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Protein

Sorting nexin-32

Gene

SNX32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking.By similarity

GO - Molecular functioni

GO - Biological processi

  • endocytosis Source: GO_Central
  • protein transport Source: UniProtKB-KW
  • regulation of macroautophagy Source: ParkinsonsUK-UCL
  • vesicle organization Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-32
Alternative name(s):
Sorting nexin-6B
Gene namesi
Name:SNX32
Synonyms:SNX6B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26423. SNX32.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172803.
PharmGKBiPA162404314.

Polymorphism and mutation databases

BioMutaiSNX32.
DMDMi74727816.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003207071 – 403Sorting nexin-32Add BLAST403

Proteomic databases

EPDiQ86XE0.
MaxQBiQ86XE0.
PaxDbiQ86XE0.
PeptideAtlasiQ86XE0.
PRIDEiQ86XE0.

PTM databases

iPTMnetiQ86XE0.
PhosphoSitePlusiQ86XE0.

Expressioni

Gene expression databases

BgeeiENSG00000172803.
CleanExiHS_SNX32.
GenevisibleiQ86XE0. HS.

Organism-specific databases

HPAiHPA041775.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SNX1Q135966EBI-8099743,EBI-2822329

Protein-protein interaction databases

BioGridi129016. 9 interactors.
IntActiQ86XE0. 5 interactors.
MINTiMINT-6940005.
STRINGi9606.ENSP00000310620.

Structurei

3D structure databases

ProteinModelPortaliQ86XE0.
SMRiQ86XE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 168PXPROSITE-ProRule annotationAdd BLAST149

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili258 – 335Sequence analysisAdd BLAST78

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1660. Eukaryota.
ENOG410XPZY. LUCA.
GeneTreeiENSGT00840000129756.
HOGENOMiHOG000231691.
HOVERGENiHBG000716.
InParanoidiQ86XE0.
KOiK17920.
OMAiCCQRFER.
OrthoDBiEOG091G08NT.
PhylomeDBiQ86XE0.
TreeFamiTF313698.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR014637. SNX5/SNX6/SNX32.
IPR015404. Vps5_C.
[Graphical view]
PfamiPF00787. PX. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view]
PIRSFiPIRSF036924. Snx5_Snx6. 1 hit.
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86XE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METYAEVGKE GKPSCASVDL QGDSSLQVEI SDAVSERDKV KFTVQTKSCL
60 70 80 90 100
PHFAQTEFSV VRQHEEFIWL HDAYVENEEY AGLIIPPAPP RPDFEASREK
110 120 130 140 150
LQKLGEGDSS VTREEFAKMK QELEAEYLAI FKKTVAMHEV FLQRLAAHPT
160 170 180 190 200
LRRDHNFFVF LEYGQDLSVR GKNRKELLGG FLRNIVKSAD EALITGMSGL
210 220 230 240 250
KEVDDFFEHE RTFLLEYHTR IRDACLRADR VMRAHKCLAD DYIPISAALS
260 270 280 290 300
SLGTQEVNQL RTSFLKLAEL FERLRKLEGR VASDEDLKLS DMLRYYMRDS
310 320 330 340 350
QAAKDLLYRR LRALADYENA NKALDKARTR NREVRPAESH QQLCCQRFER
360 370 380 390 400
LSDSAKQELM DFKSRRVSSF RKNLIELAEL ELKHAKASTL ILRNTLVALK

GEP
Length:403
Mass (Da):46,399
Last modified:June 1, 2003 - v1
Checksum:i9100676299AE2C19
GO
Isoform 2 (identifier: Q86XE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-277: LADDYIPISA...AELFERLRKL → TQGPRGPGSP...CLSVATSTKA
     278-403: Missing.

Note: No experimental confirmation available.
Show »
Length:277
Mass (Da):31,369
Checksum:iEAB0DD2C432C0FAB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14S → P in BAB70935 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039298155H → N.1 PublicationCorresponds to variant rs17854065dbSNPEnsembl.1
Natural variantiVAR_039299282A → V.1 PublicationCorresponds to variant rs17855647dbSNPEnsembl.1
Natural variantiVAR_039300354S → Y.1 PublicationCorresponds to variant rs17857243dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031742238 – 277LADDY…RLRKL → TQGPRGPGSPCPSPQRFNSL GERREQGVPCCLSVATSTKA in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_031743278 – 403Missing in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055496 mRNA. Translation: BAB70935.1.
AK289587 mRNA. Translation: BAF82276.1.
CH471076 Genomic DNA. Translation: EAW74441.1.
BC040981 mRNA. Translation: AAH40981.1.
BC045563 mRNA. Translation: AAH45563.1.
CCDSiCCDS8113.2. [Q86XE0-1]
RefSeqiNP_689973.2. NM_152760.2. [Q86XE0-1]
UniGeneiHs.591950.

Genome annotation databases

EnsembliENST00000308342; ENSP00000310620; ENSG00000172803. [Q86XE0-1]
GeneIDi254122.
KEGGihsa:254122.
UCSCiuc001ofr.4. human. [Q86XE0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055496 mRNA. Translation: BAB70935.1.
AK289587 mRNA. Translation: BAF82276.1.
CH471076 Genomic DNA. Translation: EAW74441.1.
BC040981 mRNA. Translation: AAH40981.1.
BC045563 mRNA. Translation: AAH45563.1.
CCDSiCCDS8113.2. [Q86XE0-1]
RefSeqiNP_689973.2. NM_152760.2. [Q86XE0-1]
UniGeneiHs.591950.

3D structure databases

ProteinModelPortaliQ86XE0.
SMRiQ86XE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129016. 9 interactors.
IntActiQ86XE0. 5 interactors.
MINTiMINT-6940005.
STRINGi9606.ENSP00000310620.

PTM databases

iPTMnetiQ86XE0.
PhosphoSitePlusiQ86XE0.

Polymorphism and mutation databases

BioMutaiSNX32.
DMDMi74727816.

Proteomic databases

EPDiQ86XE0.
MaxQBiQ86XE0.
PaxDbiQ86XE0.
PeptideAtlasiQ86XE0.
PRIDEiQ86XE0.

Protocols and materials databases

DNASUi254122.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308342; ENSP00000310620; ENSG00000172803. [Q86XE0-1]
GeneIDi254122.
KEGGihsa:254122.
UCSCiuc001ofr.4. human. [Q86XE0-1]

Organism-specific databases

CTDi254122.
GeneCardsiSNX32.
HGNCiHGNC:26423. SNX32.
HPAiHPA041775.
neXtProtiNX_Q86XE0.
OpenTargetsiENSG00000172803.
PharmGKBiPA162404314.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1660. Eukaryota.
ENOG410XPZY. LUCA.
GeneTreeiENSGT00840000129756.
HOGENOMiHOG000231691.
HOVERGENiHBG000716.
InParanoidiQ86XE0.
KOiK17920.
OMAiCCQRFER.
OrthoDBiEOG091G08NT.
PhylomeDBiQ86XE0.
TreeFamiTF313698.

Miscellaneous databases

GenomeRNAii254122.
PROiQ86XE0.

Gene expression databases

BgeeiENSG00000172803.
CleanExiHS_SNX32.
GenevisibleiQ86XE0. HS.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR014637. SNX5/SNX6/SNX32.
IPR015404. Vps5_C.
[Graphical view]
PfamiPF00787. PX. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view]
PIRSFiPIRSF036924. Snx5_Snx6. 1 hit.
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX32_HUMAN
AccessioniPrimary (citable) accession number: Q86XE0
Secondary accession number(s): Q8IW53, Q96NG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.