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Q86XA9

- HTR5A_HUMAN

UniProt

Q86XA9 - HTR5A_HUMAN

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Protein

HEAT repeat-containing protein 5A

Gene

HEATR5A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
HEAT repeat-containing protein 5A
Gene namesi
Name:HEATR5A
Synonyms:C14orf125, KIAA1316
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20276. HEATR5A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162390632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20402040HEAT repeat-containing protein 5APRO_0000311990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1110 – 11101Phosphoserine1 Publication
Modified residuei1115 – 11151Phosphothreonine1 Publication
Modified residuei1647 – 16471Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86XA9.
PaxDbiQ86XA9.
PRIDEiQ86XA9.

PTM databases

PhosphoSiteiQ86XA9.

Expressioni

Gene expression databases

BgeeiQ86XA9.
CleanExiHS_HEATR5A.
ExpressionAtlasiQ86XA9. baseline and differential.
GenevestigatoriQ86XA9.

Organism-specific databases

HPAiHPA049539.

Interactioni

Protein-protein interaction databases

BioGridi117435. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ86XA9.
SMRiQ86XA9. Positions 444-471, 854-879, 1067-1092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati846 – 88338HEAT 1Add
BLAST
Repeati1079 – 111638HEAT 2Add
BLAST

Sequence similaritiesi

Belongs to the HEATR5 family.Curated
Contains 2 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG289817.
GeneTreeiENSGT00390000006205.
HOVERGENiHBG056837.
InParanoidiQ86XA9.
PhylomeDBiQ86XA9.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 7 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86XA9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELAHSLLLN EEAYNQLGEV QKAEFIFEWL RYLEKLLLAT SRNDVREKQK
60 70 80 90 100
TLVEQLLSLL NSSPGPPTRK LLAKNLAILY SIGDTFSVHE AIDKCNDLIR
110 120 130 140 150
SKDDSPSYLP TKLAAVVCLG SLYKKLGRIL GNTFTDTVGN ILKAMKSAES
160 170 180 190 200
QGRYEIMLSL QNILNGLGAA AAPCHRDVYK AARSCLTDRS MAVRCAAAKN
210 220 230 240 250
EAIFMWSTDL DSVATLCFKS FEGSNYDVRI SVSKLLGIIL AKAVISKHPG
260 270 280 290 300
TAASRQSIRR VSLEEVLELL GTGFLRGSSG FLRASGDMLK GTSSVSRDVR
310 320 330 340 350
VGVTQAYVVF VSTLGGAWLE KNFAAFFSHI LSLASPSHPK ATQTQIDAVC
360 370 380 390 400
CRRCVSFILR TTIGGLLGEK AQLAAVKDIC QAIWKLKKVM DAVMSDGNLE
410 420 430 440 450
TRLGSTDVAA SQHMLVCALQ ELGNLIHNLG TTAAPLLQDS STGLLDSILS
460 470 480 490 500
VILHPSISVR LAAAWCLHCI AVALPSYLTP LLDRCLERLT GHKSSPEAVT
510 520 530 540 550
GFSFAVAALL GAVKHCPLGI PHGKGKIIMT LAEDLLCSAA QNSRLSAQRT
560 570 580 590 600
QAGWLLISAL MTLGPAVVSH HLARVLLLWK CVFPASPKDL ETEKSRGDSF
610 620 630 640 650
