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Protein

Zinc finger protein 227

Gene

ZNF227

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri250 – 272C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 291C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri576 – 598C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri604 – 626C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri632 – 654C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri660 – 682C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri688 – 710C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri716 – 738C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri744 – 766C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri772 – 794C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 227
Gene namesi
Name:ZNF227
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13020. ZNF227.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131115.
PharmGKBiPA37599.

Polymorphism and mutation databases

BioMutaiZNF227.
DMDMi55976727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474681 – 799Zinc finger protein 227Add BLAST799

Proteomic databases

EPDiQ86WZ6.
MaxQBiQ86WZ6.
PaxDbiQ86WZ6.
PeptideAtlasiQ86WZ6.
PRIDEiQ86WZ6.

PTM databases

iPTMnetiQ86WZ6.
PhosphoSitePlusiQ86WZ6.

Expressioni

Gene expression databases

BgeeiENSG00000131115.
CleanExiHS_ZNF227.
ExpressionAtlasiQ86WZ6. baseline and differential.
GenevisibleiQ86WZ6. HS.

Organism-specific databases

HPAiHPA030573.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ15EBI-2799529,EBI-739624

Protein-protein interaction databases

BioGridi113553. 8 interactors.
IntActiQ86WZ6. 7 interactors.
MINTiMINT-8247419.
STRINGi9606.ENSP00000321049.

Structurei

3D structure databases

ProteinModelPortaliQ86WZ6.
SMRiQ86WZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 94KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri250 – 272C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 291C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri576 – 598C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri604 – 626C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri632 – 654C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri660 – 682C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri688 – 710C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri716 – 738C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri744 – 766C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri772 – 794C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ86WZ6.
KOiK09228.
OMAiRLTYHQK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ86WZ6.
TreeFamiTF350845.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86WZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSQNYDLPQ KKQEKMTKFQ EAVTFKDVAV VFSREELRLL DLTQRKLYRD
60 70 80 90 100
VMVENFKNLV AVGHLPFQPD MVSQLEAEEK LWMMETETQR SSKHQNKMET
110 120 130 140 150
LQKFALKYLS NQELSCWQIW KQVASELTRC LQGKSSQLLQ GDSIQVSENE
160 170 180 190 200
NNIMNPKGDS SIYIENQEFP FWRTQHSCGN TYLSESQIQS RGKQIDVKNN
210 220 230 240 250
LQIHEDFMKK SPFHEHIKTD TEPKPCKGNE YGKIISDGSN QKLPLGEKPH
260 270 280 290 300
PCGECGRGFS YSPRLPLHPN VHTGEKCFSQ SSHLRTHQRI HPGEKLNRCH
310 320 330 340 350
ESGDCFNKSS FHSYQSNHTG EKSYRCDSCG KGFSSSTGLI IHYRTHTGEK
360 370 380 390 400
PYKCEECGKC FSQSSNFQCH QRVHTEEKPY KCEECGKGFG WSVNLRVHQR
410 420 430 440 450
VHRGEKPYKC EECGKGFTQA AHFHIHQRVH TGEKPYKCDV CGKGFSHNSP
460 470 480 490 500
LICHRRVHTG EKPYKCEACG KGFTRNTDLH IHFRVHTGEK PYKCKECGKG
510 520 530 540 550
FSQASNLQVH QNVHTGEKRF KCETCGKGFS QSSKLQTHQR VHTGEKPYRC
560 570 580 590 600
DVCGKDFSYS SNLKLHQVIH TGEKPYKCEE CGKGFSWRSN LHAHQRVHSG
610 620 630 640 650
EKPYKCEQCD KSFSQAIDFR VHQRVHTGEK PYKCGVCGKG FSQSSGLQSH
660 670 680 690 700
QRVHTGEKPY KCDVCGKGFR YSSQFIYHQR GHTGEKPYKC EECGKGFGRS
710 720 730 740 750
LNLRHHQRVH TGEKPHICEE CGKAFSLPSN LRVHLGVHTR EKLFKCEECG
760 770 780 790
KGFSQSARLE AHQRVHTGEK PYKCDICDKD FRHRSRLTYH QKVHTGKKL
Length:799
Mass (Da):92,033
Last modified:June 1, 2003 - v1
Checksum:i8D3506F40D71FA8A
GO
Isoform 2 (identifier: Q86WZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.

