Q86X10 (RLGPB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ral GTPase-activating protein subunit beta

Alternative name(s):
p170

Gene names

Name:	RALGAPB
Synonyms:	KIAA1219

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1494 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB By similarity.
Subunit structure	Component of the heterodimeric RalGAP1 complex with RALGAPA1 and of the heterodimeric RalGAP2 complex with RALGAPA2. Heterodimerization is required for activity By similarity.
Tissue specificity	Highly expressed in brain, mostly in amygdala.
Sequence similarities	Contains 1 Rap-GAP domain.
Sequence caution	The sequence BAA86533.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAC85649.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAB61346.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAD39096.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Ral protein signal transduction Inferred from electronic annotation. Source: Compara activation of Ral GTPase activity Inferred from sequence or structural similarity. Source: UniProtKB regulation of exocyst localization Inferred from electronic annotation. Source: Compara
Molecular_function	Ral GTPase activator activity Inferred from sequence or structural similarity. Source: UniProtKB protein heterodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86X10-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86X10-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.
     1233-1233: E → EE

Note: May be due to a competing acceptor splice site. No experimental confirmation available.

Isoform 3 (identifier: Q86X10-3)

The sequence of this isoform differs from the canonical sequence as follows:
     749-752: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.

Isoform 4 (identifier: Q86X10-4)

The sequence of this isoform differs from the canonical sequence as follows:
     943-1473: Missing.