TWQVTLEGRA GALCAIKSFV SHCGDLLTEE VTQRLLPPLP CAVDLLTQLS
660 670 680 690 700
SILKMYGSPL KTPSVVYRQR LYELLILLPP ETYEGNLCAI LRELAADLTA
710 720 730 740 750
PDIQVAASTF LLPPLCHQDD LLILSPFLQE TDHRFIEEQL LLGNGVACGS
760 770 780 790 800
LEYDPYSIYE KDVEGDSVPK PLPPALSVIS SASKLFGVVC AHVGETQRLL
810 820 830 840 850
ILEQLLDSIK HTKGARQQVV QLHVVSSVSS FLKYVAGSKG CLGPEEMKRF
860 870 880 890 900
ALTLVMGALE SPNPLLRCAA AESWARLAQV VDDGAFTAGL AQVSFDKLKS
910 920 930 940 950
ARDVVTRTGH SLALGSLHRY LGGISSSQHL NSCIGILYTL AQDSTSPDVQ
960 970 980 990 1000
TWALHSLSLI IDSAGPLYYV HVEPTLSLII MLLLNVPPTH AEVHQSLGRC
1010 1020 1030 1040 1050
LNALITTLGP ELQGNSTSIS TLRTSCLLGC AVMQDNPDCL VQAQAISCLQ
1060 1070 1080 1090 1100
QLHMFAPRHV NLSSLVSCLC VNLCSPYLLL RRAVLACLRQ LVQREAAEVS
1110 1120 1130 1140 1150
EHAVMLAKDS REELTPDANI REVGLEGALL ILLDKETDER LCHDIKETLN
1160 1170 1180 1190 1200
YMLTSMAVEK LSLWLKLCKD VLAASADFTA VTCVDTMQEE EGDKGDDASV
1210 1220 1230 1240 1250
LTTRRDEKSH PFTNPRWATR VFAAECVCRI INQCENANSA HFDIALAQEM
1260 1270 1280 1290 1300
KKRDSRNDFL VLHLADLIRM AFMAATDHSD QLRLSGLEML LVVIRRFATV
1310 1320 1330 1340 1350
PEPEFPGHVI LEQYQANVGA ALRPAFTSET PPDVTAKACQ VCSAWIASGV
1360 1370 1380 1390 1400
VSDLNDLRRV HQLLVSSLTK IQAGKEALSH LYNESASTME ILAVLKAWAE
1410 1420 1430 1440 1450
VYIIAVQRHK NHRQPLKTTT CLEDGIRNGS CSSDGLLDLV YADLGTLSRL
1460 1470 1480 1490 1500
WLAALQDFAL LTLPSEFASQ LPAEGGAFYT AETSENAKLH YYNSWALILH
1510 1520 1530 1540 1550
ATALWLTSTG FVVADPDEGA SNLSRPVTPT SMCQGSSSGA TIKSPEDVYT
1560 1570 1580 1590 1600
DRFHLILGIS VEFLCSLRSD ATMESITACL HALQALLDVP WPRSKIGSDQ
1610 1620 1630 1640 1650
DLGIELLNVL HRVILTRESP SIQLASLEVV RQIICAAQEH VKEKRRSAEV
1660 1670 1680 1690 1700
DDGAAEKETL PEFGEGKDTG GLVPGKSLVF ATLELCVCIL VRQLPELNPK
1710 1720 1730 1740 1750
LTGSPGVKAT KPQILLEDGS RLVSAALVIL SELPAVCSPE GSISILPTIL
1760 1770 1780 1790 1800
YLTIGVLRET AVKLPGGQLS STVAASLQAL KGILSSPMAR AEKSRTAWTD
1810 1820 1830 1840 1850
LLRSALTTIL DCWDPVDETH QELDEVSLLT AITVFILSTS PEVTTIPCLQ
1860 1870 1880 1890 1900
KRCIDKFKAT LEIKDPVVQI KTYQLLHSIF QYPNPAVSYP YIYSLASCIM
1910 1920 1930 1940 1950
EKLQEIDKRK PENTAELEIF QEGIKVLETL VTVAEEHHRA QLVACLLPIL
1960 1970 1980 1990 2000
ISFLLDENSL GSATSIMRNL HDFALQNLMQ IGPQYSSVFK SLVASSPALK
2010 2020 2030 2040
ARLEAAIKGN QESVKVKIPT SKYTKSPGKN SSIQLKTSFL
Length:2,040
Mass (Da):222,004
Last modified:December 4, 2007 - v2
Checksum:iE6598AA06A7D51DB
GO
Isoform 2 (identifier: Q86XA9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1741-1815: Missing.

Note: No experimental confirmation available.

Show »
Length:1,965
Mass (Da):214,083
Checksum:iE4589DBD3C413E33
GO
Isoform 3 (identifier: Q86XA9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-2040: Missing.

