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Q86XI2

- CNDG2_HUMAN

UniProt

Q86XI2 - CNDG2_HUMAN

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Protein

Condensin-2 complex subunit G2

Gene
NCAPG2, LUZP5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.1 Publication

GO - Molecular functioni

  1. methylated histone binding Source: UniProtKB
  2. protein binding Source: IntAct

GO - Biological processi

  1. chromosome condensation Source: UniProtKB-KW
  2. inner cell mass cell proliferation Source: Ensembl
  3. mitotic cell cycle Source: Reactome
  4. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

ReactomeiREACT_172744. Condensation of Prophase Chromosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin-2 complex subunit G2
Alternative name(s):
Chromosome-associated protein G2
Short name:
CAP-G2
Short name:
hCAP-G2
Leucine zipper protein 5
Non-SMC condensin II complex subunit G2
Gene namesi
Name:NCAPG2
Synonyms:LUZP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21904. NCAPG2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162397212.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11431143Condensin-2 complex subunit G2PRO_0000255942Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301Phosphoserine2 Publications
Modified residuei805 – 8051Phosphothreonine2 Publications
Modified residuei1119 – 11191Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86XI2.
PaxDbiQ86XI2.
PRIDEiQ86XI2.

PTM databases

PhosphoSiteiQ86XI2.

Expressioni

Gene expression databases

ArrayExpressiQ86XI2.
BgeeiQ86XI2.
CleanExiHS_NCAPG2.
GenevestigatoriQ86XI2.

Organism-specific databases

HPAiHPA026631.
HPA049637.

Interactioni

Subunit structurei

Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NCAPH2Q6IBW42EBI-1047404,EBI-2548296

Protein-protein interaction databases

BioGridi120239. 6 interactions.
DIPiDIP-43902N.
IntActiQ86XI2. 2 interactions.
MINTiMINT-4329936.
STRINGi9606.ENSP00000348657.

Structurei

3D structure databases

ProteinModelPortaliQ86XI2.
SMRiQ86XI2. Positions 380-486.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati460 – 49839HEATAdd
BLAST

Sequence similaritiesi

Contains 1 HEAT repeat.

Phylogenomic databases

eggNOGiNOG261934.
HOVERGENiHBG074124.
KOiK11492.
OMAiTSKYWEM.
OrthoDBiEOG73V6N3.
PhylomeDBiQ86XI2.
TreeFamiTF101163.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024741. Condensin2_G2.
[Graphical view]
PfamiPF12422. Condensin2nSMC. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86XI2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEKRETFVQA VSKELVGEFL QFVQLDKEAS DPFSLNELLD ELSRKQKEEL     50
WQRLKNLLTD VLLESPVDGW QVVEAQGEDN METEHGSKMR KSIEIIYAIT 100
SVILASVSVI NESENYEALL ECVIILNGIL YALPESERKL QSSIQDLCVT 150
WWEKGLPAKE DTGKTAFVML LRRSLETKTG ADVCRLWRIH QALYCFDYDL 200
EESGEIKDML LECFININYI KKEEGRRFLS CLFNWNINFI KMIHGTIKNQ 250
LQGLQKSLMV YIAEIYFRAW KKASGKILEA IENDCIQDFM FHGIHLPRRS 300
PVHSKVREVL SYFHHQKKVR QGVEEMLYRL YKPILWRGLK ARNSEVRSNA 350
ALLFVEAFPI RDPNLHAIEM DSEIQKQFEE LYSLLEDPYP MVRSTGILGV 400
CKITSKYWEM MPPTILIDLL KKVTGELAFD TSSADVRCSV FKCLPMILDN 450
KLSHPLLEQL LPALRYSLHD NSEKVRVAFV DMLLKIKAVR AAKFWKICPM 500
EHILVRLETD SRPVSRRLVS LIFNSFLPVN QPEEVWCERC VTLVQMNHAA 550
ARRFYQYAHE HTACTNIAKL IHVIRHCLNA CIQRAVREPP EDEEEEDGRE 600
KENVTVLDKT LSVNDVACMA GLLEIIVILW KSIDRSMENN KEAKLYTINK 650
FASVLPEYLK VFKDDRCKIP LFMLMSFMPA SAVPPFSCGV ISTLRSREEG 700
AVDKSYCTLL DCLCSWGQVG HILELVDNWL PTEHAQAKSN TASKGRVQIH 750
DTRPVKPELA LVYIEYLLTH PKNRECLLSA PRKKLNHLLK ALETSKADLE 800
SLLQTPGGKP RGFSEAAAPR AFGLHCRLSI HLQHKFCSEG KVYLSMLEDT 850
GFWLESKILS FIQDQEEDYL KLHRVIYQQI IQTYLTVCKD VVMVGLGDHQ 900
FQMQLLQRSL GIMQTVKGFF YVSLLLDILK EITGSSLIQK TDSDEEVAML 950
LDTVQKVFQK MLECIARSFR KQPEEGLRLL YSVQRPLHEF ITAVQSRHTD 1000
TPVHRGVLST LIAGPVVEIS HQLRKVSDVE ELTPPEHLSD LPPFSRCLIG 1050
IIIKSSNVVR SFLDELKACV ASNDIEGIVC LTAAVHIILV INAGKHKSSK 1100
VREVAATVHR KLKTFMEITL EEDSIERFLY ESSSRTLGEL LNS 1143
Length:1,143
Mass (Da):130,960
Last modified:June 1, 2003 - v1
Checksum:i7C7B7FA2A7F0683C
GO
Isoform 2 (identifier: Q86XI2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1128-1143: FLYESSSRTLGELLNS → YEDLLCCPGWALTPGLLDSIYPSASVPIG

