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Q86XA9

- HTR5A_HUMAN

UniProt

Q86XA9 - HTR5A_HUMAN

Protein

HEAT repeat-containing protein 5A

Gene

HEATR5A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (04 Dec 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HEAT repeat-containing protein 5A
    Gene namesi
    Name:HEATR5A
    Synonyms:C14orf125, KIAA1316
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20276. HEATR5A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162390632.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20402040HEAT repeat-containing protein 5APRO_0000311990Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1110 – 11101Phosphoserine1 Publication
    Modified residuei1115 – 11151Phosphothreonine1 Publication
    Modified residuei1647 – 16471Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ86XA9.
    PaxDbiQ86XA9.
    PRIDEiQ86XA9.

    PTM databases

    PhosphoSiteiQ86XA9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86XA9.
    BgeeiQ86XA9.
    CleanExiHS_HEATR5A.
    GenevestigatoriQ86XA9.

    Organism-specific databases

    HPAiHPA049539.

    Interactioni

    Protein-protein interaction databases

    BioGridi117435. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86XA9.
    SMRiQ86XA9. Positions 210-240, 412-469, 844-963, 1064-1094, 1827-1901, 1969-2005.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati846 – 88338HEAT 1Add
    BLAST
    Repeati1079 – 111638HEAT 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the HEATR5 family.Curated
    Contains 2 HEAT repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG289817.
    HOVERGENiHBG056837.
    InParanoidiQ86XA9.
    PhylomeDBiQ86XA9.

