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Q86XD8

- ZFAN4_HUMAN

UniProt

Q86XD8 - ZFAN4_HUMAN

Protein

AN1-type zinc finger protein 4

Gene

ZFAND4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri664 – 70845AN1-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AN1-type zinc finger protein 4
    Alternative name(s):
    AN1-type zinc finger and ubiquitin domain-containing protein-like 1
    Gene namesi
    Name:ZFAND4
    Synonyms:ANUBL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23504. ZFAND4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134976557.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 727727AN1-type zinc finger protein 4PRO_0000269892Add
    BLAST

    Proteomic databases

    PaxDbiQ86XD8.
    PRIDEiQ86XD8.

    PTM databases

    PhosphoSiteiQ86XD8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86XD8.
    BgeeiQ86XD8.
    CleanExiHS_ANUBL1.
    GenevestigatoriQ86XD8.

    Organism-specific databases

    HPAiHPA037839.

    Interactioni

    Protein-protein interaction databases

    BioGridi125033. 1 interaction.
    IntActiQ86XD8. 1 interaction.
    STRINGi9606.ENSP00000339484.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86XD8.
    SMRiQ86XD8. Positions 28-103, 641-718.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 10376Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 AN1-type zinc finger.PROSITE-ProRule annotation
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri664 – 70845AN1-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5272.
    HOGENOMiHOG000033974.
    HOVERGENiHBG059193.
    InParanoidiQ86XD8.
    KOiK12163.
    OMAiHNSLVKP.
    OrthoDBiEOG7TTQ9W.
    PhylomeDBiQ86XD8.
    TreeFamiTF329607.

    Family and domain databases

    Gene3Di4.10.1110.10. 1 hit.
    InterProiIPR019956. Ubiquitin.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR000058. Znf_AN1.
    [Graphical view]
    PfamiPF00240. ubiquitin. 1 hit.
    PF01428. zf-AN1. 1 hit.
    [Graphical view]
    PRINTSiPR00348. UBIQUITIN.
    SMARTiSM00213. UBQ. 1 hit.
    SM00154. ZnF_AN1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50053. UBIQUITIN_2. 1 hit.
    PS51039. ZF_AN1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86XD8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNRKEPPFF NDDNMGPFYY RLHFCDTMEL FIETLTGTCF ELRVSPFETV    50
    ISVKAKIRRL EGIPICRQHL IWNNMELEND YCLNDYNISE GCTLKLVLAM 100
    RGGPINTRRV PTDDPLRKMA EYLDSSRVEV WEKTSCSKQV TFLVYQEGDQ 150
    LNFFPAVDRG DGTLTPLSDS SKKIDFHLHV LRRKGEHRMS GGSMYNSDTD 200
    EDEETEPSSS GQQIIENSIT MNKMKLLKAK MKNMNLSKKP KKAVKIKPHP 250
    PVAPRPSSGS TAPSRHRLLR VLPNIGQSCS PAFGNAYPPE ISRNGISSLA 300
    TQLSAERYIS SITGEFLKED NSWENNTLSH FSSNVKLPPQ IPHLELGNDQ 350
    ELADSVLHLG SSLPRQTKHF LGNLPSSNGN IVLPSEECVT EQSLLPKVGS 400
    LASFAEGNAD EQSSGLEGAC KVNLELLLTN ADKGLKAPEQ HLKHVAGVLN 450
    GESVETSVLN YRELSPHKNR LLSPLRCSAP MSLHNSLVKP ERQSKCFEFG 500
    KLQPSSSQSL DVQNITDSSF SRTTCFQGVK VDSLGKRSDV ISKVEARDIT 550
    EMTNKASKEP VGCVNNISFL ASLAGSTSRN RLQSTRGAGR LQNSGTGLST 600
    NLQHFQEENF RKSSPQLEHT GVFLSTHGVG MNGNNAAAGK SVGECTTHHL 650
    PPVKAPLQTK KKTTNHCFLC GKKTGLASSY ECRCGNNFCA SHRYAETHGC 700
    TYDYKSAGRR YLHEANPVVN APKLPKI 727
    Length:727
    Mass (Da):80,358
    Last modified:August 30, 2005 - v2
    Checksum:i3D162959CFFC544C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti118 – 1181K → T.1 Publication
    Corresponds to variant rs17854567 [ dbSNP | Ensembl ].
    VAR_053773
    Natural varianti358 – 3581H → Y.
    Corresponds to variant rs12267385 [ dbSNP | Ensembl ].
    VAR_053774
    Natural varianti523 – 5231T → A.
    Corresponds to variant rs34082391 [ dbSNP | Ensembl ].
    VAR_062163

