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Protein

IQ and AAA domain-containing protein 1

Gene

IQCA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi575 – 5828ATPSequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ86XH1.

Names & Taxonomyi

Protein namesi
Recommended name:
IQ and AAA domain-containing protein 1
Gene namesi
Name:IQCA1
Synonyms:IQCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26195. IQCA1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162392257.

Polymorphism and mutation databases

DMDMi74727830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 822822IQ and AAA domain-containing protein 1PRO_0000283572Add
BLAST

Proteomic databases

EPDiQ86XH1.
MaxQBiQ86XH1.
PaxDbiQ86XH1.
PeptideAtlasiQ86XH1.
PRIDEiQ86XH1.

PTM databases

iPTMnetiQ86XH1.
PhosphoSiteiQ86XH1.

Expressioni

Gene expression databases

BgeeiENSG00000132321.
CleanExiHS_IQCA1.
ExpressionAtlasiQ86XH1. baseline and differential.
GenevisibleiQ86XH1. HS.

Organism-specific databases

HPAiHPA031548.
HPA057320.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000387347.

Structurei

3D structure databases

ProteinModelPortaliQ86XH1.
SMRiQ86XH1. Positions 543-791.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini207 – 23630IQPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi351 – 487137Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated
Contains 1 IQ domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0740. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00570000078874.
HOGENOMiHOG000285934.
InParanoidiQ86XH1.
PhylomeDBiQ86XH1.
TreeFamiTF324350.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003959. ATPase_AAA_core.
IPR000048. IQ_motif_EF-hand-BS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86XH1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNAMYNKMW HQTQEALGAL LDKEPQKMIE PQRNQVFIFQ TLATFYVKYV
60 70 80 90 100
QIFRNLENVY DQFVHPQKRI LIRKVLDGVM GRILELKNEM VELELTEFHY
110 120 130 140 150
FDDILQDLKL APQQLDIPIP KYFLKEKLEV IKGREKILAQ ILADSGIDTS
160 170 180 190 200
DMKYPVKSIP FDEAVKLIQI AERARQGRLR ALFMKQIYLQ EYRAKQSKML
210 220 230 240 250
GKKVTDTWAA ALRIQKVWRR FHQRKETEKL REEEMIFLGM NPPPLFNEVS
260 270 280 290 300
ATVIQAEKVD RLRNEVQIKH EEDYREALVT IKNDLKLIEG VDIKENLQDQ
310 320 330 340 350
IRHWFIECRN LTGTFPDYPD VEEGGSAIIF SDKTIQQVIE DIIANQEEEE
360 370 380 390 400
KNKKKKKKKE KQPKKAKKQK KGTKEKNKEE DEKWKMSPSL FLPAMKEGCN
410 420 430 440 450
AYKEIWMKKD ESWNFSQDYD PELIKEEKRK ELQSEIRIQV DELMRQELKN
460 470 480 490 500
LKLAVDRERE RPVKAGKKKD KKGKKGKKKE KKAKKDKDLT ADRTIESLYK
510 520 530 540 550
ELVEEGLLIQ ALKVNLSDYI GEYSYLGTTL RQVSIEPMPS LLDVRQLITL
560 570 580 590 600
YGIWPLGSAA VHEKAPLVKS LLLAGPSGVG KKMLVHAICT ETGANLFNLS
610 620 630 640 650
SSNIAGKYPG KNGLQMMLHA VFKVARQLQP SVVWIEDTEK TFYKKVPNAE
660 670 680 690 700
KMNEPKRLKK HLPQILKLLK PDDRILIVGT TRRPFDAELQ SFCKVYQKII
710 720 730 740 750
LVPRPDYASR YVLWKQIIER NGGVLTSALN VSCLAKVTDG FTQGHIVEVV
760 770 780 790 800
KGVLTDQRIR RQIHKPLTAV EFITAITSMN PVYKEEEESF KNWYAKTPLG
810 820
KKRALAITGG STEKAKDKGK RK
Length:822
Mass (Da):95,341
Last modified:June 1, 2003 - v1
Checksum:i0318214614A39399
GO
Isoform 2 (identifier: Q86XH1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     470-470: D → DK
     653-678: NEPKRLKKHLPQILKLLKPDDRILIV → FTPSAGEVAALQKNLKRSTSRMNLNA
     679-822: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:679
Mass (Da):78,905
Checksum:iC06C6A000FF6F7BE
GO
Isoform 3 (identifier: Q86XH1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-378: Missing.