    Family and domain databases

    Gene3Di1.25.10.10. 4 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 7 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86XA9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELAHSLLLN EEAYNQLGEV QKAEFIFEWL RYLEKLLLAT SRNDVREKQK     50
    TLVEQLLSLL NSSPGPPTRK LLAKNLAILY SIGDTFSVHE AIDKCNDLIR 100
    SKDDSPSYLP TKLAAVVCLG SLYKKLGRIL GNTFTDTVGN ILKAMKSAES 150
    QGRYEIMLSL QNILNGLGAA AAPCHRDVYK AARSCLTDRS MAVRCAAAKN 200
    EAIFMWSTDL DSVATLCFKS FEGSNYDVRI SVSKLLGIIL AKAVISKHPG 250
    TAASRQSIRR VSLEEVLELL GTGFLRGSSG FLRASGDMLK GTSSVSRDVR 300
    VGVTQAYVVF VSTLGGAWLE KNFAAFFSHI LSLASPSHPK ATQTQIDAVC 350
    CRRCVSFILR TTIGGLLGEK AQLAAVKDIC QAIWKLKKVM DAVMSDGNLE 400
    TRLGSTDVAA SQHMLVCALQ ELGNLIHNLG TTAAPLLQDS STGLLDSILS 450
    VILHPSISVR LAAAWCLHCI AVALPSYLTP LLDRCLERLT GHKSSPEAVT 500
    GFSFAVAALL GAVKHCPLGI PHGKGKIIMT LAEDLLCSAA QNSRLSAQRT 550
    QAGWLLISAL MTLGPAVVSH HLARVLLLWK CVFPASPKDL ETEKSRGDSF 600
    TWQVTLEGRA GALCAIKSFV SHCGDLLTEE VTQRLLPPLP CAVDLLTQLS 650
    SILKMYGSPL KTPSVVYRQR LYELLILLPP ETYEGNLCAI LRELAADLTA 700
    PDIQVAASTF LLPPLCHQDD LLILSPFLQE TDHRFIEEQL LLGNGVACGS 750
    LEYDPYSIYE KDVEGDSVPK PLPPALSVIS SASKLFGVVC AHVGETQRLL 800
    ILEQLLDSIK HTKGARQQVV QLHVVSSVSS FLKYVAGSKG CLGPEEMKRF 850
    ALTLVMGALE SPNPLLRCAA AESWARLAQV VDDGAFTAGL AQVSFDKLKS 900
    ARDVVTRTGH SLALGSLHRY LGGISSSQHL NSCIGILYTL AQDSTSPDVQ 950
    TWALHSLSLI IDSAGPLYYV HVEPTLSLII MLLLNVPPTH AEVHQSLGRC 1000
    LNALITTLGP ELQGNSTSIS TLRTSCLLGC AVMQDNPDCL VQAQAISCLQ 1050
    QLHMFAPRHV NLSSLVSCLC VNLCSPYLLL RRAVLACLRQ LVQREAAEVS 1100
    EHAVMLAKDS REELTPDANI REVGLEGALL ILLDKETDER LCHDIKETLN 1150
    YMLTSMAVEK LSLWLKLCKD VLAASADFTA VTCVDTMQEE EGDKGDDASV 1200
    LTTRRDEKSH PFTNPRWATR VFAAECVCRI INQCENANSA HFDIALAQEM 1250
    KKRDSRNDFL VLHLADLIRM AFMAATDHSD QLRLSGLEML LVVIRRFATV 1300
    PEPEFPGHVI LEQYQANVGA ALRPAFTSET PPDVTAKACQ VCSAWIASGV 1350
    VSDLNDLRRV HQLLVSSLTK IQAGKEALSH LYNESASTME ILAVLKAWAE 1400
    VYIIAVQRHK NHRQPLKTTT CLEDGIRNGS CSSDGLLDLV YADLGTLSRL 1450
    WLAALQDFAL LTLPSEFASQ LPAEGGAFYT AETSENAKLH YYNSWALILH 1500
    ATALWLTSTG FVVADPDEGA SNLSRPVTPT SMCQGSSSGA TIKSPEDVYT 1550
    DRFHLILGIS VEFLCSLRSD ATMESITACL HALQALLDVP WPRSKIGSDQ 1600
    DLGIELLNVL HRVILTRESP SIQLASLEVV RQIICAAQEH VKEKRRSAEV 1650
    DDGAAEKETL PEFGEGKDTG GLVPGKSLVF ATLELCVCIL VRQLPELNPK 1700
    LTGSPGVKAT KPQILLEDGS RLVSAALVIL SELPAVCSPE GSISILPTIL 1750
    YLTIGVLRET AVKLPGGQLS STVAASLQAL KGILSSPMAR AEKSRTAWTD 1800
    LLRSALTTIL DCWDPVDETH QELDEVSLLT AITVFILSTS PEVTTIPCLQ 1850
    KRCIDKFKAT LEIKDPVVQI KTYQLLHSIF QYPNPAVSYP YIYSLASCIM 1900
    EKLQEIDKRK PENTAELEIF QEGIKVLETL VTVAEEHHRA QLVACLLPIL 1950
    ISFLLDENSL GSATSIMRNL HDFALQNLMQ IGPQYSSVFK SLVASSPALK 2000
    ARLEAAIKGN QESVKVKIPT SKYTKSPGKN SSIQLKTSFL 2040
    Length:2,040
    Mass (Da):222,004
    Last modified:December 4, 2007 - v2
    Checksum:iE6598AA06A7D51DB
    GO
    Isoform 2 (identifier: Q86XA9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1741-1815: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,965
    Mass (Da):214,083
    Checksum:iE4589DBD3C413E33
    GO
    Isoform 3 (identifier: Q86XA9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         114-2040: Missing.

