Q86XI2 (CNDG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Condensin-2 complex subunit G2

Alternative name(s):
Chromosome-associated protein G2
Short name=CAP-G2
Short name=hCAP-G2
Leucine zipper protein 5
Non-SMC condensin II complex subunit G2

Gene names

Name:	NCAPG2
Synonyms:	LUZP5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1143 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Ref.5
Subunit structure	Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2. Ref.5
Subcellular location	Nucleus Ref.5.
Sequence similarities	Contains 1 HEAT repeat.
Sequence caution	The sequence AAH20560.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14219.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14534.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell cycle Cell division DNA condensation Mitosis
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW chromosome condensation Inferred from electronic annotation. Source: UniProtKB-KW inner cell mass cell proliferation Inferred from electronic annotation. Source: Compara mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay. Source: HPA
Molecular_function	methylated histone residue binding Inferred from direct assay PubMed 20622854. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86XI2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86XI2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1128-1143: FLYESSSRTLGELLNS → YEDLLCCPGWALTPGLLDSIYPSASVPIG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1143	1143	Condensin-2 complex subunit G2		PRO_0000255942
Regions
	Repeat	460 – 498	39	HEAT
Amino acid modifications
	Modified residue	30	1	Phosphoserine Ref.6 Ref.8
	Modified residue	805	1	Phosphothreonine Ref.7 Ref.8
	Modified residue	1119	1	Phosphothreonine Ref.7
Natural variations
	Alternative sequence	1128 – 1143	16	FLYES…ELLNS → YEDLLCCPGWALTPGLLDSI YPSASVPIG in isoform 2.		VSP_021311
	Natural variant	794	1	T → M. Corresponds to variant rs10248318 [ dbSNP | Ensembl ].		VAR_053046
	Natural variant	867	1	E → D. Corresponds to variant rs3214000 [ dbSNP | Ensembl ].		VAR_053047
Experimental info
	Sequence conflict	369	1	E → G in BAB14219. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7C7B7FA2A7F0683C	FASTA	1,143	130,960
	10 20 30 40 50 60 MEKRETFVQA VSKELVGEFL QFVQLDKEAS DPFSLNELLD ELSRKQKEEL WQRLKNLLTD 70 80 90 100 110 120 VLLESPVDGW QVVEAQGEDN METEHGSKMR KSIEIIYAIT SVILASVSVI NESENYEALL 130 140 150 160 170 180 ECVIILNGIL YALPESERKL QSSIQDLCVT WWEKGLPAKE DTGKTAFVML LRRSLETKTG 190 200 210 220 230 240 ADVCRLWRIH QALYCFDYDL EESGEIKDML LECFININYI KKEEGRRFLS CLFNWNINFI 250 260 270 280 290 300 KMIHGTIKNQ LQGLQKSLMV YIAEIYFRAW KKASGKILEA IENDCIQDFM FHGIHLPRRS 310 320 330 340 350 360 PVHSKVREVL SYFHHQKKVR QGVEEMLYRL YKPILWRGLK ARNSEVRSNA ALLFVEAFPI 370 380 390 400 410 420 