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Protein

Active regulator of SIRT1

Gene

RPS19BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.1 Publication

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Active regulator of SIRT1
Alternative name(s):
40S ribosomal protein S19-binding protein 1
Short name:
RPS19-binding protein 1
Short name:
S19BP
Gene namesi
Name:RPS19BP1
Synonyms:AROS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:28749. RPS19BP1.

Subcellular locationi

  • Nucleusnucleolus 1 Publication

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleolus Source: HGNC
  • nucleoplasm Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485599.

Polymorphism and mutation databases

BioMutaiRPS19BP1.
DMDMi74727734.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 136136Active regulator of SIRT1PRO_0000252393Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71CitrullineBy similarity

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination

Proteomic databases

EPDiQ86WX3.
MaxQBiQ86WX3.
PaxDbiQ86WX3.
PRIDEiQ86WX3.

PTM databases

PhosphoSiteiQ86WX3.

Expressioni

Tissue specificityi

Widely expressed (at protein level).1 Publication

Gene expression databases

BgeeiQ86WX3.
CleanExiHS_RPS19BP1.
ExpressionAtlasiQ86WX3. baseline and differential.
GenevisibleiQ86WX3. HS.

Organism-specific databases

HPAiHPA042874.

Interactioni

Subunit structurei

Interacts with RPS19 (By similarity). Interacts with SIRT1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-4479407,EBI-747107
SIRT1Q96EB611EBI-4479407,EBI-1802965

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124848. 18 interactions.
IntActiQ86WX3. 8 interactions.
MINTiMINT-4995480.
STRINGi9606.ENSP00000333948.

Structurei

3D structure databases

ProteinModelPortaliQ86WX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AROS family.Curated

Phylogenomic databases

eggNOGiENOG410J1DB. Eukaryota.
ENOG41126PZ. LUCA.
GeneTreeiENSGT00390000016774.
HOGENOMiHOG000034068.
HOVERGENiHBG097440.
InParanoidiQ86WX3.
OMAiKFQREYF.
OrthoDBiEOG7SR4PS.
PhylomeDBiQ86WX3.
TreeFamiTF333429.

Family and domain databases

InterProiIPR023262. AROS.
[Graphical view]
PfamiPF15684. AROS. 1 hit.
[Graphical view]
PRINTSiPR02029. ACTREGSIRT1.

Sequencei

Sequence statusi: Complete.

Q86WX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAALLRRGL ELLAASEAPR DPPGQAKPRG APVKRPRKTK AIQAQKLRNS
60 70 80 90 100
AKGKVPKSAL DEYRKRECRD HLRVNLKFLT RTRSTVAESV SQQILRQNRG
110 120 130
RKACDRPVAK TKKKKAEGTV FTEEDFQKFQ QEYFGS
Length:136
Mass (Da):15,434
Last modified:June 1, 2003 - v1
Checksum:iF7CE798D68CC0941
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241E → A.
Corresponds to variant rs17001278 [ dbSNP | Ensembl ].
VAR_051330

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456443 mRNA. Translation: CAG30329.1.
AL022312 Genomic DNA. Translation: CAQ08288.1.
CH471095 Genomic DNA. Translation: EAW60343.1.
BC047711 mRNA. Translation: AAH47711.1.
BC037573 mRNA. Translation: AAH37573.1.
CCDSiCCDS13997.1.
RefSeqiNP_919307.1. NM_194326.3.
UniGeneiHs.526933.

Genome annotation databases

EnsembliENST00000334678; ENSP00000333948; ENSG00000187051.
GeneIDi91582.
KEGGihsa:91582.
UCSCiuc003ayb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456443 mRNA. Translation: CAG30329.1.
AL022312 Genomic DNA. Translation: CAQ08288.1.
CH471095 Genomic DNA. Translation: EAW60343.1.
BC047711 mRNA. Translation: AAH47711.1.
BC037573 mRNA. Translation: AAH37573.1.
CCDSiCCDS13997.1.
RefSeqiNP_919307.1. NM_194326.3.
UniGeneiHs.526933.

3D structure databases

ProteinModelPortaliQ86WX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124848. 18 interactions.
IntActiQ86WX3. 8 interactions.
MINTiMINT-4995480.
STRINGi9606.ENSP00000333948.

PTM databases

PhosphoSiteiQ86WX3.

Polymorphism and mutation databases

BioMutaiRPS19BP1.
DMDMi74727734.

Proteomic databases

EPDiQ86WX3.
MaxQBiQ86WX3.
PaxDbiQ86WX3.
PRIDEiQ86WX3.

Protocols and materials databases

DNASUi91582.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334678; ENSP00000333948; ENSG00000187051.
GeneIDi91582.
KEGGihsa:91582.
UCSCiuc003ayb.3. human.

Organism-specific databases

CTDi91582.
GeneCardsiRPS19BP1.
HGNCiHGNC:28749. RPS19BP1.
HPAiHPA042874.
MIMi610225. gene.
neXtProtiNX_Q86WX3.
PharmGKBiPA143485599.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1DB. Eukaryota.
ENOG41126PZ. LUCA.
GeneTreeiENSGT00390000016774.
HOGENOMiHOG000034068.
HOVERGENiHBG097440.
InParanoidiQ86WX3.
OMAiKFQREYF.
OrthoDBiEOG7SR4PS.
PhylomeDBiQ86WX3.
TreeFamiTF333429.

Enzyme and pathway databases

ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

ChiTaRSiRPS19BP1. human.
GenomeRNAii91582.
NextBioi77307.
PROiQ86WX3.
SOURCEiSearch...

Gene expression databases

BgeeiQ86WX3.
CleanExiHS_RPS19BP1.
ExpressionAtlasiQ86WX3. baseline and differential.
GenevisibleiQ86WX3. HS.

Family and domain databases

InterProiIPR023262. AROS.
[Graphical view]
PfamiPF15684. AROS. 1 hit.
[Graphical view]
PRINTSiPR02029. ACTREGSIRT1.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland and Skin.
  5. "Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity."
    Kim E.-J., Kho J.-H., Kang M.-R., Um S.-J.
    Mol. Cell 28:277-290(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SIRT1.
  6. Erratum
    Kim E.-J., Kho J.-H., Kang M.-R., Um S.-J.
    Mol. Cell 28:513-513(2007)
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAROS_HUMAN
AccessioniPrimary (citable) accession number: Q86WX3
Secondary accession number(s): B0QY96, Q5JZA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2003
Last modified: April 13, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.