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Q86XD8

- ZFAN4_HUMAN

UniProt

Q86XD8 - ZFAN4_HUMAN

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Protein
AN1-type zinc finger protein 4
Gene
ZFAND4, ANUBL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri664 – 70845AN1-type
Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
AN1-type zinc finger protein 4
Alternative name(s):
AN1-type zinc finger and ubiquitin domain-containing protein-like 1
Gene namesi
Name:ZFAND4
Synonyms:ANUBL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23504. ZFAND4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134976557.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727AN1-type zinc finger protein 4
PRO_0000269892Add
BLAST

Proteomic databases

PaxDbiQ86XD8.
PRIDEiQ86XD8.

PTM databases

PhosphoSiteiQ86XD8.

Expressioni

Gene expression databases

ArrayExpressiQ86XD8.
BgeeiQ86XD8.
CleanExiHS_ANUBL1.
GenevestigatoriQ86XD8.

Organism-specific databases

HPAiHPA037839.

Interactioni

Protein-protein interaction databases

BioGridi125033. 1 interaction.
IntActiQ86XD8. 1 interaction.
STRINGi9606.ENSP00000339484.

Structurei

3D structure databases

ProteinModelPortaliQ86XD8.
SMRiQ86XD8. Positions 28-103, 641-718.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10376Ubiquitin-like
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5272.
HOGENOMiHOG000033974.
HOVERGENiHBG059193.
InParanoidiQ86XD8.
KOiK12163.
OMAiHNSLVKP.
OrthoDBiEOG7TTQ9W.
PhylomeDBiQ86XD8.
TreeFamiTF329607.

Family and domain databases

Gene3Di4.10.1110.10. 1 hit.
InterProiIPR019956. Ubiquitin.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR000058. Znf_AN1.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
PF01428. zf-AN1. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM00213. UBQ. 1 hit.
SM00154. ZnF_AN1. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
PS51039. ZF_AN1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86XD8-1 [UniParc]FASTAAdd to Basket

« Hide

MDNRKEPPFF NDDNMGPFYY RLHFCDTMEL FIETLTGTCF ELRVSPFETV    50
ISVKAKIRRL EGIPICRQHL IWNNMELEND YCLNDYNISE GCTLKLVLAM 100
RGGPINTRRV PTDDPLRKMA EYLDSSRVEV WEKTSCSKQV TFLVYQEGDQ 150
LNFFPAVDRG DGTLTPLSDS SKKIDFHLHV LRRKGEHRMS GGSMYNSDTD 200
EDEETEPSSS GQQIIENSIT MNKMKLLKAK MKNMNLSKKP KKAVKIKPHP 250
PVAPRPSSGS TAPSRHRLLR VLPNIGQSCS PAFGNAYPPE ISRNGISSLA 300
TQLSAERYIS SITGEFLKED NSWENNTLSH FSSNVKLPPQ IPHLELGNDQ 350
ELADSVLHLG SSLPRQTKHF LGNLPSSNGN IVLPSEECVT EQSLLPKVGS 400
LASFAEGNAD EQSSGLEGAC KVNLELLLTN ADKGLKAPEQ HLKHVAGVLN 450
GESVETSVLN YRELSPHKNR LLSPLRCSAP MSLHNSLVKP ERQSKCFEFG 500
KLQPSSSQSL DVQNITDSSF SRTTCFQGVK VDSLGKRSDV ISKVEARDIT 550
EMTNKASKEP VGCVNNISFL ASLAGSTSRN RLQSTRGAGR LQNSGTGLST 600
NLQHFQEENF RKSSPQLEHT GVFLSTHGVG MNGNNAAAGK SVGECTTHHL 650
PPVKAPLQTK KKTTNHCFLC GKKTGLASSY ECRCGNNFCA SHRYAETHGC 700
TYDYKSAGRR YLHEANPVVN APKLPKI 727
Length:727
Mass (Da):80,358
Last modified:August 30, 2005 - v2
Checksum:i3D162959CFFC544C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181K → T.1 Publication
Corresponds to variant rs17854567 [ dbSNP | Ensembl ].
VAR_053773
Natural varianti358 – 3581H → Y.
Corresponds to variant rs12267385 [ dbSNP | Ensembl ].
VAR_053774
Natural varianti523 – 5231T → A.
Corresponds to variant rs34082391 [ dbSNP | Ensembl ].
VAR_062163