Note: Splicing acceptor site is not canonical. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1494	1494	Ral GTPase-activating protein subunit beta		PRO_0000056756
Regions
	Domain	1149 – 1392	244	Rap-GAP
Amino acid modifications
	Modified residue	720	1	Phosphoserine By similarity
	Modified residue	734	1	Phosphothreonine Ref.10
Natural variations
	Alternative sequence	1 – 222	222	Missing in isoform 2.		VSP_009693
	Alternative sequence	749 – 752	4	Missing in isoform 3.		VSP_009694
	Alternative sequence	943 – 1473	531	Missing in isoform 4.		VSP_009695
	Alternative sequence	1233	1	E → EE in isoform 2.		VSP_009696
Experimental info
	Sequence conflict	326	1	P → S in CAD39096. Ref.1
	Sequence conflict	1072	1	Y → G in AAH18668. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 5FEDBB0CB269F8CE	FASTA	1,494	166,799
	10 20 30 40 50 60 MYSEWRSLHL VIQNDQGHTS VLHSYPESVG REVANAVVRP LGQVLGTPSV AGSENLLKTD 70 80 90 100 110 120 KEVKWTMEVI CYGLTLPLDG ETVKYCVDVY TDWIMALVLP KDSIPLPVIK EPNQYVQTIL 130 140 150 160 170 180 KHLQNLFVPR QEQGSSQIRL CLQVLRAIQK LARESSLMAR ETWEVLLLFL LQINDILLAP 190 200 210 220 230 240 PTVQGGIAEN LAEKLIGVLF EVWLLACTRC FPTPPYWKTA KEMVANWRHH PAVVEQWSKV 250 260 270 280 290 300 ICALTSRLLR FTYGPSFPAF KVPDEDASLI PPEMDNECVA QTWFRFLHML SNPVDLSNPA 310 320 330 340 350 360 IISSTPKFQE QFLNVSGMPQ ELNQYPCLKH LPQIFFRAMR GISCLVDAFL GISRPRSDSA 370 380 390 400 410 420 PPTPVNRLSM PQSAAVSTTP PHNRRHRAVT VNKATMKTST VSTAHASKVQ HQTSSTSPLS 430 440 450 460 470 480 SPNQTSSEPR PLPAPRRPKV NSILNLFGSW LFDAAFVHCK LHNGINRDSS MTAITTQASM 490 500 510 520 530 540 EFRRKGSQMS TDTMVSNPMF DASEFPDNYE AGRAEACGTL CRIFCSKKTG EEILPAYLSR 550 560 570 580 590 600 FYMLLIQGLQ INDYVCHPVL ASVILNSPPL FCCDLKGIDV VVPYFISALE TILPDRELSK 610 620 630 640 650 660 FKSYVNPTEL RRSSINILLS LLPLPHHFGT VKSEVVLEGK FSNDDSSSYD KPITFLSLKL 670 680 690 700 710 720 RLVNILIGAL QTETDPNNTQ MILGAMLNIV QDSALLEAIG CQMEMGGGEN NLKSHSRTNS 730 740 750 760 770 780 GISSASGGST EPTTPDSERP AQALLRDYAL NTDSAAGLLI RSIHLVTQRL NSQWRQDMSI 790 800 810 820 830 840 SLAALELLSG LAKVKVMVDS GDRKRAISSV CTYIVYQCSR PAPLHSRDLH SMIVAAFQCL 850 860 870 880 890 900 CVWLTEHPDM LDEKDCLKEV LEIVELGISG SKSKNNEQEV KYKGDKEPNP ASMRVKDAAE 910 920 930 940 950 960 ATLTCIMQLL GAFPSPSGPA SPCSLVNETT LIKYSRLPTI NKHSFRYFVL DNSVILAMLE 970 980 990 1000 1010 1020 QPLGNEQNDF FPSVTVLVRG MSGRLAWAQQ LCLLPRGAKA NQKLFVPEPR PVPKNDVGFK 1030 1040 1050 1060 1070 1080 YSVKHRPFPE EVDKIPFVKA DLSIPDLHEI VTEELEERHE KLRSGMAQQI AYEIHLEQQS 1090 1100 1110 1120 1130 1140 EEELQKRSFP DPVTDCKPPP PAQEFQTARL FLSHFGFLSL EALKEPANSR LPPHLIALDS 1150 1160 1170 1180 1190 1200 TIPGFFDDIG YLDLLPCRPF DTVFIFYMKP GQKTNQEILK NVESSRTVQP HFLEFLLSLG 1210 1220 1230 1240 1250 1260 WSVDVGRHPG WTGHVSTSWS INCCDDGEGS QQEVISSEDI GASIFNGQKK VLYYADALTE 1270 1280 1290 1300 1310 1320 IAFVVPSPVE SLTDSLESNI SDQDSDSNMD LMPGILKQPS LTLELFPNHT DNLNSSQRLS 1330 1340 1350 1360 1370 1380 PSSRMRKLPQ GRPVPPLGPE TRVSVVWVER YDDIENFPLS ELMTEISTGV ETTANSSTSL 1390 1400 1410 1420 1430 1440 RSTTLEKEVP VIFIHPLNTG LFRIKIQGAT GKFNMVIPLV DGMIVSRRAL GFLVRQTVIN 1450 1460 1470 1480 1490 ICRRKRLESD SYSPPHVRRK QKITDIVNKY RNKQLEPEFY TSLFQEVGLK NCSS