RDPNLHAIEM DSEIQKQFEE LYSLLEDPYP MVRSTGILGV CKITSKYWEM MPPTILIDLL 430 440 450 460 470 480 KKVTGELAFD TSSADVRCSV FKCLPMILDN KLSHPLLEQL LPALRYSLHD NSEKVRVAFV 490 500 510 520 530 540 DMLLKIKAVR AAKFWKICPM EHILVRLETD SRPVSRRLVS LIFNSFLPVN QPEEVWCERC 550 560 570 580 590 600 VTLVQMNHAA ARRFYQYAHE HTACTNIAKL IHVIRHCLNA CIQRAVREPP EDEEEEDGRE 610 620 630 640 650 660 KENVTVLDKT LSVNDVACMA GLLEIIVILW KSIDRSMENN KEAKLYTINK FASVLPEYLK 670 680 690 700 710 720 VFKDDRCKIP LFMLMSFMPA SAVPPFSCGV ISTLRSREEG AVDKSYCTLL DCLCSWGQVG 730 740 750 760 770 780 HILELVDNWL PTEHAQAKSN TASKGRVQIH DTRPVKPELA LVYIEYLLTH PKNRECLLSA 790 800 810 820 830 840 PRKKLNHLLK ALETSKADLE SLLQTPGGKP RGFSEAAAPR AFGLHCRLSI HLQHKFCSEG 850 860 870 880 890 900 KVYLSMLEDT GFWLESKILS FIQDQEEDYL KLHRVIYQQI IQTYLTVCKD VVMVGLGDHQ 910 920 930 940 950 960 FQMQLLQRSL GIMQTVKGFF YVSLLLDILK EITGSSLIQK TDSDEEVAML LDTVQKVFQK 970 980 990 1000 1010 1020 MLECIARSFR KQPEEGLRLL YSVQRPLHEF ITAVQSRHTD TPVHRGVLST LIAGPVVEIS 1030 1040 1050 1060 1070 1080 HQLRKVSDVE ELTPPEHLSD LPPFSRCLIG IIIKSSNVVR SFLDELKACV ASNDIEGIVC 1090 1100 1110 1120 1130 1140 LTAAVHIILV INAGKHKSSK VREVAATVHR KLKTFMEITL EEDSIERFLY ESSSRTLGEL LNS
	Isoform 2 [UniParc]. Checksum: C0BAFFC159FEB783	FASTA	1,156	132,196
	10 20 30 40 50 60 MEKRETFVQA VSKELVGEFL QFVQLDKEAS DPFSLNELLD ELSRKQKEEL WQRLKNLLTD 70 80 90 100 110 120 VLLESPVDGW QVVEAQGEDN METEHGSKMR KSIEIIYAIT SVILASVSVI NESENYEALL 130 140 150 160 170 180 ECVIILNGIL YALPESERKL QSSIQDLCVT WWEKGLPAKE DTGKTAFVML LRRSLETKTG 190 200 210 220 230 240 ADVCRLWRIH QALYCFDYDL EESGEIKDML LECFININYI KKEEGRRFLS CLFNWNINFI 250 260 270 280 290 300 KMIHGTIKNQ LQGLQKSLMV YIAEIYFRAW KKASGKILEA IENDCIQDFM FHGIHLPRRS 310 320 330 340 350 360 PVHSKVREVL SYFHHQKKVR QGVEEMLYRL YKPILWRGLK ARNSEVRSNA ALLFVEAFPI 370 380 390 400 410 420 RDPNLHAIEM DSEIQKQFEE LYSLLEDPYP MVRSTGILGV CKITSKYWEM MPPTILIDLL 430 440 450 460 470 480 KKVTGELAFD TSSADVRCSV FKCLPMILDN KLSHPLLEQL LPALRYSLHD NSEKVRVAFV 490 500 510 520 530 540 DMLLKIKAVR AAKFWKICPM EHILVRLETD SRPVSRRLVS LIFNSFLPVN QPEEVWCERC 550 560 570 580 590 600 VTLVQMNHAA ARRFYQYAHE HTACTNIAKL IHVIRHCLNA CIQRAVREPP EDEEEEDGRE 610 620 630 640 650 660 KENVTVLDKT LSVNDVACMA GLLEIIVILW KSIDRSMENN KEAKLYTINK FASVLPEYLK 670 680 690 700 710 720 VFKDDRCKIP LFMLMSFMPA SAVPPFSCGV ISTLRSREEG AVDKSYCTLL DCLCSWGQVG 730 740 750 760 770 780 HILELVDNWL PTEHAQAKSN TASKGRVQIH DTRPVKPELA LVYIEYLLTH PKNRECLLSA 790 800 810 820 830 840 PRKKLNHLLK ALETSKADLE SLLQTPGGKP RGFSEAAAPR AFGLHCRLSI HLQHKFCSEG 850 860 870 880 890 900 KVYLSMLEDT GFWLESKILS FIQDQEEDYL KLHRVIYQQI IQTYLTVCKD VVMVGLGDHQ 910 920 930 940 950 960 FQMQLLQRSL GIMQTVKGFF YVSLLLDILK EITGSSLIQK TDSDEEVAML LDTVQKVFQK 970 980 990 1000 1010 1020 MLECIARSFR KQPEEGLRLL YSVQRPLHEF ITAVQSRHTD TPVHRGVLST LIAGPVVEIS 1030 1040 1050 1060 1070 1080 HQLRKVSDVE ELTPPEHLSD LPPFSRCLIG IIIKSSNVVR SFLDELKACV ASNDIEGIVC 1090 1100 1110 1120 1130 1140 LTAAVHIILV INAGKHKSSK VREVAATVHR KLKTFMEITL EEDSIERYED LLCCPGWALT 1150 PGLLDSIYPS ASVPIG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Endometrium.
