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Q86XD8 (ZFAN4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
AN1-type zinc finger protein 4
Alternative name(s):
AN1-type zinc finger and ubiquitin domain-containing protein-like 1
Gene names
Name:ZFAND4
Synonyms:ANUBL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length727 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 AN1-type zinc finger.

Contains 1 ubiquitin-like domain.

Caution

A report observed N-glycosylation at Asn-235 (Ref.5). However, as the protein is not predicted to localize in an extracellular compartment of the cell, additional evidences are required to confirm this result.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainZinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 727727AN1-type zinc finger protein 4
PRO_0000269892

Regions

Domain28 – 10376Ubiquitin-like
Zinc finger664 – 70845AN1-type

Natural variations

Natural variant1181K → T. Ref.1
Corresponds to variant rs17854567 [ dbSNP | Ensembl ].
VAR_053773
Natural variant3581H → Y.
Corresponds to variant rs12267385 [ dbSNP | Ensembl ].
VAR_053774
Natural variant5231T → A.
Corresponds to variant rs34082391 [ dbSNP | Ensembl ].
VAR_062163

Sequences

Sequence LengthMass (Da)Tools
Q86XD8 [UniParc].

Last modified August 30, 2005. Version 2.
Checksum: 3D162959CFFC544C

FASTA72780,358
        10         20         30         40         50         60 
MDNRKEPPFF NDDNMGPFYY RLHFCDTMEL FIETLTGTCF ELRVSPFETV ISVKAKIRRL 

        70         80         90        100        110        120 
EGIPICRQHL IWNNMELEND YCLNDYNISE GCTLKLVLAM RGGPINTRRV PTDDPLRKMA 

       130        140        150        160        170        180 
EYLDSSRVEV WEKTSCSKQV TFLVYQEGDQ LNFFPAVDRG DGTLTPLSDS SKKIDFHLHV 

       190        200        210        220        230        240 
LRRKGEHRMS GGSMYNSDTD EDEETEPSSS GQQIIENSIT MNKMKLLKAK MKNMNLSKKP 

       250        260        270        280        290        300 
KKAVKIKPHP PVAPRPSSGS TAPSRHRLLR VLPNIGQSCS PAFGNAYPPE ISRNGISSLA 

       310        320        330        340        350        360 
TQLSAERYIS SITGEFLKED NSWENNTLSH FSSNVKLPPQ IPHLELGNDQ ELADSVLHLG 

       370        380        390        400        410        420 
SSLPRQTKHF LGNLPSSNGN IVLPSEECVT EQSLLPKVGS LASFAEGNAD EQSSGLEGAC 

       430        440        450        460        470        480 
KVNLELLLTN ADKGLKAPEQ HLKHVAGVLN GESVETSVLN YRELSPHKNR LLSPLRCSAP 

       490        500        510        520        530        540 
MSLHNSLVKP ERQSKCFEFG KLQPSSSQSL DVQNITDSSF SRTTCFQGVK VDSLGKRSDV 

       550        560        570        580        590        600 
ISKVEARDIT EMTNKASKEP VGCVNNISFL ASLAGSTSRN RLQSTRGAGR LQNSGTGLST 

       610        620        630        640        650        660 
NLQHFQEENF RKSSPQLEHT GVFLSTHGVG MNGNNAAAGK SVGECTTHHL PPVKAPLQTK 

       670        680        690        700        710        720 
KKTTNHCFLC GKKTGLASSY ECRCGNNFCA SHRYAETHGC TYDYKSAGRR YLHEANPVVN 


APKLPKI 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-118.
Tissue: Testis.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[5]"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK292469 mRNA. Translation: BAF85158.1.
AK314395 mRNA. Translation: BAG37019.1.
AL445201 Genomic DNA. Translation: CAH72967.1.
CH471160 Genomic DNA. Translation: EAW86653.1.
BC045587 mRNA. Translation: AAH45587.2.
RefSeqNP_001121796.1. NM_001128324.2.
NP_001269835.1. NM_001282906.1.
NP_777550.2. NM_174890.3.
UniGeneHs.659717.
Hs.89029.

3D structure databases

ProteinModelPortalQ86XD8.
SMRQ86XD8. Positions 28-151, 641-718.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125033. 1 interaction.
IntActQ86XD8. 1 interaction.
STRING9606.ENSP00000339484.

PTM databases

PhosphoSiteQ86XD8.

Polymorphism databases

DMDM121944435.

Proteomic databases

PaxDbQ86XD8.
PRIDEQ86XD8.

Protocols and materials databases

DNASU93550.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344646; ENSP00000339484; ENSG00000172671.
GeneID93550.
KEGGhsa:93550.
UCSCuc001jcm.4. human.

Organism-specific databases

CTD93550.
GeneCardsGC10M046112.
HGNCHGNC:23504. ZFAND4.
HPAHPA037839.
neXtProtNX_Q86XD8.
PharmGKBPA134976557.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5272.
HOGENOMHOG000033974.
HOVERGENHBG059193.
InParanoidQ86XD8.
KOK12163.
OMAHNSLVKP.
OrthoDBEOG7TTQ9W.
PhylomeDBQ86XD8.
TreeFamTF329607.

Gene expression databases

ArrayExpressQ86XD8.
BgeeQ86XD8.
CleanExHS_ANUBL1.
GenevestigatorQ86XD8.

Family and domain databases

Gene3D4.10.1110.10. 1 hit.
InterProIPR019956. Ubiquitin.
IPR000626. Ubiquitin-like.
IPR000058. Znf_AN1.
[Graphical view]
PfamPF00240. ubiquitin. 1 hit.
PF01428. zf-AN1. 1 hit.
[Graphical view]
PRINTSPR00348. UBIQUITIN.
SMARTSM00213. UBQ. 1 hit.
SM00154. ZnF_AN1. 1 hit.
[Graphical view]
PROSITEPS50053. UBIQUITIN_2. 1 hit.
PS51039. ZF_AN1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZFAND4. human.
GenomeRNAi93550.
NextBio78113.
PROQ86XD8.

Entry information

Entry nameZFAN4_HUMAN
AccessionPrimary (citable) accession number: Q86XD8
Secondary accession number(s): A8K8V4, B2RAX2, Q5VVY5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 30, 2005
Last modified: April 16, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM