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Q86X27

- RGPS2_HUMAN

UniProt

Q86X27 - RGPS2_HUMAN

Protein

Ras-specific guanine nucleotide-releasing factor RalGPS2

Gene

RALGPS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion By similarity.By similarity

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-specific guanine nucleotide-releasing factor RalGPS2
    Alternative name(s):
    Ral GEF with PH domain and SH3-binding motif 2
    RalA exchange factor RalGPS2
    Gene namesi
    Name:RALGPS2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:30279. RALGPS2.

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity
    Note: Associates with membranes through the PH domain.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    RALGPS2 is a potential candidate gene for susceptibility to Alzheimer disease linked to 1q24.1 Publication

    Keywords - Diseasei

    Alzheimer disease

    Organism-specific databases

    PharmGKBiPA134864387.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 583583Ras-specific guanine nucleotide-releasing factor RalGPS2PRO_0000322600Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei308 – 3081Phosphoserine1 Publication
    Modified residuei311 – 3111Phosphoserine1 Publication
    Modified residuei326 – 3261Phosphothreonine2 Publications
    Modified residuei329 – 3291Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ86X27.
    PaxDbiQ86X27.
    PRIDEiQ86X27.

    PTM databases

    PhosphoSiteiQ86X27.

    Expressioni

    Gene expression databases

    BgeeiQ86X27.
    CleanExiHS_RALGPS2.
    GenevestigatoriQ86X27.

    Organism-specific databases

    HPAiHPA027143.
    HPA028328.

    Interactioni

    Subunit structurei

    Interacts with the SH3 domains of GRB2 and PLCG1. Interacts with RALA.By similarity

    Protein-protein interaction databases

    BioGridi120413. 5 interactions.
    IntActiQ86X27. 2 interactions.
    MINTiMINT-1631677.
    STRINGi9606.ENSP00000356607.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86X27.
    SMRiQ86X27. Positions 43-286, 459-572.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 287239Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini457 – 569113PHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni459 – 583125Required for stimulation of nucleotide exchange by RALABy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi324 – 3274PXXP

    Domaini

    The PH domain mediates binding to phosphatidylinositol 4,5-bisphosphate.By similarity

    Sequence similaritiesi

    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG275669.
    HOGENOMiHOG000008021.
    HOVERGENiHBG059258.
    InParanoidiQ86X27.
    OMAiYGHRKCH.
    OrthoDBiEOG70KGP7.
    PhylomeDBiQ86X27.
    TreeFamiTF352150.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view]
    PfamiPF00617. RasGEF. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00147. RasGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 1 hit.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86X27-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLMNGQASS VNIAATASEK SSSSESLSDK GSELKKSFDA VVFDVLKVTP    50
    EEYAGQITLM DVPVFKAIQP DELSSCGWNK KEKYSSAPNA VAFTRRFNHV 100
    SFWVVREILH AQTLKIRAEV LSHYIKTAKK LYELNNLHAL MAVVSGLQSA 150
    PIFRLTKTWA LLSRKDKTTF EKLEYVMSKE DNYKRLRDYI SSLKMTPCIP 200
    YLGIYLSDLT YIDSAYPSTG SILENEQRSN LMNNILRIIS DLQQSCEYDI 250
    PMLPHVQKYL NSVQYIEELQ KFVEDDNYKL SLKIEPGTST PRSAASREDL 300
    VGPEVGASPQ SGRKSVAAEG ALLPQTPPSP RNLIPHGHRK CHSLGYNFIH 350
    KMNTAEFKSA TFPNAGPRHL LDDSVMEPHA PSRGQAESST LSSGISIGSS 400
    DGSELSEETS WPAFERNRLY HSLGPVTRVA RNGYRSHMKA SSSAESEDLA 450
    VHLYPGAVTI QGVLRRKTLL KEGKKPTVAS WTKYWAALCG TQLFYYAAKS 500
    LKATERKHFK STSNKNVSVI GWMVMMADDP EHPDLFLLTD SEKGNSYKFQ 550
    AGNRMNAMLW FKHLSAACQS NKQQVPTNLM TFE 583
    Length:583
    Mass (Da):65,167
    Last modified:June 1, 2003 - v1
    Checksum:iB6D85A8ACBEBED15
    GO
    Isoform 2 (identifier: Q86X27-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         280-583: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:279
    Mass (Da):31,856
    Checksum:i92195039C78F56EA
    GO
    Isoform 3 (identifier: Q86X27-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         416-441: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:557
    Mass (Da):62,158
    Checksum:iEB18191A6C7200CA
    GO

    Sequence cautioni

    The sequence CAH71098.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI21919.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI21925.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti395 – 3951I → V in BAH13547. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti225 – 2251N → S.
    Corresponds to variant rs35161510 [ dbSNP | Ensembl ].
    VAR_039468

