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Q86XE5

- HOGA1_HUMAN

UniProt

Q86XE5 - HOGA1_HUMAN

Protein

4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Gene

HOGA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the final step in the metabolic pathway of hydroxyproline.2 Publications

    Catalytic activityi

    4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.1 Publication

    Enzyme regulationi

    Inhibited by divalent cations.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei168 – 1681Involved in proton transfer during cleavage
    Active sitei196 – 1961Schiff-base intermediate with substrate1 Publication
    Binding sitei198 – 1981Substrate
    Binding sitei222 – 2221Substrate; via carbonyl oxygen

    GO - Molecular functioni

    1. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB
    2. protein homodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. 4-hydroxyproline catabolic process Source: BHF-UCL
    2. glyoxylate catabolic process Source: UniProtKB
    3. glyoxylate metabolic process Source: BHF-UCL
    4. oxalate metabolic process Source: BHF-UCL
    5. pyruvate biosynthetic process Source: BHF-UCL

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciMetaCyc:G66-31234-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC:4.1.3.16)
    Alternative name(s):
    Dihydrodipicolinate synthase-like
    Short name:
    DHDPS-like protein
    Probable 2-keto-4-hydroxyglutarate aldolase
    Short name:
    Probable KHG-aldolase
    Protein 569272
    Gene namesi
    Name:HOGA1
    Synonyms:C10orf65, DHDPSL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:25155. HOGA1.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. mitochondrion Source: BHF-UCL

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Involvement in diseasei

    Hyperoxaluria primary 3 (HP3) [MIM:613616]: A disorder phenotypically similar to hyperoxaluria type 1 and type 2. It is characterized by increase in urinary oxalate excretion and mild glycolic aciduria. Clinical manifestations include calcium oxalate urolithiasis, hematuria, pain, and/or urinary tract infection.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti257 – 2571C → G in HP3. 1 Publication
    VAR_064035
    Natural varianti287 – 2871G → V in HP3. 1 Publication
    VAR_064036
    Natural varianti315 – 3151Missing in HP3. 1 Publication
    VAR_064037

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi77 – 771S → A: 2-fold decrease in Kcat and a nearly 8-fold increase in KM. 1 Publication
    Mutagenesisi77 – 771S → T: Significant loss of activity. 1 Publication
    Mutagenesisi78 – 781N → A: 6-fold increase in KM. 1 Publication
    Mutagenesisi78 – 781N → Q: 25-fold increase in KM. 1 Publication
    Mutagenesisi140 – 1401Y → F: No change in activity. 1 Publication
    Mutagenesisi168 – 1681Y → F: No enzymatic activity. 1 Publication
    Mutagenesisi196 – 1961K → A: No enzymatic activity. 1 Publication
    Mutagenesisi198 – 1981S → A: 2.5-fold decrease in Kcat and 4.2 fold increase in KM. 1 Publication
    Mutagenesisi198 – 1981S → T: 7-fold increase in KM. 1 Publication

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi613616. phenotype.
    Orphaneti93600. Primary hyperoxaluria type 3.
    PharmGKBiPA165548441.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2525MitochondrionBy similarityAdd
    BLAST
    Chaini26 – 3273024-hydroxy-2-oxoglutarate aldolase, mitochondrialPRO_0000273346Add
    BLAST

    Proteomic databases

    MaxQBiQ86XE5.
    PaxDbiQ86XE5.
    PRIDEiQ86XE5.

    PTM databases

    PhosphoSiteiQ86XE5.

    Expressioni

    Gene expression databases

    BgeeiQ86XE5.
    CleanExiHS_C10orf65.
    GenevestigatoriQ86XE5.

    Organism-specific databases

    HPAiHPA039466.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    IntActiQ86XE5. 1 interaction.

