ID RGPS2_HUMAN Reviewed; 583 AA. AC Q86X27; B7Z7B1; Q5T5Z1; Q5VZ67; Q9NW78; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2003, sequence version 1. DT 24-JAN-2024, entry version 177. DE RecName: Full=Ras-specific guanine nucleotide-releasing factor RalGPS2; DE AltName: Full=Ral GEF with PH domain and SH3-binding motif 2; DE AltName: Full=RalA exchange factor RalGPS2; GN Name=RALGPS2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). RC TISSUE=Embryo, and Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP POSSIBLE INVOLVEMENT IN ALZHEIMER DISEASE. RX PubMed=17564960; DOI=10.1086/518720; RA Liu F., Arias-Vasquez A., Sleegers K., Aulchenko Y.S., Kayser M., RA Sanchez-Juan P., Feng B.J., Bertoli-Avella A.M., van Swieten J., RA Axenovich T.I., Heutink P., van Broeckhoven C., Oostra B.A., RA van Duijn C.M.; RT "A genomewide screen for late-onset Alzheimer disease in a genetically RT isolated Dutch population."; RL Am. J. Hum. Genet. 81:17-31(2007). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=T-cell; RX PubMed=19367720; DOI=10.1021/pr800500r; RA Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.; RT "Phosphorylation analysis of primary human T lymphocytes using sequential RT IMAC and titanium oxide enrichment."; RL J. Proteome Res. 7:5167-5176(2008). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-308; SER-311; THR-326 AND RP SER-329, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a RT refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-326 AND SER-329, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-308; SER-329; SER-343; RP THR-361; SER-374 AND SER-422, AND IDENTIFICATION BY MASS SPECTROMETRY RP [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [11] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-326; SER-329 AND THR-361, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: Guanine nucleotide exchange factor for the small GTPase RALA. CC May be involved in cytoskeletal organization. May also be involved in CC the stimulation of transcription in a Ras-independent fashion (By CC similarity). {ECO:0000250}. CC -!- SUBUNIT: Interacts with the SH3 domains of GRB2 and PLCG1. Interacts CC with RALA. {ECO:0000250}. CC -!- INTERACTION: CC Q86X27; Q9H4L5: OSBPL3; NbExp=3; IntAct=EBI-1050841, EBI-1051317; CC Q86X27; P31947: SFN; NbExp=2; IntAct=EBI-1050841, EBI-476295; CC Q86X27; P62258: YWHAE; NbExp=2; IntAct=EBI-1050841, EBI-356498; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane CC {ECO:0000250}. Note=Associates with membranes through the PH domain. CC {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q86X27-1; Sequence=Displayed; CC Name=2; CC IsoId=Q86X27-2; Sequence=VSP_031971; CC Name=3; CC IsoId=Q86X27-3; Sequence=VSP_054909; CC -!- DOMAIN: The PH domain mediates binding to phosphatidylinositol 4,5- CC bisphosphate. {ECO:0000250}. CC -!- DISEASE: Note=RALGPS2 is a potential candidate gene for susceptibility CC to Alzheimer disease linked to 1q24. {ECO:0000269|PubMed:17564960}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK001106; BAA91506.1; -; mRNA. DR EMBL; AK301753; BAH13547.1; -; mRNA. DR EMBL; AL162255; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL355520; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471067; EAW91028.1; -; Genomic_DNA. DR EMBL; CH471067; EAW91029.1; -; Genomic_DNA. DR EMBL; BC047391; AAH47391.1; -; mRNA. DR CCDS; CCDS1325.1; -. [Q86X27-1] DR CCDS; CCDS65733.1; -. [Q86X27-3] DR RefSeq; NP_001273176.1; NM_001286247.1. [Q86X27-3] DR RefSeq; NP_689876.2; NM_152663.4. [Q86X27-1] DR RefSeq; XP_006711473.1; XM_006711410.3. [Q86X27-1] DR AlphaFoldDB; Q86X27; -. DR SMR; Q86X27; -. DR BioGRID; 120413; 49. DR IntAct; Q86X27; 12. DR MINT; Q86X27; -. DR STRING; 9606.ENSP00000356607; -. DR GlyCosmos; Q86X27; 1 site, 1 glycan. DR GlyGen; Q86X27; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q86X27; -. DR PhosphoSitePlus; Q86X27; -. DR BioMuta; RALGPS2; -. DR DMDM; 74750518; -. DR EPD; Q86X27; -. DR jPOST; Q86X27; -. DR MassIVE; Q86X27; -. DR MaxQB; Q86X27; -. DR PaxDb; 9606-ENSP00000356607; -. DR PeptideAtlas; Q86X27; -. DR ProteomicsDB; 70228; -. [Q86X27-1] DR ProteomicsDB; 70229; -. [Q86X27-2] DR Pumba; Q86X27; -. DR Antibodypedia; 34414; 113 antibodies from 17 providers. DR DNASU; 55103; -. DR Ensembl; ENST00000367634.7; ENSP00000356606.2; ENSG00000116191.19. [Q86X27-3] DR Ensembl; ENST00000367635.8; ENSP00000356607.3; ENSG00000116191.19. [Q86X27-1] DR GeneID; 55103; -. DR KEGG; hsa:55103; -. DR MANE-Select; ENST00000367635.8; ENSP00000356607.3; NM_152663.5; NP_689876.2. DR UCSC; uc001glz.5; human. [Q86X27-1] DR AGR; HGNC:30279; -. DR CTD; 55103; -. DR