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Protein

Calcium uptake protein 3, mitochondrial

Gene

MICU3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in mitochondrial calcium uptake.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi245 – 256121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi483 – 494122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium uptake protein 3, mitochondrial
Alternative name(s):
EF-hand domain-containing family member A2
Gene namesi
Name:MICU3
Synonyms:EFHA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:27820. MICU3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei67 – 8317HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134953154.

Polymorphism and mutation databases

BioMutaiMICU3.
DMDMi74762459.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Calcium uptake protein 3, mitochondrialPRO_0000251230Add
BLAST

Proteomic databases

MaxQBiQ86XE3.
PaxDbiQ86XE3.
PRIDEiQ86XE3.

PTM databases

iPTMnetiQ86XE3.
PhosphoSiteiQ86XE3.

Expressioni

Gene expression databases

BgeeiQ86XE3.
CleanExiHS_EFHA2.
ExpressionAtlasiQ86XE3. baseline and differential.
GenevisibleiQ86XE3. HS.

Organism-specific databases

HPAiHPA024048.
HPA024771.
HPA024779.

Interactioni

Protein-protein interaction databases

BioGridi130297. 3 interactions.
STRINGi9606.ENSP00000321455.

Structurei

3D structure databases

ProteinModelPortaliQ86XE3.
SMRiQ86XE3. Positions 143-265, 334-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini232 – 26736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini401 – 43636EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini470 – 50536EF-hand 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 635Poly-Arg
Compositional biasi70 – 734Poly-Ala

Sequence similaritiesi

Belongs to the MICU1 family. MICU3 subfamily.Curated
Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2643. Eukaryota.
ENOG410ZSC1. LUCA.
GeneTreeiENSGT00530000063089.
HOGENOMiHOG000007649.
HOVERGENiHBG054562.
InParanoidiQ86XE3.
OMAiTTFKSCV.
OrthoDBiEOG7966KN.
PhylomeDBiQ86XE3.
TreeFamiTF320374.

Family and domain databases

Gene3Di1.10.238.10. 5 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13833. EF-hand_8. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 3 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86XE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALRRLLWP PPRVSPPLCA HQPLLGPWGR PAVTTLGLPG RPFSSREDEE
60 70 80 90 100
RAVAEAAWRR RRRWGELSVA AAAGGGLVGL VCYQLYGDPR AGSPATGRPS
110 120 130 140 150
KSAATEPEDP PRGRGMLPIP VAAAKETVAI GRTDIEDLDL YATSRERRFR
160 170 180 190 200
LFASIECEGQ LFMTPYDFIL AVTTDEPKVA KTWKSLSKQE LNQMLAETPP
210 220 230 240 250
VWKGSSKLFR NLKEKGVISY TEYLFLLCIL TKPHAGFRIA FNMFDTDGNE
260 270 280 290 300
MVDKKEFLVL QEIFRKKNEK REIKGDEEKR AMLRLQLYGY HSPTNSVLKT
310 320 330 340 350
DAEELVSRSY WDTLRRNTSQ ALFSDLAERA DDITSLVTDT TLLVHFFGKK
360 370 380 390 400
GKAELNFEDF YRFMDNLQTE VLEIEFLSYS NGMNTISEED FAHILLRYTN
410 420 430 440 450
VENTSVFLEN VRYSIPEEKG ITFDEFRSFF QFLNNLEDFA IALNMYNFAS
460 470 480 490 500
RSIGQDEFKR AVYVATGLKF SPHLVNTVFK IFDVDKDDQL SYKEFIGIMK
510 520 530
DRLHRGFRGY KTVQKYPTFK SCLKKELHSR
Length:530
Mass (Da):60,711
Last modified:June 1, 2003 - v1
Checksum:iC51CAC12C3021F5C
GO

Sequence cautioni

The sequence AAH32868.1 differs from that shown. Reason: Frameshift at position 29. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31A → C in AAH32868 (PubMed:16421571).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079193 Genomic DNA. No translation available.
AC136305 Genomic DNA. No translation available.
BC032868 mRNA. Translation: AAH32868.1. Frameshift.
BC045553 mRNA. Translation: AAH45553.1.
CCDSiCCDS5999.1.
RefSeqiNP_859074.1. NM_181723.2.
UniGeneiHs.403594.

Genome annotation databases

EnsembliENST00000318063; ENSP00000321455; ENSG00000155970.
GeneIDi286097.
KEGGihsa:286097.
UCSCiuc003wxd.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079193 Genomic DNA. No translation available.
AC136305 Genomic DNA. No translation available.
BC032868 mRNA. Translation: AAH32868.1. Frameshift.
BC045553 mRNA. Translation: AAH45553.1.
CCDSiCCDS5999.1.
RefSeqiNP_859074.1. NM_181723.2.
UniGeneiHs.403594.

3D structure databases

ProteinModelPortaliQ86XE3.
SMRiQ86XE3. Positions 143-265, 334-507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130297. 3 interactions.
STRINGi9606.ENSP00000321455.

PTM databases

iPTMnetiQ86XE3.
PhosphoSiteiQ86XE3.

Polymorphism and mutation databases

BioMutaiMICU3.
DMDMi74762459.

Proteomic databases

MaxQBiQ86XE3.
PaxDbiQ86XE3.
PRIDEiQ86XE3.

Protocols and materials databases

DNASUi286097.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318063; ENSP00000321455; ENSG00000155970.
GeneIDi286097.
KEGGihsa:286097.
UCSCiuc003wxd.3. human.

Organism-specific databases

CTDi286097.
GeneCardsiMICU3.
HGNCiHGNC:27820. MICU3.
HPAiHPA024048.
HPA024771.
HPA024779.
MIMi610633. gene.
neXtProtiNX_Q86XE3.
PharmGKBiPA134953154.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2643. Eukaryota.
ENOG410ZSC1. LUCA.
GeneTreeiENSGT00530000063089.
HOGENOMiHOG000007649.
HOVERGENiHBG054562.
InParanoidiQ86XE3.
OMAiTTFKSCV.
OrthoDBiEOG7966KN.
PhylomeDBiQ86XE3.
TreeFamiTF320374.

Miscellaneous databases

ChiTaRSiMICU3. human.
GenomeRNAii286097.
PROiQ86XE3.
SOURCEiSearch...

Gene expression databases

BgeeiQ86XE3.
CleanExiHS_EFHA2.
ExpressionAtlasiQ86XE3. baseline and differential.
GenevisibleiQ86XE3. HS.

Family and domain databases

Gene3Di1.10.238.10. 5 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13833. EF-hand_8. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 3 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiMICU3_HUMAN
AccessioniPrimary (citable) accession number: Q86XE3
Secondary accession number(s): Q8IYZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binds calcium.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.