    Structurei

    Secondary structure

    1
    327
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi37 – 393
    Helixi54 – 6411
    Beta strandi70 – 767
    Helixi77 – 793
    Helixi81 – 833
    Helixi86 – 9813
    Beta strandi104 – 1096
    Helixi115 – 12713
    Beta strandi131 – 1366
    Helixi142 – 1443
    Helixi147 – 16014
    Beta strandi165 – 1695
    Helixi171 – 1744
    Helixi180 – 1878
    Beta strandi192 – 1976
    Helixi202 – 21110
    Turni212 – 2143
    Beta strandi218 – 2236
    Helixi224 – 2263
    Helixi227 – 2337
    Beta strandi237 – 2393
    Helixi241 – 2444
    Helixi247 – 25812
    Helixi262 – 27817
    Turni279 – 2835
    Helixi284 – 29512
    Helixi311 – 32212
    Turni323 – 3253

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3S5NX-ray2.50A26-327[»]
    3S5OX-ray1.97A26-327[»]
    ProteinModelPortaliQ86XE5.
    SMRiQ86XE5. Positions 33-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni77 – 782Substrate binding

    Sequence similaritiesi

    Belongs to the DapA family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0329.
    HOVERGENiHBG081405.
    InParanoidiQ86XE5.
    KOiK18123.
    OMAiLADHENI.
    PhylomeDBiQ86XE5.
    TreeFamiTF324600.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    IPR020625. Dihydrodipicolinate_synth_AS.
    [Graphical view]
    PANTHERiPTHR12128. PTHR12128. 1 hit.
    PfamiPF00701. DHDPS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001365. DHDPS. 1 hit.
    PRINTSiPR00146. DHPICSNTHASE.
    PROSITEiPS00666. DHDPS_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86XE5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLGPQVWSSV RQGLSRSLSR NVGVWASGEG KKVDIAGIYP PVTTPFTATA    50
    EVDYGKLEEN LHKLGTFPFR GFVVQGSNGE FPFLTSSERL EVVSRVRQAM 100
    PKNRLLLAGS GCESTQATVE MTVSMAQVGA DAAMVVTPCY YRGRMSSAAL 150
    IHHYTKVADL SPIPVVLYSV PANTGLDLPV DAVVTLSQHP NIVGMKDSGG 200
    DVTRIGLIVH KTRKQDFQVL AGSAGFLMAS YALGAVGGVC ALANVLGAQV 250
    CQLERLCCTG QWEDAQKLQH RLIEPNAAVT RRFGIPGLKK IMDWFGYYGG 300
    PCRAPLQELS PAEEEALRMD FTSNGWL 327
    Length:327
    Mass (Da):35,249
    Last modified:June 1, 2003 - v1
    Checksum:i2DC011E4F9FD32C9
    GO
    Isoform 2 (identifier: Q86XE5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         71-233: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:164
    Mass (Da):17,954
    Checksum:i5DC5ADF3B9A891B4
    GO

    Sequence cautioni

    The sequence CAC84901.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI15457.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti257 – 2571C → G in HP3. 1 Publication
    VAR_064035
    Natural varianti287 – 2871G → V in HP3. 1 Publication
    VAR_064036
    Natural varianti315 – 3151Missing in HP3. 1 Publication
    VAR_064037

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei71 – 233163Missing in isoform 2. 1 PublicationVSP_022515Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK289440 mRNA. Translation: BAF82129.1.
    AL355315 Genomic DNA. Translation: CAI15454.1.
    AL355315 Genomic DNA. Translation: CAI15455.1.
    AL355315 Genomic DNA. Translation: CAI15457.1. Sequence problems.
    CH471066 Genomic DNA. Translation: EAW49912.1.
    BC011916 mRNA. Translation: AAH11916.1.
    BC045550 mRNA. Translation: AAH45550.1.
    BC057821 mRNA. Translation: AAH57821.1.
    AJ312051 Genomic DNA. Translation: CAC84901.1. Sequence problems.
    CCDSiCCDS44469.1. [Q86XE5-3]
    CCDS7467.1. [Q86XE5-1]
    RefSeqiNP_001128142.1. NM_001134670.1. [Q86XE5-3]
    NP_612422.2. NM_138413.3. [Q86XE5-1]
    UniGeneiHs.180346.