DisGeNET; 55103; -. DR GeneCards; RALGPS2; -. DR HGNC; HGNC:30279; RALGPS2. DR HPA; ENSG00000116191; Tissue enhanced (lymphoid tissue, retina, testis). DR MIM; 617819; gene. DR neXtProt; NX_Q86X27; -. DR NIAGADS; ENSG00000116191; -. DR OpenTargets; ENSG00000116191; -. DR PharmGKB; PA134864387; -. DR VEuPathDB; HostDB:ENSG00000116191; -. DR eggNOG; KOG3417; Eukaryota. DR GeneTree; ENSGT00940000154079; -. DR HOGENOM; CLU_021333_0_1_1; -. DR InParanoid; Q86X27; -. DR OMA; QAYATTQ; -. DR OrthoDB; 68574at2759; -. DR PhylomeDB; Q86X27; -. DR TreeFam; TF352150; -. DR PathwayCommons; Q86X27; -. DR SignaLink; Q86X27; -. DR BioGRID-ORCS; 55103; 12 hits in 1167 CRISPR screens. DR ChiTaRS; RALGPS2; human. DR GenomeRNAi; 55103; -. DR Pharos; Q86X27; Tdark. DR PRO; PR:Q86X27; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q86X27; Protein. DR Bgee; ENSG00000116191; Expressed in gingival epithelium and 170 other cell types or tissues. DR ExpressionAtlas; Q86X27; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central. DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central. DR CDD; cd13310; PH_RalGPS1_2; 1. DR CDD; cd00155; RasGEF; 1. DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1. DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR001849; PH_domain. DR InterPro; IPR008937; Ras-like_GEF. DR InterPro; IPR023578; Ras_GEF_dom_sf. DR InterPro; IPR001895; RASGEF_cat_dom. DR InterPro; IPR036964; RASGEF_cat_dom_sf. DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1. DR PANTHER; PTHR23113:SF357; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS2; 1. DR Pfam; PF00169; PH; 1. DR Pfam; PF00617; RasGEF; 1. DR SMART; SM00233; PH; 1. DR SMART; SM00147; RasGEF; 1. DR SUPFAM; SSF50729; PH domain-like; 1. DR SUPFAM; SSF48366; Ras GEF; 1. DR PROSITE; PS50003; PH_DOMAIN; 1. DR PROSITE; PS50009; RASGEF_CAT; 1. DR Genevisible; Q86X27; HS. PE 1: Evidence at protein level; KW Alternative splicing; Alzheimer disease; Cell membrane; Cytoplasm; KW Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; KW Reference proteome. FT CHAIN 1..583 FT /note="Ras-specific guanine nucleotide-releasing factor FT RalGPS2" FT /id="PRO_0000322600" FT DOMAIN 49..287 FT /note="Ras-GEF" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00168" FT DOMAIN 457..569 FT /note="PH" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145" FT REGION 283..314 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 372..406 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 459..583 FT /note="Required for stimulation of nucleotide exchange by FT RALA" FT /evidence="ECO:0000250" FT MOTIF 324..327 FT /note="PXXP" FT COMPBIAS 383..406 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 293 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q9ERD6" FT MOD_RES 296 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q9ERD6" FT MOD_RES 308 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648, FT ECO:0007744|PubMed:23186163" FT MOD_RES 311 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648" FT MOD_RES 326 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:18669648, FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569" FT MOD_RES 329 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648, FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, FT ECO:0007744|PubMed:24275569" FT MOD_RES 343 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 361 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:23186163, FT ECO:0007744|PubMed:24275569" FT MOD_RES 374 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 422 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT VAR_SEQ 280..583 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_031971" FT VAR_SEQ 416..441 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_054909" FT VARIANT 225 FT /note="N -> S (in dbSNP:rs35161510)" FT /id="VAR_039468" FT CONFLICT 395 FT /note="I -> V (in Ref. 1; BAH13547)" FT /evidence="ECO:0000305" SQ SEQUENCE 583 AA; 65167 MW; B6D85A8ACBEBED15 CRC64; MDLMNGQASS VNIAATASEK SSSSESLSDK GSELKKSFDA VVFDVLKVTP EEYAGQITLM DVPVFKAIQP DELSSCGWNK KEKYSSAPNA VAFTRRFNHV SFWVVREILH AQTLKIRAEV LSHYIKTAKK LYELNNLHAL MAVVSGLQSA PIFRLTKTWA LLSRKDKTTF EKLEYVMSKE DNYKRLRDYI SSLKMTPCIP YLGIYLSDLT YIDSAYPSTG SILENEQRSN LMNNILRIIS DLQQSCEYDI PMLPHVQKYL NSVQYIEELQ KFVEDDNYKL SLKIEPGTST PRSAASREDL VGPEVGASPQ SGRKSVAAEG ALLPQTPPSP RNLIPHGHRK CHSLGYNFIH KMNTAEFKSA TFPNAGPRHL LDDSVMEPHA PSRGQAESST LSSGISIGSS DGSELSEETS WPAFERNRLY HSLGPVTRVA RNGYRSHMKA SSSAESEDLA VHLYPGAVTI QGVLRRKTLL KEGKKPTVAS WTKYWAALCG TQLFYYAAKS LKATERKHFK STSNKNVSVI GWMVMMADDP EHPDLFLLTD SEKGNSYKFQ AGNRMNAMLW FKHLSAACQS NKQQVPTNLM TFE //