Show »
Length:781
Mass (Da):90,452
Checksum:i8E74E2A360238673
GO

Sequence cautioni

The sequence BAB15384 differs from that shown.Chimeric cDNA.Curated
The sequence BAB15384 differs from that shown. Reason: Frameshift at position 802. Curated
The sequence BAB70798 differs from that shown.Unlikely isoform. Aberrant splice sites.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711L → P in BAG57440 (PubMed:14702039).Curated
Sequence conflicti199 – 1991M → I in BAB70798 (PubMed:14702039).Curated
Sequence conflicti250 – 2501S → G in BAB70798 (PubMed:14702039).Curated
Sequence conflicti816 – 8161K → R in BAB15384 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81K → M.
Corresponds to variant rs35114730 [ dbSNP | Ensembl ].
VAR_060983
Natural varianti362 – 3621Q → R.
Corresponds to variant rs3754644 [ dbSNP | Ensembl ].
VAR_060984
Natural varianti452 – 4521K → R.
Corresponds to variant rs10204742 [ dbSNP | Ensembl ].
VAR_031495

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei338 – 37841Missing in isoform 3. 1 PublicationVSP_047012Add
BLAST
Alternative sequencei470 – 4701D → DK in isoform 2. 2 PublicationsVSP_024327
Alternative sequencei653 – 67826NEPKR…RILIV → FTPSAGEVAALQKNLKRSTS RMNLNA in isoform 2. 2 PublicationsVSP_024330Add
BLAST
Alternative sequencei679 – 822144Missing in isoform 2. 2 PublicationsVSP_024331Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026180 mRNA. Translation: BAB15384.1. Sequence problems.
AK054711 mRNA. Translation: BAB70798.1. Sequence problems.
AK294105 mRNA. Translation: BAG57440.1.
AC019068 Genomic DNA. No translation available.
AC079611 Genomic DNA. Translation: AAX93085.1.
AC093915 Genomic DNA. Translation: AAY24064.1.
BC028699 mRNA. Translation: AAH28699.1.
BC043504 mRNA. Translation: AAH43504.1.
CCDSiCCDS46549.1. [Q86XH1-1]
CCDS59441.1. [Q86XH1-5]
RefSeqiNP_001257513.1. NM_001270584.1. [Q86XH1-5]
NP_001257514.1. NM_001270585.1.
NP_079002.3. NM_024726.4. [Q86XH1-1]
UniGeneiHs.591594.
Hs.621320.
Hs.711488.

Genome annotation databases

EnsembliENST00000254653; ENSP00000254653; ENSG00000132321. [Q86XH1-2]
ENST00000309507; ENSP00000311951; ENSG00000132321. [Q86XH1-5]
ENST00000409907; ENSP00000387347; ENSG00000132321. [Q86XH1-1]
GeneIDi79781.
KEGGihsa:79781.
UCSCiuc002vvz.3. human. [Q86XH1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026180 mRNA. Translation: BAB15384.1. Sequence problems.
AK054711 mRNA. Translation: BAB70798.1. Sequence problems.
AK294105 mRNA. Translation: BAG57440.1.
AC019068 Genomic DNA. No translation available.
AC079611 Genomic DNA. Translation: AAX93085.1.
AC093915 Genomic DNA. Translation: AAY24064.1.
BC028699 mRNA. Translation: AAH28699.1.
BC043504 mRNA. Translation: AAH43504.1.
CCDSiCCDS46549.1. [Q86XH1-1]
CCDS59441.1. [Q86XH1-5]
RefSeqiNP_001257513.1. NM_001270584.1. [Q86XH1-5]
NP_001257514.1. NM_001270585.1.
NP_079002.3. NM_024726.4. [Q86XH1-1]
UniGeneiHs.591594.
Hs.621320.
Hs.711488.

3D structure databases

ProteinModelPortaliQ86XH1.
SMRiQ86XH1. Positions 543-791.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000387347.

PTM databases

iPTMnetiQ86XH1.
PhosphoSiteiQ86XH1.

Polymorphism and mutation databases

DMDMi74727830.

Proteomic databases

EPDiQ86XH1.
MaxQBiQ86XH1.
PaxDbiQ86XH1.
PeptideAtlasiQ86XH1.
PRIDEiQ86XH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254653; ENSP00000254653; ENSG00000132321. [Q86XH1-2]
ENST00000309507; ENSP00000311951; ENSG00000132321. [Q86XH1-5]
ENST00000409907; ENSP00000387347; ENSG00000132321. [Q86XH1-1]
GeneIDi79781.
KEGGihsa:79781.
UCSCiuc002vvz.3. human. [Q86XH1-1]

Organism-specific databases

CTDi79781.
GeneCardsiIQCA1.
HGNCiHGNC:26195. IQCA1.
HPAiHPA031548.
HPA057320.
neXtProtiNX_Q86XH1.
PharmGKBiPA162392257.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0740. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00570000078874.
HOGENOMiHOG000285934.
InParanoidiQ86XH1.
PhylomeDBiQ86XH1.
TreeFamiTF324350.

Enzyme and pathway databases

SignaLinkiQ86XH1.

Miscellaneous databases

ChiTaRSiIQCA1. human.
GenomeRNAii79781.
PROiQ86XH1.

Gene expression databases

BgeeiENSG00000132321.
CleanExiHS_IQCA1.
ExpressionAtlasiQ86XH1. baseline and differential.
GenevisibleiQ86XH1. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003959. ATPase_AAA_core.
IPR000048. IQ_motif_EF-hand-BS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIQCA1_HUMAN
AccessioniPrimary (citable) accession number: Q86XH1
Secondary accession number(s): B4DFH9
, E7EWQ0, Q4G164, Q53R37, Q53RV3, Q96NS7, Q9H680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.