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Protein

Condensin-2 complex subunit G2

Gene

NCAPG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.1 Publication

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2299718 Condensation of Prophase Chromosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin-2 complex subunit G2
Alternative name(s):
Chromosome-associated protein G2
Short name:
CAP-G2
Short name:
hCAP-G2
Leucine zipper protein 5
Non-SMC condensin II complex subunit G2
Gene namesi
Name:NCAPG2
Synonyms:LUZP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000146918.19
HGNCiHGNC:21904 NCAPG2
MIMi608532 gene
neXtProtiNX_Q86XI2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54892
OpenTargetsiENSG00000146918
PharmGKBiPA162397212

Polymorphism and mutation databases

DMDMi74727834

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002559421 – 1143Condensin-2 complex subunit G2Add BLAST1143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphoserineCombined sources1
Modified residuei805PhosphothreonineCombined sources1
Modified residuei1119PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86XI2
MaxQBiQ86XI2
PaxDbiQ86XI2
PeptideAtlasiQ86XI2
PRIDEiQ86XI2

PTM databases

iPTMnetiQ86XI2
PhosphoSitePlusiQ86XI2

Expressioni

Gene expression databases

BgeeiENSG00000146918
CleanExiHS_NCAPG2
ExpressionAtlasiQ86XI2 baseline and differential
GenevisibleiQ86XI2 HS

Organism-specific databases

HPAiHPA026631

Interactioni

Subunit structurei

Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2.1 Publication

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120239, 20 interactors
CORUMiQ86XI2
DIPiDIP-43902N
IntActiQ86XI2, 7 interactors
MINTiQ86XI2
STRINGi9606.ENSP00000348657

Structurei

3D structure databases

ProteinModelPortaliQ86XI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati460 – 498HEATAdd BLAST39

Phylogenomic databases

eggNOGiKOG1949 Eukaryota
ENOG410XSM3 LUCA
GeneTreeiENSGT00490000043432
HOVERGENiHBG074124
InParanoidiQ86XI2
KOiK11492
OMAiVWCERCV
OrthoDBiEOG091G03K6
PhylomeDBiQ86XI2
TreeFamiTF101163

