Q86XD5 (F131B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM131B

Gene names

Name:	FAM131B
Synonyms:	KIAA0773

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the FAM131 family.
Sequence caution	The sequence AAS07501.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Lipoprotein Myristate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86XD5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86XD5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MDSTSSLHGSSLHRPSTEQTRTDFSWDGIN → MGCIGSRTVG...GSSLHRPSTE

Note: Myristoylated at Gly-2.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Protein FAM131B		PRO_0000253032
Regions
	Compositional bias	283 – 286	4	Poly-Glu
Amino acid modifications
	Modified residue	47	1	Phosphoserine By similarity
	Modified residue	114	1	Phosphoserine By similarity
	Modified residue	117	1	Phosphoserine Ref.8
	Modified residue	297	1	Phosphoserine By similarity
	Modified residue	322	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 30	30	MDSTS…WDGIN → MGCIGSRTVGNEVIAVDWKG LKDVDQINMDSTSSLHGSSL HRPSTE in isoform 2.		VSP_041633
	Natural variant	307	1	A → T. Ref.6 Corresponds to variant rs17854363 [ dbSNP | Ensembl ].		VAR_053920
Experimental info
	Sequence conflict	47	1	S → F in CAD89938. Ref.2
	Sequence conflict	141	1	M → T in CAD89938. Ref.2
	Sequence conflict	285	1	E → G in AAH45611. Ref.6
	Sequence conflict	291	1	R → Q in AAH45611. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 3. Checksum: 35FE42189855034F	FASTA	332	35,769
	10 20 30 40 50 60 MDSTSSLHGS SLHRPSTEQT RTDFSWDGIN LSMEDTTSIL PKLKRNSNAY GIGALAKSSF 70 80 90 100 110 120 SGISRSMKDH VTKPTAMGQG RVAHMIEWQG WGKTPAVQPQ HSHESVRRDT DAYSDLSDGE 130 140 150 160 170 180 KEARFLAGVM EQFAISEATL MAWSSMDGED MSVNSTQEPL GCNYSDNYQE LMDSQDALAQ 190 200 210 220 230 240 APMDGWPHSY VSQGMYCLGS SDAWEASDQS LIASPATGSY LGPAFDDSQP SLHEMGPSQP 250 260 270 280 290 300 ASGYSALEPP PLLGGDTDWA PGVGAVDLAR GPAEEEKRPL APEEEEDAGC RDLESLSPRE 310 320 330 DPEMSTALSR KVSDVTSSGV QSFDEEEGEA NN
	Isoform 2 [UniParc]. Checksum: 99FDC411A64F5D05	FASTA	348	37,348
	10 20 30 40 50 60 MGCIGSRTVG NEVIAVDWKG LKDVDQINMD STSSLHGSSL HRPSTELSME DTTSILPKLK 70 80 90 100 110 120 RNSNAYGIGA LAKSSFSGIS RSMKDHVTKP TAMGQGRVAH MIEWQGWGKT PAVQPQHSHE 130 140 150 160 170 180 SVRRDTDAYS DLSDGEKEAR FLAGVMEQFA ISEATLMAWS SMDGEDMSVN STQEPLGCNY 190 200 210 220 230 240 SDNYQELMDS QDALAQAPMD GWPHSYVSQG MYCLGSSDAW EASDQSLIAS PATGSYLGPA 250 260 270 280 290 300 FDDSQPSLHE MGPSQPASGY SALEPPPLLG GDTDWAPGVG AVDLARGPAE EEKRPLAPEE 310 320 330 340 EEDAGCRDLE SLSPREDPEM STALSRKVSD VTSSGVQSFD EEEGEANN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spinal cord.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-307. Tissue: Brain and Hypothalamus.
[7]	"Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system." Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E., Tsunasawa S., Utsumi T. Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract] Cited for: MYRISTOYLATION AT GLY-2 (ISOFORM 2).
[8]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK291470 mRNA. Translation: BAF84159.1. AL832579 mRNA. Translation: CAD89938.1. AC093673 Genomic DNA. Translation: AAS07501.1. Sequence problems. CH236959 Genomic DNA. Translation: EAL23787.1. CH471198 Genomic DNA. Translation: EAW51853.1. CH471198 Genomic DNA. Translation: EAW51854.1. BC045611 mRNA. Translation: AAH45611.2. BC050543 mRNA. Translation: AAH50543.2.
IPI	IPI00641986. IPI00917945.
RefSeq	NP_001026860.2. NM_001031690.2. NP_055505.3. NM_014690.4.
UniGene	Hs.648908.
3D structure databases
ProteinModelPortal	Q86XD5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000410603.
PTM databases
PhosphoSite	Q86XD5.
Proteomic databases
PaxDb	Q86XD5.
PeptideAtlas	Q86XD5.
PRIDE	Q86XD5.
Protocols and materials databases
DNASU	9715.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000409222; ENSP00000387147; ENSG00000159784. ENST00000409346; ENSP00000386984; ENSG00000159784. ENST00000409408; ENSP00000387017; ENSG00000159784. ENST00000409578; ENSP00000386568; ENSG00000159784.
GeneID	9715.
KEGG	hsa:9715.
UCSC	uc003wct.3. human.
Organism-specific databases
CTD	9715.
GeneCards	GC07M143050.
H-InvDB	HIX0007170.
HGNC	HGNC:22202. FAM131B.
HPA	HPA021371.
neXtProt	NX_Q86XD5.
PharmGKB	PA162386065.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43720.
HOVERGEN	HBG081012.
InParanoid	Q86XD5.
OrthoDB	EOG4THVT9.
PhylomeDB	Q86XD5.
Gene expression databases
ArrayExpress	Q86XD5.
Bgee	Q86XD5.
CleanEx	HS_FAM131B.
Genevestigator	Q86XD5.
GermOnline	ENSG00000159784. Homo sapiens.
Family and domain databases
InterPro	IPR026782. FAM131. [Graphical view]
PANTHER	PTHR15736. PTHR15736. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	FAM131B. human.
GenomeRNAi	9715.
NextBio	36519.

Entry information

Entry name

F131B_HUMAN

Accession

Primary (citable) accession number: Q86XD5
Secondary accession number(s): A4D2H6 , A8K605, B8ZZN2, D3DXE3, Q7L0D6, Q86T97

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	October 17, 2006
Last modified:	April 3, 2013
This is version 70 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.