	Isoform 2 [UniParc]. Checksum: 024E924F27623CC2	FASTA	1,273	141,866
	10 20 30 40 50 60 MVANWRHHPA VVEQWSKVIC ALTSRLLRFT YGPSFPAFKV PDEDASLIPP EMDNECVAQT 70 80 90 100 110 120 WFRFLHMLSN PVDLSNPAII SSTPKFQEQF LNVSGMPQEL NQYPCLKHLP QIFFRAMRGI 130 140 150 160 170 180 SCLVDAFLGI SRPRSDSAPP TPVNRLSMPQ SAAVSTTPPH NRRHRAVTVN KATMKTSTVS 190 200 210 220 230 240 TAHASKVQHQ TSSTSPLSSP NQTSSEPRPL PAPRRPKVNS ILNLFGSWLF DAAFVHCKLH 250 260 270 280 290 300 NGINRDSSMT AITTQASMEF RRKGSQMSTD TMVSNPMFDA SEFPDNYEAG RAEACGTLCR 310 320 330 340 350 360 IFCSKKTGEE ILPAYLSRFY MLLIQGLQIN DYVCHPVLAS VILNSPPLFC CDLKGIDVVV 370 380 390 400 410 420 PYFISALETI LPDRELSKFK SYVNPTELRR SSINILLSLL PLPHHFGTVK SEVVLEGKFS 430 440 450 460 470 480 NDDSSSYDKP ITFLSLKLRL VNILIGALQT ETDPNNTQMI LGAMLNIVQD SALLEAIGCQ 490 500 510 520 530 540 MEMGGGENNL KSHSRTNSGI SSASGGSTEP TTPDSERPAQ ALLRDYALNT DSAAGLLIRS 550 560 570 580 590 600 IHLVTQRLNS QWRQDMSISL AALELLSGLA KVKVMVDSGD RKRAISSVCT YIVYQCSRPA 610 620 630 640 650 660 PLHSRDLHSM IVAAFQCLCV WLTEHPDMLD EKDCLKEVLE IVELGISGSK SKNNEQEVKY 670 680 690 700 710 720 KGDKEPNPAS MRVKDAAEAT LTCIMQLLGA FPSPSGPASP CSLVNETTLI KYSRLPTINK 730 740 750 760 770 780 HSFRYFVLDN SVILAMLEQP LGNEQNDFFP SVTVLVRGMS GRLAWAQQLC LLPRGAKANQ 790 800 810 820 830 840 KLFVPEPRPV PKNDVGFKYS VKHRPFPEEV DKIPFVKADL SIPDLHEIVT EELEERHEKL 850 860 870 880 890 900 RSGMAQQIAY EIHLEQQSEE ELQKRSFPDP VTDCKPPPPA QEFQTARLFL SHFGFLSLEA 910 920 930 940 950 960 LKEPANSRLP PHLIALDSTI PGFFDDIGYL DLLPCRPFDT VFIFYMKPGQ KTNQEILKNV 970 980 990 1000 1010 1020 ESSRTVQPHF LEFLLSLGWS VDVGRHPGWT GHVSTSWSIN CCDDGEGSQQ EEVISSEDIG 1030 1040 1050 1060 1070 1080 ASIFNGQKKV LYYADALTEI AFVVPSPVES LTDSLESNIS DQDSDSNMDL MPGILKQPSL 1090 1100 1110 1120 1130 1140 TLELFPNHTD NLNSSQRLSP SSRMRKLPQG RPVPPLGPET RVSVVWVERY DDIENFPLSE 1150 1160 1170 1180 1190 1200 LMTEISTGVE TTANSSTSLR STTLEKEVPV IFIHPLNTGL FRIKIQGATG KFNMVIPLVD 1210 1220 1230 1240 1250 1260 GMIVSRRALG FLVRQTVINI CRRKRLESDS YSPPHVRRKQ KITDIVNKYR NKQLEPEFYT 1270 SLFQEVGLKN CSS
	Isoform 3 [UniParc]. Checksum: A563AECFFF89DEDD	FASTA	1,490	166,399
	10 20 30 40 50 60 MYSEWRSLHL VIQNDQGHTS VLHSYPESVG REVANAVVRP LGQVLGTPSV AGSENLLKTD 70 80 90 100 110 120 KEVKWTMEVI CYGLTLPLDG ETVKYCVDVY TDWIMALVLP KDSIPLPVIK EPNQYVQTIL 130 140 150 160 170 180 KHLQNLFVPR QEQGSSQIRL CLQVLRAIQK LARESSLMAR ETWEVLLLFL LQINDILLAP 190 200 210 220 230 240 PTVQGGIAEN LAEKLIGVLF EVWLLACTRC FPTPPYWKTA KEMVANWRHH PAVVEQWSKV 250 260 270 280 290 300 ICALTSRLLR FTYGPSFPAF KVPDEDASLI PPEMDNECVA QTWFRFLHML SNPVDLSNPA 310 320 330 340 350 360 IISSTPKFQE QFLNVSGMPQ ELNQYPCLKH LPQIFFRAMR GISCLVDAFL GISRPRSDSA 370 380 390 400 410 420 PPTPVNRLSM PQSAAVSTTP PHNRRHRAVT VNKATMKTST VSTAHASKVQ HQTSSTSPLS 430 440 450 460 470 480 SPNQTSSEPR PLPAPRRPKV