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024741 Condensin2_G2
PfamiView protein in Pfam
PF12422 Condensin2nSMC, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86XI2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKRETFVQA VSKELVGEFL QFVQLDKEAS DPFSLNELLD ELSRKQKEEL
60 70 80 90 100
WQRLKNLLTD VLLESPVDGW QVVEAQGEDN METEHGSKMR KSIEIIYAIT
110 120 130 140 150
SVILASVSVI NESENYEALL ECVIILNGIL YALPESERKL QSSIQDLCVT
160 170 180 190 200
WWEKGLPAKE DTGKTAFVML LRRSLETKTG ADVCRLWRIH QALYCFDYDL
210 220 230 240 250
EESGEIKDML LECFININYI KKEEGRRFLS CLFNWNINFI KMIHGTIKNQ
260 270 280 290 300
LQGLQKSLMV YIAEIYFRAW KKASGKILEA IENDCIQDFM FHGIHLPRRS
310 320 330 340 350
PVHSKVREVL SYFHHQKKVR QGVEEMLYRL YKPILWRGLK ARNSEVRSNA
360 370 380 390 400
ALLFVEAFPI RDPNLHAIEM DSEIQKQFEE LYSLLEDPYP MVRSTGILGV
410 420 430 440 450
CKITSKYWEM MPPTILIDLL KKVTGELAFD TSSADVRCSV FKCLPMILDN
460 470 480 490 500
KLSHPLLEQL LPALRYSLHD NSEKVRVAFV DMLLKIKAVR AAKFWKICPM
510 520 530 540 550
EHILVRLETD SRPVSRRLVS LIFNSFLPVN QPEEVWCERC VTLVQMNHAA
560 570 580 590 600
ARRFYQYAHE HTACTNIAKL IHVIRHCLNA CIQRAVREPP EDEEEEDGRE
610 620 630 640 650
KENVTVLDKT LSVNDVACMA GLLEIIVILW KSIDRSMENN KEAKLYTINK
660 670 680 690 700
FASVLPEYLK VFKDDRCKIP LFMLMSFMPA SAVPPFSCGV ISTLRSREEG
710 720 730 740 750
AVDKSYCTLL DCLCSWGQVG HILELVDNWL PTEHAQAKSN TASKGRVQIH
760 770 780 790 800
DTRPVKPELA LVYIEYLLTH PKNRECLLSA PRKKLNHLLK ALETSKADLE
810 820 830 840 850
SLLQTPGGKP RGFSEAAAPR AFGLHCRLSI HLQHKFCSEG KVYLSMLEDT
860 870 880 890 900
GFWLESKILS FIQDQEEDYL KLHRVIYQQI IQTYLTVCKD VVMVGLGDHQ
910 920 930 940 950
FQMQLLQRSL GIMQTVKGFF YVSLLLDILK EITGSSLIQK TDSDEEVAML
960 970 980 990 1000
LDTVQKVFQK MLECIARSFR KQPEEGLRLL YSVQRPLHEF ITAVQSRHTD
1010 1020 1030 1040 1050
TPVHRGVLST LIAGPVVEIS HQLRKVSDVE ELTPPEHLSD LPPFSRCLIG
1060 1070 1080 1090 1100
IIIKSSNVVR SFLDELKACV ASNDIEGIVC LTAAVHIILV INAGKHKSSK
1110 1120 1130 1140
VREVAATVHR KLKTFMEITL EEDSIERFLY ESSSRTLGEL LNS
Length:1,143
Mass (Da):130,960
Last modified:June 1, 2003 - v1
Checksum:i7C7B7FA2A7F0683C
GO
Isoform 2 (identifier: Q86XI2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1128-1143: FLYESSSRTLGELLNS → YEDLLCCPGWALTPGLLDSIYPSASVPIG

Show »
Length:1,156
Mass (Da):132,196
Checksum:iC0BAFFC159FEB783
GO

Sequence cautioni

The sequence AAH20560 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14219 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14534 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti369E → G in BAB14219 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053046794T → M. Corresponds to variant dbSNP:rs10248318Ensembl.1
Natural variantiVAR_053047867E → D. Corresponds to variant dbSNP:rs3214000Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0213111128 – 1143FLYES…ELLNS → YEDLLCCPGWALTPGLLDSI YPSASVPIG in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537845 mRNA Translation: CAD97854.1
CH236954 Genomic DNA Translation: EAL23929.1
BC005878 mRNA Translation: AAH05878.2
BC020560 mRNA Translation: AAH20560.1 Different initiation.
BC043404 mRNA Translation: AAH43404.1
AK022744 mRNA Translation: BAB14219.1 Different initiation.
AK023347 mRNA Translation: BAB14534.1 Different initiation.
CCDSiCCDS43686.1 [Q86XI2-1]
CCDS64816.1 [Q86XI2-2]
RefSeqiNP_001268861.1, NM_001281932.1 [Q86XI2-1]
NP_001268862.1, NM_001281933.1 [Q86XI2-2]
NP_060230.5, NM_017760.6 [Q86XI2-1]
XP_011514658.1, XM_011516356.2 [Q86XI2-2]
XP_011514659.1, XM_011516357.2 [Q86XI2-2]
UniGeneiHs.18616

Genome annotation databases

EnsembliENST00000356309; ENSP00000348657; ENSG00000146918 [Q86XI2-1]
ENST00000409339; ENSP00000387007; ENSG00000146918 [Q86XI2-2]
ENST00000409423; ENSP00000386569; ENSG00000146918 [Q86XI2-1]
GeneIDi54892
KEGGihsa:54892
UCSCiuc003wnv.3 human [Q86XI2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCNDG2_HUMAN
AccessioniPrimary (citable) accession number: Q86XI2
Secondary accession number(s): A4D228
, Q7Z3J9, Q8WUG8, Q9BRX6, Q9H8S2, Q9H9K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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