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK292469 mRNA. Translation: BAF85158.1.
    AK314395 mRNA. Translation: BAG37019.1.
    AL445201 Genomic DNA. Translation: CAH72967.1.
    CH471160 Genomic DNA. Translation: EAW86653.1.
    BC045587 mRNA. Translation: AAH45587.2.
    CCDSiCCDS7214.1.
    RefSeqiNP_001121796.1. NM_001128324.2.
    NP_001269835.1. NM_001282906.1.
    NP_777550.2. NM_174890.3.
    UniGeneiHs.659717.
    Hs.89029.

    Genome annotation databases

    EnsembliENST00000344646; ENSP00000339484; ENSG00000172671.
    GeneIDi93550.
    KEGGihsa:93550.
    UCSCiuc001jcm.4. human.

    Polymorphism databases

    DMDMi121944435.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK292469 mRNA. Translation: BAF85158.1 .
    AK314395 mRNA. Translation: BAG37019.1 .
    AL445201 Genomic DNA. Translation: CAH72967.1 .
    CH471160 Genomic DNA. Translation: EAW86653.1 .
    BC045587 mRNA. Translation: AAH45587.2 .
    CCDSi CCDS7214.1.
    RefSeqi NP_001121796.1. NM_001128324.2.
    NP_001269835.1. NM_001282906.1.
    NP_777550.2. NM_174890.3.
    UniGenei Hs.659717.
    Hs.89029.

    3D structure databases

    ProteinModelPortali Q86XD8.
    SMRi Q86XD8. Positions 28-103, 641-718.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125033. 1 interaction.
    IntActi Q86XD8. 1 interaction.
    STRINGi 9606.ENSP00000339484.

    PTM databases

    PhosphoSitei Q86XD8.

    Polymorphism databases

    DMDMi 121944435.

    Proteomic databases

    PaxDbi Q86XD8.
    PRIDEi Q86XD8.

    Protocols and materials databases

    DNASUi 93550.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344646 ; ENSP00000339484 ; ENSG00000172671 .
    GeneIDi 93550.
    KEGGi hsa:93550.
    UCSCi uc001jcm.4. human.

    Organism-specific databases

    CTDi 93550.
    GeneCardsi GC10M046112.
    HGNCi HGNC:23504. ZFAND4.
    HPAi HPA037839.
    neXtProti NX_Q86XD8.
    PharmGKBi PA134976557.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5272.
    HOGENOMi HOG000033974.
    HOVERGENi HBG059193.
    InParanoidi Q86XD8.
    KOi K12163.
    OMAi HNSLVKP.
    OrthoDBi EOG7TTQ9W.
    PhylomeDBi Q86XD8.
    TreeFami TF329607.

    Miscellaneous databases

    ChiTaRSi ZFAND4. human.
    GenomeRNAii 93550.
    NextBioi 78113.
    PROi Q86XD8.

    Gene expression databases

    ArrayExpressi Q86XD8.
    Bgeei Q86XD8.
    CleanExi HS_ANUBL1.
    Genevestigatori Q86XD8.

    Family and domain databases

    Gene3Di 4.10.1110.10. 1 hit.
    InterProi IPR019956. Ubiquitin.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR000058. Znf_AN1.
    [Graphical view ]
    Pfami PF00240. ubiquitin. 1 hit.
    PF01428. zf-AN1. 1 hit.
    [Graphical view ]
    PRINTSi PR00348. UBIQUITIN.
    SMARTi SM00213. UBQ. 1 hit.
    SM00154. ZnF_AN1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50053. UBIQUITIN_2. 1 hit.
    PS51039. ZF_AN1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-118.
      Tissue: Testis.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiZFAN4_HUMAN
    AccessioniPrimary (citable) accession number: Q86XD8
    Secondary accession number(s): A8K8V4, B2RAX2, Q5VVY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    A report observed N-glycosylation at Asn-235 (PubMed:19139490). However, as the protein is not predicted to localize in an extracellular compartment of the cell, additional evidences are required to confirm this result.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3