NSILNLFGSW LFDAAFVHCK LHNGINRDSS MTAITTQASM 490 500 510 520 530 540 EFRRKGSQMS TDTMVSNPMF DASEFPDNYE AGRAEACGTL CRIFCSKKTG EEILPAYLSR 550 560 570 580 590 600 FYMLLIQGLQ INDYVCHPVL ASVILNSPPL FCCDLKGIDV VVPYFISALE TILPDRELSK 610 620 630 640 650 660 FKSYVNPTEL RRSSINILLS LLPLPHHFGT VKSEVVLEGK FSNDDSSSYD KPITFLSLKL 670 680 690 700 710 720 RLVNILIGAL QTETDPNNTQ MILGAMLNIV QDSALLEAIG CQMEMGGGEN NLKSHSRTNS 730 740 750 760 770 780 GISSASGGST EPTTPDSERP AQALLRDYDS AAGLLIRSIH LVTQRLNSQW RQDMSISLAA 790 800 810 820 830 840 LELLSGLAKV KVMVDSGDRK RAISSVCTYI VYQCSRPAPL HSRDLHSMIV AAFQCLCVWL 850 860 870 880 890 900 TEHPDMLDEK DCLKEVLEIV ELGISGSKSK NNEQEVKYKG DKEPNPASMR VKDAAEATLT 910 920 930 940 950 960 CIMQLLGAFP SPSGPASPCS LVNETTLIKY SRLPTINKHS FRYFVLDNSV ILAMLEQPLG 970 980 990 1000 1010 1020 NEQNDFFPSV TVLVRGMSGR LAWAQQLCLL PRGAKANQKL FVPEPRPVPK NDVGFKYSVK 1030 1040 1050 1060 1070 1080 HRPFPEEVDK IPFVKADLSI PDLHEIVTEE LEERHEKLRS GMAQQIAYEI HLEQQSEEEL 1090 1100 1110 1120 1130 1140 QKRSFPDPVT DCKPPPPAQE FQTARLFLSH FGFLSLEALK EPANSRLPPH LIALDSTIPG 1150 1160 1170 1180 1190 1200 FFDDIGYLDL LPCRPFDTVF IFYMKPGQKT NQEILKNVES SRTVQPHFLE FLLSLGWSVD 1210 1220 1230 1240 1250 1260 VGRHPGWTGH VSTSWSINCC DDGEGSQQEV ISSEDIGASI FNGQKKVLYY ADALTEIAFV 1270 1280 1290 1300 1310 1320 VPSPVESLTD SLESNISDQD SDSNMDLMPG ILKQPSLTLE LFPNHTDNLN SSQRLSPSSR 1330 1340 1350 1360 1370 1380 MRKLPQGRPV PPLGPETRVS VVWVERYDDI ENFPLSELMT EISTGVETTA NSSTSLRSTT 1390 1400 1410 1420 1430 1440 LEKEVPVIFI HPLNTGLFRI KIQGATGKFN MVIPLVDGMI VSRRALGFLV RQTVINICRR 1450 1460 1470 1480 1490 KRLESDSYSP PHVRRKQKIT DIVNKYRNKQ LEPEFYTSLF QEVGLKNCSS
	Isoform 4 [UniParc]. Checksum: 13AF758962E013A4	FASTA	963	106,838
	10 20 30 40 50 60 MYSEWRSLHL VIQNDQGHTS VLHSYPESVG REVANAVVRP LGQVLGTPSV AGSENLLKTD 70 80 90 100 110 120 KEVKWTMEVI CYGLTLPLDG ETVKYCVDVY TDWIMALVLP KDSIPLPVIK EPNQYVQTIL 130 140 150 160 170 180 KHLQNLFVPR QEQGSSQIRL CLQVLRAIQK LARESSLMAR ETWEVLLLFL LQINDILLAP 190 200 210 220 230 240 PTVQGGIAEN LAEKLIGVLF EVWLLACTRC FPTPPYWKTA KEMVANWRHH PAVVEQWSKV 250 260 270 280 290 300 ICALTSRLLR FTYGPSFPAF KVPDEDASLI PPEMDNECVA QTWFRFLHML SNPVDLSNPA 310 320 330 340 350 360 IISSTPKFQE QFLNVSGMPQ ELNQYPCLKH LPQIFFRAMR GISCLVDAFL GISRPRSDSA 370 380 390 400 410 420 PPTPVNRLSM PQSAAVSTTP PHNRRHRAVT VNKATMKTST VSTAHASKVQ HQTSSTSPLS 430 440 450 460 470 480 SPNQTSSEPR PLPAPRRPKV NSILNLFGSW LFDAAFVHCK LHNGINRDSS MTAITTQASM 490 500 510 520 530 540 EFRRKGSQMS TDTMVSNPMF DASEFPDNYE AGRAEACGTL CRIFCSKKTG EEILPAYLSR 550 560 570 580 590 600 FYMLLIQGLQ INDYVCHPVL ASVILNSPPL FCCDLKGIDV VVPYFISALE TILPDRELSK 610 620 630 640 650 660 FKSYVNPTEL RRSSINILLS LLPLPHHFGT VKSEVVLEGK FSNDDSSSYD KPITFLSLKL 670 680 690 700 710 720 RLVNILIGAL QTETDPNNTQ MILGAMLNIV QDSALLEAIG CQMEMGGGEN NLKSHSRTNS 730 740 750 760 770 780 GISSASGGST EPTTPDSERP AQALLRDYAL NTDSAAGLLI RSIHLVTQRL NSQWRQDMSI 790 800 810 820 830 840 SLAALELLSG LAKVKVMVDS GDRKRAISSV CTYIVYQCSR PAPLHSRDLH SMIVAAFQCL 850 860 870 880 890 900 CVWLTEHPDM LDEKDCLKEV LEIVELGISG SKSKNNEQEV KYKGDKEPNP ASMRVKDAAE 910 920 930 940 950 960 ATLTCIMQLL GAFPSPSGPA SPCSLVNETT LIKYSRLPTI NKQLEPEFYT SLFQEVGLKN CSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[3]	Ohara O., Nagase T., Kikuno R. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Melanoma.
