 300
    PVHSKVREVL SYFHHQKKVR QGVEEMLYRL YKPILWRGLK ARNSEVRSNA 350
    ALLFVEAFPI RDPNLHAIEM DSEIQKQFEE LYSLLEDPYP MVRSTGILGV 400
    CKITSKYWEM MPPTILIDLL KKVTGELAFD TSSADVRCSV FKCLPMILDN 450
    KLSHPLLEQL LPALRYSLHD NSEKVRVAFV DMLLKIKAVR AAKFWKICPM 500
    EHILVRLETD SRPVSRRLVS LIFNSFLPVN QPEEVWCERC VTLVQMNHAA 550
    ARRFYQYAHE HTACTNIAKL IHVIRHCLNA CIQRAVREPP EDEEEEDGRE 600
    KENVTVLDKT LSVNDVACMA GLLEIIVILW KSIDRSMENN KEAKLYTINK 650
    FASVLPEYLK VFKDDRCKIP LFMLMSFMPA SAVPPFSCGV ISTLRSREEG 700
    AVDKSYCTLL DCLCSWGQVG HILELVDNWL PTEHAQAKSN TASKGRVQIH 750
    DTRPVKPELA LVYIEYLLTH PKNRECLLSA PRKKLNHLLK ALETSKADLE 800
    SLLQTPGGKP RGFSEAAAPR AFGLHCRLSI HLQHKFCSEG KVYLSMLEDT 850
    GFWLESKILS FIQDQEEDYL KLHRVIYQQI IQTYLTVCKD VVMVGLGDHQ 900
    FQMQLLQRSL GIMQTVKGFF YVSLLLDILK EITGSSLIQK TDSDEEVAML 950
    LDTVQKVFQK MLECIARSFR KQPEEGLRLL YSVQRPLHEF ITAVQSRHTD 1000
    TPVHRGVLST LIAGPVVEIS HQLRKVSDVE ELTPPEHLSD LPPFSRCLIG 1050
    IIIKSSNVVR SFLDELKACV ASNDIEGIVC LTAAVHIILV INAGKHKSSK 1100
    VREVAATVHR KLKTFMEITL EEDSIERFLY ESSSRTLGEL LNS 1143
    Length:1,143
    Mass (Da):130,960
    Last modified:June 1, 2003 - v1
    Checksum:i7C7B7FA2A7F0683C
    GO
    Isoform 2 (identifier: Q86XI2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1128-1143: FLYESSSRTLGELLNS → YEDLLCCPGWALTPGLLDSIYPSASVPIG

    Show »
    Length:1,156
    Mass (Da):132,196
    Checksum:iC0BAFFC159FEB783
    GO

    Sequence cautioni

    The sequence AAH20560.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB14219.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB14534.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti369 – 3691E → G in BAB14219. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti794 – 7941T → M.
    Corresponds to variant rs10248318 [ dbSNP | Ensembl ].
    VAR_053046
    Natural varianti867 – 8671E → D.
    Corresponds to variant rs3214000 [ dbSNP | Ensembl ].
    VAR_053047

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1128 – 114316FLYES…ELLNS → YEDLLCCPGWALTPGLLDSI YPSASVPIG in isoform 2. 1 PublicationVSP_021311Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX537845 mRNA. Translation: CAD97854.1.
    CH236954 Genomic DNA. Translation: EAL23929.1.
    BC005878 mRNA. Translation: AAH05878.2.
    BC020560 mRNA. Translation: AAH20560.1. Different initiation.
    BC043404 mRNA. Translation: AAH43404.1.
    AK022744 mRNA. Translation: BAB14219.1. Different initiation.
    AK023347 mRNA. Translation: BAB14534.1. Different initiation.
    CCDSiCCDS43686.1. [Q86XI2-1]
    CCDS64816.1. [Q86XI2-2]
    RefSeqiNP_001268861.1. NM_001281932.1. [Q86XI2-1]
    NP_001268862.1. NM_001281933.1. [Q86XI2-2]
    NP_060230.5. NM_017760.6. [Q86XI2-1]
    UniGeneiHs.18616.

