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Q86XA9 (HTR5A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HEAT repeat-containing protein 5A
Gene names
Name:HEATR5A
Synonyms:C14orf125, KIAA1316
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2040 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the HEATR5 family.

Contains 2 HEAT repeats.

Sequence caution

The sequence BAA91098.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainRepeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86XA9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86XA9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1741-1815: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q86XA9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     114-2040: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 20402040HEAT repeat-containing protein 5A
PRO_0000311990

Regions

Repeat846 – 88338HEAT 1
Repeat1079 – 111638HEAT 2

Amino acid modifications

Modified residue11101Phosphoserine Ref.7
Modified residue11151Phosphothreonine Ref.7
Modified residue16471Phosphoserine Ref.7

Natural variations

Alternative sequence114 – 20401927Missing in isoform 3.
VSP_029685
Alternative sequence1741 – 181575Missing in isoform 2.
VSP_029686

Experimental info

Sequence conflict4291L → P in CAH18282. Ref.4
Sequence conflict8801V → M in AAH45764. Ref.3
Sequence conflict8801V → M in CAH18282. Ref.4
Sequence conflict8801V → M in BAA92554. Ref.5
Sequence conflict11991S → P in BAA91098. Ref.6
Sequence conflict12571N → T in AAH63867. Ref.3
Sequence conflict15251R → T in CAH18282. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 4, 2007. Version 2.
Checksum: E6598AA06A7D51DB

FASTA2,040222,004
        10         20         30         40         50         60 
MELAHSLLLN EEAYNQLGEV QKAEFIFEWL RYLEKLLLAT SRNDVREKQK TLVEQLLSLL 

        70         80         90        100        110        120 
NSSPGPPTRK LLAKNLAILY SIGDTFSVHE AIDKCNDLIR SKDDSPSYLP TKLAAVVCLG 

       130        140        150        160        170        180 
SLYKKLGRIL GNTFTDTVGN ILKAMKSAES QGRYEIMLSL QNILNGLGAA AAPCHRDVYK 

       190        200        210        220        230        240 
AARSCLTDRS MAVRCAAAKN EAIFMWSTDL DSVATLCFKS FEGSNYDVRI SVSKLLGIIL 

       250        260        270        280        290        300 
AKAVISKHPG TAASRQSIRR VSLEEVLELL GTGFLRGSSG FLRASGDMLK GTSSVSRDVR 

       310        320        330        340        350        360 
VGVTQAYVVF VSTLGGAWLE KNFAAFFSHI LSLASPSHPK ATQTQIDAVC CRRCVSFILR 

       370        380        390        400        410        420 
TTIGGLLGEK AQLAAVKDIC QAIWKLKKVM DAVMSDGNLE TRLGSTDVAA SQHMLVCALQ 

       430        440        450        460        470        480 
ELGNLIHNLG TTAAPLLQDS STGLLDSILS VILHPSISVR LAAAWCLHCI AVALPSYLTP 

       490        500        510        520        530        540 
LLDRCLERLT GHKSSPEAVT GFSFAVAALL GAVKHCPLGI PHGKGKIIMT LAEDLLCSAA 

       550        560        570        580        590        600 
QNSRLSAQRT QAGWLLISAL MTLGPAVVSH HLARVLLLWK CVFPASPKDL ETEKSRGDSF 

       610        620        630        640        650        660 
TWQVTLEGRA GALCAIKSFV SHCGDLLTEE VTQRLLPPLP CAVDLLTQLS SILKMYGSPL 

       670        680        690        700        710        720 
KTPSVVYRQR LYELLILLPP ETYEGNLCAI LRELAADLTA PDIQVAASTF LLPPLCHQDD 

       730        740        750        760        770        780 
LLILSPFLQE TDHRFIEEQL LLGNGVACGS LEYDPYSIYE KDVEGDSVPK PLPPALSVIS 

       790        800        810        820        830        840 
SASKLFGVVC AHVGETQRLL ILEQLLDSIK HTKGARQQVV QLHVVSSVSS FLKYVAGSKG 

       850        860        870        880        890        900 
CLGPEEMKRF ALTLVMGALE SPNPLLRCAA AESWARLAQV VDDGAFTAGL AQVSFDKLKS 

       910        920        930        940        950        960 
ARDVVTRTGH SLALGSLHRY LGGISSSQHL NSCIGILYTL AQDSTSPDVQ TWALHSLSLI 

       970        980        990       1000       1010       1020 
IDSAGPLYYV HVEPTLSLII MLLLNVPPTH AEVHQSLGRC LNALITTLGP ELQGNSTSIS 

      1030       1040       1050       1060       1070       1080 
TLRTSCLLGC AVMQDNPDCL VQAQAISCLQ QLHMFAPRHV NLSSLVSCLC VNLCSPYLLL 

      1090       1100       1110       1120       1130       1140 
RRAVLACLRQ LVQREAAEVS EHAVMLAKDS REELTPDANI REVGLEGALL ILLDKETDER 

      1150       1160       1170       1180       1190       1200 
LCHDIKETLN YMLTSMAVEK LSLWLKLCKD VLAASADFTA VTCVDTMQEE EGDKGDDASV 

      1210       1220       1230       1240       1250       1260 
LTTRRDEKSH PFTNPRWATR VFAAECVCRI INQCENANSA HFDIALAQEM KKRDSRNDFL 

      1270       1280       1290       1300       1310       1320 
VLHLADLIRM AFMAATDHSD QLRLSGLEML LVVIRRFATV PEPEFPGHVI LEQYQANVGA 

