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Protein

Zinc finger protein 575

Gene

ZNF575

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri63 – 8523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri91 – 11323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri119 – 14123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri147 – 16923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri177 – 19923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri213 – 24028C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 575
Gene namesi
Name:ZNF575
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:27606. ZNF575.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958979.

Polymorphism and mutation databases

BioMutaiZNF575.
DMDMi74762460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Zinc finger protein 575PRO_0000047664Add
BLAST

Proteomic databases

PaxDbiQ86XF7.
PRIDEiQ86XF7.

PTM databases

PhosphoSiteiQ86XF7.

Expressioni

Gene expression databases

BgeeiQ86XF7.
CleanExiHS_ZNF575.
ExpressionAtlasiQ86XF7. baseline and differential.

Organism-specific databases

HPAiHPA051865.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000315870.

Structurei

3D structure databases

ProteinModelPortaliQ86XF7.
SMRiQ86XF7. Positions 61-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri63 – 8523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri91 – 11323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri119 – 14123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri147 – 16923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri177 – 19923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri213 – 24028C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129960.
HOGENOMiHOG000060290.
HOVERGENiHBG018163.
InParanoidiQ86XF7.
PhylomeDBiQ86XF7.
TreeFamiTF338022.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86XF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLERGAESAA GATDPSPTGK EPVTKEAPHQ GPPQKPSQSA PGPTASAGSP
60 70 80 90 100
PRPRRRPPPQ RPHRCPDCDK AFSYPSKLAT HRLAHGGARP HPCPDCPKAF
110 120 130 140 150
SYPSKLAAHR LTHSGARPHP CPHCPKSFGH RSKLAAHLWT HAPTRPYPCP
160 170 180 190 200
DCPKSFCYPS KLAAHRHTHH ATDARPYPCP HCPKAFSFPS KLAAHRLCHD
210 220 230 240
PPTAPGSQAT AWHRCSSCGQ AFGQRRLLLL HQRSHHQVEH KGERD
Length:245
Mass (Da):26,763
Last modified:June 1, 2003 - v1
Checksum:i14AA1DD275F8ABB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301820 mRNA. Translation: BAG63266.1.
CH471126 Genomic DNA. Translation: EAW57198.1.
BC043611 mRNA. Translation: AAH43611.1.
CCDSiCCDS12623.1.
RefSeqiNP_777605.1. NM_174945.2.
XP_005258840.1. XM_005258783.2.
XP_006723218.1. XM_006723155.2.
XP_011525095.1. XM_011526793.1.
UniGeneiHs.213534.

Genome annotation databases

EnsembliENST00000314228; ENSP00000315870; ENSG00000176472.
ENST00000601282; ENSP00000472578; ENSG00000176472.
GeneIDi284346.
KEGGihsa:284346.
UCSCiuc002ows.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301820 mRNA. Translation: BAG63266.1.
CH471126 Genomic DNA. Translation: EAW57198.1.
BC043611 mRNA. Translation: AAH43611.1.
CCDSiCCDS12623.1.
RefSeqiNP_777605.1. NM_174945.2.
XP_005258840.1. XM_005258783.2.
XP_006723218.1. XM_006723155.2.
XP_011525095.1. XM_011526793.1.
UniGeneiHs.213534.

3D structure databases

ProteinModelPortaliQ86XF7.
SMRiQ86XF7. Positions 61-238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000315870.

PTM databases

PhosphoSiteiQ86XF7.

Polymorphism and mutation databases

BioMutaiZNF575.
DMDMi74762460.

Proteomic databases

PaxDbiQ86XF7.
PRIDEiQ86XF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314228; ENSP00000315870; ENSG00000176472.
ENST00000601282; ENSP00000472578; ENSG00000176472.
GeneIDi284346.
KEGGihsa:284346.
UCSCiuc002ows.4. human.

Organism-specific databases

CTDi284346.
GeneCardsiZNF575.
HGNCiHGNC:27606. ZNF575.
HPAiHPA051865.
neXtProtiNX_Q86XF7.
PharmGKBiPA134958979.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129960.
HOGENOMiHOG000060290.
HOVERGENiHBG018163.
InParanoidiQ86XF7.
PhylomeDBiQ86XF7.
TreeFamiTF338022.

Miscellaneous databases

GenomeRNAii284346.
NextBioi94746.
PROiQ86XF7.

Gene expression databases

BgeeiQ86XF7.
CleanExiHS_ZNF575.
ExpressionAtlasiQ86XF7. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiZN575_HUMAN
AccessioniPrimary (citable) accession number: Q86XF7
Secondary accession number(s): B4DX54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.