Show »
Length:113
Mass (Da):12,903
Checksum:iD2F13A11E214CFD3
GO

Sequence cautioni

The sequence BAA91098.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti429 – 4291L → P in CAH18282. (PubMed:17974005)Curated
Sequence conflicti880 – 8801V → M in AAH45764. (PubMed:15489334)Curated
Sequence conflicti880 – 8801V → M in CAH18282. (PubMed:17974005)Curated
Sequence conflicti880 – 8801V → M in BAA92554. (PubMed:10718198)Curated
Sequence conflicti1199 – 11991S → P in BAA91098. (PubMed:14702039)Curated
Sequence conflicti1257 – 12571N → T in AAH63867. (PubMed:15489334)Curated
Sequence conflicti1525 – 15251R → T in CAH18282. (PubMed:17974005)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei114 – 20401927Missing in isoform 3. 1 PublicationVSP_029685Add
BLAST
Alternative sequencei1741 – 181575Missing in isoform 2. 1 PublicationVSP_029686Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136418 Genomic DNA. No translation available.
AL139353 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65949.1.
BC045764 mRNA. Translation: AAH45764.1.
BC062720 mRNA. Translation: AAH62720.1.
BC063867 mRNA. Translation: AAH63867.1.
AL117511 mRNA. Translation: CAB55971.1.
CR749444 mRNA. Translation: CAH18282.1.
AB037737 mRNA. Translation: BAA92554.1.
AK000343 mRNA. Translation: BAA91098.1. Different initiation.
PIRiT17281.
RefSeqiNP_056288.2. NM_015473.3.
UniGeneiHs.744979.

Genome annotation databases

EnsembliENST00000382464; ENSP00000371903; ENSG00000129493. [Q86XA9-3]
GeneIDi25938.
KEGGihsa:25938.
UCSCiuc001wrh.3. human. [Q86XA9-3]

Polymorphism databases

DMDMi162416245.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136418 Genomic DNA. No translation available.
AL139353 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65949.1 .
BC045764 mRNA. Translation: AAH45764.1 .
BC062720 mRNA. Translation: AAH62720.1 .
BC063867 mRNA. Translation: AAH63867.1 .
AL117511 mRNA. Translation: CAB55971.1 .
CR749444 mRNA. Translation: CAH18282.1 .
AB037737 mRNA. Translation: BAA92554.1 .
AK000343 mRNA. Translation: BAA91098.1 . Different initiation.
PIRi T17281.
RefSeqi NP_056288.2. NM_015473.3.
UniGenei Hs.744979.

3D structure databases

ProteinModelPortali Q86XA9.
SMRi Q86XA9. Positions 444-471, 854-879, 1067-1092.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117435. 4 interactions.

PTM databases

PhosphoSitei Q86XA9.

Polymorphism databases

DMDMi 162416245.

Proteomic databases

MaxQBi Q86XA9.
PaxDbi Q86XA9.
PRIDEi Q86XA9.

Protocols and materials databases

DNASUi 25938.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382464 ; ENSP00000371903 ; ENSG00000129493 . [Q86XA9-3 ]
GeneIDi 25938.
KEGGi hsa:25938.
UCSCi uc001wrh.3. human. [Q86XA9-3 ]

Organism-specific databases

CTDi 25938.
GeneCardsi GC14M031760.
H-InvDB HIX0011581.
HGNCi HGNC:20276. HEATR5A.
HPAi HPA049539.
neXtProti NX_Q86XA9.
PharmGKBi PA162390632.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289817.
GeneTreei ENSGT00390000006205.
HOVERGENi HBG056837.
InParanoidi Q86XA9.
PhylomeDBi Q86XA9.

Miscellaneous databases

ChiTaRSi HEATR5A. human.
GenomeRNAii 25938.
NextBioi 47498.
PROi Q86XA9.

Gene expression databases

Bgeei Q86XA9.
CleanExi HS_HEATR5A.
ExpressionAtlasi Q86XA9. baseline and differential.
Genevestigatori Q86XA9.

Family and domain databases

Gene3Di 1.25.10.10. 4 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 7 hits.
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 263-2040 (ISOFORM 1).
    Tissue: PNS and Uterus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 368-2040 (ISOFORM 2).
    Tissue: Amygdala and Testis.
  5. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 451-2040 (ISOFORM 1).
    Tissue: Brain.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1172-1758 (ISOFORM 1).
    Tissue: Hepatoma and Placenta.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1110; THR-1115 AND SER-1647, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHTR5A_HUMAN
AccessioniPrimary (citable) accession number: Q86XA9
Secondary accession number(s): Q68DD8
, Q6P3S5, Q6P5R9, Q9H8D7, Q9NXB7, Q9P2N0, Q9UFQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 26, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3