Note: No experimental confirmation available.
Show »
Length:748
Mass (Da):85,889
Checksum:iD33F3FD4F0541C36
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565441 – 51Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092253 mRNA. Translation: BAG52509.1.
AK299266 mRNA. Translation: BAH12985.1.
AK316048 mRNA. Translation: BAH14419.1.
AC138470 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57261.1.
BC047570 mRNA. Translation: AAH47570.1.
CCDSiCCDS12636.1. [Q86WZ6-1]
CCDS74388.1. [Q86WZ6-2]
RefSeqiNP_001276095.1. NM_001289166.1. [Q86WZ6-1]
NP_001276096.1. NM_001289167.1. [Q86WZ6-2]
NP_001276097.1. NM_001289168.1. [Q86WZ6-2]
NP_001276098.1. NM_001289169.1. [Q86WZ6-2]
NP_001276099.1. NM_001289170.1.
NP_872296.1. NM_182490.2. [Q86WZ6-1]
XP_005259289.1. XM_005259232.2. [Q86WZ6-1]
XP_011525591.1. XM_011527289.2. [Q86WZ6-1]
XP_016882755.1. XM_017027266.1. [Q86WZ6-1]
XP_016882757.1. XM_017027268.1. [Q86WZ6-2]
XP_016882758.1. XM_017027269.1. [Q86WZ6-2]
XP_016882759.1. XM_017027270.1. [Q86WZ6-2]
XP_016882760.1. XM_017027271.1. [Q86WZ6-2]
UniGeneiHs.298089.

Genome annotation databases

EnsembliENST00000313040; ENSP00000321049; ENSG00000131115. [Q86WZ6-1]
ENST00000391961; ENSP00000375823; ENSG00000131115. [Q86WZ6-2]
ENST00000589005; ENSP00000467577; ENSG00000131115. [Q86WZ6-2]
ENST00000621083; ENSP00000482749; ENSG00000131115. [Q86WZ6-1]
GeneIDi7770.
KEGGihsa:7770.
UCSCiuc002oyu.5. human. [Q86WZ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092253 mRNA. Translation: BAG52509.1.
AK299266 mRNA. Translation: BAH12985.1.
AK316048 mRNA. Translation: BAH14419.1.
AC138470 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57261.1.
BC047570 mRNA. Translation: AAH47570.1.
CCDSiCCDS12636.1. [Q86WZ6-1]
CCDS74388.1. [Q86WZ6-2]
RefSeqiNP_001276095.1. NM_001289166.1. [Q86WZ6-1]
NP_001276096.1. NM_001289167.1. [Q86WZ6-2]
NP_001276097.1. NM_001289168.1. [Q86WZ6-2]
NP_001276098.1. NM_001289169.1. [Q86WZ6-2]
NP_001276099.1. NM_001289170.1.
NP_872296.1. NM_182490.2. [Q86WZ6-1]
XP_005259289.1. XM_005259232.2. [Q86WZ6-1]
XP_011525591.1. XM_011527289.2. [Q86WZ6-1]
XP_016882755.1. XM_017027266.1. [Q86WZ6-1]
XP_016882757.1. XM_017027268.1. [Q86WZ6-2]
XP_016882758.1. XM_017027269.1. [Q86WZ6-2]
XP_016882759.1. XM_017027270.1. [Q86WZ6-2]
XP_016882760.1. XM_017027271.1. [Q86WZ6-2]
UniGeneiHs.298089.

3D structure databases

ProteinModelPortaliQ86WZ6.
SMRiQ86WZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113553. 8 interactors.
IntActiQ86WZ6. 7 interactors.
MINTiMINT-8247419.
STRINGi9606.ENSP00000321049.

PTM databases

iPTMnetiQ86WZ6.
PhosphoSitePlusiQ86WZ6.

Polymorphism and mutation databases

BioMutaiZNF227.
DMDMi55976727.

Proteomic databases

EPDiQ86WZ6.
MaxQBiQ86WZ6.
PaxDbiQ86WZ6.
PeptideAtlasiQ86WZ6.
PRIDEiQ86WZ6.

Protocols and materials databases

DNASUi7770.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313040; ENSP00000321049; ENSG00000131115. [Q86WZ6-1]
ENST00000391961; ENSP00000375823; ENSG00000131115. [Q86WZ6-2]
ENST00000589005; ENSP00000467577; ENSG00000131115. [Q86WZ6-2]
ENST00000621083; ENSP00000482749; ENSG00000131115. [Q86WZ6-1]
GeneIDi7770.
KEGGihsa:7770.
UCSCiuc002oyu.5. human. [Q86WZ6-1]

Organism-specific databases

CTDi7770.
GeneCardsiZNF227.
HGNCiHGNC:13020. ZNF227.
HPAiHPA030573.
neXtProtiNX_Q86WZ6.
OpenTargetsiENSG00000131115.
PharmGKBiPA37599.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ86WZ6.
KOiK09228.
OMAiRLTYHQK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ86WZ6.
TreeFamiTF350845.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF227. human.
GenomeRNAii7770.
PROiQ86WZ6.

Gene expression databases

BgeeiENSG00000131115.
CleanExiHS_ZNF227.
ExpressionAtlasiQ86WZ6. baseline and differential.
GenevisibleiQ86WZ6. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN227_HUMAN
AccessioniPrimary (citable) accession number: Q86WZ6
Secondary accession number(s): B3KRU7, B7Z5P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.