    Genome annotation databases

    EnsembliENST00000356309; ENSP00000348657; ENSG00000146918. [Q86XI2-1]
    ENST00000409339; ENSP00000387007; ENSG00000146918. [Q86XI2-2]
    ENST00000409423; ENSP00000386569; ENSG00000146918. [Q86XI2-1]
    GeneIDi54892.
    KEGGihsa:54892.
    UCSCiuc003wnv.1. human. [Q86XI2-1]
    uc011kwe.1. human. [Q86XI2-2]

    Polymorphism databases

    DMDMi74727834.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX537845 mRNA. Translation: CAD97854.1 .
    CH236954 Genomic DNA. Translation: EAL23929.1 .
    BC005878 mRNA. Translation: AAH05878.2 .
    BC020560 mRNA. Translation: AAH20560.1 . Different initiation.
    BC043404 mRNA. Translation: AAH43404.1 .
    AK022744 mRNA. Translation: BAB14219.1 . Different initiation.
    AK023347 mRNA. Translation: BAB14534.1 . Different initiation.
    CCDSi CCDS43686.1. [Q86XI2-1 ]
    CCDS64816.1. [Q86XI2-2 ]
    RefSeqi NP_001268861.1. NM_001281932.1. [Q86XI2-1 ]
    NP_001268862.1. NM_001281933.1. [Q86XI2-2 ]
    NP_060230.5. NM_017760.6. [Q86XI2-1 ]
    UniGenei Hs.18616.

    3D structure databases

    ProteinModelPortali Q86XI2.
    SMRi Q86XI2. Positions 380-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120239. 6 interactions.
    DIPi DIP-43902N.
    IntActi Q86XI2. 2 interactions.
    MINTi MINT-4329936.
    STRINGi 9606.ENSP00000348657.

    PTM databases

    PhosphoSitei Q86XI2.

    Polymorphism databases

    DMDMi 74727834.

    Proteomic databases

    MaxQBi Q86XI2.
    PaxDbi Q86XI2.
    PRIDEi Q86XI2.

    Protocols and materials databases

    DNASUi 54892.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356309 ; ENSP00000348657 ; ENSG00000146918 . [Q86XI2-1 ]
    ENST00000409339 ; ENSP00000387007 ; ENSG00000146918 . [Q86XI2-2 ]
    ENST00000409423 ; ENSP00000386569 ; ENSG00000146918 . [Q86XI2-1 ]
    GeneIDi 54892.
    KEGGi hsa:54892.
    UCSCi uc003wnv.1. human. [Q86XI2-1 ]
    uc011kwe.1. human. [Q86XI2-2 ]

    Organism-specific databases

    CTDi 54892.
    GeneCardsi GC07M158424.
    HGNCi HGNC:21904. NCAPG2.
    HPAi HPA026631.
    HPA049637.
    MIMi 608532. gene.
    neXtProti NX_Q86XI2.
    PharmGKBi PA162397212.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG261934.
    HOVERGENi HBG074124.
    KOi K11492.
    OMAi TSKYWEM.
    OrthoDBi EOG73V6N3.
    PhylomeDBi Q86XI2.
    TreeFami TF101163.

    Enzyme and pathway databases

    Reactomei REACT_172744. Condensation of Prophase Chromosomes.

    Miscellaneous databases

    ChiTaRSi NCAPG2. human.
    GeneWikii NCAPG2.
    GenomeRNAii 54892.
    NextBioi 57890.
    PROi Q86XI2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86XI2.
    Bgeei Q86XI2.
    CleanExi HS_NCAPG2.
    Genevestigatori Q86XI2.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR024741. Condensin2_G2.
    [Graphical view ]
    Pfami PF12422. Condensin2nSMC. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Endometrium.
    2. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 352-1143.
      Tissue: Ovary.
    5. "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells."
      Ono T., Losada A., Hirano M., Myers M.P., Neuwald A.F., Hirano T.
      Cell 115:109-121(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE CONDENSIN-II COMPLEX, FUNCTION, SUBCELLULAR LOCATION.
    6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-805 AND THR-1119, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30 AND THR-805, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCNDG2_HUMAN
    AccessioniPrimary (citable) accession number: Q86XI2
    Secondary accession number(s): A4D228
    , Q7Z3J9, Q8WUG8, Q9BRX6, Q9H8S2, Q9H9K6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3