      1330       1340       1350       1360       1370       1380 
ALRPAFTSET PPDVTAKACQ VCSAWIASGV VSDLNDLRRV HQLLVSSLTK IQAGKEALSH 

      1390       1400       1410       1420       1430       1440 
LYNESASTME ILAVLKAWAE VYIIAVQRHK NHRQPLKTTT CLEDGIRNGS CSSDGLLDLV 

      1450       1460       1470       1480       1490       1500 
YADLGTLSRL WLAALQDFAL LTLPSEFASQ LPAEGGAFYT AETSENAKLH YYNSWALILH 

      1510       1520       1530       1540       1550       1560 
ATALWLTSTG FVVADPDEGA SNLSRPVTPT SMCQGSSSGA TIKSPEDVYT DRFHLILGIS 

      1570       1580       1590       1600       1610       1620 
VEFLCSLRSD ATMESITACL HALQALLDVP WPRSKIGSDQ DLGIELLNVL HRVILTRESP 

      1630       1640       1650       1660       1670       1680 
SIQLASLEVV RQIICAAQEH VKEKRRSAEV DDGAAEKETL PEFGEGKDTG GLVPGKSLVF 

      1690       1700       1710       1720       1730       1740 
ATLELCVCIL VRQLPELNPK LTGSPGVKAT KPQILLEDGS RLVSAALVIL SELPAVCSPE 

      1750       1760       1770       1780       1790       1800 
GSISILPTIL YLTIGVLRET AVKLPGGQLS STVAASLQAL KGILSSPMAR AEKSRTAWTD 

      1810       1820       1830       1840       1850       1860 
LLRSALTTIL DCWDPVDETH QELDEVSLLT AITVFILSTS PEVTTIPCLQ KRCIDKFKAT 

      1870       1880       1890       1900       1910       1920 
LEIKDPVVQI KTYQLLHSIF QYPNPAVSYP YIYSLASCIM EKLQEIDKRK PENTAELEIF 

      1930       1940       1950       1960       1970       1980 
QEGIKVLETL VTVAEEHHRA QLVACLLPIL ISFLLDENSL GSATSIMRNL HDFALQNLMQ 

      1990       2000       2010       2020       2030       2040 
IGPQYSSVFK SLVASSPALK ARLEAAIKGN QESVKVKIPT SKYTKSPGKN SSIQLKTSFL 

« Hide

Isoform 2 [UniParc].

Checksum: E4589DBD3C413E33
Show »

FASTA1,965214,083
Isoform 3 [UniParc].

Checksum: D2F13A11E214CFD3
Show »

FASTA11312,903

References

[1]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 263-2040 (ISOFORM 1).
Tissue: PNS and Uterus.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 368-2040 (ISOFORM 2).
Tissue: Amygdala and Testis.
[5]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 451-2040 (ISOFORM 1).
Tissue: Brain.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1172-1758 (ISOFORM 1).
Tissue: Hepatoma and Placenta.
[7]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1110; THR-1115 AND SER-1647, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136418 Genomic DNA. No translation available.
AL139353 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65949.1.
BC045764 mRNA. Translation: AAH45764.1.
BC062720 mRNA. Translation: AAH62720.1.
BC063867 mRNA. Translation: AAH63867.1.
AL117511 mRNA. Translation: CAB55971.1.
CR749444 mRNA. Translation: CAH18282.1.
AB037737 mRNA. Translation: BAA92554.1.
AK000343 mRNA. Translation: BAA91098.1. Different initiation.
PIRT17281.
RefSeqNP_056288.2. NM_015473.3.
UniGeneHs.744979.

3D structure databases

ProteinModelPortalQ86XA9.
SMRQ86XA9. Positions 210-240, 412-469, 844-963, 1064-1094, 1827-1901, 1969-2005.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117435. 3 interactions.

PTM databases

PhosphoSiteQ86XA9.

Polymorphism databases

DMDM162416245.

Proteomic databases

MaxQBQ86XA9.
PaxDbQ86XA9.
PRIDEQ86XA9.

Protocols and materials databases

DNASU25938.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000382464; ENSP00000371903; ENSG00000129493. [Q86XA9-3]
ENST00000389961; ENSP00000374611; ENSG00000129493. [Q86XA9-1]
ENST00000439348; ENSP00000405407; ENSG00000129493. [Q86XA9-2]
GeneID25938.
KEGGhsa:25938.
UCSCuc001wrh.3. human. [Q86XA9-3]

Organism-specific databases

CTD25938.
GeneCardsGC14M031760.
H-InvDBHIX0011581.
HGNCHGNC:20276. HEATR5A.
HPAHPA049539.
neXtProtNX_Q86XA9.
PharmGKBPA162390632.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG289817.
HOVERGENHBG056837.
InParanoidQ86XA9.
PhylomeDBQ86XA9.

Gene expression databases

ArrayExpressQ86XA9.
BgeeQ86XA9.
CleanExHS_HEATR5A.
GenevestigatorQ86XA9.

Family and domain databases

Gene3D1.25.10.10. 4 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMSSF48371. SSF48371. 7 hits.
ProtoNetSearch...

Other

ChiTaRSHEATR5A. human.
GenomeRNAi25938.
NextBio47498.
PROQ86XA9.

Entry information

Entry nameHTR5A_HUMAN
AccessionPrimary (citable) accession number: Q86XA9
Secondary accession number(s): Q68DD8 expand/collapse secondary AC list , Q6P3S5, Q6P5R9, Q9H8D7, Q9NXB7, Q9P2N0, Q9UFQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM