Q86XD8 (ZFAN4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
AN1-type zinc finger protein 4

Alternative name(s):
AN1-type zinc finger and ubiquitin domain-containing protein-like 1

Gene names

Name:	ZFAND4
Synonyms:	ANUBL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	727 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 AN1-type zinc finger. Contains 1 ubiquitin-like domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 727	727	AN1-type zinc finger protein 4		PRO_0000269892
Regions
	Domain	28 – 103	76	Ubiquitin-like
	Zinc finger	664 – 708	45	AN1-type
Natural variations
	Natural variant	118	1	K → T. Ref.1 Corresponds to variant rs17854567 [ dbSNP | Ensembl ].		VAR_053773
	Natural variant	358	1	H → Y. Corresponds to variant rs12267385 [ dbSNP | Ensembl ].		VAR_053774
	Natural variant	523	1	T → A. Corresponds to variant rs34082391 [ dbSNP | Ensembl ].		VAR_062163

Sequences

	Sequence		Length	Mass (Da)
	Q86XD8 [UniParc]. Last modified August 30, 2005. Version 2. Checksum: 3D162959CFFC544C	FASTA	727	80,358
	10 20 30 40 50 60 MDNRKEPPFF NDDNMGPFYY RLHFCDTMEL FIETLTGTCF ELRVSPFETV ISVKAKIRRL 70 80 90 100 110 120 EGIPICRQHL IWNNMELEND YCLNDYNISE GCTLKLVLAM RGGPINTRRV PTDDPLRKMA 130 140 150 160 170 180 EYLDSSRVEV WEKTSCSKQV TFLVYQEGDQ LNFFPAVDRG DGTLTPLSDS SKKIDFHLHV 190 200 210 220 230 240 LRRKGEHRMS GGSMYNSDTD EDEETEPSSS GQQIIENSIT MNKMKLLKAK MKNMNLSKKP 250 260 270 280 290 300 KKAVKIKPHP PVAPRPSSGS TAPSRHRLLR VLPNIGQSCS PAFGNAYPPE ISRNGISSLA 310 320 330 340 350 360 TQLSAERYIS SITGEFLKED NSWENNTLSH FSSNVKLPPQ IPHLELGNDQ ELADSVLHLG 370 380 390 400 410 420 SSLPRQTKHF LGNLPSSNGN IVLPSEECVT EQSLLPKVGS LASFAEGNAD EQSSGLEGAC 430 440 450 460 470 480 KVNLELLLTN ADKGLKAPEQ HLKHVAGVLN GESVETSVLN YRELSPHKNR LLSPLRCSAP 490 500 510 520 530 540 MSLHNSLVKP ERQSKCFEFG KLQPSSSQSL DVQNITDSSF SRTTCFQGVK VDSLGKRSDV 550 560 570 580 590 600 ISKVEARDIT EMTNKASKEP VGCVNNISFL ASLAGSTSRN RLQSTRGAGR LQNSGTGLST 610 620 630 640 650 660 NLQHFQEENF RKSSPQLEHT GVFLSTHGVG MNGNNAAAGK SVGECTTHHL PPVKAPLQTK 670 680 690 700 710 720 KKTTNHCFLC GKKTGLASSY ECRCGNNFCA SHRYAETHGC TYDYKSAGRR YLHEANPVVN APKLPKI

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-118. Tissue: Testis.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK292469 mRNA. Translation: BAF85158.1. AK314395 mRNA. Translation: BAG37019.1. AL445201 Genomic DNA. Translation: CAH72967.1. CH471160 Genomic DNA. Translation: EAW86653.1. BC045587 mRNA. Translation: AAH45587.2.
IPI	IPI00549731.
RefSeq	NP_001121796.1. NM_001128324.1. NP_777550.2. NM_174890.2.
UniGene	Hs.89029.
3D structure databases
HSSP	HSSP built from PDB template 1WRD based on UniProtKB Q862M4.
ProteinModelPortal	Q86XD8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86XD8. 1 interaction.
STRING	9606.ENSP00000339484.
PTM databases
PhosphoSite	Q86XD8.
Polymorphism databases
DMDM	121944435.
Proteomic databases
PaxDb	Q86XD8.
PRIDE	Q86XD8.
Protocols and materials databases
DNASU	93550.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000344646; ENSP00000339484; ENSG00000172671.
GeneID	93550.
KEGG	hsa:93550.
UCSC	uc001jcm.4. human.
Organism-specific databases
CTD	93550.
GeneCards	GC10M046112.
HGNC	HGNC:23504. ZFAND4.
HPA	HPA037839.
neXtProt	NX_Q86XD8.
PharmGKB	PA134976557.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5272.
HOGENOM	HOG000033974.
HOVERGEN	HBG059193.
InParanoid	Q86XD8.
KO	K12163.
OMA	HNSLVKP.
OrthoDB	EOG4XSKPQ.
PhylomeDB	Q86XD8.
Gene expression databases
ArrayExpress	Q86XD8.
Bgee	Q86XD8.
CleanEx	HS_ANUBL1.
Genevestigator	Q86XD8.
Family and domain databases
Gene3D	4.10.1110.10. 1 hit.
InterPro	IPR000626. Ubiquitin. IPR019956. Ubiquitin_subgr. IPR019955. Ubiquitin_supergroup. IPR000058. Znf_AN1. [Graphical view]
Pfam	PF00240. ubiquitin. 1 hit. PF01428. zf-AN1. 1 hit. [Graphical view]
PRINTS	PR00348. UBIQUITIN.
SMART	SM00213. UBQ. 1 hit. SM00154. ZnF_AN1. 1 hit. [Graphical view]
PROSITE	PS00299. UBIQUITIN_1. False negative. PS50053. UBIQUITIN_2. 1 hit. PS51039. ZF_AN1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZFAND4. human.
GenomeRNAi	93550.
NextBio	78113.

Entry information

Entry name

ZFAN4_HUMAN

Accession

Primary (citable) accession number: Q86XD8
Secondary accession number(s): A8K8V4, B2RAX2, Q5VVY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.