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Protein

Nucleoside diphosphate-linked moiety X motif 13

Gene

NUDT13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-HSA-499943. Interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 13 (EC:3.-.-.-)
Short name:
Nudix motif 13
Alternative name(s):
Protein KiSS-16
Gene namesi
Name:NUDT13Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:18827. NUDT13.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166321.
PharmGKBiPA38700.

Polymorphism and mutation databases

BioMutaiNUDT13.
DMDMi51701672.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000571111 – 352Nucleoside diphosphate-linked moiety X motif 13Add BLAST352

Proteomic databases

PaxDbiQ86X67.
PeptideAtlasiQ86X67.
PRIDEiQ86X67.

PTM databases

iPTMnetiQ86X67.
PhosphoSitePlusiQ86X67.

Expressioni

Tissue specificityi

Highly expressed in metastasis-suppressed chromosome 6 melanoma hybrids.1 Publication

Gene expression databases

BgeeiENSG00000166321.
CleanExiHS_NUDT13.
ExpressionAtlasiQ86X67. baseline and differential.
GenevisibleiQ86X67. HS.

Organism-specific databases

HPAiHPA040636.

Interactioni

Protein-protein interaction databases

BioGridi117451. 4 interactors.
STRINGi9606.ENSP00000349874.

Structurei

3D structure databases

ProteinModelPortaliQ86X67.
SMRiQ86X67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 323Nudix hydrolasePROSITE-ProRule annotationAdd BLAST128

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi216 – 240Nudix boxAdd BLAST25

Phylogenomic databases

eggNOGiKOG3084. Eukaryota.
COG2816. LUCA.
GeneTreeiENSGT00530000063600.
HOGENOMiHOG000247937.
HOVERGENiHBG052688.
InParanoidiQ86X67.
OMAiYYPQMAP.
OrthoDBiEOG091G0SLC.
PhylomeDBiQ86X67.
TreeFamiTF106352.

Family and domain databases

InterProiView protein in InterPro
IPR015375. NADH_PPase-like_N.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR015376. Znr_NADH_PPase.
PfamiView protein in Pfam
PF00293. NUDIX. 1 hit.
PF09296. NUDIX-like. 1 hit.
PF09297. zf-NADH-PPase. 1 hit.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiView protein in PROSITE
PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86X67-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLYCGIACR RKFFWCYRLL STYVTKTRYL FELKEDDDAC KKAQQTGAFY
60 70 80 90 100
LFHSLAPLLQ TSAHQYLAPR HSLLELERLL GKFGQDAQRI EDSVLIGCSE
110 120 130 140 150
QQEAWFALDL GLDSSFSISA SLHKPEMETE LKGSFIELRK ALFQLNARDA
160 170 180 190 200
SLLSTAQALL RWHDAHQFCS RSGQPTKKNV AGSKRVCPSN NIIYYPQMAP
210 220 230 240 250
VAITLVSDGT RCLLARQSSF PKGMYSALAG FCDIGESVEE TIRREVAEEV
260 270 280 290 300
GLEVESLQYY ASQHWPFPSG SLMIACHATV KPGQTEIQVN LRELETAAWF
310 320 330 340 350
SHDEVATALK RKGPYTQQQN GTFPFWLPPK LAISHQLIKE WVEKQTCSSL

PA
Length:352
Mass (Da):39,688
Last modified:August 31, 2004 - v3
Checksum:i1FBBDB1ECD50BCAE
GO
Isoform 2 (identifier: Q86X67-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-286: Missing.

Note: No experimental confirmation available.
Show »
Length:263
Mass (Da):30,055
Checksum:i5ECC6312AD535DBF
GO
Isoform 3 (identifier: Q86X67-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Note: No experimental confirmation available.
Show »
Length:226
Mass (Da):25,230
Checksum:i2680F26AFDB3915D
GO
Isoform 4 (identifier: Q86X67-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-235: MAPVAITLVS...SALAGFCDIG → VKVWKRPSAE...SIGPSLVAHS
     236-352: Missing.

Show »
Length:235
Mass (Da):26,965
Checksum:iD3BDED445B56B254
GO

Sequence cautioni

The sequence AAD00649 differs from that shown. Reason: Frameshift at several positions.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03416081G → D. Corresponds to variant dbSNP:rs34284214Ensembl.1
Natural variantiVAR_050413273M → V. Corresponds to variant dbSNP:rs17658872Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0545591 – 126Missing in isoform 3. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_011417198 – 286Missing in isoform 2. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_055695198 – 235MAPVA…FCDIG → VKVWKRPSAEKLQKRWDWRW KACSTMHPSIGPSLVAHS in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_055696236 – 352Missing in isoform 4. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300980 mRNA. Translation: BAG62602.1.
AL731721, AC016394 Genomic DNA. Translation: CAI14548.1.
AL731721, AC016394 Genomic DNA. Translation: CAI14549.1.
CH471083 Genomic DNA. Translation: EAW54472.1.
BC038833 mRNA. No translation available.
BC046173 mRNA. Translation: AAH46173.2.
AL050114 mRNA. Translation: CAB43279.1.
U88048 mRNA. Translation: AAD00649.1. Frameshift.
CCDSiCCDS31220.1. [Q86X67-1]
CCDS60551.1. [Q86X67-4]
CCDS60552.1. [Q86X67-2]
CCDS60553.1. [Q86X67-3]
PIRiT08762.
RefSeqiNP_001269943.1. NM_001283014.1. [Q86X67-2]
NP_001269944.1. NM_001283015.1. [Q86X67-4]
NP_001269945.1. NM_001283016.1. [Q86X67-3]
NP_001269946.1. NM_001283017.1.
NP_001269948.1. NM_001283019.1.
NP_056985.3. NM_015901.5. [Q86X67-1]
XP_016871522.1. XM_017016033.1. [Q86X67-4]
UniGeneiHs.533657.

Genome annotation databases

EnsembliENST00000349051; ENSP00000335326; ENSG00000166321. [Q86X67-2]
ENST00000357321; ENSP00000349874; ENSG00000166321. [Q86X67-1]
ENST00000372997; ENSP00000362088; ENSG00000166321. [Q86X67-4]
ENST00000544879; ENSP00000440760; ENSG00000166321. [Q86X67-3]
GeneIDi25961.
KEGGihsa:25961.
UCSCiuc001jtj.5. human. [Q86X67-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNUD13_HUMAN
AccessioniPrimary (citable) accession number: Q86X67
Secondary accession number(s): B4DV90
, O95650, Q5SQM4, Q5SQM5, Q5SQM6, Q9Y3X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: August 30, 2017
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot