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Q86XA9

- HTR5A_HUMAN

UniProt

Q86XA9 - HTR5A_HUMAN

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Protein

HEAT repeat-containing protein 5A

Gene
HEATR5A, C14orf125, KIAA1316
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
HEAT repeat-containing protein 5A
Gene namesi
Name:HEATR5A
Synonyms:C14orf125, KIAA1316
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20276. HEATR5A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162390632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20402040HEAT repeat-containing protein 5APRO_0000311990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1110 – 11101Phosphoserine1 Publication
Modified residuei1115 – 11151Phosphothreonine1 Publication
Modified residuei1647 – 16471Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ86XA9.
PaxDbiQ86XA9.
PRIDEiQ86XA9.

PTM databases

PhosphoSiteiQ86XA9.

Expressioni

Gene expression databases

ArrayExpressiQ86XA9.
BgeeiQ86XA9.
CleanExiHS_HEATR5A.
GenevestigatoriQ86XA9.

Organism-specific databases

HPAiHPA049539.

Interactioni

Protein-protein interaction databases

BioGridi117435. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ86XA9.
SMRiQ86XA9. Positions 210-240, 412-469, 844-963, 1064-1094, 1827-1901, 1969-2005.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati846 – 88338HEAT 1Add
BLAST
Repeati1079 – 111638HEAT 2Add
BLAST

