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Protein

Calcium uptake protein 3, mitochondrial

Gene

MICU3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in mitochondrial calcium uptake.By similarity

Miscellaneous

Binds calcium.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi245 – 2561PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi483 – 4942PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-8949215 Mitochondrial calcium ion transport
R-HSA-8949664 Processing of SMDT1

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium uptake protein 3, mitochondrial
Alternative name(s):
EF-hand domain-containing family member A2
Gene namesi
Name:MICU3
Synonyms:EFHA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000155970.11
HGNCiHGNC:27820 MICU3
MIMi610633 gene
neXtProtiNX_Q86XE3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei67 – 83HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000155970
PharmGKBiPA134953154

Polymorphism and mutation databases

BioMutaiMICU3
DMDMi74762459

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002512301 – 530Calcium uptake protein 3, mitochondrialAdd BLAST530

Proteomic databases

MaxQBiQ86XE3
PaxDbiQ86XE3
PeptideAtlasiQ86XE3
PRIDEiQ86XE3
ProteomicsDBi70270

PTM databases

iPTMnetiQ86XE3
PhosphoSitePlusiQ86XE3

Expressioni

Gene expression databases

BgeeiENSG00000155970
CleanExiHS_EFHA2
ExpressionAtlasiQ86XE3 baseline and differential
GenevisibleiQ86XE3 HS

Organism-specific databases

HPAiHPA024048
HPA024771
HPA024779

Interactioni

Protein-protein interaction databases

BioGridi130297, 4 interactors
STRINGi9606.ENSP00000321455

Structurei

3D structure databases

ProteinModelPortaliQ86XE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 267EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini401 – 436EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini470 – 505EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 63Poly-Arg5
Compositional biasi70 – 73Poly-Ala4

Sequence similaritiesi

Belongs to the MICU1 family. MICU3 subfamily.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2643 Eukaryota
ENOG410ZSC1 LUCA
GeneTreeiENSGT00530000063089
HOGENOMiHOG000007649
HOVERGENiHBG054562
InParanoidiQ86XE3
OMAiKTVQKYP
OrthoDBiEOG091G0WLM
PhylomeDBiQ86XE3
TreeFamiTF320374

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13833 EF-hand_8, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 3 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q86XE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALRRLLWP PPRVSPPLCA HQPLLGPWGR PAVTTLGLPG RPFSSREDEE
60 70 80 90 100
RAVAEAAWRR RRRWGELSVA AAAGGGLVGL VCYQLYGDPR AGSPATGRPS
110 120 130 140 150
KSAATEPEDP PRGRGMLPIP VAAAKETVAI GRTDIEDLDL YATSRERRFR
160 170 180 190 200
LFASIECEGQ LFMTPYDFIL AVTTDEPKVA KTWKSLSKQE LNQMLAETPP
210 220 230 240 250
VWKGSSKLFR NLKEKGVISY TEYLFLLCIL TKPHAGFRIA FNMFDTDGNE
260 270 280 290 300
MVDKKEFLVL QEIFRKKNEK REIKGDEEKR AMLRLQLYGY HSPTNSVLKT
310 320 330 340 350
DAEELVSRSY WDTLRRNTSQ ALFSDLAERA DDITSLVTDT TLLVHFFGKK
360 370 380 390 400
GKAELNFEDF YRFMDNLQTE VLEIEFLSYS NGMNTISEED FAHILLRYTN
410 420 430 440 450
VENTSVFLEN VRYSIPEEKG ITFDEFRSFF QFLNNLEDFA IALNMYNFAS
460 470 480 490 500
RSIGQDEFKR AVYVATGLKF SPHLVNTVFK IFDVDKDDQL SYKEFIGIMK
510 520 530
DRLHRGFRGY KTVQKYPTFK SCLKKELHSR
Length:530
Mass (Da):60,711
Last modified:June 1, 2003 - v1
Checksum:iC51CAC12C3021F5C
GO

Sequence cautioni

The sequence AAH32868 differs from that shown. Reason: Frameshift at position 29.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3A → C in AAH32868 (PubMed:16421571).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079193 Genomic DNA No translation available.
AC136305 Genomic DNA No translation available.
BC032868 mRNA Translation: AAH32868.1 Frameshift.
BC045553 mRNA Translation: AAH45553.1
CCDSiCCDS5999.1
RefSeqiNP_859074.1, NM_181723.2
UniGeneiHs.403594

Genome annotation databases

EnsembliENST00000318063; ENSP00000321455; ENSG00000155970
GeneIDi286097
KEGGihsa:286097
UCSCiuc003wxd.3 human

Similar proteinsi

Entry informationi

Entry nameiMICU3_HUMAN
AccessioniPrimary (citable) accession number: Q86XE3
Secondary accession number(s): Q8IYZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2003
Last modified: June 20, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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