Show »
Length:1,156
Mass (Da):132,196
Checksum:iC0BAFFC159FEB783
GO

Sequence cautioni

The sequence AAH20560.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB14219.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB14534.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti794 – 7941T → M.
Corresponds to variant rs10248318 [ dbSNP | Ensembl ].
VAR_053046
Natural varianti867 – 8671E → D.
Corresponds to variant rs3214000 [ dbSNP | Ensembl ].
VAR_053047

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1128 – 114316FLYES…ELLNS → YEDLLCCPGWALTPGLLDSI YPSASVPIG in isoform 2. VSP_021311Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti369 – 3691E → G in BAB14219. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX537845 mRNA. Translation: CAD97854.1.
CH236954 Genomic DNA. Translation: EAL23929.1.
BC005878 mRNA. Translation: AAH05878.2.
BC020560 mRNA. Translation: AAH20560.1. Different initiation.
BC043404 mRNA. Translation: AAH43404.1.
AK022744 mRNA. Translation: BAB14219.1. Different initiation.
AK023347 mRNA. Translation: BAB14534.1. Different initiation.
CCDSiCCDS43686.1. [Q86XI2-1]
CCDS64816.1. [Q86XI2-2]
RefSeqiNP_001268861.1. NM_001281932.1. [Q86XI2-1]
NP_001268862.1. NM_001281933.1. [Q86XI2-2]
NP_060230.5. NM_017760.6. [Q86XI2-1]
UniGeneiHs.18616.

Genome annotation databases

EnsembliENST00000356309; ENSP00000348657; ENSG00000146918. [Q86XI2-1]
ENST00000409339; ENSP00000387007; ENSG00000146918. [Q86XI2-2]
ENST00000409423; ENSP00000386569; ENSG00000146918. [Q86XI2-1]
ENST00000449727; ENSP00000388326; ENSG00000146918. [Q86XI2-2]
GeneIDi54892.
KEGGihsa:54892.
UCSCiuc003wnv.1. human. [Q86XI2-1]
uc011kwe.1. human. [Q86XI2-2]

Polymorphism databases

DMDMi74727834.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX537845 mRNA. Translation: CAD97854.1 .
CH236954 Genomic DNA. Translation: EAL23929.1 .
BC005878 mRNA. Translation: AAH05878.2 .
BC020560 mRNA. Translation: AAH20560.1 . Different initiation.
BC043404 mRNA. Translation: AAH43404.1 .
AK022744 mRNA. Translation: BAB14219.1 . Different initiation.
AK023347 mRNA. Translation: BAB14534.1 . Different initiation.
CCDSi CCDS43686.1. [Q86XI2-1 ]
CCDS64816.1. [Q86XI2-2 ]
RefSeqi NP_001268861.1. NM_001281932.1. [Q86XI2-1 ]
NP_001268862.1. NM_001281933.1. [Q86XI2-2 ]
NP_060230.5. NM_017760.6. [Q86XI2-1 ]
UniGenei Hs.18616.

3D structure databases

ProteinModelPortali Q86XI2.
SMRi Q86XI2. Positions 380-486.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120239. 6 interactions.
DIPi DIP-43902N.
IntActi Q86XI2. 2 interactions.
MINTi MINT-4329936.
STRINGi 9606.ENSP00000348657.

PTM databases

PhosphoSitei Q86XI2.

Polymorphism databases

DMDMi 74727834.

Proteomic databases

MaxQBi Q86XI2.
PaxDbi Q86XI2.
PRIDEi Q86XI2.

Protocols and materials databases

DNASUi 54892.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356309 ; ENSP00000348657 ; ENSG00000146918 . [Q86XI2-1 ]
ENST00000409339 ; ENSP00000387007 ; ENSG00000146918 . [Q86XI2-2 ]
ENST00000409423 ; ENSP00000386569 ; ENSG00000146918 . [Q86XI2-1 ]
ENST00000449727 ; ENSP00000388326 ; ENSG00000146918 . [Q86XI2-2 ]
GeneIDi 54892.
KEGGi hsa:54892.
UCSCi uc003wnv.1. human. [Q86XI2-1 ]
uc011kwe.1. human. [Q86XI2-2 ]

Organism-specific databases

CTDi 54892.
GeneCardsi GC07M158424.
HGNCi HGNC:21904. NCAPG2.
HPAi HPA026631.
HPA049637.
MIMi 608532. gene.
neXtProti NX_Q86XI2.
PharmGKBi PA162397212.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG261934.
HOVERGENi HBG074124.
KOi K11492.
OMAi TSKYWEM.
OrthoDBi EOG73V6N3.
PhylomeDBi Q86XI2.
TreeFami TF101163.

Enzyme and pathway databases

Reactomei REACT_172744. Condensation of Prophase Chromosomes.

Miscellaneous databases

ChiTaRSi NCAPG2. human.
GeneWikii NCAPG2.
GenomeRNAii 54892.
NextBioi 57890.
PROi Q86XI2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q86XI2.
Bgeei Q86XI2.
CleanExi HS_NCAPG2.
Genevestigatori Q86XI2.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024741. Condensin2_G2.
[Graphical view ]
Pfami PF12422. Condensin2nSMC. 2 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Endometrium.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 352-1143.
    Tissue: Ovary.
  5. "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells."
    Ono T., Losada A., Hirano M., Myers M.P., Neuwald A.F., Hirano T.
    Cell 115:109-121(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE CONDENSIN-II COMPLEX, FUNCTION, SUBCELLULAR LOCATION.
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-805 AND THR-1119, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30 AND THR-805, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCNDG2_HUMAN
AccessioniPrimary (citable) accession number: Q86XI2
Secondary accession number(s): A4D228
, Q7Z3J9, Q8WUG8, Q9BRX6, Q9H8S2, Q9H9K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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