Q86X83 (COMD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
COMM domain-containing protein 2

Gene names

Name:	COMMD2
ORF Names:	HSPC042, My004

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May down-regulate activation of NF-kappa-B. Ref.1
Subunit structure	Interacts (via COMM domain) with COMMD1 (via COMM domain). Ref.1
Tissue specificity	Ubiquitous. Ref.1
Sequence similarities	Contains 1 COMM domain.
Sequence caution	The sequence AAD39913.1 differs from that shown. Reason: Frameshift at positions 111, 160, 174 and 188.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	COMM domain-containing protein 2		PRO_0000077386
Regions
	Domain	123 – 190	68	COMM
Natural variations
	Natural variant	113	1	I → L. Ref.1 Ref.3 Ref.4 Corresponds to variant rs9843784 [ dbSNP | Ensembl ].		VAR_028010
	Natural variant	177	1	Q → H. Corresponds to variant rs1546732 [ dbSNP | Ensembl ].		VAR_028011
Experimental info
	Sequence conflict	199	1	K → Q in AAD39913. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q86X83 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: ECB4B7C26FCEA0F2	FASTA	199	22,745
	10 20 30 40 50 60 MLLELSEEHK EHLAFLPQVD SAVVAEFGRI AVEFLRRGAN PKIYEGAARK LNVSSDTVQH 70 80 90 100 110 120 GVEGLTYLLT ESSKLMISEL DFQDSVFVLG FSEELNKLLL QLYLDNRKEI RTILSELAPS 130 140 150 160 170 180 LPSYHNLEWR LDVQLASRSL RQQIKPAVTI KLHLNQNGDH NTKVLQTDPA TLLHLVQQLE 190 QALEEMKTNH CRRVVRNIK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"COMMD proteins, a novel family of structural and functional homologs of MURR1." Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S. J. Biol. Chem. 280:22222-22232(2005) [PubMed: 15799966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH COMMD1, TISSUE SPECIFICITY, VARIANT LEU-113.
[2]	Mao Y.M., Xie Y., Zhou Z.X. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fetal brain.
[3]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-113. Tissue: Umbilical cord blood.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-113. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY542158 mRNA. Translation: AAS22240.1. AF059618 mRNA. Translation: AAG43117.1. AF125096 mRNA. Translation: AAD39913.1. Frameshift. BC046131 mRNA. Translation: AAH46131.1.
IPI	IPI00456048.
RefSeq	NP_057178.2. NM_016094.3.
UniGene	Hs.432729. Hs.730365.
3D structure databases
ProteinModelPortal	Q86X83.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86X83. 5 interactions.
STRING	Q86X83.
Polymorphism databases
DMDM	116241310.
Proteomic databases
PeptideAtlas	Q86X83.
PRIDE	Q86X83.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000473414; ENSP00000419475; ENSG00000114744.
GeneID	51122.
KEGG	hsa:51122.
UCSC	uc003exk.1. human.
Organism-specific databases
CTD	51122.
GeneCards	GC03M149448.
H-InvDB	HIX0200475.
HGNC	HGNC:24993. COMMD2.
HPA	HPA044190.
neXtProt	NX_Q86X83.
PharmGKB	PA134923363.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000008489.
HOGENOM	HBG716304.
HOVERGEN	HBG060564.
InParanoid	Q86X83.
OMA	KLLLQLY.
OrthoDB	EOG4B8JF3.
PhylomeDB	Q86X83.
Gene expression databases
ArrayExpress	Q86X83.
Bgee	Q86X83.
CleanEx	HS_COMMD2.
Genevestigator	Q86X83.
GermOnline	ENSG00000114744. Homo sapiens.
Family and domain databases
InterPro	IPR017920. COMM. IPR009886. HCaRG. [Graphical view]
Pfam	PF07258. HCaRG. 1 hit. [Graphical view]
PROSITE	PS51269. COMM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	53905.

Entry information

Entry name

COMD2_HUMAN

Accession

Primary (citable) accession number: Q86X83
Secondary accession number(s): Q9H3L5, Q9Y5V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.