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK292469 mRNA. Translation: BAF85158.1.
AK314395 mRNA. Translation: BAG37019.1.
AL445201 Genomic DNA. Translation: CAH72967.1.
CH471160 Genomic DNA. Translation: EAW86653.1.
BC045587 mRNA. Translation: AAH45587.2.
CCDSiCCDS7214.1.
RefSeqiNP_001121796.1. NM_001128324.2.
NP_001269835.1. NM_001282906.1.
NP_777550.2. NM_174890.3.
UniGeneiHs.659717.
Hs.89029.

Genome annotation databases

EnsembliENST00000344646; ENSP00000339484; ENSG00000172671.
GeneIDi93550.
KEGGihsa:93550.
UCSCiuc001jcm.4. human.

Polymorphism databases

DMDMi121944435.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK292469 mRNA. Translation: BAF85158.1 .
AK314395 mRNA. Translation: BAG37019.1 .
AL445201 Genomic DNA. Translation: CAH72967.1 .
CH471160 Genomic DNA. Translation: EAW86653.1 .
BC045587 mRNA. Translation: AAH45587.2 .
CCDSi CCDS7214.1.
RefSeqi NP_001121796.1. NM_001128324.2.
NP_001269835.1. NM_001282906.1.
NP_777550.2. NM_174890.3.
UniGenei Hs.659717.
Hs.89029.

3D structure databases

ProteinModelPortali Q86XD8.
SMRi Q86XD8. Positions 28-103, 641-718.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125033. 1 interaction.
IntActi Q86XD8. 1 interaction.
STRINGi 9606.ENSP00000339484.

PTM databases

PhosphoSitei Q86XD8.

Polymorphism databases

DMDMi 121944435.

Proteomic databases

PaxDbi Q86XD8.
PRIDEi Q86XD8.

Protocols and materials databases

DNASUi 93550.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344646 ; ENSP00000339484 ; ENSG00000172671 .
GeneIDi 93550.
KEGGi hsa:93550.
UCSCi uc001jcm.4. human.

Organism-specific databases

CTDi 93550.
GeneCardsi GC10M046112.
HGNCi HGNC:23504. ZFAND4.
HPAi HPA037839.
neXtProti NX_Q86XD8.
PharmGKBi PA134976557.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5272.
HOGENOMi HOG000033974.
HOVERGENi HBG059193.
InParanoidi Q86XD8.
KOi K12163.
OMAi HNSLVKP.
OrthoDBi EOG7TTQ9W.
PhylomeDBi Q86XD8.
TreeFami TF329607.

Miscellaneous databases

ChiTaRSi ZFAND4. human.
GenomeRNAii 93550.
NextBioi 78113.
PROi Q86XD8.

Gene expression databases

ArrayExpressi Q86XD8.
Bgeei Q86XD8.
CleanExi HS_ANUBL1.
Genevestigatori Q86XD8.

Family and domain databases

Gene3Di 4.10.1110.10. 1 hit.
InterProi IPR019956. Ubiquitin.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR000058. Znf_AN1.
[Graphical view ]
Pfami PF00240. ubiquitin. 1 hit.
PF01428. zf-AN1. 1 hit.
[Graphical view ]
PRINTSi PR00348. UBIQUITIN.
SMARTi SM00213. UBQ. 1 hit.
SM00154. ZnF_AN1. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS50053. UBIQUITIN_2. 1 hit.
PS51039. ZF_AN1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-118.
    Tissue: Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: IDENTIFICATION.

Entry informationi

Entry nameiZFAN4_HUMAN
AccessioniPrimary (citable) accession number: Q86XD8
Secondary accession number(s): A8K8V4, B2RAX2, Q5VVY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 30, 2005
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

A report observed N-glycosylation at Asn-235 (1 Publication). However, as the protein is not predicted to localize in an extracellular compartment of the cell, additional evidences are required to confirm this result.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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