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Protein
Submitted name:

Hamartin

Gene

TSC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
HamartinImported
Submitted name:
Tuberous sclerosis 1Imported
Gene namesi
Name:TSC1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:12362. TSC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165699.
PharmGKBiPA37034.

Expressioni

Gene expression databases

BgeeiENSG00000165699.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000298552.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IG36. Eukaryota.
ENOG411020J. LUCA.
GeneTreeiENSGT00390000014148.
HOVERGENiHBG054903.
KOiK07206.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007483. Hamartin.
[Graphical view]
PANTHERiPTHR15154. PTHR15154. 1 hit.
PfamiPF04388. Hamartin. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86WV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQQANVGEL LAMLDSPMLG VRDDVTAVFK ENLNSDRGPM LVNTLVDYYL
60 70 80 90 100
ETSSQPALHI LTTLQEPHDK HLLDRINEYV GKAATRLSIL SLLGHVIRLQ
110 120 130 140 150
PSWKHKLSQA PLLPSLLKCL KMDTDVVVLT TGVLVLITML PMIPQSGKQH
160 170 180 190 200
LLDFFDIFGR LSSWCLKKPG HVAEVYLVHL HASVYALFHR LYGMYPCNFV
210 220 230 240 250
SFLRSHYSMK ENLETFEEVV KPMMEHVRIH PELVTGSKDH ELDPRRWKRL
260 270 280 290 300
ETHDVVIECA KISLDPTEAS YEDGYSVSHQ ISARFPHRSA DVTTSPYADT
310 320 330 340 350
QNSYGCATST PYSTSRLMLL NMPGQLPQTL SSPSTRLITE PPQVWCQLVC
360
LLSPLLSGEA DPLGQI
Length:366
Mass (Da):41,155
Last modified:June 1, 2003 - v1
Checksum:i9DBE1D9A25B83618
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445645 Genomic DNA. No translation available.
BC047772 mRNA. Translation: AAH47772.1.
BC070032 mRNA. Translation: AAH70032.1.
RefSeqiNP_000359.1. NM_000368.4.
UniGeneiHs.370854.

Genome annotation databases

EnsembliENST00000403810; ENSP00000386093; ENSG00000165699.
GeneIDi7248.
KEGGihsa:7248.
UCSCiuc004cce.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445645 Genomic DNA. No translation available.
BC047772 mRNA. Translation: AAH47772.1.
BC070032 mRNA. Translation: AAH70032.1.
RefSeqiNP_000359.1. NM_000368.4.
UniGeneiHs.370854.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000298552.

Protocols and materials databases

DNASUi7248.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000403810; ENSP00000386093; ENSG00000165699.
GeneIDi7248.
KEGGihsa:7248.
UCSCiuc004cce.2. human.

Organism-specific databases

CTDi7248.
HGNCiHGNC:12362. TSC1.
OpenTargetsiENSG00000165699.
PharmGKBiPA37034.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG36. Eukaryota.
ENOG411020J. LUCA.
GeneTreeiENSGT00390000014148.
HOVERGENiHBG054903.
KOiK07206.

Miscellaneous databases

ChiTaRSiTSC1. human.
GenomeRNAii7248.

Gene expression databases

BgeeiENSG00000165699.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007483. Hamartin.
[Graphical view]
PANTHERiPTHR15154. PTHR15154. 1 hit.
PfamiPF04388. Hamartin. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ86WV8_HUMAN
AccessioniPrimary (citable) accession number: Q86WV8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.