RALGPS2

Functionⁱ

Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity).By similarity

GO - Molecular functionⁱ

guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

regulation of Ral protein signal transduction Source: InterPro
small GTPase mediated signal transduction Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factor

Molecular function

Guanine-nucleotide releasing factor

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-specific guanine nucleotide-releasing factor RalGPS2 Alternative name(s): Ral GEF with PH domain and SH3-binding motif 2 RalA exchange factor RalGPS2
Gene namesⁱ	Name:RALGPS2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30279. RALGPS2.

HGNCⁱ

HGNC:30279. RALGPS2.

Subcellular locationⁱ

Cytoplasm By similarity
Cell membrane By similarity

Note:

Associates with membranes through the PH domain.By similarity

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell
plasma membrane Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

RALGPS2 is a potential candidate gene for susceptibility to Alzheimer disease linked to 1q24.1 Publication

Keywords - Diseaseⁱ

Alzheimer disease

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000116191.
PharmGKBⁱ	PA134864387.

Polymorphism and mutation databases

DMDMⁱ	74750518.

DMDMⁱ

74750518.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000322600	1 – 583	Ras-specific guanine nucleotide-releasing factor RalGPS2Add BLAST		583

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	293	PhosphoserineBy similarity	1
Modified residueⁱ	296	PhosphoserineBy similarity	1
Modified residueⁱ	308	PhosphoserineCombined sources	1
Modified residueⁱ	311	PhosphoserineCombined sources	1
Modified residueⁱ	326	PhosphothreonineCombined sources	1
Modified residueⁱ	329	PhosphoserineCombined sources	1
Modified residueⁱ	343	PhosphoserineCombined sources	1
Modified residueⁱ	361	PhosphothreonineCombined sources	1
Modified residueⁱ	374	PhosphoserineCombined sources	1
Modified residueⁱ	422	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q86X27.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86X27.
PaxDbⁱ	Q86X27.
PeptideAtlas More...PeptideAtlasⁱ	Q86X27.
PRIDEⁱ	Q86X27.

PTM databases

iPTMnetⁱ	Q86X27.
PhosphoSitePlusⁱ	Q86X27.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000116191.
CleanExⁱ	HS_RALGPS2.
ExpressionAtlasⁱ	Q86X27. baseline and differential.
Genevisibleⁱ	Q86X27. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027143. HPA028328.

HPAⁱ

HPA027143.
HPA028328.

Interactionⁱ

Subunit structureⁱ

Interacts with the SH3 domains of GRB2 and PLCG1. Interacts with RALA.By similarity

Protein-protein interaction databases

BioGridⁱ	120413. 4 interactors.
IntActⁱ	Q86X27. 3 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1631677.
STRINGⁱ	9606.ENSP00000356607.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86X27.
SMRⁱ	Q86X27.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	49 – 287	Ras-GEFPROSITE-ProRule annotationAdd BLAST		239
Domainⁱ	457 – 569	PHPROSITE-ProRule annotationAdd BLAST		113

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	459 – 583	Required for stimulation of nucleotide exchange by RALABy similarityAdd BLAST		125

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	324 – 327	PXXP		4

Domainⁱ

The PH domain mediates binding to phosphatidylinositol 4,5-bisphosphate.By similarity

Phylogenomic databases

eggNOGⁱ	ENOG410IQ6R. Eukaryota. ENOG410YV9P. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137850.
HOGENOMⁱ	HOG000008021.
HOVERGENⁱ	HBG059258.
InParanoidⁱ	Q86X27.
OMAⁱ	ACQSNRQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NUM.
PhylomeDBⁱ	Q86X27.
TreeFamⁱ	TF352150.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00155. RasGEF. 1 hit.
Gene3Dⁱ	1.10.840.10. 1 hit. 2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR011993. PH_dom-like. IPR001849. PH_domain. IPR030708. RalGPS1/2. IPR023578. Ras_GEF_dom. IPR001895. RASGEF_cat_dom.
PANTHERⁱ	PTHR23113:SF293. PTHR23113:SF293. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169. PH. 1 hit. PF00617. RasGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00233. PH. 1 hit. SM00147. RasGEF. 1 hit.
SUPFAMⁱ	SSF48366. SSF48366. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50003. PH_DOMAIN. 1 hit. PS50009. RASGEF_CAT. 1 hit.

