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Protein

Corepressor interacting with RBPJ 1

Gene

CIR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.By similarity2 Publications

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • transcription corepressor activity Source: ProtInc
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: BHF-UCL
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ86X95.
SIGNORiQ86X95.

Names & Taxonomyi

Protein namesi
Recommended name:
Corepressor interacting with RBPJ 1
Alternative name(s):
CBF1-interacting corepressor
Recepin
Gene namesi
Name:CIR1
Synonyms:CIR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138433.15.
HGNCiHGNC:24217. CIR1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9541.
OpenTargetsiENSG00000138433.
PharmGKBiPA165696415.

Polymorphism and mutation databases

BioMutaiCIR1.
DMDMi74727790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002479841 – 450Corepressor interacting with RBPJ 1Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki79Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei202PhosphoserineCombined sources1
Cross-linki340Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Phosphorylated by NEK6.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ86X95.
MaxQBiQ86X95.
PaxDbiQ86X95.
PeptideAtlasiQ86X95.
PRIDEiQ86X95.

PTM databases

iPTMnetiQ86X95.
PhosphoSitePlusiQ86X95.

Expressioni

Tissue specificityi

Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000138433.
ExpressionAtlasiQ86X95. baseline and differential.
GenevisibleiQ86X95. HS.

Organism-specific databases

HPAiHPA015784.

Interactioni

Subunit structurei

Interacts with RP9, SNW1, SFRS1, SFRS2,U2AF1, RBPJ, SAP30, HDAC2 NKAP and NEK6. Interacts with Epstein-Barr virus RPMS1. Component of the histone deacetylase complex. Component of the Notch corepressor complex. Interacts with NKAPL (By similarity).By similarity5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114916. 23 interactors.
IntActiQ86X95. 17 interactors.
MINTiMINT-207899.
STRINGi9606.ENSP00000339723.

Structurei

3D structure databases

ProteinModelPortaliQ86X95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 121Interaction with RBPJ1 PublicationAdd BLAST121
Regioni204 – 232Interaction with RP9By similarityAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 245Nuclear localization signalSequence analysisAdd BLAST11
Motifi291 – 298Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi214 – 368Lys/Ser-richAdd BLAST155
Compositional biasi369 – 450Arg/Ser-rich (RS domain)Add BLAST82

Phylogenomic databases

eggNOGiKOG3794. Eukaryota.
ENOG410ZVMR. LUCA.
GeneTreeiENSGT00730000111135.
InParanoidiQ86X95.
KOiK06066.
OMAiCSMYSIS.
OrthoDBiEOG091G0QUH.
PhylomeDBiQ86X95.
TreeFamiTF317567.

Family and domain databases

InterProiView protein in InterPro
IPR019339. CIR_N_dom.
PfamiView protein in Pfam
PF10197. Cir_N. 1 hit.
SMARTiView protein in SMART
SM01083. Cir_N. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86X95-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKSFANFMC KKDFHPASKS NIKKVWMAEQ KISYDKKKQE ELMQQYLKEQ
60 70 80 90 100
ESYDNRLLMG DERVKNGLNF MYEAPPGAKK ENKEKEETEG ETEYKFEWQK
110 120 130 140 150
GAPREKYAKD DMNIRDQPFG IQVRNVRCIK CHKWGHVNTD RECPLFGLSG
160 170 180 190 200
INASSVPTDG SGPSMHPSEL IAEMRNSGFA LKRNVLGRNL TANDPSQEYV
210 220 230 240 250
ASEGEEDPEV EFLKSLTTKQ KQKLLRKLDR LEKKKKKKDR KKKKFQKSRS
260 270 280 290 300
KHKKHKSSSS SSSSSSSSSS TETSESSSES ESNNKEKKIQ RKKRKKNKCS
310 320 330 340 350
GHNNSDSEEK DKSKKRKLHE ELSSSHHNRE KAKEKPRFLK HESSREDSKW
360 370 380 390 400
SHSDSDKKSR THKHSPEKRG SERKEGSSRS HGREERSRRS RSRSPGSYKQ
410 420 430 440 450
RETRKRAQRN PGEEQSRRND SRSHGTDLYR GEKMYREHPG GTHTKVTQRE
Length:450
Mass (Da):52,313
Last modified:June 1, 2003 - v1
Checksum:i5D0C1CBD9C87569D
GO
Isoform 2 (identifier: Q86X95-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-202: GPSMHPSELI...NDPSQEYVAS → DAVLQIEGFW...KCTGEKLDRK
     203-450: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:202
Mass (Da):23,274
Checksum:i6C16582B3E91B8DE
GO

Sequence cautioni

The sequence AAA17853 differs from that shown. Reason: Frameshift at positions 135, 151, 177, 203, 261, 299, 391 and 410.Curated
The sequence AAH21175 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH38987 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48K → R in AAD05243 (PubMed:9874765).Curated1
Sequence conflicti113N → S in AAD05243 (PubMed:9874765).Curated1
Sequence conflicti172A → G in AAA17853 (Ref. 2) Curated1
Sequence conflicti325S → T in AAD05243 (PubMed:9874765).Curated1
Sequence conflicti325S → T in AAA17853 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020091162 – 202GPSMH…EYVAS → DAVLQIEGFWAIDAPLGANS GDEKQWVCTETKCTGEKLDR K in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_020092203 – 450Missing in isoform 2. 1 PublicationAdd BLAST248

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098297 mRNA. Translation: AAD05243.1.
U03644 mRNA. Translation: AAA17853.1. Frameshift.
AK292389 mRNA. Translation: BAF85078.1.
AC018470 Genomic DNA. Translation: AAY24216.1.
BC015040 mRNA. No translation available.
BC021175 mRNA. Translation: AAH21175.1. Sequence problems.
BC038987 mRNA. Translation: AAH38987.1. Sequence problems.
BC046098 mRNA. Translation: AAH46098.1.
CCDSiCCDS2256.1. [Q86X95-1]
PIRiG01227.
RefSeqiNP_004873.3. NM_004882.3. [Q86X95-1]
UniGeneiHs.632531.

Genome annotation databases

EnsembliENST00000342016; ENSP00000339723; ENSG00000138433. [Q86X95-1]
GeneIDi9541.
KEGGihsa:9541.
UCSCiuc002uim.4. human. [Q86X95-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCIR1_HUMAN
AccessioniPrimary (citable) accession number: Q86X95
Secondary accession number(s): A6NFI6
, A8K8M4, O95367, Q12804, Q4G1B9, Q6PJI4, Q8IWI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2003
Last modified: September 27, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot