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Protein

HEAT repeat-containing protein 4

Gene

HEATR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31552-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HEAT repeat-containing protein 4
Gene namesi
Name:HEATR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:16761. HEATR4.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187105.
PharmGKBiPA162390631.

Polymorphism and mutation databases

BioMutaiHEATR4.
DMDMi347595657.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002541291 – 1026HEAT repeat-containing protein 4Add BLAST1026

Proteomic databases

EPDiQ86WZ0.
PaxDbiQ86WZ0.
PeptideAtlasiQ86WZ0.
PRIDEiQ86WZ0.

PTM databases

iPTMnetiQ86WZ0.
PhosphoSitePlusiQ86WZ0.

Expressioni

Gene expression databases

BgeeiENSG00000187105.
CleanExiHS_HEATR4.
ExpressionAtlasiQ86WZ0. baseline and differential.
GenevisibleiQ86WZ0. HS.

Organism-specific databases

HPAiHPA003642.
HPA019767.

Interactioni

Protein-protein interaction databases

IntActiQ86WZ0. 1 interactor.
STRINGi9606.ENSP00000335447.

Structurei

3D structure databases

ProteinModelPortaliQ86WZ0.
SMRiQ86WZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati530 – 568HEAT 1Add BLAST39
Repeati724 – 760HEAT 2Add BLAST37
Repeati761 – 794HEAT 3Add BLAST34

Sequence similaritiesi

Contains 3 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJT8. Eukaryota.
ENOG410YWTX. LUCA.
GeneTreeiENSGT00390000013207.
HOGENOMiHOG000112877.
HOVERGENiHBG081595.
InParanoidiQ86WZ0.
OMAiNFQERVE.
OrthoDBiEOG091G0A1F.
TreeFamiTF329278.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
[Graphical view]
PfamiPF02985. HEAT. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86WZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRTQKGKTF LPHCFYQSLP PRLGWGMILN YSKLKGKEEC ASVSSVPMVF
60 70 80 90 100
FSSQYRLHRK SQYLKMAAAN LTFSQEVVWQ RGLPSIPYSQ YSFDHLYNTN
110 120 130 140 150
DIIHTPQIRK ARPQKPVSFK FLGSSSPLTG DTSLAVKTES SANPEKKLKK
160 170 180 190 200
SKPASTVREA PRPLIHHPCM HPDMLGRPPS LDVNLEEREA WLLPPEKEAR
210 220 230 240 250
AWEATVLEKL NERTARWIQS KRPRRPGASP NKWQSFLRQQ YDWSHIRDEL
260 270 280 290 300
TSASDLELLK QLEAEETAEF EDQSVILPPQ EKKKPELLLP VYYRLPSYFQ
310 320 330 340 350
QAETVEIMPG NKSTEDIHEK TSLSQPQTQS YFRQVTPRAG KFAYSTDNTF
360 370 380 390 400
EQEIYFDEVQ IIHQIGAKRD QIVLENLNRY NKQLSKVFPE TPEKWSAQAI
410 420 430 440 450
PEASYRPVQG ALRWTALPTP AKDMLLQVGE KDVPIKTRRL KKQAKSLQED
460 470 480 490 500
VTWELVVLRR MLKEWKTAWA LIIEWHHETV ENLLQSLGDL HDDVRIKAIT
510 520 530 540 550
TCATAALERP RIATSQRDSD KTIQDLPEVL LPALEAALCD KNAHVRMAAA
560 570 580 590 600
ICQYAIQSHN PLARNIMQTA LLKGNSVDSW AAAQCLALEG TATYPVIKRI
610 620 630 640 650
LHQLFTKKNE DTEEQSYILL SYLSEKTTLI HTMLAVELNS CQWKNRIVAC
660 670 680 690 700
QAFSRISGNV CLDMKHKLIQ LMWNDWNKEV RRAAAQALGQ MSLGKEVHDI
710 720 730 740 750
IRVKLGQGNS QERVEALYLI GELKLMTAKL LPSFLHCFSD DFTAVRRAAC
760 770 780 790 800
LAAGALQIRD KMVLECLLNL MQRDPYWKIK AFAIRALGQI GQVSPELTDL
810 820 830 840 850
LLWAIHYEES PGVRLEACRS ILALKLQGDR VRDTFLDVLL LENHDAVLKE
860 870 880 890 900
MYQTMKILNL GNEGNQEMLQ EIKNRIKTLS QKDLLTHKIL KLEMVMGKVR
910 920 930 940 950
EEAKRVYLKP KGEQGPLTLQ TLLQETFQDE MVLPRRPSEV CDTEAVIKPV
960 970 980 990 1000
KPRAPNPWLQ SSVPGLTTRS KVRSSLVKDL RTSPEKRIAV GPFRSDYPAL
1010 1020
YLGKFSERTF FSPIMSSPSG KKGAHL
Length:1,026
Mass (Da):117,175
Last modified:September 21, 2011 - v2
Checksum:i7B44D419F58A7B6A
GO