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q86X27-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLMNGQASS VNIAATASEK SSSSESLSDK GSELKKSFDA VVFDVLKVTP 
        60         70         80         90        100
EEYAGQITLM DVPVFKAIQP DELSSCGWNK KEKYSSAPNA VAFTRRFNHV 
       110        120        130        140        150
SFWVVREILH AQTLKIRAEV LSHYIKTAKK LYELNNLHAL MAVVSGLQSA 
       160        170        180        190        200
PIFRLTKTWA LLSRKDKTTF EKLEYVMSKE DNYKRLRDYI SSLKMTPCIP 
       210        220        230        240        250
YLGIYLSDLT YIDSAYPSTG SILENEQRSN LMNNILRIIS DLQQSCEYDI 
       260        270        280        290        300
PMLPHVQKYL NSVQYIEELQ KFVEDDNYKL SLKIEPGTST PRSAASREDL 
       310        320        330        340        350
VGPEVGASPQ SGRKSVAAEG ALLPQTPPSP RNLIPHGHRK CHSLGYNFIH 
       360        370        380        390        400
KMNTAEFKSA TFPNAGPRHL LDDSVMEPHA PSRGQAESST LSSGISIGSS 
       410        420        430        440        450
DGSELSEETS WPAFERNRLY HSLGPVTRVA RNGYRSHMKA SSSAESEDLA 
       460        470        480        490        500
VHLYPGAVTI QGVLRRKTLL KEGKKPTVAS WTKYWAALCG TQLFYYAAKS 
       510        520        530        540        550
LKATERKHFK STSNKNVSVI GWMVMMADDP EHPDLFLLTD SEKGNSYKFQ 
       560        570        580 
AGNRMNAMLW FKHLSAACQS NKQQVPTNLM TFE

Length:583

Mass (Da):65,167

Last modified:June 1, 2003 - v1

Checksum:ⁱB6D85A8ACBEBED15

GO

Isoform 2 (identifier: Q86X27-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
280-583: Missing.

« Hide

        10         20         30         40         50
MDLMNGQASS VNIAATASEK SSSSESLSDK GSELKKSFDA VVFDVLKVTP 
        60         70         80         90        100
EEYAGQITLM DVPVFKAIQP DELSSCGWNK KEKYSSAPNA VAFTRRFNHV 
       110        120        130        140        150
SFWVVREILH AQTLKIRAEV LSHYIKTAKK LYELNNLHAL MAVVSGLQSA 
       160        170        180        190        200
PIFRLTKTWA LLSRKDKTTF EKLEYVMSKE DNYKRLRDYI SSLKMTPCIP 
       210        220        230        240        250
YLGIYLSDLT YIDSAYPSTG SILENEQRSN LMNNILRIIS DLQQSCEYDI 
       260        270 
PMLPHVQKYL NSVQYIEELQ KFVEDDNYK

Note: No experimental confirmation available.

Show »

Length:279

Mass (Da):31,856

Checksum:ⁱ92195039C78F56EA

GO

Isoform 3 (identifier: Q86X27-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
416-441: Missing.