[5]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain, Lung and Testis.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-1494 (ISOFORM 4). Tissue: Tongue.
[8]	"Adipocytes contain a novel complex similar to the tuberous sclerosis complex." Gridley S., Chavez J.A., Lane W.S., Lienhard G.E. Cell. Signal. 18:1626-1632(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RALGAPA2.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-734, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB033045 mRNA. Translation: BAA86533.3. Different initiation. AL834436 mRNA. Translation: CAD39096.1. Different initiation. AL132998 mRNA. Translation: CAB61346.1. Different initiation. AL035419, AL049868 Genomic DNA. Translation: CAM27455.1. AL049868, AL035419 Genomic DNA. Translation: CAM28344.1. BC010916 mRNA. Translation: AAH10916.2. BC018668 mRNA. Translation: AAH18668.1. BC047482 mRNA. Translation: AAH47482.1. AK123576 mRNA. Translation: BAC85649.1. Different initiation.
IPI	IPI00409601. IPI00410120. IPI00410121. IPI00748653.
RefSeq	NP_065069.1. NM_020336.2.
UniGene	Hs.598850.
3D structure databases
ProteinModelPortal	Q86X10.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86X10. 1 interaction.
MINT	MINT-3035957.
PTM databases
PhosphoSite	Q86X10.
Polymorphism databases
DMDM	45477126.
Proteomic databases
PaxDb	Q86X10.
PRIDE	Q86X10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262879; ENSP00000262879; ENSG00000170471. ENST00000397038; ENSP00000380231; ENSG00000170471. ENST00000397040; ENSP00000380233; ENSG00000170471.
GeneID	57148.
KEGG	hsa:57148.
UCSC	uc002xiw.3. human. uc002xiz.3. human.
Organism-specific databases
CTD	57148.
GeneCards	GC20P037102.
H-InvDB	HIX0203031.
HGNC	HGNC:29221. RALGAPB.
HPA	HPA051454.
neXtProt	NX_Q86X10.
PharmGKB	PA165392608.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG293167.
HOVERGEN	HBG052199.
InParanoid	Q86X10.
OMA	QNLFVPR.
OrthoDB	EOG43N7BS.
PhylomeDB	Q86X10.
Enzyme and pathway databases
Reactome	REACT_11123. Membrane Trafficking.
Gene expression databases
ArrayExpress	Q86X10.
Bgee	Q86X10.
CleanEx	HS_KIAA1219.
Genevestigator	Q86X10.
GermOnline	ENSG00000170471. Homo sapiens.
Family and domain databases
InterPro	IPR000331. Rap_GAP_dom. [Graphical view]
PROSITE	PS50085. RAPGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57148.
NextBio	63107.

Entry information

Entry name

RLGPB_HUMAN

Accession

Primary (citable) accession number: Q86X10
Secondary accession number(s): A2A2E8 , Q5TG31, Q8N3D1, Q8WWC0, Q9H3X8, Q9UJR1, Q9ULK1, Q9Y3G9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.