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 352-1143. Tissue: Ovary.
[5]	"Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells." Ono T., Losada A., Hirano M., Myers M.P., Neuwald A.F., Hirano T. Cell 115:109-121(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE CONDENSIN-II COMPLEX, FUNCTION, SUBCELLULAR LOCATION.
[6]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-805 AND THR-1119, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30 AND THR-805, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX537845 mRNA. Translation: CAD97854.1. CH236954 Genomic DNA. Translation: EAL23929.1. BC005878 mRNA. Translation: AAH05878.2. BC020560 mRNA. Translation: AAH20560.1. Different initiation. BC043404 mRNA. Translation: AAH43404.1. AK022744 mRNA. Translation: BAB14219.1. Different initiation. AK023347 mRNA. Translation: BAB14534.1. Different initiation.
IPI	IPI00396058. IPI00797030.
RefSeq	NP_060230.5. NM_017760.5.
UniGene	Hs.18616.
3D structure databases
ProteinModelPortal	Q86XI2.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4329936.
STRING	9606.ENSP00000348657.
PTM databases
PhosphoSite	Q86XI2.
Polymorphism databases
DMDM	74727834.
Proteomic databases
PaxDb	Q86XI2.
PRIDE	Q86XI2.
Protocols and materials databases
DNASU	54892.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356309; ENSP00000348657; ENSG00000146918. ENST00000409339; ENSP00000387007; ENSG00000146918. ENST00000409423; ENSP00000386569; ENSG00000146918. ENST00000449727; ENSP00000388326; ENSG00000146918.
GeneID	54892.
KEGG	hsa:54892.
UCSC	uc003wnv.1. human. uc011kwe.1. human.
Organism-specific databases
CTD	54892.
GeneCards	GC07M158424.
HGNC	HGNC:21904. NCAPG2.
HPA	HPA026631.
MIM	608532. gene.
neXtProt	NX_Q86XI2.
PharmGKB	PA162397212.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG261934.
HOVERGEN	HBG074124.
KO	K11492.
OMA	FPIRDPN.
OrthoDB	EOG4SQWW1.
Gene expression databases
ArrayExpress	Q86XI2.
Bgee	Q86XI2.
CleanEx	HS_NCAPG2.
Genevestigator	Q86XI2.
GermOnline	ENSG00000146918. Homo sapiens.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR024741. Condensin2_G2. [Graphical view]
Pfam	PF12422. Condensin2nSMC. 2 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50077. HEAT_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NCAPG2. human.
GenomeRNAi	54892.
NextBio	57890.
SOURCE	Search...

Entry information

Entry name

CNDG2_HUMAN

Accession

Primary (citable) accession number: Q86XI2
Secondary accession number(s): A4D228 , Q7Z3J9, Q8WUG8, Q9BRX6, Q9H8S2, Q9H9K6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.