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei280 – 583304Missing in isoform 2. 1 PublicationVSP_031971Add
    BLAST
    Alternative sequencei416 – 44126Missing in isoform 3. 1 PublicationVSP_054909Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001106 mRNA. Translation: BAA91506.1.
    AK301753 mRNA. Translation: BAH13547.1.
    AL162255, AL355520 Genomic DNA. Translation: CAH71096.1.
    AL162255, AL355520 Genomic DNA. Translation: CAH71097.1.
    AL162255, AL355520 Genomic DNA. Translation: CAH71098.1. Sequence problems.
    AL355520, AL162255 Genomic DNA. Translation: CAI21918.1.
    AL355520, AL162255 Genomic DNA. Translation: CAI21919.1. Sequence problems.
    AL355520, AL162255 Genomic DNA. Translation: CAI21920.1.
    AL355520 Genomic DNA. Translation: CAI21925.1. Sequence problems.
    CH471067 Genomic DNA. Translation: EAW91028.1.
    CH471067 Genomic DNA. Translation: EAW91029.1.
    BC047391 mRNA. Translation: AAH47391.1.
    CCDSiCCDS1325.1. [Q86X27-1]
    CCDS65733.1. [Q86X27-3]
    RefSeqiNP_001273176.1. NM_001286247.1. [Q86X27-3]
    NP_689876.2. NM_152663.4. [Q86X27-1]
    XP_006711472.1. XM_006711409.1. [Q86X27-1]
    XP_006711473.1. XM_006711410.1. [Q86X27-1]
    UniGeneiHs.632485.
    Hs.657592.

    Genome annotation databases

    EnsembliENST00000367634; ENSP00000356606; ENSG00000116191. [Q86X27-3]
    ENST00000367635; ENSP00000356607; ENSG00000116191. [Q86X27-1]
    GeneIDi55103.
    KEGGihsa:55103.
    UCSCiuc001gly.1. human. [Q86X27-2]
    uc001glz.3. human. [Q86X27-1]

    Polymorphism databases

    DMDMi74750518.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001106 mRNA. Translation: BAA91506.1 .
    AK301753 mRNA. Translation: BAH13547.1 .
    AL162255 , AL355520 Genomic DNA. Translation: CAH71096.1 .
    AL162255 , AL355520 Genomic DNA. Translation: CAH71097.1 .
    AL162255 , AL355520 Genomic DNA. Translation: CAH71098.1 . Sequence problems.
    AL355520 , AL162255 Genomic DNA. Translation: CAI21918.1 .
    AL355520 , AL162255 Genomic DNA. Translation: CAI21919.1 . Sequence problems.
    AL355520 , AL162255 Genomic DNA. Translation: CAI21920.1 .
    AL355520 Genomic DNA. Translation: CAI21925.1 . Sequence problems.
    CH471067 Genomic DNA. Translation: EAW91028.1 .
    CH471067 Genomic DNA. Translation: EAW91029.1 .
    BC047391 mRNA. Translation: AAH47391.1 .
    CCDSi CCDS1325.1. [Q86X27-1 ]
    CCDS65733.1. [Q86X27-3 ]
    RefSeqi NP_001273176.1. NM_001286247.1. [Q86X27-3 ]
    NP_689876.2. NM_152663.4. [Q86X27-1 ]
    XP_006711472.1. XM_006711409.1. [Q86X27-1 ]
    XP_006711473.1. XM_006711410.1. [Q86X27-1 ]
    UniGenei Hs.632485.
    Hs.657592.

    3D structure databases

    ProteinModelPortali Q86X27.
    SMRi Q86X27. Positions 43-286, 459-572.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120413. 5 interactions.
    IntActi Q86X27. 2 interactions.
    MINTi MINT-1631677.
    STRINGi 9606.ENSP00000356607.

    PTM databases

    PhosphoSitei Q86X27.

    Polymorphism databases

    DMDMi 74750518.

    Proteomic databases

    MaxQBi Q86X27.
    PaxDbi Q86X27.
    PRIDEi Q86X27.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367634 ; ENSP00000356606 ; ENSG00000116191 . [Q86X27-3 ]
    ENST00000367635 ; ENSP00000356607 ; ENSG00000116191 . [Q86X27-1 ]
    GeneIDi 55103.
    KEGGi hsa:55103.
    UCSCi uc001gly.1. human. [Q86X27-2 ]
    uc001glz.3. human. [Q86X27-1 ]

    Organism-specific databases

    CTDi 55103.
    GeneCardsi GC01P178694.
    HGNCi HGNC:30279. RALGPS2.
    HPAi HPA027143.
    HPA028328.
    neXtProti NX_Q86X27.
    PharmGKBi PA134864387.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG275669.
    HOGENOMi HOG000008021.
    HOVERGENi HBG059258.
    InParanoidi Q86X27.
    OMAi YGHRKCH.
    OrthoDBi EOG70KGP7.
    PhylomeDBi Q86X27.
    TreeFami TF352150.

    Miscellaneous databases

    ChiTaRSi RALGPS2. human.
    GenomeRNAii 55103.
    NextBioi 35480188.
    PROi Q86X27.

    Gene expression databases

    Bgeei Q86X27.
    CleanExi HS_RALGPS2.
    Genevestigatori Q86X27.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view ]
    Pfami PF00617. RasGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00147. RasGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 1 hit.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Embryo and Testis.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    5. Cited for: POSSIBLE INVOLVEMENT IN ALZHEIMER DISEASE.
    6. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
      J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: T-cell.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-308; SER-311; THR-326 AND SER-329, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-326 AND SER-329, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRGPS2_HUMAN
    AccessioniPrimary (citable) accession number: Q86X27
    Secondary accession number(s): B7Z7B1
    , Q5T5Z1, Q5VZ67, Q9NW78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3