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Protein

Active regulator of SIRT1

Gene

RPS19BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.1 Publication

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • RNA binding Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Active regulator of SIRT1
Alternative name(s):
40S ribosomal protein S19-binding protein 1
Short name:
RPS19-binding protein 1
Short name:
S19BP
Gene namesi
Name:RPS19BP1
Synonyms:AROS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000187051.8.
HGNCiHGNC:28749. RPS19BP1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi91582.
OpenTargetsiENSG00000187051.
PharmGKBiPA143485599.

Polymorphism and mutation databases

BioMutaiRPS19BP1.
DMDMi74727734.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002523931 – 136Active regulator of SIRT1Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7CitrullineBy similarity1
Modified residuei84PhosphoserineCombined sources1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

EPDiQ86WX3.
MaxQBiQ86WX3.
PaxDbiQ86WX3.
PeptideAtlasiQ86WX3.
PRIDEiQ86WX3.

PTM databases

iPTMnetiQ86WX3.
PhosphoSitePlusiQ86WX3.

Expressioni

Tissue specificityi

Widely expressed (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000187051.
CleanExiHS_RPS19BP1.
ExpressionAtlasiQ86WX3. baseline and differential.
GenevisibleiQ86WX3. HS.

Organism-specific databases

HPAiHPA042874.

Interactioni

Subunit structurei

Interacts with RPS19 (By similarity). Interacts with SIRT1.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124848. 27 interactors.
IntActiQ86WX3. 15 interactors.
MINTiMINT-4995480.
STRINGi9606.ENSP00000333948.

Structurei

3D structure databases

ProteinModelPortaliQ86WX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AROS family.Curated

Phylogenomic databases

eggNOGiENOG410J1DB. Eukaryota.
ENOG41126PZ. LUCA.
GeneTreeiENSGT00390000016774.
HOGENOMiHOG000034068.
HOVERGENiHBG097440.
InParanoidiQ86WX3.
OMAiQGRKACD.
OrthoDBiEOG091G0YGT.
PhylomeDBiQ86WX3.
TreeFamiTF333429.

Family and domain databases

InterProiView protein in InterPro
IPR023262. AROS.
PfamiView protein in Pfam
PF15684. AROS. 1 hit.
PRINTSiPR02029. ACTREGSIRT1.

Sequencei

Sequence statusi: Complete.

Q86WX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAALLRRGL ELLAASEAPR DPPGQAKPRG APVKRPRKTK AIQAQKLRNS
60 70 80 90 100
AKGKVPKSAL DEYRKRECRD HLRVNLKFLT RTRSTVAESV SQQILRQNRG
110 120 130
RKACDRPVAK TKKKKAEGTV FTEEDFQKFQ QEYFGS
Length:136
Mass (Da):15,434
Last modified:June 1, 2003 - v1
Checksum:iF7CE798D68CC0941
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051330124E → A. Corresponds to variant dbSNP:rs17001278Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456443 mRNA. Translation: CAG30329.1.
AL022312 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW60343.1.
BC047711 mRNA. Translation: AAH47711.1.
BC037573 mRNA. Translation: AAH37573.1.
CCDSiCCDS13997.1.
RefSeqiNP_919307.1. NM_194326.3.
UniGeneiHs.526933.

Genome annotation databases

EnsembliENST00000334678; ENSP00000333948; ENSG00000187051.
GeneIDi91582.
KEGGihsa:91582.
UCSCiuc003ayb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAROS_HUMAN
AccessioniPrimary (citable) accession number: Q86WX3
Secondary accession number(s): B0QY96, Q5JZA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2003
Last modified: September 27, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families