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Protein

Nucleoside diphosphate-linked moiety X motif 13

Gene

NUDT13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 13 (EC:3.-.-.-)
Short name:
Nudix motif 13
Alternative name(s):
Protein KiSS-16
Gene namesi
Name:NUDT13Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000166321.13
HGNCiHGNC:18827 NUDT13
MIMi609233 gene
neXtProtiNX_Q86X67

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166321
PharmGKBiPA38700

Polymorphism and mutation databases

BioMutaiNUDT13
DMDMi51701672

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000571111 – 352Nucleoside diphosphate-linked moiety X motif 13Add BLAST352

Proteomic databases

PaxDbiQ86X67
PeptideAtlasiQ86X67
PRIDEiQ86X67

PTM databases

iPTMnetiQ86X67
PhosphoSitePlusiQ86X67

Expressioni

Tissue specificityi

Highly expressed in metastasis-suppressed chromosome 6 melanoma hybrids.1 Publication

Gene expression databases

BgeeiENSG00000166321
CleanExiHS_NUDT13
ExpressionAtlasiQ86X67 baseline and differential
GenevisibleiQ86X67 HS

Organism-specific databases

HPAiHPA040636

Interactioni

Protein-protein interaction databases

BioGridi117451, 4 interactors
STRINGi9606.ENSP00000349874

Structurei

3D structure databases

ProteinModelPortaliQ86X67
SMRiQ86X67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 323Nudix hydrolasePROSITE-ProRule annotationAdd BLAST128

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi216 – 240Nudix boxAdd BLAST25

Phylogenomic databases

eggNOGiKOG3084 Eukaryota
COG2816 LUCA
GeneTreeiENSGT00530000063600
HOGENOMiHOG000247937
HOVERGENiHBG052688
InParanoidiQ86X67
OMAiYYPQMAP
OrthoDBiEOG091G0SLC
PhylomeDBiQ86X67
TreeFamiTF106352

Family and domain databases

InterProiView protein in InterPro
IPR015375 NADH_PPase-like_N
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
IPR015376 Znr_NADH_PPase
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PF09296 NUDIX-like, 1 hit
PF09297 zf-NADH-PPase, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86X67-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLYCGIACR RKFFWCYRLL STYVTKTRYL FELKEDDDAC KKAQQTGAFY
60 70 80 90 100
LFHSLAPLLQ TSAHQYLAPR HSLLELERLL GKFGQDAQRI EDSVLIGCSE
110 120 130 140 150
QQEAWFALDL GLDSSFSISA SLHKPEMETE LKGSFIELRK ALFQLNARDA
160 170 180 190 200
SLLSTAQALL RWHDAHQFCS RSGQPTKKNV AGSKRVCPSN NIIYYPQMAP
210 220 230 240 250
VAITLVSDGT RCLLARQSSF PKGMYSALAG FCDIGESVEE TIRREVAEEV
260 270 280 290 300
GLEVESLQYY ASQHWPFPSG SLMIACHATV KPGQTEIQVN LRELETAAWF
310 320 330 340 350
SHDEVATALK RKGPYTQQQN GTFPFWLPPK LAISHQLIKE WVEKQTCSSL

PA
Length:352
Mass (Da):39,688
Last modified:August 31, 2004 - v3
Checksum:i1FBBDB1ECD50BCAE
GO
Isoform 2 (identifier: Q86X67-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-286: Missing.

Note: No experimental confirmation available.
Show »
Length:263
Mass (Da):30,055
Checksum:i5ECC6312AD535DBF
GO
Isoform 3 (identifier: Q86X67-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Note: No experimental confirmation available.
Show »
Length:226
Mass (Da):25,230
Checksum:i2680F26AFDB3915D
GO
Isoform 4 (identifier: Q86X67-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-235: MAPVAITLVS...SALAGFCDIG → VKVWKRPSAE...SIGPSLVAHS
     236-352: Missing.

Show »
Length:235
Mass (Da):26,965
Checksum:iD3BDED445B56B254
GO

Sequence cautioni

The sequence AAD00649 differs from that shown. Reason: Frameshift at several positions.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03416081G → D. Corresponds to variant dbSNP:rs34284214Ensembl.1
Natural variantiVAR_050413273M → V. Corresponds to variant dbSNP:rs17658872Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0545591 – 126Missing in isoform 3. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_011417198 – 286Missing in isoform 2. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_055695198 – 235MAPVA…FCDIG → VKVWKRPSAEKLQKRWDWRW KACSTMHPSIGPSLVAHS in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_055696236 – 352Missing in isoform 4. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300980 mRNA Translation: BAG62602.1
AC016394 Genomic DNA No translation available.
AL731721 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54472.1
BC038833 mRNA No translation available.
BC046173 mRNA Translation: AAH46173.2
AL050114 mRNA Translation: CAB43279.1
U88048 mRNA Translation: AAD00649.1 Frameshift.
CCDSiCCDS31220.1 [Q86X67-1]
CCDS60551.1 [Q86X67-4]
CCDS60552.1 [Q86X67-2]
CCDS60553.1 [Q86X67-3]
PIRiT08762
RefSeqiNP_001269943.1, NM_001283014.1 [Q86X67-2]
NP_001269944.1, NM_001283015.1 [Q86X67-4]
NP_001269945.1, NM_001283016.1 [Q86X67-3]
NP_001269946.1, NM_001283017.1
NP_001269948.1, NM_001283019.1
NP_056985.3, NM_015901.5 [Q86X67-1]
XP_016871522.1, XM_017016033.1 [Q86X67-4]
UniGeneiHs.533657

Genome annotation databases

EnsembliENST00000349051; ENSP00000335326; ENSG00000166321 [Q86X67-2]
ENST00000357321; ENSP00000349874; ENSG00000166321 [Q86X67-1]
ENST00000372997; ENSP00000362088; ENSG00000166321 [Q86X67-4]
ENST00000544879; ENSP00000440760; ENSG00000166321 [Q86X67-3]
GeneIDi25961
KEGGihsa:25961
UCSCiuc001jtj.5 human [Q86X67-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNUD13_HUMAN
AccessioniPrimary (citable) accession number: Q86X67
Secondary accession number(s): B4DV90
, O95650, Q5SQM4, Q5SQM5, Q5SQM6, Q9Y3X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: May 23, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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