« Hide

        10         20         30         40         50
MDLMNGQASS VNIAATASEK SSSSESLSDK GSELKKSFDA VVFDVLKVTP 
        60         70         80         90        100
EEYAGQITLM DVPVFKAIQP DELSSCGWNK KEKYSSAPNA VAFTRRFNHV 
       110        120        130        140        150
SFWVVREILH AQTLKIRAEV LSHYIKTAKK LYELNNLHAL MAVVSGLQSA 
       160        170        180        190        200
PIFRLTKTWA LLSRKDKTTF EKLEYVMSKE DNYKRLRDYI SSLKMTPCIP 
       210        220        230        240        250
YLGIYLSDLT YIDSAYPSTG SILENEQRSN LMNNILRIIS DLQQSCEYDI 
       260        270        280        290        300
PMLPHVQKYL NSVQYIEELQ KFVEDDNYKL SLKIEPGTST PRSAASREDL 
       310        320        330        340        350
VGPEVGASPQ SGRKSVAAEG ALLPQTPPSP RNLIPHGHRK CHSLGYNFIH 
       360        370        380        390        400
KMNTAEFKSA TFPNAGPRHL LDDSVMEPHA PSRGQAESST LSSGISIGSS 
       410        420        430        440        450
DGSELSEETS WPAFESSAES EDLAVHLYPG AVTIQGVLRR KTLLKEGKKP 
       460        470        480        490        500
TVASWTKYWA ALCGTQLFYY AAKSLKATER KHFKSTSNKN VSVIGWMVMM 
       510        520        530        540        550
ADDPEHPDLF LLTDSEKGNS YKFQAGNRMN AMLWFKHLSA ACQSNKQQVP 

TNLMTFE

Note: No experimental confirmation available.

Show »

Length:557

Mass (Da):62,158

Checksum:ⁱEB18191A6C7200CA

GO

Sequence cautionⁱ

The sequence CAH71098 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence CAI21919 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence CAI21925 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	395	I → V in BAH13547 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_039468	225	N → S. Corresponds to variant dbSNP:rs35161510Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_031971	280 – 583	Missing in isoform 2. 1 PublicationAdd BLAST		304
Alternative sequenceⁱVSP_054909	416 – 441	Missing in isoform 3. 1 PublicationAdd BLAST		26

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK001106 mRNA. Translation: BAA91506.1. AK301753 mRNA. Translation: BAH13547.1. AL162255, AL355520 Genomic DNA. Translation: CAH71096.1. AL162255, AL355520 Genomic DNA. Translation: CAH71097.1. AL162255, AL355520 Genomic DNA. Translation: CAH71098.1. Sequence problems. AL355520, AL162255 Genomic DNA. Translation: CAI21918.1. AL355520, AL162255 Genomic DNA. Translation: CAI21919.1. Sequence problems. AL355520, AL162255 Genomic DNA. Translation: CAI21920.1. AL355520 Genomic DNA. Translation: CAI21925.1. Sequence problems. CH471067 Genomic DNA. Translation: EAW91028.1. CH471067 Genomic DNA. Translation: EAW91029.1. BC047391 mRNA. Translation: AAH47391.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1325.1. [Q86X27-1] CCDS65733.1. [Q86X27-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273176.1. NM_001286247.1. [Q86X27-3] NP_689876.2. NM_152663.4. [Q86X27-1] XP_006711473.1. XM_006711410.3. [Q86X27-1]
UniGeneⁱ	Hs.632485. Hs.657592.

Genome annotation databases

Ensemblⁱ	ENST00000367634; ENSP00000356606; ENSG00000116191. [Q86X27-3] ENST00000367635; ENSP00000356607; ENSG00000116191. [Q86X27-1]
GeneIDⁱ	55103.
KEGGⁱ	hsa:55103.
UCSC genome browser More...UCSCⁱ	uc001glz.5. human. [Q86X27-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK001106 mRNA. Translation: BAA91506.1. AK301753 mRNA. Translation: BAH13547.1. AL162255, AL355520 Genomic DNA. Translation: CAH71096.1. AL162255, AL355520 Genomic DNA. Translation: CAH71097.1. AL162255, AL355520 Genomic DNA. Translation: CAH71098.1. Sequence problems. AL355520, AL162255 Genomic DNA. Translation: CAI21918.1. AL355520, AL162255 Genomic DNA. Translation: CAI21919.1. Sequence problems. AL355520, AL162255 Genomic DNA. Translation: CAI21920.1. AL355520 Genomic DNA. Translation: CAI21925.1. Sequence problems. CH471067 Genomic DNA. Translation: EAW91028.1. CH471067 Genomic DNA. Translation: EAW91029.1. BC047391 mRNA. Translation: AAH47391.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1325.1. [Q86X27-1] CCDS65733.1. [Q86X27-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273176.1. NM_001286247.1. [Q86X27-3] NP_689876.2. NM_152663.4. [Q86X27-1] XP_006711473.1. XM_006711410.3. [Q86X27-1]
UniGeneⁱ	Hs.632485. Hs.657592.

