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Protein

Dynein regulatory complex protein 11

Gene

IQCA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi575 – 582ATPSequence analysis8

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ86XH1

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein regulatory complex protein 11By similarity
Alternative name(s):
IQ and AAA domain-containing protein 1
Gene namesi
Name:IQCA1
Synonyms:DRC11By similarity, IQCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000132321.16
HGNCiHGNC:26195 IQCA1
neXtProtiNX_Q86XH1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132321
PharmGKBiPA162392257

Polymorphism and mutation databases

DMDMi74727830

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002835721 – 822Dynein regulatory complex protein 11Add BLAST822

Proteomic databases

EPDiQ86XH1
PaxDbiQ86XH1
PeptideAtlasiQ86XH1
PRIDEiQ86XH1

PTM databases

iPTMnetiQ86XH1
PhosphoSitePlusiQ86XH1

Expressioni

Gene expression databases

BgeeiENSG00000132321
CleanExiHS_IQCA1
ExpressionAtlasiQ86XH1 baseline and differential
GenevisibleiQ86XH1 HS

Organism-specific databases

HPAiHPA057320

Interactioni

Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000387347

Structurei

3D structure databases

ProteinModelPortaliQ86XH1
SMRiQ86XH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 236IQPROSITE-ProRule annotationAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi351 – 487Lys-richAdd BLAST137

Sequence similaritiesi

Belongs to the AAA ATPase family. DRC11 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0740 Eukaryota
COG0464 LUCA
GeneTreeiENSGT00570000078874
HOGENOMiHOG000285934
InParanoidiQ86XH1
PhylomeDBiQ86XH1
TreeFamiTF324350

Family and domain databases

InterProiView protein in InterPro
IPR003959 ATPase_AAA_core
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86XH1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNAMYNKMW HQTQEALGAL LDKEPQKMIE PQRNQVFIFQ TLATFYVKYV
60 70 80 90 100
QIFRNLENVY DQFVHPQKRI LIRKVLDGVM GRILELKNEM VELELTEFHY
110 120 130 140 150
FDDILQDLKL APQQLDIPIP KYFLKEKLEV IKGREKILAQ ILADSGIDTS
160 170 180 190 200
DMKYPVKSIP FDEAVKLIQI AERARQGRLR ALFMKQIYLQ EYRAKQSKML
210 220 230 240 250
GKKVTDTWAA ALRIQKVWRR FHQRKETEKL REEEMIFLGM NPPPLFNEVS
260 270 280 290 300
ATVIQAEKVD RLRNEVQIKH EEDYREALVT IKNDLKLIEG VDIKENLQDQ
310 320 330 340 350
IRHWFIECRN LTGTFPDYPD VEEGGSAIIF SDKTIQQVIE DIIANQEEEE
360 370 380 390 400
KNKKKKKKKE KQPKKAKKQK KGTKEKNKEE DEKWKMSPSL FLPAMKEGCN
410 420 430 440 450
AYKEIWMKKD ESWNFSQDYD PELIKEEKRK ELQSEIRIQV DELMRQELKN
460 470 480 490 500
LKLAVDRERE RPVKAGKKKD KKGKKGKKKE KKAKKDKDLT ADRTIESLYK
510 520 530 540 550
ELVEEGLLIQ ALKVNLSDYI GEYSYLGTTL RQVSIEPMPS LLDVRQLITL
560 570 580 590 600
YGIWPLGSAA VHEKAPLVKS LLLAGPSGVG KKMLVHAICT ETGANLFNLS
610 620 630 640 650
SSNIAGKYPG KNGLQMMLHA VFKVARQLQP SVVWIEDTEK TFYKKVPNAE
660 670 680 690 700
KMNEPKRLKK HLPQILKLLK PDDRILIVGT TRRPFDAELQ SFCKVYQKII
710 720 730 740 750
LVPRPDYASR YVLWKQIIER NGGVLTSALN VSCLAKVTDG FTQGHIVEVV
760 770 780 790 800
KGVLTDQRIR RQIHKPLTAV EFITAITSMN PVYKEEEESF KNWYAKTPLG
810 820
KKRALAITGG STEKAKDKGK RK
Length:822
Mass (Da):95,341
Last modified:June 1, 2003 - v1
Checksum:i0318214614A39399
GO
Isoform 2 (identifier: Q86XH1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     470-470: D → DK
     653-678: NEPKRLKKHLPQILKLLKPDDRILIV → FTPSAGEVAALQKNLKRSTSRMNLNA
     679-822: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:679
Mass (Da):78,905
Checksum:iC06C6A000FF6F7BE
GO
Isoform 3 (identifier: Q86XH1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-378: Missing.

Show »
Length:781
Mass (Da):90,452
Checksum:i8E74E2A360238673
GO

Sequence cautioni

The sequence BAB15384 differs from that shown. Chimeric cDNA.Curated
The sequence BAB15384 differs from that shown. Reason: Frameshift at position 802.Curated
The sequence BAB70798 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71L → P in BAG57440 (PubMed:14702039).Curated1
Sequence conflicti199M → I in BAB70798 (PubMed:14702039).Curated1
Sequence conflicti250S → G in BAB70798 (PubMed:14702039).Curated1
Sequence conflicti816K → R in BAB15384 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0609838K → M. Corresponds to variant dbSNP:rs35114730Ensembl.1
Natural variantiVAR_060984362Q → R. Corresponds to variant dbSNP:rs3754644Ensembl.1
Natural variantiVAR_031495452K → R. Corresponds to variant dbSNP:rs10204742Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047012338 – 378Missing in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_024327470D → DK in isoform 2. 2 Publications1
Alternative sequenceiVSP_024330653 – 678NEPKR…RILIV → FTPSAGEVAALQKNLKRSTS RMNLNA in isoform 2. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_024331679 – 822Missing in isoform 2. 2 PublicationsAdd BLAST144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026180 mRNA Translation: BAB15384.1 Sequence problems.
AK054711 mRNA Translation: BAB70798.1 Sequence problems.
AK294105 mRNA Translation: BAG57440.1
AC019068 Genomic DNA No translation available.
AC079611 Genomic DNA Translation: AAX93085.1
AC093915 Genomic DNA Translation: AAY24064.1
BC028699 mRNA Translation: AAH28699.1
BC043504 mRNA Translation: AAH43504.1
CCDSiCCDS46549.1 [Q86XH1-1]
CCDS59441.1 [Q86XH1-5]
RefSeqiNP_001257513.1, NM_001270584.1 [Q86XH1-5]
NP_001257514.1, NM_001270585.1
NP_079002.3, NM_024726.4 [Q86XH1-1]
UniGeneiHs.591594
Hs.621320
Hs.711488

Genome annotation databases

EnsembliENST00000254653; ENSP00000254653; ENSG00000132321 [Q86XH1-2]
ENST00000309507; ENSP00000311951; ENSG00000132321 [Q86XH1-5]
ENST00000409907; ENSP00000387347; ENSG00000132321 [Q86XH1-1]
GeneIDi79781
KEGGihsa:79781
UCSCiuc002vvz.3 human [Q86XH1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDRC11_HUMAN
AccessioniPrimary (citable) accession number: Q86XH1
Secondary accession number(s): B4DFH9
, E7EWQ0, Q4G164, Q53R37, Q53RV3, Q96NS7, Q9H680
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health