    Show »
    Length:113
    Mass (Da):12,903
    Checksum:iD2F13A11E214CFD3
    GO

    Sequence cautioni

    The sequence BAA91098.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti429 – 4291L → P in CAH18282. (PubMed:17974005)Curated
    Sequence conflicti880 – 8801V → M in AAH45764. (PubMed:15489334)Curated
    Sequence conflicti880 – 8801V → M in CAH18282. (PubMed:17974005)Curated
    Sequence conflicti880 – 8801V → M in BAA92554. (PubMed:10718198)Curated
    Sequence conflicti1199 – 11991S → P in BAA91098. (PubMed:14702039)Curated
    Sequence conflicti1257 – 12571N → T in AAH63867. (PubMed:15489334)Curated
    Sequence conflicti1525 – 15251R → T in CAH18282. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei114 – 20401927Missing in isoform 3. 1 PublicationVSP_029685Add
    BLAST
    Alternative sequencei1741 – 181575Missing in isoform 2. 1 PublicationVSP_029686Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136418 Genomic DNA. No translation available.
    AL139353 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65949.1.
    BC045764 mRNA. Translation: AAH45764.1.
    BC062720 mRNA. Translation: AAH62720.1.
    BC063867 mRNA. Translation: AAH63867.1.
    AL117511 mRNA. Translation: CAB55971.1.
    CR749444 mRNA. Translation: CAH18282.1.
    AB037737 mRNA. Translation: BAA92554.1.
    AK000343 mRNA. Translation: BAA91098.1. Different initiation.
    PIRiT17281.
    RefSeqiNP_056288.2. NM_015473.3.
    UniGeneiHs.744979.

    Genome annotation databases

    EnsembliENST00000382464; ENSP00000371903; ENSG00000129493. [Q86XA9-3]
    GeneIDi25938.
    KEGGihsa:25938.
    UCSCiuc001wrh.3. human. [Q86XA9-3]

    Polymorphism databases

    DMDMi162416245.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136418 Genomic DNA. No translation available.
    AL139353 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65949.1 .
    BC045764 mRNA. Translation: AAH45764.1 .
    BC062720 mRNA. Translation: AAH62720.1 .
    BC063867 mRNA. Translation: AAH63867.1 .
    AL117511 mRNA. Translation: CAB55971.1 .
    CR749444 mRNA. Translation: CAH18282.1 .
    AB037737 mRNA. Translation: BAA92554.1 .
    AK000343 mRNA. Translation: BAA91098.1 . Different initiation.
    PIRi T17281.
    RefSeqi NP_056288.2. NM_015473.3.
    UniGenei Hs.744979.

    3D structure databases

    ProteinModelPortali Q86XA9.
    SMRi Q86XA9. Positions 210-240, 412-469, 844-963, 1064-1094, 1827-1901, 1969-2005.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117435. 3 interactions.

    PTM databases

    PhosphoSitei Q86XA9.

    Polymorphism databases

    DMDMi 162416245.

    Proteomic databases

    MaxQBi Q86XA9.
    PaxDbi Q86XA9.
    PRIDEi Q86XA9.

    Protocols and materials databases

    DNASUi 25938.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382464 ; ENSP00000371903 ; ENSG00000129493 . [Q86XA9-3 ]
    GeneIDi 25938.
    KEGGi hsa:25938.
    UCSCi uc001wrh.3. human. [Q86XA9-3 ]

    Organism-specific databases

    CTDi 25938.
    GeneCardsi GC14M031760.
    H-InvDB HIX0011581.
    HGNCi HGNC:20276. HEATR5A.
    HPAi HPA049539.
    neXtProti NX_Q86XA9.
    PharmGKBi PA162390632.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289817.
    HOVERGENi HBG056837.
    InParanoidi Q86XA9.
    PhylomeDBi Q86XA9.

    Miscellaneous databases

    ChiTaRSi HEATR5A. human.
    GenomeRNAii 25938.
    NextBioi 47498.
    PROi Q86XA9.

    Gene expression databases

    ArrayExpressi Q86XA9.
    Bgeei Q86XA9.
    CleanExi HS_HEATR5A.
    Genevestigatori Q86XA9.

    Family and domain databases

    Gene3Di 1.25.10.10. 4 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 7 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 263-2040 (ISOFORM 1).
      Tissue: PNS and Uterus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 368-2040 (ISOFORM 2).
      Tissue: Amygdala and Testis.
    5. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 451-2040 (ISOFORM 1).
      Tissue: Brain.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1172-1758 (ISOFORM 1).
      Tissue: Hepatoma and Placenta.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1110; THR-1115 AND SER-1647, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHTR5A_HUMAN
    AccessioniPrimary (citable) accession number: Q86XA9
    Secondary accession number(s): Q68DD8
    , Q6P3S5, Q6P5R9, Q9H8D7, Q9NXB7, Q9P2N0, Q9UFQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3