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Protein

Transmembrane protein 17

Gene

TMEM17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 17
Gene namesi
Name:TMEM17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26623. TMEM17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei45 – 6521HelicalSequence analysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence analysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence analysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134962933.

Polymorphism and mutation databases

BioMutaiTMEM17.
DMDMi117949799.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Transmembrane protein 17PRO_0000255260Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence analysis
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86X19.
PRIDEiQ86X19.

Expressioni

Gene expression databases

BgeeiQ86X19.
CleanExiHS_TMEM17.
GenevisibleiQ86X19. HS.

Organism-specific databases

HPAiHPA018100.

Interactioni

Subunit structurei

Part of the tectonic-like complex (also named B9 complex).By similarity

Protein-protein interaction databases

BioGridi128342. 400 interactions.
IntActiQ86X19. 400 interactions.
STRINGi9606.ENSP00000335094.

Structurei

3D structure databases

ProteinModelPortaliQ86X19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM17 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4694. Eukaryota.
ENOG4111T47. LUCA.
GeneTreeiENSGT00390000006643.
HOGENOMiHOG000253940.
HOVERGENiHBG088848.
InParanoidiQ86X19.
KOiK19384.
OMAiRTGPEYN.
OrthoDBiEOG70CR89.
PhylomeDBiQ86X19.
TreeFamiTF323824.

Family and domain databases

InterProiIPR019184. Uncharacterised_TM-17.
[Graphical view]
PfamiPF09799. Transmemb_17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86X19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELPDPVRQR LGNFSRAVFS DSNRTGPESN EGPENEMVSS LALQMSLYFN
60 70 80 90 100
TYYFPLWWVS SIMMLHMKYS ILPDYYKFIV ITVIILITLI EAIRLYLGYV
110 120 130 140 150
GNLQEKVPEL AGFWLLSLLL QLPLILFLLF NEGLTNLPLE KAIHIIFTLF
160 170 180 190
LAFQVVAAFL TLRKMVNQLA VRFHLQDFDR LSANRGDMRR MRSCIEEI
Length:198
Mass (Da):23,046
Last modified:October 31, 2006 - v2
Checksum:i5865AD283F595C3F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261G → S.1 Publication
Corresponds to variant rs17854454 [ dbSNP | Ensembl ].
VAR_028864

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093159 Genomic DNA. Translation: AAY24170.1.
AC107083 Genomic DNA. Translation: AAY24048.1.
BC047439 mRNA. Translation: AAH47439.1.
CCDSiCCDS1871.1.
RefSeqiNP_938017.2. NM_198276.2.
UniGeneiHs.308028.

Genome annotation databases

EnsembliENST00000335390; ENSP00000335094; ENSG00000186889.
GeneIDi200728.
KEGGihsa:200728.
UCSCiuc002sbt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093159 Genomic DNA. Translation: AAY24170.1.
AC107083 Genomic DNA. Translation: AAY24048.1.
BC047439 mRNA. Translation: AAH47439.1.
CCDSiCCDS1871.1.
RefSeqiNP_938017.2. NM_198276.2.
UniGeneiHs.308028.

3D structure databases

ProteinModelPortaliQ86X19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128342. 400 interactions.
IntActiQ86X19. 400 interactions.
STRINGi9606.ENSP00000335094.

Polymorphism and mutation databases

BioMutaiTMEM17.
DMDMi117949799.

Proteomic databases

PaxDbiQ86X19.
PRIDEiQ86X19.

Protocols and materials databases

DNASUi200728.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335390; ENSP00000335094; ENSG00000186889.
GeneIDi200728.
KEGGihsa:200728.
UCSCiuc002sbt.3. human.

Organism-specific databases

CTDi200728.
GeneCardsiTMEM17.
HGNCiHGNC:26623. TMEM17.
HPAiHPA018100.
MIMi614950. gene.
neXtProtiNX_Q86X19.
PharmGKBiPA134962933.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4694. Eukaryota.
ENOG4111T47. LUCA.
GeneTreeiENSGT00390000006643.
HOGENOMiHOG000253940.
HOVERGENiHBG088848.
InParanoidiQ86X19.
KOiK19384.
OMAiRTGPEYN.
OrthoDBiEOG70CR89.
PhylomeDBiQ86X19.
TreeFamiTF323824.

Miscellaneous databases

GenomeRNAii200728.
NextBioi89965.
PROiQ86X19.
SOURCEiSearch...

Gene expression databases

BgeeiQ86X19.
CleanExiHS_TMEM17.
GenevisibleiQ86X19. HS.

Family and domain databases

InterProiIPR019184. Uncharacterised_TM-17.
[Graphical view]
PfamiPF09799. Transmemb_17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-26.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiTMM17_HUMAN
AccessioniPrimary (citable) accession number: Q86X19
Secondary accession number(s): Q53QP7, Q53R98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: March 16, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.