    Genome annotation databases

    EnsembliENST00000370646; ENSP00000359680; ENSG00000241935. [Q86XE5-1]
    ENST00000370647; ENSP00000359681; ENSG00000241935. [Q86XE5-3]
    GeneIDi112817.
    KEGGihsa:112817.
    UCSCiuc001kny.3. human. [Q86XE5-1]
    uc001knz.3. human. [Q86XE5-3]

    Polymorphism databases

    DMDMi74750531.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK289440 mRNA. Translation: BAF82129.1 .
    AL355315 Genomic DNA. Translation: CAI15454.1 .
    AL355315 Genomic DNA. Translation: CAI15455.1 .
    AL355315 Genomic DNA. Translation: CAI15457.1 . Sequence problems.
    CH471066 Genomic DNA. Translation: EAW49912.1 .
    BC011916 mRNA. Translation: AAH11916.1 .
    BC045550 mRNA. Translation: AAH45550.1 .
    BC057821 mRNA. Translation: AAH57821.1 .
    AJ312051 Genomic DNA. Translation: CAC84901.1 . Sequence problems.
    CCDSi CCDS44469.1. [Q86XE5-3 ]
    CCDS7467.1. [Q86XE5-1 ]
    RefSeqi NP_001128142.1. NM_001134670.1. [Q86XE5-3 ]
    NP_612422.2. NM_138413.3. [Q86XE5-1 ]
    UniGenei Hs.180346.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3S5N X-ray 2.50 A 26-327 [» ]
    3S5O X-ray 1.97 A 26-327 [» ]
    ProteinModelPortali Q86XE5.
    SMRi Q86XE5. Positions 33-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q86XE5. 1 interaction.

    Chemistry

    BindingDBi Q86XE5.
    ChEMBLi CHEMBL5996.

    PTM databases

    PhosphoSitei Q86XE5.

    Polymorphism databases

    DMDMi 74750531.

    Proteomic databases

    MaxQBi Q86XE5.
    PaxDbi Q86XE5.
    PRIDEi Q86XE5.

    Protocols and materials databases

    DNASUi 112817.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370646 ; ENSP00000359680 ; ENSG00000241935 . [Q86XE5-1 ]
    ENST00000370647 ; ENSP00000359681 ; ENSG00000241935 . [Q86XE5-3 ]
    GeneIDi 112817.
    KEGGi hsa:112817.
    UCSCi uc001kny.3. human. [Q86XE5-1 ]
    uc001knz.3. human. [Q86XE5-3 ]

    Organism-specific databases

    CTDi 112817.
    GeneCardsi GC10P099356.
    HGNCi HGNC:25155. HOGA1.
    HPAi HPA039466.
    MIMi 613597. gene.
    613616. phenotype.
    neXtProti NX_Q86XE5.
    Orphaneti 93600. Primary hyperoxaluria type 3.
    PharmGKBi PA165548441.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0329.
    HOVERGENi HBG081405.
    InParanoidi Q86XE5.
    KOi K18123.
    OMAi LADHENI.
    PhylomeDBi Q86XE5.
    TreeFami TF324600.

    Enzyme and pathway databases

    BioCyci MetaCyc:G66-31234-MONOMER.

    Miscellaneous databases

    ChiTaRSi HOGA1. human.
    GenomeRNAii 112817.
    NextBioi 78673.
    PROi Q86XE5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86XE5.
    CleanExi HS_C10orf65.
    Genevestigatori Q86XE5.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    IPR020625. Dihydrodipicolinate_synth_AS.
    [Graphical view ]
    PANTHERi PTHR12128. PTHR12128. 1 hit.
    Pfami PF00701. DHDPS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001365. DHDPS. 1 hit.
    PRINTSi PR00146. DHPICSNTHASE.
    PROSITEi PS00666. DHDPS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Urinary bladder.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Hippocampus and Kidney.
    5. "Homo sapiens gene 569272."
      Moschonas N.K.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-279 (ISOFORM 1).
    6. Cited for: FUNCTION, VARIANTS HP3 GLY-257; VAL-287 AND GLU-315 DEL.
    7. "Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria."
      Riedel T.J., Johnson L.C., Knight J., Hantgan R.R., Holmes R.P., Lowther W.T.
      PLoS ONE 6:E26021-E26021(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 26-327 IN COMPLEX WITH PYRUVATE, SUBUNIT, ACTIVE SITE, MUTAGENESIS OF SER-77; ASN-78; TYR-140; TYR-168; LYS-196 AND SER-198, FUNCTION, CATALYTIC ACTIVITY.

    Entry informationi

    Entry nameiHOGA1_HUMAN
    AccessioniPrimary (citable) accession number: Q86XE5
    Secondary accession number(s): A8K075
    , Q5T680, Q5T684, Q711P0, Q8N9F2, Q96EV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3