Sequence similaritiesi

Belongs to the HEATR5 family.
Contains 2 HEAT repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG289817.
HOVERGENiHBG056837.
InParanoidiQ86XA9.
PhylomeDBiQ86XA9.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 7 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86XA9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MELAHSLLLN EEAYNQLGEV QKAEFIFEWL RYLEKLLLAT SRNDVREKQK     50
TLVEQLLSLL NSSPGPPTRK LLAKNLAILY SIGDTFSVHE AIDKCNDLIR 100
SKDDSPSYLP TKLAAVVCLG SLYKKLGRIL GNTFTDTVGN ILKAMKSAES 150
QGRYEIMLSL QNILNGLGAA AAPCHRDVYK AARSCLTDRS MAVRCAAAKN 200
EAIFMWSTDL DSVATLCFKS FEGSNYDVRI SVSKLLGIIL AKAVISKHPG 250
TAASRQSIRR VSLEEVLELL GTGFLRGSSG FLRASGDMLK GTSSVSRDVR 300
VGVTQAYVVF VSTLGGAWLE KNFAAFFSHI LSLASPSHPK ATQTQIDAVC 350
CRRCVSFILR TTIGGLLGEK AQLAAVKDIC QAIWKLKKVM DAVMSDGNLE 400
TRLGSTDVAA SQHMLVCALQ ELGNLIHNLG TTAAPLLQDS STGLLDSILS 450
VILHPSISVR LAAAWCLHCI AVALPSYLTP LLDRCLERLT GHKSSPEAVT 500
GFSFAVAALL GAVKHCPLGI PHGKGKIIMT LAEDLLCSAA QNSRLSAQRT 550
QAGWLLISAL MTLGPAVVSH HLARVLLLWK CVFPASPKDL ETEKSRGDSF 600
TWQVTLEGRA GALCAIKSFV SHCGDLLTEE VTQRLLPPLP CAVDLLTQLS 650
SILKMYGSPL KTPSVVYRQR LYELLILLPP ETYEGNLCAI LRELAADLTA 700
PDIQVAASTF LLPPLCHQDD LLILSPFLQE TDHRFIEEQL LLGNGVACGS 750
LEYDPYSIYE KDVEGDSVPK PLPPALSVIS SASKLFGVVC AHVGETQRLL 800
ILEQLLDSIK HTKGARQQVV QLHVVSSVSS FLKYVAGSKG CLGPEEMKRF 850
ALTLVMGALE SPNPLLRCAA AESWARLAQV VDDGAFTAGL AQVSFDKLKS 900
ARDVVTRTGH SLALGSLHRY LGGISSSQHL NSCIGILYTL AQDSTSPDVQ 950
TWALHSLSLI IDSAGPLYYV HVEPTLSLII MLLLNVPPTH AEVHQSLGRC 1000
LNALITTLGP ELQGNSTSIS TLRTSCLLGC AVMQDNPDCL VQAQAISCLQ 1050
QLHMFAPRHV NLSSLVSCLC VNLCSPYLLL RRAVLACLRQ LVQREAAEVS 1100
EHAVMLAKDS REELTPDANI REVGLEGALL ILLDKETDER LCHDIKETLN 1150
YMLTSMAVEK LSLWLKLCKD VLAASADFTA VTCVDTMQEE EGDKGDDASV 1200
LTTRRDEKSH PFTNPRWATR VFAAECVCRI INQCENANSA HFDIALAQEM 1250
KKRDSRNDFL VLHLADLIRM AFMAATDHSD QLRLSGLEML LVVIRRFATV 1300
PEPEFPGHVI LEQYQANVGA ALRPAFTSET PPDVTAKACQ VCSAWIASGV 1350
VSDLNDLRRV HQLLVSSLTK IQAGKEALSH LYNESASTME ILAVLKAWAE 1400
VYIIAVQRHK NHRQPLKTTT CLEDGIRNGS CSSDGLLDLV YADLGTLSRL 1450
WLAALQDFAL LTLPSEFASQ LPAEGGAFYT AETSENAKLH YYNSWALILH 1500
ATALWLTSTG FVVADPDEGA SNLSRPVTPT SMCQGSSSGA TIKSPEDVYT 1550
DRFHLILGIS VEFLCSLRSD ATMESITACL HALQALLDVP WPRSKIGSDQ 1600
DLGIELLNVL HRVILTRESP SIQLASLEVV RQIICAAQEH VKEKRRSAEV 1650
DDGAAEKETL PEFGEGKDTG GLVPGKSLVF ATLELCVCIL VRQLPELNPK 1700
LTGSPGVKAT KPQILLEDGS RLVSAALVIL SELPAVCSPE GSISILPTIL 1750
YLTIGVLRET AVKLPGGQLS STVAASLQAL KGILSSPMAR AEKSRTAWTD 1800
LLRSALTTIL DCWDPVDETH QELDEVSLLT AITVFILSTS PEVTTIPCLQ 1850
KRCIDKFKAT LEIKDPVVQI KTYQLLHSIF QYPNPAVSYP YIYSLASCIM 1900
EKLQEIDKRK PENTAELEIF QEGIKVLETL VTVAEEHHRA QLVACLLPIL 1950
ISFLLDENSL GSATSIMRNL HDFALQNLMQ IGPQYSSVFK SLVASSPALK 2000
ARLEAAIKGN QESVKVKIPT SKYTKSPGKN SSIQLKTSFL 2040
Length:2,040
Mass (Da):222,004
Last modified:December 4, 2007 - v2
Checksum:iE6598AA06A7D51DB
GO
Isoform 2 (identifier: Q86XA9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1741-1815: Missing.

Note: No experimental confirmation available.

Show »
Length:1,965
Mass (Da):214,083
Checksum:iE4589DBD3C413E33
GO
Isoform 3 (identifier: Q86XA9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-2040: Missing.

Show »
Length:113
Mass (Da):12,903
Checksum:iD2F13A11E214CFD3
GO

Sequence cautioni

The sequence BAA91098.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei114 – 20401927Missing in isoform 3. VSP_029685Add
BLAST
Alternative sequencei1741 – 181575Missing in isoform 2. VSP_029686Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti429 – 4291L → P in CAH18282. 1 Publication
Sequence conflicti880 – 8801V → M in AAH45764. 1 Publication
Sequence conflicti880 – 8801V → M in CAH18282. 1 Publication
Sequence conflicti880 – 8801V → M in BAA92554. 1 Publication
Sequence conflicti1199 – 11991S → P in BAA91098. 1 Publication
Sequence conflicti1257 – 12571N → T in AAH63867. 1 Publication
Sequence conflicti1525 – 15251R → T in CAH18282. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136418 Genomic DNA. No translation available.
AL139353 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65949.1.
BC045764 mRNA. Translation: AAH45764.1.
BC062720 mRNA. Translation: AAH62720.1.
BC063867 mRNA. Translation: AAH63867.1.
AL117511 mRNA. Translation: CAB55971.1.
CR749444 mRNA. Translation: CAH18282.1.
AB037737 mRNA. Translation: BAA92554.1.
AK000343 mRNA. Translation: BAA91098.1. Different initiation.
PIRiT17281.
RefSeqiNP_056288.2. NM_015473.3.
UniGeneiHs.744979.