Sequence cautioni

The sequence AAH47590 differs from that shown. Reason: Erroneous termination at position 39. Translated as Glu.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028817634L → H.Corresponds to variant rs12894435dbSNPEnsembl.1
Natural variantiVAR_028818643W → G.Corresponds to variant rs12894425dbSNPEnsembl.1
Natural variantiVAR_028819660V → A.Corresponds to variant rs12894400dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302564 mRNA. Translation: BAH13745.1.
AC005225 Genomic DNA. No translation available.
AC005280 Genomic DNA. No translation available.
BC047590 mRNA. Translation: AAH47590.1. Sequence problems.
GU727638 mRNA. Translation: ADU87640.1.
CCDSiCCDS9815.2.
RefSeqiNP_001207413.1. NM_001220484.1.
NP_976054.2. NM_203309.2.
XP_006720206.1. XM_006720143.2.
XP_011535062.1. XM_011536760.2.
XP_016876778.1. XM_017021289.1.
UniGeneiHs.660774.

Genome annotation databases

EnsembliENST00000334988; ENSP00000335447; ENSG00000187105.
ENST00000553558; ENSP00000450444; ENSG00000187105.
GeneIDi399671.
KEGGihsa:399671.
UCSCiuc021rwe.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302564 mRNA. Translation: BAH13745.1.
AC005225 Genomic DNA. No translation available.
AC005280 Genomic DNA. No translation available.
BC047590 mRNA. Translation: AAH47590.1. Sequence problems.
GU727638 mRNA. Translation: ADU87640.1.
CCDSiCCDS9815.2.
RefSeqiNP_001207413.1. NM_001220484.1.
NP_976054.2. NM_203309.2.
XP_006720206.1. XM_006720143.2.
XP_011535062.1. XM_011536760.2.
XP_016876778.1. XM_017021289.1.
UniGeneiHs.660774.

3D structure databases

ProteinModelPortaliQ86WZ0.
SMRiQ86WZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ86WZ0. 1 interactor.
STRINGi9606.ENSP00000335447.

PTM databases

iPTMnetiQ86WZ0.
PhosphoSitePlusiQ86WZ0.

Polymorphism and mutation databases

BioMutaiHEATR4.
DMDMi347595657.

Proteomic databases

EPDiQ86WZ0.
PaxDbiQ86WZ0.
PeptideAtlasiQ86WZ0.
PRIDEiQ86WZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334988; ENSP00000335447; ENSG00000187105.
ENST00000553558; ENSP00000450444; ENSG00000187105.
GeneIDi399671.
KEGGihsa:399671.
UCSCiuc021rwe.2. human.

Organism-specific databases

CTDi399671.
GeneCardsiHEATR4.
H-InvDBHIX0011793.
HIX0018563.
HIX0037875.
HGNCiHGNC:16761. HEATR4.
HPAiHPA003642.
HPA019767.
neXtProtiNX_Q86WZ0.
OpenTargetsiENSG00000187105.
PharmGKBiPA162390631.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJT8. Eukaryota.
ENOG410YWTX. LUCA.
GeneTreeiENSGT00390000013207.
HOGENOMiHOG000112877.
HOVERGENiHBG081595.
InParanoidiQ86WZ0.
OMAiNFQERVE.
OrthoDBiEOG091G0A1F.
TreeFamiTF329278.

Enzyme and pathway databases

BioCyciZFISH:G66-31552-MONOMER.

Miscellaneous databases

ChiTaRSiHEATR4. human.
GenomeRNAii399671.
PROiQ86WZ0.

Gene expression databases

BgeeiENSG00000187105.
CleanExiHS_HEATR4.
ExpressionAtlasiQ86WZ0. baseline and differential.
GenevisibleiQ86WZ0. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
[Graphical view]
PfamiPF02985. HEAT. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHEAT4_HUMAN
AccessioniPrimary (citable) accession number: Q86WZ0
Secondary accession number(s): B7Z7V9, E9KL41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 21, 2011
Last modified: November 30, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.