3D structure databases

ProteinModelPortalⁱ	Q86X27.
SMRⁱ	Q86X27.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120413. 4 interactors.
IntActⁱ	Q86X27. 3 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1631677.
STRINGⁱ	9606.ENSP00000356607.

PTM databases

iPTMnetⁱ	Q86X27.
PhosphoSitePlusⁱ	Q86X27.

Polymorphism and mutation databases

DMDMⁱ	74750518.

DMDMⁱ

74750518.

Proteomic databases

EPDⁱ	Q86X27.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86X27.
PaxDbⁱ	Q86X27.
PeptideAtlas More...PeptideAtlasⁱ	Q86X27.
PRIDEⁱ	Q86X27.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000367634; ENSP00000356606; ENSG00000116191. [Q86X27-3] ENST00000367635; ENSP00000356607; ENSG00000116191. [Q86X27-1]
GeneIDⁱ	55103.
KEGGⁱ	hsa:55103.
UCSC genome browser More...UCSCⁱ	uc001glz.5. human. [Q86X27-1]

Organism-specific databases

CTDⁱ	55103.
GeneCardsⁱ	RALGPS2.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30279. RALGPS2.
Human Protein Atlas More...HPAⁱ	HPA027143. HPA028328.
neXtProtⁱ	NX_Q86X27.
Open Targets More...OpenTargetsⁱ	ENSG00000116191.
PharmGKBⁱ	PA134864387.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IQ6R. Eukaryota. ENOG410YV9P. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137850.
HOGENOMⁱ	HOG000008021.
HOVERGENⁱ	HBG059258.
InParanoidⁱ	Q86X27.
OMAⁱ	ACQSNRQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NUM.
PhylomeDBⁱ	Q86X27.
TreeFamⁱ	TF352150.

Miscellaneous databases

ChiTaRSⁱ	RALGPS2. human.
GenomeRNAiⁱ	55103.
Protein Ontology More...PROⁱ	PR:Q86X27.

Gene expression databases

Bgeeⁱ	ENSG00000116191.
CleanExⁱ	HS_RALGPS2.
ExpressionAtlasⁱ	Q86X27. baseline and differential.
Genevisibleⁱ	Q86X27. HS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00155. RasGEF. 1 hit.
Gene3Dⁱ	1.10.840.10. 1 hit. 2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR011993. PH_dom-like. IPR001849. PH_domain. IPR030708. RalGPS1/2. IPR023578. Ras_GEF_dom. IPR001895. RASGEF_cat_dom.
PANTHERⁱ	PTHR23113:SF293. PTHR23113:SF293. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169. PH. 1 hit. PF00617. RasGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00233. PH. 1 hit. SM00147. RasGEF. 1 hit.
SUPFAMⁱ	SSF48366. SSF48366. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50003. PH_DOMAIN. 1 hit. PS50009. RASGEF_CAT. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGPS2_HUMAN
Accessionⁱ	Q86X27Primary (citable) accession number: Q86X27 Secondary accession number(s): B7Z7B1 , Q5T5Z1, Q5VZ67, Q9NW78
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	June 1, 2003
	Last modified:	June 7, 2017
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q86X27 (RGPS2_HUMAN)

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Ras-specific guanine nucleotide-releasing factor RalGPS2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequences (3)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