Genome annotation databases

EnsembliENST00000382464; ENSP00000371903; ENSG00000129493. [Q86XA9-3]
ENST00000389961; ENSP00000374611; ENSG00000129493. [Q86XA9-1]
ENST00000439348; ENSP00000405407; ENSG00000129493. [Q86XA9-2]
GeneIDi25938.
KEGGihsa:25938.
UCSCiuc001wrh.3. human. [Q86XA9-3]

Polymorphism databases

DMDMi162416245.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136418 Genomic DNA. No translation available.
AL139353 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65949.1 .
BC045764 mRNA. Translation: AAH45764.1 .
BC062720 mRNA. Translation: AAH62720.1 .
BC063867 mRNA. Translation: AAH63867.1 .
AL117511 mRNA. Translation: CAB55971.1 .
CR749444 mRNA. Translation: CAH18282.1 .
AB037737 mRNA. Translation: BAA92554.1 .
AK000343 mRNA. Translation: BAA91098.1 . Different initiation.
PIRi T17281.
RefSeqi NP_056288.2. NM_015473.3.
UniGenei Hs.744979.

3D structure databases

ProteinModelPortali Q86XA9.
SMRi Q86XA9. Positions 210-240, 412-469, 844-963, 1064-1094, 1827-1901, 1969-2005.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117435. 3 interactions.

PTM databases

PhosphoSitei Q86XA9.

Polymorphism databases

DMDMi 162416245.

Proteomic databases

MaxQBi Q86XA9.
PaxDbi Q86XA9.
PRIDEi Q86XA9.

Protocols and materials databases

DNASUi 25938.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382464 ; ENSP00000371903 ; ENSG00000129493 . [Q86XA9-3 ]
ENST00000389961 ; ENSP00000374611 ; ENSG00000129493 . [Q86XA9-1 ]
ENST00000439348 ; ENSP00000405407 ; ENSG00000129493 . [Q86XA9-2 ]
GeneIDi 25938.
KEGGi hsa:25938.
UCSCi uc001wrh.3. human. [Q86XA9-3 ]

Organism-specific databases

CTDi 25938.
GeneCardsi GC14M031760.
H-InvDB HIX0011581.
HGNCi HGNC:20276. HEATR5A.
HPAi HPA049539.
neXtProti NX_Q86XA9.
PharmGKBi PA162390632.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289817.
HOVERGENi HBG056837.
InParanoidi Q86XA9.
PhylomeDBi Q86XA9.

Miscellaneous databases

ChiTaRSi HEATR5A. human.
GenomeRNAii 25938.
NextBioi 47498.
PROi Q86XA9.

Gene expression databases

ArrayExpressi Q86XA9.
Bgeei Q86XA9.
CleanExi HS_HEATR5A.
Genevestigatori Q86XA9.

Family and domain databases

Gene3Di 1.25.10.10. 4 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 7 hits.
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 263-2040 (ISOFORM 1).
    Tissue: PNS and Uterus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 368-2040 (ISOFORM 2).
    Tissue: Amygdala and Testis.
  5. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 451-2040 (ISOFORM 1).
    Tissue: Brain.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1172-1758 (ISOFORM 1).
    Tissue: Hepatoma and Placenta.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1110; THR-1115 AND SER-1647, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHTR5A_HUMAN
AccessioniPrimary (citable) accession number: Q86XA9
Secondary accession number(s): Q68DD8
, Q6P3S5, Q6P5R9, Q9H8D7, Q9NXB7, Q9P2N0, Q9UFQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: May 14, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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